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https://www.readbyqxmd.com/read/28208060/rna-toxicity-and-foci-formation-in-microsatellite-expansion-diseases
#1
REVIEW
Nan Zhang, Tetsuo Ashizawa
More than 30 incurable neurological and neuromuscular diseases are caused by simple microsatellite expansions consisted of 3-6 nucleotides. These repeats can occur in non-coding regions and often result in a dominantly inherited disease phenotype that is characteristic of a toxic RNA gain-of-function. The expanded RNA adopts unusual secondary structures, sequesters various RNA binding proteins to form insoluble nuclear foci, and causes cellular defects at a multisystem level. Nuclear foci are dynamic in size, shape and colocalization of RNA binding proteins in different expansion diseases and tissue types...
February 13, 2017: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/28207399/motor-unit-potential-jitter-a-new-measure-of-neuromuscular-transmission-instability
#2
Meena AbdelMaseeh, Daniel Stashuk
OBJECTIVE: A new measure of neuromuscular transmission instability, motor unit potential (MUP) jitter, is introduced. MUP jitter can be estimated quickly using motor unit potential trains (MUPTs) extracted from electromyographic (EMG) signals acquired using conventional clinical equipment and needle EMG electrodiagnostic protocols. The primary motivation for developing MUP jitter is to avoid the technical demands associated with estimating jitter using conventional single fibre EMG techniques...
February 9, 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28198601/the-effect-of-high-speed-strength-training-with-heavy-and-low-workloads-on-neuromuscular-function-and-maximal-concentric-quadriceps-strength
#3
Ali A Mazani, Mohamed R Hamdinia, Amir H Haghigi, Nosratollah Hedayatpour
BACKGROUND: Dynamic strength training has been widely used to increase the ability of skeletal muscle to produce muscle force. Manipulating resistance training program variables has been commonly used as a tool to optimize maximum strength. This study examined the effects of 12 weeks of high-speed strength training with low and heavy workloads on muscle strength and neuromuscular function of quadriceps muscle. METHODS: Thirty male subjects (age, mean ± SD, 20.6 ± 2...
February 14, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28192831/training-effects-of-the-fifa-11-and-harmoknee-on-several-neuromuscular-parameters-of-physical-performance-measures
#4
Francisco Ayala, Carlos Pomares-Noguera, Francisco Javier Robles-Palazón, Maria Del Pilar García-Vaquero, Ignacio Ruiz-Pérez, Sergio Hernández-Sánchez, Mark De Ste Croix
The main purpose of this study was to analyse the training effects of the FIFA 11+ and Harmoknee on several parameters of physical performance measures in youth amateur football players. 41 adolescent players were randomised within each team into 2 groups (team 1: control vs. FIFA 11+; team 2: control vs. Harmoknee). The FIFA 11+ and Harmoknee groups performed the program 3 times a week for 4 weeks; the control groups completed their usual warm-up routines. 13 physical performance measures (joint range of motion, dynamic postural control, single legged hop limb symmetry, sprint time, jumping height and agility) were assessed...
February 13, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28191352/hybrid-assistive-neuromuscular-dynamic-stimulation-therapy-a-new-strategy-for-improving-upper-extremity-function-in-patients-with-hemiparesis-following-stroke
#5
REVIEW
Toshiyuki Fujiwara, Michiyuki Kawakami, Kaoru Honaga, Michi Tochikura, Kaoru Abe
Hybrid Assistive Neuromuscular Dynamic Stimulation (HANDS) therapy is one of the neurorehabilitation therapeutic approaches that facilitates the use of the paretic upper extremity (UE) in daily life by combining closed-loop electromyography- (EMG-) controlled neuromuscular electrical stimulation (NMES) with a wrist-hand splint. This closed-loop EMG-controlled NMES can change its stimulation intensity in direct proportion to the changes in voluntary generated EMG amplitudes recorded with surface electrodes placed on the target muscle...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28173788/real-time-optimized-biofeedback-utilizing-sport-techniques-robust-a-study-protocol-for-a-randomized-controlled-trial
#6
Jeffrey B Taylor, Anh-Dung Nguyen, Mark V Paterno, Bin Huang, Kevin R Ford
BACKGROUND: Anterior cruciate ligament (ACL) injuries in female athletes lead to a variety of short- and long-term physical, financial, and psychosocial ramifications. While dedicated injury prevention training programs have shown promise, ACL injury rates remain high as implementation has not become widespread. Conventional prevention programs use a combination of resistance, plyometric, balance and agility training to improve high-risk biomechanics and reduce the risk of injury. While many of these programs focus on reducing knee abduction load and posture during dynamic activity, targeting hip extensor strength and utilization may be more efficacious, as it is theorized to be an underlying mechanism of injury in adolescent female athletes...
February 7, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28154888/permanent-knee-sensorimotor-system-changes-following-acl-injury-and-surgery
#7
John Nyland, Collin Gamble, Tiffany Franklin, David N M Caborn
The cruciate ligaments are components of the knee capsuloligamentous system providing vital neurosensory and biomechanical function. Since most historical primary ACL repair attempts were unsuccessful, reconstruction has become the preferred surgery. However, an increased understanding of the efficacy of lesion-site scaffolding, innovative suturing methods and materials, and evolving use of biological healing mediators such as platelet-rich plasma and stem cells has prompted reconsideration of what was once believed to be impossible...
February 2, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28144405/the-impact-of-kitesurfing-on-the-dynamic-equilibrium
#8
Rafael Leonardo Ferreira da Luz, Fernando Alves da Silva, Marcelo Coertjens
BACKGROUND: The kitesurfing athletes endure unexpected conditions in terms of the function of irregularities in the surface of the water that requires a correct proprioceptive response in order to maintain equilibrium and execute the required movements while maintaining contact with the board and the water. OBJECTIVES: The objective of this work was to use the star excursion balance test to compare the dynamic equilibrium of athletes who engage in kitesurfing activities with non-athletic subjects...
December 2016: Asian Journal of Sports Medicine
https://www.readbyqxmd.com/read/28141512/sonomyography-analysis-on-thickness-of-skeletal-muscle-during-dynamic-contraction-induced-by-neuromuscular-electrical-stimulation-a-pilot-study
#9
Shuang Qiu, Jing Feng, Jiapeng Xu, Rui Xu, Xin Zhao, Peng Zhou, Hongzhi Qi, Lixin Zhang, Dong Ming
Neuromuscular electrical stimulation (NMES) that stimulates skeletal muscles to induce contractions has been widely applied to restore functions of paralyzed muscles. However, the architectural changes of stimulated muscles induced by NMES are still not well understood. The present study applies sonomyography (SMG) to evaluate muscle architecture under NMES-induced and voluntary movements. The quadriceps muscles of seven healthy subjects were tested for eight cycles during an extension exercise of the knee joint with/without NMES, and SMG and the knee joint angle were recorded during the process of knee extension...
January 2017: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28130447/pseudouridine-modification-inhibits-muscleblind-like-1-mbnl1-binding-to-ccug-repeats-and-minimally-structured-rna-through-reduced-rna-flexibility
#10
Elaine deLorimier, Melissa N Hinman, Jeremy Copperman, Kausiki Datta, Marina Guenza, J Andrew Berglund
Myotonic dystrophy type 2 is a genetic neuromuscular disease caused by the expression of expanded CCUG-repeat RNAs from the non-coding region of the CCHC-Type Zinc Finger Nucleic Acid Binding Protein (CNBP) gene. These CCUG repeats bind and sequester a family of RNA binding proteins known as Muscleblind-like 1, 2, and 3 (MBNL1, MBNL2, and MBNL3), and sequestration plays a significant role in pathogenicity. MBNL proteins are alternative splicing regulators that bind to the consensus RNA sequence YGCY (Y = pyrimidine)...
January 27, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28119879/influence-of-the-proprioceptive-neuromuscular-facilitation-exercise-programs-on-idiopathic-scoliosis-patient-in-the-early-20s-in-terms-of-curves-and-balancing-abilities-single-case-study
#11
Byung-Ki Lee
The purpose of this study was to determine the influence of the proprioceptive neuromuscular facilitation (PNF) exercise programs for idiopathic scoliosis with a female patient in the early 20s in terms of her spinal curve and balancing abilities. The study subject was selected among 21-year-old female college students. There were no particular activities that the subject could not perform, but patient complained of difficulty in maintaining the standing position for a prolonged time. Patient chest X-ray results showed S-shaped curves tilted towards the left or right in the lumbar spine, thoracic spine, and cervical spine areas...
December 2016: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/28114303/mfn1-structures-reveal-nucleotide-triggered-dimerization-critical-for-mitochondrial-fusion
#12
Yu-Lu Cao, Shuxia Meng, Yang Chen, Jian-Xiong Feng, Dong-Dong Gu, Bing Yu, Yu-Jie Li, Jin-Yu Yang, Shuang Liao, David C Chan, Song Gao
Mitochondria are double-membraned organelles with variable shapes influenced by metabolic conditions, developmental stage, and environmental stimuli. Their dynamic morphology is a result of regulated and balanced fusion and fission processes. Fusion is crucial for the health and physiological functions of mitochondria, including complementation of damaged mitochondrial DNAs and the maintenance of membrane potential. Mitofusins are dynamin-related GTPases that are essential for mitochondrial fusion. They are embedded in the mitochondrial outer membrane and thought to fuse adjacent mitochondria via combined oligomerization and GTP hydrolysis...
February 16, 2017: Nature
https://www.readbyqxmd.com/read/28113692/admittance-adaptive-model-based-approach-to-mitigate-biodynamic-feedthrough
#13
Joost Venrooij, Max Mulder, Mark Mulder, David A Abbink, Marinus M van Paassen, Frans C T van der Helm, Heinrich H Bulthoff
Biodynamic feedthrough (BDFT) refers to the feedthrough of vehicle accelerations through the human body, leading to involuntary control device inputs. BDFT impairs control performance in a large range of vehicles under various circumstances. Research shows that BDFT strongly depends on adaptations in the neuromuscular admittance dynamics of the human body. This paper proposes a model-based approach of BDFT mitigation that accounts for these neuromuscular adaptations. The method was tested, as proof-of-concept, in an experiment where participants inside a motion simulator controlled a simulated vehicle through a virtual tunnel...
September 12, 2016: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28113401/an-emg-to-force-processing-approach-for-estimating-in-vivo-hip-muscle-forces-in-normal-human-walking
#14
Ross A Bogey, Lee A Barnes
The force of a single muscle is not directly measurable without invasive methods. Yet invasive techniques are not appropriate for clinical use, thus a non-invasive technique that combined the electromyographic (EMG) signal and a neuromuscular model was developed to determine in vivo active muscle forces at the hip. The EMG-to-force processing (EFP) model included active and passive moment components, and the net EFP moment was compared with the hip moment obtained with standard inverse dynamics techniques ("gold standard")...
October 12, 2016: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/28113221/a-subspace-approach-to-the-structural-decomposition-and-identification-of-ankle-joint-dynamic-stiffness
#15
Seyed Kian Jalaleddini, Ehsan Sobhani Tehrani, Robert Kearney
OBJECTIVE: The purpose of this paper is to present a Structural Decomposition SubSpace (SDSS) method for decomposition of the joint torque to intrinsic, reflexive and voluntary torques and identification of joint dynamic stiffness. METHODS: Firstly, it formulates a novel state-space representation for the joint dynamic stiffness modelled by a parallel-cascade structure with a concise parameter set that provides a direct link between the state-space representation matrices and the parallel-cascade parameters...
August 31, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28113200/design-and-characterization-of-an-exoskeleton-for-perturbing-the-knee-during-gait
#16
Michael R Tucker, Camila Shirota, Olivier Lambercy, James Sulzer, Roger Gassert
OBJECTIVE: An improved understanding of mechanical impedance modulation in human joints would provide insights about the neuromechanics underlying functional movements. Experimental estimation of impedance requires specialized tools with highly reproducible perturbation dynamics and reliable measurement capabilities. This paper presents the design and mechanical characterization of the ETH Knee Perturbator: an actuated exoskeleton for perturbing the knee during gait. METHODS: A novel wearable perturbation device was developed based on specific experimental objectives...
January 20, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28087330/molecular-characterization-and-functional-analysis-of-a-salmon-louse-lepeophtheirus-salmonis-kr%C3%A3-yer-1838-heme-peroxidase-with-a-potential-role-in-extracellular-matrixes
#17
Aina-Cathrine Øvergård, Christiane Eichner, Frank Nilsen, Sussie Dalvin
Heme peroxidases are the most abundant type of peroxidase catalyzing a H2O2-dependent oxidation of a wide variety of substrates. They are involved in numerous processes like the innate immune response, hormone and prostaglandin synthesis and crosslinking of proteins within extracellular matrixes (ECM) as well as molecules within the cuticle and chorion of arthropods and nematodes. In the present study, a Lepeophtheirus salmonis heme peroxidase (LsHPX) 1 was characterized. Amino acids in the active site of heme peroxidases were conserved, and the predicted protein sequence showed the highest similarity to genes annotated as chorion peroxidases and genes suggested to be involved in cuticle hardening or adhesion...
January 11, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28065847/a-drosophila-model-of-gdap1-function-reveals-the-involvement-of-insulin-signalling-in-the-mitochondria-dependent-neuromuscular-degeneration
#18
Víctor López Del Amo, Martina Palomino-Schätzlein, Marta Seco-Cervera, José Luis García-Giménez, Federico Vicente Pallardó, Antonio Pineda-Lucena, Máximo Ibo Galindo
Charcot-Marie-Tooth disease is a rare peripheral neuropathy for which there is no specific treatment. Some forms of Charcot-Marie-Tooth are due to mutations in the GDAP1 gene. A striking feature of mutations in GDAP1 is that they have a variable clinical manifestation, according to disease onset and progression, histology and mode of inheritance. Studies in cellular and animal models have revealed a role of GDAP1 in mitochondrial morphology and distribution, calcium homeostasis and oxidative stress. To get a better understanding of the disease mechanism we have generated models of over-expression and RNA interference of the Drosophila Gdap1 gene...
January 6, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28060927/acute-effects-of-three-neuromuscular-warm-up-strategies-on-several-physical-performance-measures-in-football-players
#19
Francisco Ayala, Ana Calderón-López, Juan Carlos Delgado-Gosálbez, Sergio Parra-Sánchez, Carlos Pomares-Noguera, Sergio Hernández-Sánchez, Alejandro López-Valenciano, Mark De Ste Croix
No studies have analysed the acute effects of the FIFA 11+ and Harmoknee warm-up programmes on major physical performance measures. The aim of this study was to analyse the acute (post-exercise) effects of the FIFA 11+, Harmoknee and dynamic warm-up routines on several physical performance measures in amateur football players. A randomized, crossover and counterbalanced study design was used to address the purpose of this study. A total of sixteen amateur football players completed the following protocols in a randomized order on separate days: a) FIFA 11+; b) Harmoknee; and c) dynamic warm-up (DWU)...
2017: PloS One
https://www.readbyqxmd.com/read/28039397/physical-exercise-in-aging-human-skeletal-muscle-increases-mitochondrial-calcium-uniporter-expression-levels-and-affects-mitochondria-dynamics
#20
Sandra Zampieri, Cristina Mammucari, Vanina Romanello, Laura Barberi, Laura Pietrangelo, Aurora Fusella, Simone Mosole, Gaia Gherardi, Christian Höfer, Stefan Löfler, Nejc Sarabon, Jan Cvecka, Matthias Krenn, Ugo Carraro, Helmut Kern, Feliciano Protasi, Antonio Musarò, Marco Sandri, Rosario Rizzuto
Age-related sarcopenia is characterized by a progressive loss of muscle mass with decline in specific force, having dramatic consequences on mobility and quality of life in seniors. The etiology of sarcopenia is multifactorial and underlying mechanisms are currently not fully elucidated. Physical exercise is known to have beneficial effects on muscle trophism and force production. Alterations of mitochondrial Ca(2+) homeostasis regulated by mitochondrial calcium uniporter (MCU) have been recently shown to affect muscle trophism in vivo in mice...
December 2016: Physiological Reports
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