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https://www.readbyqxmd.com/read/29144536/isolation-and-whole-genome-sequencing-of-fetal-cells-from-maternal-blood-towards-the-ultimate-non-invasive-prenatal-testing
#1
Fang Chen, Ping Liu, Ying Gu, Zhu Zhu, Amulya Nanisetti, Zhangzhang Lan, Zhiwei Huang, Sophie Jia Liu, Xiongbin Kang, Yuqing Deng, Liqiong Luo, Dan Jiang, Yong Qiu, Jianchang Pan, Jun Xia, Ken Xiong, Chao Liu, Lin Xie, Qianyu Shi, Jing Li, Xiuqing Zhang, Wei Wang, Snezana Drmanac, Hui Jiang, Radoje Drmanac, Xun Xu
OBJECTIVE: To develop a methodology of isolating fetal cells from maternal blood and use deep sequencing demonstrating the promise for more complete and accurate genetic screening compared to other non-invasive prenatal testing (NIPT). METHODS: Here in this study, we developed a double negative selection (DNS) procedure to unbiasedly enrich fetal cells. After validated by short tandem repeat (STR), the isolated CFCs were subjected to deep whole genome sequencing analysis (WGS)...
November 16, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29142401/phytochemical-compositions-and-in-vitro-assessments-of-antioxidant-and-antidiabetic-potentials-of-fractions-from-ehretia-cymosa-thonn
#2
Akintayo Ogundajo, Anofi Tom Ashafa
Background: Ehretia cymosa Thonn. is a popular medicinal plant used in different parts of West Africa for the treatment of various ailments including diabetes mellitus. Objective: The current study investigates bioactive constituents and in vitro antioxidant and antidiabetic potentials of fractions from extract of E. cymosa. Materials and Methods: Phytochemical investigation and antioxidant assays were carried out using standard procedures...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29134097/the-optimization-of-fermentation-conditions-for%C3%A2-producing-cellulase-of-bacillus-amyloliquefaciens-and-its-application-to-goose%C3%A2-feed
#3
Miao Ye, Linghong Sun, Ru Yang, Zaigui Wang, KeZong Qi
The proper culture conditions for producing cellulase of Bacillus amyloliquefaciens S1, isolated from the cecum of goose was optimized by single-factor experiment combined with orthogonal test. The properties of the cellulase were investigated by DNS method. The appropriate doses of B. amyloliquefaciens S1 were obtained by adding them to goose feed. It indicated that the suitable culture conditions of producing cellulase were the culture temperature of 37°C, the initial pH of 7.0, the incubation time of 72 h and the loaded liquid volume of 75 ml per 250 ml...
October 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29131370/mental-ill-health-among-adult-patients-at-healthcare-centres-in-sweden-district-nurses-experiences
#4
Ann-Christin Janlöv, Linda Johansson, Eva K Clausson
BACKGROUND: Mental ill-health among the general population is increasing in Sweden. Primary Health Care (PHC) and Healthcare Centres (HCC), where district nurses (DNs) work, bear the basic responsibility for treatment of mental ill-health, while severe mental ill-health fall under the responsibility of psychiatric specialist care. The increased prevalence of mental ill-health in the community means that DNs increasingly encounter people with mental health problems - not least as a comorbidity...
November 13, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/29110098/do-hydrodynamically-assisted-binary-collisions-lead-to-orientational-ordering-of-microswimmers
#5
Norihiro Oyama, John Jairo Molina, Ryoichi Yamamoto
We have investigated the onset of collective motion in systems of model microswimmers, by performing a comprehensive analysis of the binary collision dynamics using three-dimensional direct numerical simulations (DNS) with hydrodynamic interactions. From this data, we have constructed a simplified binary collision model (BCM) which accurately reproduces the collective behavior obtained from the DNS for most cases. Thus, we show that global alignment can mostly arise solely from binary collisions. Although the agreement between both models (DNS and BCM) is not perfect, the parameter range in which notable differences appear is also that for which strong density fluctuations are present in the system (where pseudo-sound mound can be observed (N...
November 8, 2017: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/29104418/direct-numerical-simulation-of-turbulent-boundary-layer-with-fully-resolved-particles-at-low-volume-fraction
#6
Kun Luo, Chenshu Hu, Fan Wu, Jianren Fan
In the present work, a direct numerical simulation (DNS) of dilute particulate flow in a turbulent boundary layer has been conducted, containing thousands of finite-sized solid rigid particles. The particle surfaces are resolved with the multi-direct forcing immersed-boundary method. This is, to the best of the authors' knowledge, the first DNS study of a turbulent boundary layer laden with finite-sized particles. The particles have a diameter of approximately 11.3 wall units, a density of 3.3 times that of the fluid, and a solid volume fraction of 1/1000...
May 2017: Physics of Fluids
https://www.readbyqxmd.com/read/29016380/comparison-of-del-nido-cardioplegia-with-blood-cardioplegia-in-adult-combined-surgery
#7
Raphael Hamad, Anthony Nguyen, Éric Laliberté, Denis Bouchard, Yoan Lamarche, Ismail El-Hamamsy, Philippe Demers
OBJECTIVE: del Nido solution (DNS) is a single-dose cardioplegia designed for pediatric use proposed to offer superior myocardial protection in adults. However, few data support this claim. We hypothesized that DNS and modified blood cardioplegia solution (BS) provide equivalent safety in combined adult valve surgery. METHODS: Between November 2014 and December 2015, 25 patients underwent primary aortic valve replacement and concomitant coronary artery bypass grafting (CABG) with DNS...
September 2017: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
https://www.readbyqxmd.com/read/28989871/prevalence-and-risk-factors-for-peripheral-neuropathy-among-type-2-diabetes-mellitus-patients-at-a-tertiary-care-hospital-in-coastal-karnataka
#8
Sonalika Gogia, Chythra R Rao
CONTEXT AND OBJECTIVE: In view of the growing burden of type 2 diabetes mellitus (T2DM) globally and associated microvascular and macrovascular complications, the study was done to assess the prevalence and risk factors for diabetic neuropathy among T2DM patients attending a tertiary care hospital. SUBJECTS AND METHODS: T2DM patients' ≥30 years of both gender, presenting to the Medicine Department at a tertiary care hospital were included in the study. Diabetic Neuropathy Symptom (DNS) questionnaire to assess symptoms and Diabetic Neuropathy Examination (DNE) scoring to assess clinical signs were used...
September 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28950509/statistics-of-velocity-and-temperature-fluctuations-in-two-dimensional-rayleigh-b%C3%A3-nard-convection
#9
Yang Zhang, Yong-Xiang Huang, Nan Jiang, Yu-Lu Liu, Zhi-Ming Lu, Xiang Qiu, Quan Zhou
We investigate fluctuations of the velocity and temperature fields in two-dimensional (2D) Rayleigh-Bénard (RB) convection by means of direct numerical simulations (DNS) over the Rayleigh number range 10^{6}≤Ra≤10^{10} and for a fixed Prandtl number Pr=5.3 and aspect ratio Γ=1. Our results show that there exists a counter-gradient turbulent transport of energy from fluctuations to the mean flow both locally and globally, implying that the Reynolds stress is one of the driving mechanisms of the large-scale circulation in 2D turbulent RB convection besides the buoyancy of thermal plumes...
August 2017: Physical Review. E
https://www.readbyqxmd.com/read/28939041/identification-of-transketolase-as-a-target-of-paris-in-substantia-nigra
#10
Hyein Kim, Hojin Kang, Yunjong Lee, Chi-Hu Park, Areum Jo, Rin Khang, Joo-Ho Shin
Recently, PARIS (ZNF746) is introduced as authentic substrate of parkin and transcriptionally represses PGC-1α by binding to insulin responsive sequences (IRSs) in the promoter of PGC-1α. The overexpression of PARIS selectively leads to the loss of dopaminergic neurons (DN) and mitochondrial abnormalities in the substantia nigra (SN) of Parkinson's disease (PD) models. To identify PARIS target molecules altered in SN region-specific manner, LC-MS/MS-based quantitative proteomic analysis is employed to investigate proteomic alteration in the cortex, striatum, and SN of AAV-PARIS injected mice...
November 18, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28893392/computational-modeling-and-validation-of-human-nasal-airflow-under-various-breathing-conditions
#11
Chengyu Li, Jianbo Jiang, Haibo Dong, Kai Zhao
The human nose serves vital physiological functions, including warming, filtration, humidification, and olfaction. These functions are based on transport phenomena that depend on nasal airflow patterns and turbulence. Accurate prediction of these airflow properties requires careful selection of computational fluid dynamics models and rigorous validation. The validation studies in the past have been limited by poor representations of the complex nasal geometry, lack of detailed airflow comparisons, and restricted ranges of flow rate...
November 7, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28880907/comparison-of-electrochemical-skin-conductance-and-vibration-perception-threshold-measurement-in-the-detection-of-early-diabetic-neuropathy
#12
COMPARATIVE STUDY
Amit Goel, Channabasappa Shivaprasad, Anish Kolly, Vijaya Sarathi H A, Sridevi Atluri
The early diagnosis of diabetic peripheral neuropathy (DPN) is challenging. Sudomotor dysfunction is one of the earliest detectable abnormalities in DPN. The present study aimed to determine the diagnostic performance of the electrochemical skin conductance (ESC) test in detecting early DPN, compared with the vibration perception threshold (VPT) test and diabetic neuropathy symptom (DNS) score, using the modified neuropathy disability score (NDS) as the reference standard. Five hundred and twenty-three patients with type 2 diabetes underwent an NDS-based clinical assessment for neuropathy...
2017: PloS One
https://www.readbyqxmd.com/read/28877763/alzheimer-s-disease-pathological-lesions-activate-the-spleen-tyrosine-kinase
#13
Jonas Elias Schweig, Hailan Yao, David Beaulieu-Abdelahad, Ghania Ait-Ghezala, Benoit Mouzon, Fiona Crawford, Michael Mullan, Daniel Paris
The pathology of Alzheimer's disease (AD) is characterized by dystrophic neurites (DNs) surrounding extracellular Aβ-plaques, microgliosis, astrogliosis, intraneuronal tau hyperphosphorylation and aggregation. We have previously shown that inhibition of the spleen tyrosine kinase (Syk) lowers Aβ production and tau hyperphosphorylation in vitro and in vivo. Here, we demonstrate that Aβ-overexpressing Tg PS1/APPsw, Tg APPsw mice, and tau overexpressing Tg Tau P301S mice exhibit a pathological activation of Syk compared to wild-type littermates...
September 6, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/28872646/the-impact-of-ionic-liquids-on-the-coordination-of-anions-with-solvatochromic-copper-complexes
#14
O Kuzmina, N H Hassan, L Patel, C Ashworth, E Bakis, A J P White, P A Hunt, T Welton
Solvatochromic transition metal (TM)-complexes with weakly associating counter-anions are often used to evaluate traditional neutral solvent and anion coordination ability. However, when employed in ionic liquids (IL) many of the common assumptions made are no longer reliable. This study investigates the coordinating ability of weakly coordinating IL anions in traditional solvents and within IL solvents employing a range of solvatochromic copper complexes. Complexes of the form [Cu(acac)(tmen)][X] (acac = acetylacetonate, tmen = tetramethylethylenediamine) where [X](-) = [ClO4](-), Cl(-), [NO3](-), [SCN](-), [OTf](-), [NTf2](-) and [PF6](-) have been synthesised and characterised both experimentally and computationally...
September 28, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28860907/endoscopic-intranasal-findings-in-unilateral-primary-acquired-nasolacrimal-duct-obstruction
#15
Swati Singh, Mohammad Shahid Alam, Mohammad Javed Ali, Milind N Naik
PURPOSE: To evaluate intranasal endoscopic findings in patients with unilateral primary acquired nasolacrimal duct obstruction and compare them with the normal cohort. METHODS: A prospective case-control study with 50 unilateral primary acquired nasolacrimal duct obstruction (PANDO) and 50 healthy controls. All patients were evaluated by endoscopic nasal examination for the presence of deviated nasal septum (DNS), type of deviation (bony or cartilaginous), side of deviation, septal spurs, caudal dislocation, any turbinate hypertrophy and endoscopic features suggestive of sinusitis...
July 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28843658/trunk-events-present-minimal-intra-and-inter-tumoral-heterogeneity-in-hepatocellular-carcinoma
#16
Sara Torrecilla, Daniela Sia, Andrew N Harrington, Zhongyang Zhang, Laia Cabellos, Helena Cornella, Agrin Moeini, Genis Camprecios, Wei-Qiang Leow, Maria Isabel Fiel, Ke Hao, Laia Bassaganyas, Milind Mahajan, Swan N Thung, Augusto Villanueva, Sander Florman, Myron E Schwartz, Josep M Llovet
BACKGROUND AND AIMS: According to the clonal model of tumor evolution, trunk alterations arise at early stages and are ubiquitous. Through the characterization of early stages of hepatocarcinogenesis, we aimed to identify trunk alterations in HCC and study their intra- and inter-tumor distribution in advanced lesions. METHODS: 151 samples representing the multi-step process of hepatocarcinogenesis were analyzed by targeted-sequencing and SNP array. Genes altered in early lesions [31 dysplastic nodules (DNs) and 38 small HCCs (sHCC)] were defined as trunk...
August 23, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28828764/randomized-controlled-trial-of-topical-insulin-for-healing-corneal-epithelial-defects-induced-during-vitreoretinal-surgery-in-diabetics
#17
Seng Fai, Amin Ahem, Mushawiathi Mustapha, Umi Kalthum Mohd Noh, Mae-Lynn Catherine Bastion
PURPOSE: To determine the effect of topical insulin of 3 concentrations [0.5, 1, and 2 units per drop 4 times per day (QID)] on postoperative corneal epithelial wound healing in diabetic patients. DESIGN: A double blind randomized controlled hospital-based study involving diabetic patients with postoperative corneal epithelial defect after vitreoretinal surgery. METHODS: Diabetic patients were randomized to 3 different concentrations of topical insulin (DTI 0...
August 22, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28812367/the-usefulness-of-diffusion-weighted-magnetic-resonance-imaging-performed-in-the-acute-phase-as-an-early-predictor-of-delayed-neuropsychiatric-sequelae-in-acute-carbon-monoxide-poisoning
#18
Y S Kim, Y S Cha, M S Kim, H J Kim, Y S Lee, H Youk, H I Kim, O H Kim, K-C Cha, H Kim, K H Lee, S O Hwang
Delayed onset of neuropsychiatric symptoms after apparent recovery from acute carbon monoxide (CO) poisoning has been described as delayed neuropsychiatric sequelae (DNS). No previous study has determined whether early use of diffusion-weighted magnetic resonance imaging (DWI) can predict which patients will develop DNS in the acute CO poisoning. This retrospective observational study was performed on adult patients with acute CO poisoning consecutively treated over a 17-month period. All included patients with acute CO poisoning underwent DWI to evaluate brain injury within 72 h after CO exposure...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28808401/in-vitro-%C3%AE-amylase-and-%C3%AE-glucosidase-inhibitory-and-cytotoxic-activities-of-extracts-from-cissus-cornifolia-planch-parts
#19
Talent Chipiti, Mohammed Auwal Ibrahim, Moganavelli Singh, Md Shahidul Islam
CONTEXT: Hyperglycemia is the hallmark of type 2 diabetes mellitus, and its prevention will go a long way in managing the disease and its associated complications. Reduction of postprandial hyperglycemia through retarding carbohydrates digesting enzymes is one of the major therapeutic approaches used in the management of diabetes. OBJECTIVE: The aim of the present study was to investigate the antidiabetic and cytotoxic effects of Cissus cornifolia extracts in vitro...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28801394/the-role-of-nurse-specialists-in-the-delivery-of-integrated-diabetes-care-a-cross-sectional-survey-of-diabetes-nurse-specialist-services
#20
Fiona Riordan, Sheena M McHugh, Katie Murphy, Julie Barrett, Patricia M Kearney
OBJECTIVES: International evidence suggests the diabetes nurse specialist (DNS) has a key role in supporting integrated management of diabetes. We examine whether hospital and community DNS currently support the integration of care, examine regional variation in aspects of the service relevant to the delivery of integrated care and identify barriers to service delivery and areas for improvement. DESIGN: A cross-sectional survey of hospital and community-based DNS in Ireland...
August 11, 2017: BMJ Open
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