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https://www.readbyqxmd.com/read/28893392/computational-modeling-and-validation-of-human-nasal-airflow-under-various-breathing-conditions
#1
Chengyu Li, Jianbo Jiang, Haibo Dong, Kai Zhao
The human nose serves vital physiological functions, including warming, filtration, humidification, and olfaction. These functions are based on transport phenomena that depend on nasal airflow patterns and turbulence. Accurate prediction of these airflow properties requires careful selection of computational fluid dynamics models and rigorous validation. The validation studies in the past have been limited by poor representations of the complex nasal geometry, lack of detailed airflow comparisons, and restricted ranges of flow rate...
September 5, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28880907/comparison-of-electrochemical-skin-conductance-and-vibration-perception-threshold-measurement-in-the-detection-of-early-diabetic-neuropathy
#2
Amit Goel, Channabasappa Shivaprasad, Anish Kolly, Vijaya Sarathi H A, Sridevi Atluri
The early diagnosis of diabetic peripheral neuropathy (DPN) is challenging. Sudomotor dysfunction is one of the earliest detectable abnormalities in DPN. The present study aimed to determine the diagnostic performance of the electrochemical skin conductance (ESC) test in detecting early DPN, compared with the vibration perception threshold (VPT) test and diabetic neuropathy symptom (DNS) score, using the modified neuropathy disability score (NDS) as the reference standard. Five hundred and twenty-three patients with type 2 diabetes underwent an NDS-based clinical assessment for neuropathy...
2017: PloS One
https://www.readbyqxmd.com/read/28877763/alzheimer-s-disease-pathological-lesions-activate-the-spleen-tyrosine-kinase
#3
Jonas Elias Schweig, Hailan Yao, David Beaulieu-Abdelahad, Ghania Ait-Ghezala, Benoit Mouzon, Fiona Crawford, Michael Mullan, Daniel Paris
The pathology of Alzheimer's disease (AD) is characterized by dystrophic neurites (DNs) surrounding extracellular Aβ-plaques, microgliosis, astrogliosis, intraneuronal tau hyperphosphorylation and aggregation. We have previously shown that inhibition of the spleen tyrosine kinase (Syk) lowers Aβ production and tau hyperphosphorylation in vitro and in vivo. Here, we demonstrate that Aβ-overexpressing Tg PS1/APPsw, Tg APPsw mice, and tau overexpressing Tg Tau P301S mice exhibit a pathological activation of Syk compared to wild-type littermates...
September 6, 2017: Acta Neuropathologica Communications
https://www.readbyqxmd.com/read/28872646/the-impact-of-ionic-liquids-on-the-coordination-of-anions-with-solvatochromic-copper-complexes
#4
O Kuzmina, N H Hassan, L Patel, C Ashworth, E Bakis, A J P White, P A Hunt, T Welton
Solvatochromic transition metal (TM)-complexes with weakly associating counter-anions are often used to evaluate traditional neutral solvent and anion coordination ability. However, when employed in ionic liquids (IL) many of the common assumptions made are no longer reliable. This study investigates the coordinating ability of weakly coordinating IL anions in traditional solvents and within IL solvents employing a range of solvatochromic copper complexes. Complexes of the form [Cu(acac)(tmen)][X] (acac = acetylacetonate, tmen = tetramethylethylenediamine) where [X](-) = [ClO4](-), Cl(-), [NO3](-), [SCN](-), [OTf](-), [NTf2](-) and [PF6](-) have been synthesised and characterised both experimentally and computationally...
September 28, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28860907/endoscopic-intranasal-findings-in-unilateral-primary-acquired-nasolacrimal-duct-obstruction
#5
Swati Singh, Mohammad Shahid Alam, Mohammad Javed Ali, Milind N Naik
PURPOSE: To evaluate intranasal endoscopic findings in patients with unilateral primary acquired nasolacrimal duct obstruction and compare them with the normal cohort. METHODS: A prospective case-control study with 50 unilateral primary acquired nasolacrimal duct obstruction (PANDO) and 50 healthy controls. All patients were evaluated by endoscopic nasal examination for the presence of deviated nasal septum (DNS), type of deviation (bony or cartilaginous), side of deviation, septal spurs, caudal dislocation, any turbinate hypertrophy and endoscopic features suggestive of sinusitis...
July 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28843658/trunk-events-present-minimal-intra-and-inter-tumoral-heterogeneity-in-hepatocellular-carcinoma
#6
Sara Torrecilla, Daniela Sia, Andrew N Harrington, Zhongyang Zhang, Laia Cabellos, Helena Cornella, Agrin Moeini, Genis Camprecios, Wei-Qiang Leow, Maria Isabel Fiel, Ke Hao, Laia Bassaganyas, Milind Mahajan, Swan N Thung, Augusto Villanueva, Sander Florman, Myron E Schwartz, Josep M Llovet
BACKGROUND AND AIMS: According to the clonal model of tumor evolution, trunk alterations arise at early stages and are ubiquitous. Through the characterization of early stages of hepatocarcinogenesis, we aimed to identify trunk alterations in HCC and study their intra- and inter-tumor distribution in advanced lesions. METHODS: 151 samples representing the multi-step process of hepatocarcinogenesis were analyzed by targeted-sequencing and SNP array. Genes altered in early lesions [31 dysplastic nodules (DNs) and 38 small HCCs (sHCC)] were defined as trunk...
August 23, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28828764/randomized-controlled-trial-of-topical-insulin-for-healing-corneal-epithelial-defects-induced-during-vitreoretinal-surgery-in-diabetics
#7
Seng Fai, Amin Ahem, Mushawiathi Mustapha, Umi Kalthum Mohd Noh, Mae-Lynn Catherine Bastion
PURPOSE: To determine the effect of topical insulin of 3 concentrations [0.5, 1, and 2 units per drop 4 times per day (QID)] on postoperative corneal epithelial wound healing in diabetic patients. DESIGN: A double blind randomized controlled hospital-based study involving diabetic patients with postoperative corneal epithelial defect after vitreoretinal surgery. METHODS: Diabetic patients were randomized to 3 different concentrations of topical insulin (DTI 0...
August 22, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28812367/the-usefulness-of-diffusion-weighted-magnetic-resonance-imaging-performed-in-the-acute-phase-as-an-early-predictor-of-delayed-neuropsychiatric-sequelae-in-acute-carbon-monoxide-poisoning
#8
Y S Kim, Y S Cha, M S Kim, H J Kim, Y S Lee, H Youk, H I Kim, O H Kim, K-C Cha, H Kim, K H Lee, S O Hwang
Delayed onset of neuropsychiatric symptoms after apparent recovery from acute carbon monoxide (CO) poisoning has been described as delayed neuropsychiatric sequelae (DNS). No previous study has determined whether early use of diffusion-weighted magnetic resonance imaging (DWI) can predict which patients will develop DNS in the acute CO poisoning. This retrospective observational study was performed on adult patients with acute CO poisoning consecutively treated over a 17-month period. All included patients with acute CO poisoning underwent DWI to evaluate brain injury within 72 h after CO exposure...
January 1, 2017: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/28808401/in-vitro-%C3%AE-amylase-and-%C3%AE-glucosidase-inhibitory-and-cytotoxic-activities-of-extracts-from-cissus-cornifolia-planch-parts
#9
Talent Chipiti, Mohammed Auwal Ibrahim, Moganavelli Singh, Md Shahidul Islam
CONTEXT: Hyperglycemia is the hallmark of type 2 diabetes mellitus, and its prevention will go a long way in managing the disease and its associated complications. Reduction of postprandial hyperglycemia through retarding carbohydrates digesting enzymes is one of the major therapeutic approaches used in the management of diabetes. OBJECTIVE: The aim of the present study was to investigate the antidiabetic and cytotoxic effects of Cissus cornifolia extracts in vitro...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28801394/the-role-of-nurse-specialists-in-the-delivery-of-integrated-diabetes-care-a-cross-sectional-survey-of-diabetes-nurse-specialist-services
#10
Fiona Riordan, Sheena M McHugh, Katie Murphy, Julie Barrett, Patricia M Kearney
OBJECTIVES: International evidence suggests the diabetes nurse specialist (DNS) has a key role in supporting integrated management of diabetes. We examine whether hospital and community DNS currently support the integration of care, examine regional variation in aspects of the service relevant to the delivery of integrated care and identify barriers to service delivery and areas for improvement. DESIGN: A cross-sectional survey of hospital and community-based DNS in Ireland...
August 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28759982/the-validity-and-reliability-of-a-dynamic-neuromuscular-stabilization-heel-sliding-test-for-core-stability
#11
Young Joo Cha, Jae Jin Lee, Do Hyun Kim, Joshua Sung H You
BACKGROUND: Core stabilization plays an important role in the regulation of postural stability. To overcome shortcomings associated with pain and severe core instability during conventional core stabilization tests, we recently developed the dynamic neuromuscular stabilization-based heel sliding (DNS-HS) test. OBJECTIVE: The purpose of this study was to establish the criterion validity and test-retest reliability of the novel DNS-HS test. METHOD: Twenty young adults with core instability completed both the bilateral straight leg lowering test (BSLLT) and DNS-HS test for the criterion validity study and repeated the DNS-HS test for the test-retest reliability study...
July 21, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/28741675/pharmacokinetics-of-dinalbuphine-sebacate-and-nalbuphine-in-human-after-intramuscular-injection-of-dinalbuphine-sebacate-in-an-extended-release-formulation
#12
Yu En Tien, Wen-Chuan Huang, Hui-Yuan Kuo, Lily Tai, Yow-Shieng Uang, Wendy H Chern, Jin-Ding Huang
Nalbuphine is a semi-synthetic opioid indicated for the relief of moderate to severe pain. Its short half-life requires frequent injections in clinical practices, resulting in greater incidences of adverse events. We have developed a prodrug of nalbuphine, dinalbuphine sebacate (DNS), dissolved in a simple oil-based injectable formulation, which could deliver and maintain effective blood nalbuphine level. An open-label, prospective, two-period study was performed in healthy volunteers to verify the extended blood concentration profile of nalbuphine...
July 25, 2017: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/28740381/chitosan-coated-diacerein-nanosuspensions-as-a-platform-for-enhancing-bioavailability-and-lowering-side-effects-preparation-characterization-and-ex-vivo-in-vivo-evaluation
#13
Ahmed N Allam, Sherif I Hamdallah, Ossama Y Abdallah
Nanodrug delivery systems have been widely reviewed for their use in several drug formulations to improve bioavailability, sustain effect, and decrease side effects of many candidate drugs. The objective of this study was to evaluate the potential of chitosan (CS)-coated nanosuspensions to enhance bioavailability and reduce the diarrheal side effect of diacerein (DCN) after oral administration. DCN nanosuspensions (DNS) were prepared by sonoprecipitation technique using different stabilizers at three different concentrations...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28738566/preparation-and-evaluation-of-a-novel-n-benzyl-phenethylamino-%C3%AE-cyclodextrin-bonded-chiral-stationary-phase-for-hplc
#14
Liang Li, Biaoping Cheng, Rendan Zhou, Zhigang Cao, Chun Zeng, Laisheng Li
A novel N-benzyl-phenethylamino-β-cyclodextrin-bonded ordered mesoporous SBA-15 chiral stationary phase (BZCDP) for high-performance liquid chromatography (HPLC) was prepared. The structure and morphology of the ligand and the stationary phase were characterized by mass spectrometry, elemental analysis, infrared spectroscopy, scanning electron microscopy, transmission electron microscopy and thermogravimetric analysis. The enantiomers of chiral compounds including nine common β-adrenergic blocker drugs (β-blockers), eight dansyl amino acids (DNS-AA) and six flavanones were successfully separated by polar organic solvent and reversed-phase chromatography, respectively...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28709298/direct-numerical-simulation-study-of-statistically-stationary-propagation-of-a-reaction-wave-in-homogeneous-turbulence
#15
Rixin Yu, Andrei N Lipatnikov
A three-dimensional (3D) direct numerical simulation (DNS) study of the propagation of a reaction wave in forced, constant-density, statistically stationary, homogeneous, isotropic turbulence is performed by solving Navier-Stokes and reaction-diffusion equations at various (from 0.5 to 10) ratios of the rms turbulent velocity U^{'} to the laminar wave speed, various (from 2.1 to 12.5) ratios of an integral length scale of the turbulence to the laminar wave thickness, and two Zeldovich numbers Ze=6.0 and 17...
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28669058/improved-neuroimaging-atlas-of-the-dentate-nucleus
#16
Naying He, Jason Langley, Daniel E Huddleston, Huawei Ling, Hongmin Xu, Chunlei Liu, Fuhua Yan, Xiaoping P Hu
The dentate nucleus (DN) of the cerebellum is the major output nucleus of the cerebellum and is rich in iron. Quantitative susceptibility mapping (QSM) provides better iron-sensitive MRI contrast to delineate the boundary of the DN than either T2-weighted images or susceptibility-weighted images. Prior DN atlases used T2-weighted or susceptibility-weighted images to create DN atlases. Here, we employ QSM images to develop an improved dentate nucleus atlas for use in imaging studies. The DN was segmented in QSM images from 38 healthy volunteers...
July 1, 2017: Cerebellum
https://www.readbyqxmd.com/read/28609205/diagnostic-performance-of-gadoxetic-acid-enhanced-liver-mr-imaging-versus-multidetector-ct-in-the-detection-of-dysplastic-nodules-and-early-hepatocellular-carcinoma
#17
Bo Ram Kim, Jeong Min Lee, Dong Ho Lee, Jeong Hee Yoon, Bo Yun Hur, Kyung Suk Suh, Nam-Joon Yi, Kyung Boon Lee, Joon Koo Han
Purpose To compare the diagnostic performance of gadoxetic acid-enhanced liver magnetic resonance (MR) imaging with that of contrast material-enhanced multidetector computed tomography (CT) in the detection of borderline hepatocellular nodules in patients with liver cirrhosis and to determine the Liver Imaging Reporting and Data System (LI-RADS) categories of these detected nodules. Materials and Methods The institutional review board approved this retrospective study and waived the informed consent requirement...
October 2017: Radiology
https://www.readbyqxmd.com/read/28606530/conversion-of-cellulose-into-reducing-sugar-by-solution-plasma-process-spp
#18
I Prasertsung, P Chutinate, A Watthanaphanit, N Saito, S Damrongsakkul
In the present study, cellulose colloids are treated with the solution plasma process in order to prepare reducing sugar. The investigated parameters are treatment time, type of electrodes, and applied pulse frequency of the bipolar supply. The reducing sugar was characterized by DNS method and the%yield of total reducing sugar (TRS) was then calculated. The crystal structure and chemical structure of plasma-treated cellulose was measured by XRD and FT-IR, respectively. The%yield of TRS was greatly enhanced by solution plasma treatment using Fe electrode...
September 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28598374/doppler-navigation-system-with-a-non-stabilized-antenna-as-a-sea-surface-wind-sensor
#19
Alexey Nekrasov, Alena Khachaturian, Vladimir Veremyev, Mikhail Bogachev
We propose a concept of the utilization of an aircraft Doppler Navigation System (DNS) as a sea-surface wind sensor complementary to its normal functionality. The DNS with an antenna, which is non-stabilized physically to the local horizontal with x-configured beams, is considered. We consider the wind measurements by the DNS configured in the multi-beam scatterometer mode for a rectilinear flight scenario. The system feasibility and the efficiency of the proposed wind algorithm retrieval are supported by computer simulations...
June 9, 2017: Sensors
https://www.readbyqxmd.com/read/28582897/reflex-mediated-dynamic-neuromuscular-stabilization-in-stroke-patients-emg-processing-and-ultrasound-imaging
#20
Hyun S Yoon, Joshua Sung H You
BACKGROUND: Postural core instability is associated with poor dynamic balance and a high risk of serious falls. Both neurodevelopmental treatment (NDT) and dynamic neuromuscular stabilization (DNS) core stabilization exercises have been used to improve core stability, but the outcomes of these treatments remain unclear. OBJECTIVE: This study was undertaken to examine the therapeutic effects of NDT and DNS core stabilization exercises on muscular activity, core stability, and core muscle thickness...
July 20, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
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