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https://www.readbyqxmd.com/read/29340874/lattice-boltzmann-simulations-of-droplet-dynamics-in-time-dependent-flows
#1
F Milan, M Sbragaglia, L Biferale, F Toschi
We study the deformation and dynamics of droplets in time-dependent flows using 3D numerical simulations of two immiscible fluids based on the lattice Boltzmann model (LBM). Analytical models are available in the literature, which assume the droplet shape to be an ellipsoid at all times (P.L. Maffettone, M. Minale, J. Non-Newton. Fluid Mech 78, 227 (1998); M. Minale, Rheol. Acta 47, 667 (2008)). Beyond the practical importance of using a mesoscale simulation to assess "ab initio" the robustness and limitations of such theoretical models, our simulations are also key to discuss --in controlled situations-- some relevant phenomenology related to the interplay between the flow time scales and the droplet time scales regarding the "transparency" transition for high enough shear frequencies for an external oscillating flow...
January 16, 2018: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/29321565/characterization-of-novel-endo-%C3%AE-n-acetylglucosaminidases-from-sphingobacterium-species-beauveria-bassiana-and-cordyceps-militaris-that-specifically-hydrolyze-fucose-containing-oligosaccharides-and-human-igg
#2
Yibo Huang, Yujiro Higuchi, Takashi Kinoshita, Ai Mitani, Yasunari Eshima, Kaoru Takegawa
Endo-β-N-acetylglucosaminidase (ENGase) catalyzes hydrolysis of N-linked oligosaccharides. Although many ENGases have been characterized from various organisms, so far no fucose-containing oligosaccharides-specific ENGase has been identified in any organism. Here, we screened soil samples, using dansyl chloride (Dns)-labeled sialylglycan (Dns-SG) as a substrate, and discovered a strain that exhibits ENGase activity in the culture supernatant; this strain, named here as strain HMA12, was identified as a Sphingobacterium species by 16S ribosomal RNA gene analysis...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29308446/the-delphian-node-revisited-an-uncommon-site-of-recurrence
#3
Benzon M Dy, Ashok R Shaha, Robert M Tuttle
The Delphian nodes (DNs) are frequently involved in cancers of the head and neck, including laryngeal and thyroid malignancies. Positivity in the DN has been considered a predictor of recurrence as well as an overall aggressive tumor biology. However, little has been written regarding the consequences of recurrence at the site of the DN. We present two case reports regarding recurrence in the DN and the unique challenges associated with DN metastases. In addition, we discuss our surgical approach to disease at the prelaryngeal space, including workup, imaging, and resection...
December 1, 2017: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29298696/enhanced-human-enterovirus-71-infection-by-endocytosis-inhibitors-reveals-multiple-entry-pathways-by-enterovirus-causing-hand-foot-and-mouth-diseases
#4
Meichun Yuan, Jingjing Yan, Jingna Xun, Chong Chen, Yuling Zhang, Min Wang, Wenqi Chu, Zhigang Song, Yunwen Hu, Shuye Zhang, Xiaoyan Zhang
BACKGROUND: Human enterovirus 71 (EV71) was previously known to enter cells through clathrin or caveolar mediated endocytic pathways. However, we observed chlorpromazine (CPZ) or dynasore (DNS), which inhibit clathrin and dynamin mediated endocytosis, did not suppress EV71 cell entry in particular cell types. So the current knowledge of entry mechanisms by EV71 is not complete. METHODS: Viral infection was examined by flow cytometry or end-point dilution assays...
January 3, 2018: Virology Journal
https://www.readbyqxmd.com/read/29291076/synthesis-and-applications-of-mans-poly-mma-co-ba-nanocomposite-latex-by-miniemulsion-polymerization
#5
Sheng Gong, Huayao Chen, Xinhua Zhou, Sundaram Gunasekaran
We have synthesized core-shell structured 3-methacryloxypropyltrimethoxysilane (MPS) functionalized antimony-doped tin oxide nanoparticles (MANs)-poly(methyl methacrylate-co-butyl acrylate) (PMMA-co-BA, PMB) nanocomposite latex particles via miniemulsion polymerization method. Polymerizable anionic surfactant DNS-86 (allyloxy polyoxyethylene(10) nonyl ammonium sulfate) was first introduced to synthesize core-shell nanocomposite. The morphologies of synthesized MANs and MANs/PMB latex nanocomposite particles were studied with transmission electron microscopy, which revealed particles, on average 70 nm in size, with a core-shell structure...
November 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29287724/paris-reprograms-glucose-metabolism-by-hif-1%C3%AE-induction-in-dopaminergic-neurodegeneration
#6
Hojin Kang, Areum Jo, Hyein Kim, Rin Khang, Ji-Yeong Lee, Hanna Kim, Chi-Hu Park, Jeong-Yun Choi, Yunjong Lee, Joo-Ho Shin
Our previous study found that PARIS (ZNF746) transcriptionally suppressed transketolase (TKT), a key enzyme in pentose phosphate pathway (PPP) in the substantia nigra (SN) of AAV-PARIS injected mice. In this study, we revealed that PARIS overexpression reprogrammed glucose metabolic pathway, leading to the increment of glycolytic proteins along with TKT reduction in the SN of AAV-PARIS injected mice. Knock-down of TKT in differentiated SH-SY5Y cells led to an increase of glycolytic enzymes and decrease of PPP-related enzymes whereas overexpression of TKT restored PARIS-mediated glucose metabolic shift, suggesting that glucose metabolic alteration by PARIS is TKT-dependent...
December 26, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29260775/-the-state-of-the-serotonin-system-in-the-patients-presenting-with-chronic-polypous-rhinosinusitis
#7
A A Shishkin, Yu V Karakulova, N V Voronchikhina
This article presents the results of the study designed to determine the concentration of the neuromediator serotonin in the blood serum and tissue homogenates prepared from the polypous tissue harvested in the patients presenting with chronic polypous rhinosinusitis (CPR). The study included 51 patients with this pathology while 11 patients with chronic maxillary rhinosinusitis (CMR) and deflection of the nasal septum (DNS) made up the group of comparison. The serum serotonin levels were measured and compared in the patients of the main and both control groups...
2017: Vestnik Otorinolaringologii
https://www.readbyqxmd.com/read/29247227/superoxide-stability-for-reversible-na-o2-electrochemistry
#8
V S Dilimon, Chihyun Hwang, Yoon-Gyo Cho, Juchan Yang, Hee-Dae Lim, Kisuk Kang, Seok Ju Kang, Hyun-Kon Song
Stabilizing superoxide (O2-) is one of the key issues of sodium-air batteries because the superoxide-based discharge product (NaO2) is more reversibly oxidized to oxygen when compared with peroxide (O22-) and oxide (O2-). Reversibly outstanding performances of sodium-oxygen batteries have been realized with the superoxide discharge product (NaO2) even if sodium peroxide (Na2O2) have been also known as the discharge products. Here we report that the Lewis basicity of anions of sodium salts as well as solvent molecules, both quantitatively represented by donor numbers (DNs), determines the superoxide stability and resultantly the reversibility of sodium-oxygen batteries...
December 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29221779/effect-of-sodium-oxybate-modafinil-and-their-combination-on-disrupted-nighttime-sleep-in-narcolepsy
#9
Yves Dauvilliers, Thomas Roth, Diane Guinta, Sarah Alvarez-Horine, Efim Dynin, Jed Black
OBJECTIVE: To assess the effects of three narcolepsy treatment modalities on sleep stage shifts associated with disrupted nighttime sleep (DNS) using data from a clinical trial. METHODS: Polysomnograms were reviewed from 155 patients (who had these data available at baseline and 8 weeks) of the 278 patients who were randomized to placebo, 9-g sodium oxybate (SXB)/nightly, 200-600 mg/d modafinil, or SXB + modafinil. Major outcomes of these post hoc analyses, analyzed using analysis of covariance, were change from baseline in number of shifts from Stages N2/3/rapid eye movement (REM) to Stage N1/Wake, and from Stage N1/Wake to REM...
December 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29219348/transition-to-turbulent-dynamo-saturation
#10
Kannabiran Seshasayanan, Basile Gallet, Alexandros Alexakis
While the saturated magnetic energy is independent of viscosity in dynamo experiments, it remains viscosity dependent in state-of-the-art 3D direct numerical simulations (DNS). Extrapolating such viscous scaling laws to realistic parameter values leads to an underestimation of the magnetic energy by several orders of magnitude. The origin of this discrepancy is that fully 3D DNS cannot reach low enough values of the magnetic Prandtl number Pm. To bypass this limitation and investigate dynamo saturation at very low Pm, we focus on the vicinity of the dynamo threshold in a rapidly rotating flow: the velocity field then depends on two spatial coordinates only, while the magnetic field consists of a single Fourier mode in the third direction...
November 17, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/29212567/the-quebec-emergency-department-guide-a-cross-sectional-study-to-evaluate-its-use-perceived-usefulness-and-implementation-in-rural-emergency-departments
#11
Richard Fleet, Sandrine Hegg-Deloye, Julie Maltais-Giguère, France Légaré, Mathieu Ouimet, Julien Poitras, Alain Tanguay, Patrick Archambault, Jean-Frédéric Levesque, Geneviève Simard-Racine, Gilles Dupuis
OBJECTIVES: The Quebec Emergency Department Management Guide (QEDMG) is a unique document with 78 recommendations designed to improve the organization of emergency departments (EDs) in the province of Quebec. However, no study has examined how this guide is perceived or used by rural health care management. METHODS: We invited all directors of professional services (DPS), directors of nursing services (DNS), head nurses (HN), and emergency department directors (EDD) working in Quebec's rural hospitals to complete an online survey (144 questions)...
December 7, 2017: CJEM
https://www.readbyqxmd.com/read/29200716/antioxidant-and-inhibitory-effects-of-saponin-extracts-from-dianthus-basuticus-burtt-davy-on-key-enzymes-implicated-in-type-2-diabetes-in-vitro
#12
Mikhail Olugbemiro Nafiu, Anofi Omotayo Tom Ashafa
Context: Dianthus basuticus is a plant of South African origin with various acclaimed pharmaceutical potentials. Aims: This study explored the antioxidant and antidiabetic activities of saponin extract from D. basuticus in vitro. Materials and Methods: Antioxidant activity of saponin was evaluated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and nitric oxide (*NO)-free radical scavenging activity while antidiabetic potentials were measured by the α-amylase and α-glucosidase inhibitory activities of the saponin extract...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29195768/failure-of-daptomycin-%C3%AE-lactam-combination-therapy-to-prevent-resistance-emergence-in-enterococcus-faecium
#13
Vidthiya Menon, Rebecca Davis, Nick Shackel, Bjorn A Espedido, Alicia G Beukers, Slade O Jensen, Sebastiaan J van Hal
Daptomycin β-Lactam combination therapy offers "protection" against daptomycin non-susceptibility (DNS) development in Enterococcus faecium. We report failure of this strategy and the importance of source control. Mutations were detected in the LiaF and cls genes in DNS isolates. A single DNS isolate contained an unrecognized mutation, which requires confirmation.
November 28, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29193627/a-vinyl-sulfone-based-fluorogenic-probe-capable-of-selective-labeling-of-phgdh-in-live-mammalian-cells
#14
Sijun Pan, Se-Young Jang, Si Si Liew, Jiaqi Fu, Danyang Wang, Jun-Seok Lee, Shao Q Yao
Chemical probes are powerful tools for interrogating small molecule-target interactions. With additional fluorescence Turn-ON functionality, such probes might enable direct measurements of target engagement in live mammalian cells. DNS-pE (and its terminal alkyne-containing version DNS-pE2) is the first small molecule that can selectively label endogenous 3-phosphoglycerate dehydrogenase (PHGDH) from various mammalian cells. Endowed with an electrophilic vinyl sulfone moiety that possesses fluorescence-quenching properties, DNS-pE/DNS-pE2 became highly fluorescent only upon irreversible covalent modification of PHGDH...
November 28, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29144536/isolation-and-whole-genome-sequencing-of-fetal-cells-from-maternal-blood-towards-the-ultimate-non-invasive-prenatal-testing
#15
Fang Chen, Ping Liu, Ying Gu, Zhu Zhu, Amulya Nanisetti, Zhangzhang Lan, Zhiwei Huang, Sophie Jia Liu, Xiongbin Kang, Yuqing Deng, Liqiong Luo, Dan Jiang, Yong Qiu, Jianchang Pan, Jun Xia, Ken Xiong, Chao Liu, Lin Xie, Qianyu Shi, Jing Li, Xiuqing Zhang, Wei Wang, Snezana Drmanac, Hui Jiang, Radoje Drmanac, Xun Xu
OBJECTIVE: To develop a methodology of isolating fetal cells from maternal blood and use deep sequencing demonstrating the promise for more complete and accurate genetic screening compared to other non-invasive prenatal testing (NIPT). METHODS: Here in this study, we developed a double negative selection (DNS) procedure to unbiasedly enrich fetal cells. After validated by short tandem repeat (STR), the isolated CFCs were subjected to deep whole genome sequencing analysis (WGS)...
November 16, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29142401/phytochemical-compositions-and-in-vitro-assessments-of-antioxidant-and-antidiabetic-potentials-of-fractions-from-ehretia-cymosa-thonn
#16
Akintayo Ogundajo, Anofi Tom Ashafa
Background: Ehretia cymosa Thonn. is a popular medicinal plant used in different parts of West Africa for the treatment of various ailments including diabetes mellitus. Objective: The current study investigates bioactive constituents and in vitro antioxidant and antidiabetic potentials of fractions from extract of E. cymosa. Materials and Methods: Phytochemical investigation and antioxidant assays were carried out using standard procedures...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29134097/the-optimization-of-fermentation-conditions-for%C3%A2-producing-cellulase-of-bacillus-amyloliquefaciens-and-its-application-to-goose%C3%A2-feed
#17
Miao Ye, Linghong Sun, Ru Yang, Zaigui Wang, KeZong Qi
The proper culture conditions for producing cellulase of Bacillus amyloliquefaciens S1, isolated from the cecum of goose was optimized by single-factor experiment combined with orthogonal test. The properties of the cellulase were investigated by DNS method. The appropriate doses of B. amyloliquefaciens S1 were obtained by adding them to goose feed. It indicated that the suitable culture conditions of producing cellulase were the culture temperature of 37°C, the initial pH of 7.0, the incubation time of 72 h and the loaded liquid volume of 75 ml per 250 ml...
October 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29131370/mental-ill-health-among-adult-patients-at-healthcare-centres-in-sweden-district-nurses-experiences
#18
Ann-Christin Janlöv, Linda Johansson, Eva K Clausson
BACKGROUND: Mental ill-health among the general population is increasing in Sweden. Primary Health Care (PHC) and Healthcare Centres (HCC), where district nurses (DNs) work, bear the basic responsibility for treatment of mental ill-health, while severe mental ill-health fall under the responsibility of psychiatric specialist care. The increased prevalence of mental ill-health in the community means that DNs increasingly encounter people with mental health problems - not least as a comorbidity...
November 13, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/29110098/do-hydrodynamically-assisted-binary-collisions-lead-to-orientational-ordering-of-microswimmers
#19
Norihiro Oyama, John Jairo Molina, Ryoichi Yamamoto
We have investigated the onset of collective motion in systems of model microswimmers, by performing a comprehensive analysis of the binary collision dynamics using three-dimensional direct numerical simulations (DNS) with hydrodynamic interactions. From this data, we have constructed a simplified binary collision model (BCM) which accurately reproduces the collective behavior obtained from the DNS for most cases. Thus, we show that global alignment can mostly arise solely from binary collisions. Although the agreement between both models (DNS and BCM) is not perfect, the parameter range in which notable differences appear is also that for which strong density fluctuations are present in the system (where pseudo-sound mound can be observed (N...
November 8, 2017: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/29104418/direct-numerical-simulation-of-turbulent-boundary-layer-with-fully-resolved-particles-at-low-volume-fraction
#20
Kun Luo, Chenshu Hu, Fan Wu, Jianren Fan
In the present work, a direct numerical simulation (DNS) of dilute particulate flow in a turbulent boundary layer has been conducted, containing thousands of finite-sized solid rigid particles. The particle surfaces are resolved with the multi-direct forcing immersed-boundary method. This is, to the best of the authors' knowledge, the first DNS study of a turbulent boundary layer laden with finite-sized particles. The particles have a diameter of approximately 11.3 wall units, a density of 3.3 times that of the fluid, and a solid volume fraction of 1/1000...
May 2017: Physics of Fluids
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