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https://www.readbyqxmd.com/read/29784358/short-probe-based-duplex-specific-nuclease-signal-amplification-strategy-enables-imaging-of-endogenous-micrornas-in-living-cells-with-ultrahigh-specificity
#1
Yingjun Ma, Jun Chen, Danping Chen, Yuzhi Xu, Li Zhang, Zong Dai, Xiaoyong Zou
Specific nucleic acids amplification at a constant and mild temperature is important for imaging assay of endogenous microRNAs (miRNAs) in living cells. Duplex-specific nuclease (DSN) is attractive in one-step isothermal assay of miRNA; however, its intrinsic limitations of low amplification specificity and high reaction temperature greatly restrict the application scope. Herein, we present a short-probe-based DSN signal amplification (spDSNSA) strategy enabling analysis of miRNAs at body temperature with significantly high specificity...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29784349/monitoring-glucose-calcium-and-magnesium-levels-in-saliva-as-a-non-invasive-analysis-by-sequential-injection-multi-parametric-determination
#2
Ana Machado, Rui Maneiras, Adriano A Bordalo, Raquel B R Mesquita
The use of saliva for diagnose and surveillance of systemic illnesses, and general health has been arousing great interest worldwide, emerging as a highly desirable goal in healthcare. The collection is non-invasive, stress-free, inexpensive, and simple representing a major asset. Glucose, calcium, and magnesium concentration are three major parameters evaluated in clinical context due to their essential role in a wide range of biochemical reactions, and consequently many health disorders. In this work, a spectrophotometric sequential injection method is described for the fast screening of glucose, calcium, and magnesium in saliva samples...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29756973/-clinical-and-economic-implications-of-disease-related-malnutrition-in-a-surgical-service
#3
Beatriz Torres Torres, María D Ballesteros Pomar, Susana García Calvo, Maria Ángeles Castro Lozano, Beatriz De la Fuente Salvador, Olatz Izaola Jaúregui, Juan José López Gómez, Emilia Gómez Hoyos, Carlos Vaquero Puertas, Daniel A De Luis Román
INTRODUCTION: disease-related malnutrition (DRM) is currently a major challenge in our hospitals, both because of its high prevalence and because of the clinical and economic impact. Our study aims to assess the feasibility and importance of establishing a nutritional screening strategy in our Health Care System. PATIENTS AND METHODS: this is a prospective study carried out in a Surgery Ward. The nutritional risk was assessed by applying to patients MUST at admission and weekly until discharge...
February 16, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29733378/assessing-the-predictability-of-idh-mutation-and-mgmt-methylation-status-in-glioma-patients-using-relaxation-compensated-multi-pool-cest-mri-at-7-0-tesla
#4
Daniel Paech, Johannes Windschuh, Johanna Oberhollenzer, Constantin Dreher, Felix Sahm, Jan-Eric Meissner, Steffen Goerke, Patrick Schuenke, Moritz Zaiss, Sebastian Regnery, Sebastian Bickelhaupt, Philipp Bäumer, Martin Bendszus, Wolfgang Wick, Andreas Unterberg, Peter Bachert, Mark Edward Ladd, Heinz-Peter Schlemmer, Alexander Radbruch
Background: Early identification of prognostic superior characteristics in glioma patients such as Isocitrate dehydrogenase(IDH)-mutation and O6-methylguanine-DNA-methyltransferase (MGMT) promotor methylation status is of great clinical importance. The study purpose was to investigate the non-invasive predictability of IDH-mutation status, MGMT promotor methylation, and differentiation of lower versus higher grade glioma (LGG vs. HGG) in newly-diagnosed patients employing relaxation-compensated multi-pool Chemical Exchange Saturation Transfer (CEST) magnetic resonance imaging (MRI) at 7...
May 4, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29732063/two-photon-fluorescent-polysiloxane-based-films-with-thermally-responsive-self-switching-properties-achieved-by-a-unique-reversible-spirocyclization-mechanism
#5
Yujing Zuo, Tingxin Yang, Yu Zhang, Zhiming Gou, Minggang Tian, Xiuqi Kong, Weiying Lin
Responsiveness and reversibility are present in nature, and are ubiquitous in biological systems. The realization of reversibility and responsiveness is of great importance in the development of properties and the design of new materials. However, two-photon fluorescent thermal-responsive materials have not been reported to date. Herein, we engineered thermally responsive polysiloxane materials ( Dns-non ) that exhibited unique two-photon luminescence, and this is the first report about thermally responsive luminescent materials with two-photon fluorescence...
March 14, 2018: Chemical Science
https://www.readbyqxmd.com/read/29718725/bispecific-antibodies-anti-mpeg-anti-her2-for-active-tumor-targeting-of-docetaxel-dtx-loaded-mpegylated-nanocarriers-to-enhance-the-chemotherapeutic-efficacy-of-her2-overexpressing-tumors
#6
Chia-Yu Su, Michael Chen, Ling-Chun Chen, Yuan-Soon Ho, Hsiu-O Ho, Shyr-Yi Lin, Kuo-Hsiang Chuang, Ming-Thau Sheu
Anti-mPEG/anti-human epidermal growth factor receptor 2 (HER2) bispecific antibodies (BsAbs) non-covalently bound to a docetaxel (DTX)-loaded mPEGylated lecithin-stabilized micellar drug delivery system (Lsb MDDs) were endowed with active targetability to improve the chemotherapeutic efficacy of DTX. DTX-loaded mPEGylated Lsb MDDs formulations were prepared using lecithin/DSPE-PEG(2K or 5K) nanosuspensions to hydrate the thin film, and then they were subjected to ultrasonication. Two BsAbs (anti-mPEG/anti-DNS or anti-HER2) were simply mixed with the Lsb MDDs to form BsAbs-Lsb MDDs formulations, respectively, referred as the DNS-Lsb MDDs and HER2-Lsb MDDs...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29715645/fouling-resilient-perforated-feed-spacers-for-membrane-filtration
#7
Sarah Kerdi, Adnan Qamar, Johannes S Vrouwenvelder, Noreddine Ghaffour
The improvement of feed spacers with optimal geometry remains a key challenge for spiral-wound membrane systems in water treatment due to their impact on the hydrodynamic performance and fouling development. In this work, novel spacer designs are proposed by intrinsically modifying cylindrical filaments through perforations. Three symmetric perforated spacers (1-Hole, 2-Hole, and 3-Hole) were in-house 3D-printed and experimentally evaluated in terms of permeate flux, feed channel pressure drop and membrane fouling...
April 24, 2018: Water Research
https://www.readbyqxmd.com/read/29680701/enhanced-peroxidase-like-properties-of-au-pt-dns-ng-cu-2-and-application-of-sandwich-type-electrochemical-immunosensor-for-highly-sensitive-detection-of-cea
#8
Hui Lv, Yueyun Li, Xiaobo Zhang, Zengqiang Gao, Chunyan Zhang, Shuan Zhang, Yunhui Dong
Effective treatment of cancer depends upon the early detection of the tumor marker. Here, we report on the development of a new immunosensor for early detection of carcinoembryonic antigen (CEA). Cubic Au@Pt dendritic nanomaterials functionalized nitrogen-doped graphene loaded with copper ion (Au@Pt DNs/NG/Cu2+ ) with enhanced peroxidase-like properties was synthesized as labels to effectively capture and immobilize secondary anti-CEA. The Au@Pt DNs with more active surface area could efficiently enhance electrocatalysis for reduction of hydrogen peroxide (H2 O2 )...
April 16, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29657359/direct-numerical-simulation-of-fluid-flow-and-mass-transfer-in-particle-clusters
#9
Jiangtao Lu, Elias A J F Peters, Johannes A M Kuipers
In this paper, an efficient ghost-cell based immersed boundary method is applied to perform direct numerical simulation (DNS) of mass transfer problems in particle clusters. To be specific, a nine-sphere cuboid cluster and a random-generated spherical cluster consisting of 100 spheres are studied. In both cases, the cluster is composed of active catalysts and inert particles, and the mutual influence of particles on their mass transfer performance is studied. To simulate active catalysts the Dirichlet boundary condition is imposed at the external surface of spheres, while the zero-flux Neumann boundary condition is applied for inert particles...
April 4, 2018: Industrial & Engineering Chemistry Research
https://www.readbyqxmd.com/read/29614707/best-core-stabilization-exercise-to-facilitate-subcortical-neuroplasticity-a-functional-mri-neuroimaging-study
#10
Do Hyun Kim, Jae Jin Lee, Sung Joshua Hyun You
OBJECTIVE: To investigate the effects of conscious (ADIM) and subconscious (DNS) core stabilization exercises on cortical changes in adults with core instability. PARTICIPANTS: Five non-symptomatic participants with core instability. METHODS: A novel core stabilization task switching paradigm was designed to separate cortical or subcortical neural substrates during a series of DNS or ADIM core stabilization tasks. RESULTS: fMRI blood BOLD analysis revealed a distinctive subcortical activation pattern during the performance of the DNS, whereas the cortical motor network was primarily activated during an ADIM...
March 23, 2018: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29599856/influence-of-dynamic-neuromuscular-stabilization-approach-on-maximum-kayak-paddling-force
#11
Pavel Davidek, Ross Andel, Alena Kobesova
The purpose of this study was to examine the effect of Dynamic Neuromuscular Stabilization (DNS) exercise on maximum paddling force (PF) and self-reported pain perception in the shoulder girdle area in flatwater kayakers. Twenty male flatwater kayakers from a local club (age = 21.9 ± 2.4 years, body height = 185.1 ± 7.9 cm, body mass = 83.9 ± 9.1 kg) were randomly assigned to the intervention or control groups. During the 6-week study, subjects from both groups performed standard off-season training. Additionally, the intervention group engaged in a DNS-based core stabilization exercise program (quadruped exercise, side sitting exercise, sitting exercise and squat exercise) after each standard training session...
March 2018: Journal of Human Kinetics
https://www.readbyqxmd.com/read/29582616/-determination-of-cyanamide-residue-in-grapes-and-cherries-by-liquid-chromatography-tandem-mass-spectrometry-coupled-with-precolumn-derivatization
#12
Feng Lan, Chuande Liu
A method was developed for the quantitative determination of cyanamide in grapes and cherries by liquid chromatography-tandem mass spectrometry (LC-MS/MS) coupled with dansyl chloride (DNS) precolumn derivatization. First, the samples were homogenized, and then extracted with ethyl acetate under ultrasonication. The water was removed using anhydrous sodium sulfate, and the extract was concentrated and derivatized with dansyl chloride under alkaline condition. The separation was performed on a Shimadzu Shim-pack XR-ODS column (75 mm×2...
January 8, 2018: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/29492781/purification-and-analytical-application-of-vigna-mungo-chitinase-for-determination-of-total-fungal-load-of-stored-cereals
#13
Preety, Swati Sharma, Vinita Hooda
A novel chitinase from urd bean (Vigna mungo) seeds was purified up to homogeneity and optimized with respect to its optimum working conditions of pH, temperature, and substrate concentration. Overall, 145-fold purification with 70% yield of the purified chitinase was achieved. The notable features of the purified enzyme were its appreciative substrate affinity as well as catalytic efficiency, high thermo stability (70% retention of initial activity at 70 °C after 60 min of continuous exposure), and pretty good storage stability (half-life of 45 days at 5 °C)...
March 1, 2018: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/29476713/best-core-stabilization-for-anticipatory-postural-adjustment-and-falls-in-hemiparetic-stroke
#14
Nam G Lee, Joshua Sung H You, Chung H Yi, Hye S Jeon, Bong S Choi, Dong R Lee, Jae M Park, Tae H Lee, In T Ryu, Hyun S Yoon
OBJECTIVES: To compare the effects of conventional core stabilization and dynamic neuromuscular stabilization (DNS) on anticipatory postural adjustment (APA) time, balance performance, and fear of falls in chronic hemiparetic stroke. DESIGN: Two-group randomized controlled trial with pretest-posttest design. SETTING: Hospital rehabilitation center. PARTICIPANTS: Adults with chronic hemiparetic stroke (N=28). INTERVENTIONS: Participants were randomly divided into either conventional core stabilization (n=14) or DNS (n=14) groups...
February 21, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29470767/the-effects-of-tramadol-administration-on-hippocampal-cell-apoptosis-learning-and-memory-in-adult-rats-and-neuroprotective-effects-of-crocin
#15
Farideh Baghishani, Abbas Mohammadipour, Hossain Hosseinzadeh, Mahmoud Hosseini, Alireza Ebrahimzadeh-Bideskan
Tramadol, a frequently used pain reliever drug, present neurotoxic effects associated to cognitive dysfunction. Moreover, crocin has been reported to have neuroprotective effects. The aim of this study was to assess crocin's capacity to protect learning, and memory abilities on tramadol-treated rats. A total of 35 rats were divided into five groups: Control, Saline, tramadol (50 mg/kg), tramadol + crocin(30 mg/kg), crocin groups and treated orally for 28 consecutive days. Morris water maze (MWM) and passive avoidance (PA) tests were done, followed by dissection of the rat's brains for toluidine blue and TUNEL staining...
February 22, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29463408/synthesis-characterization-and-efficacy-of-silver-nanoparticles-against-aedes-albopictus-larvae-and-pupae
#16
Hassan Ga'al, Hatem Fouad, Jiaxin Tian, Yin Hu, Ghulam Abbas, Jianchu Mo
Silver nanoparticles have been studied in a wide range of medical and entomological research works due to their eco-friendly aspects. In our study salicylic acid (SA) and its derivative, 3,5-dinitrosalicylic acid (DNS), were used in a one-step synthesis of silver nanoparticles (AgNPs). First, UV-vis absorption spectroscopy was used to detect the formation of AgNPs. Second, the synthesized nanoparticles were characterized using scanning electron microscope, transmission electron microscope; energy-dispersive spectroscopy, X-ray diffraction analysis and Fourier transform infrared spectroscopy...
January 2018: Pesticide Biochemistry and Physiology
https://www.readbyqxmd.com/read/29444736/recognition-of-the-complexity-facing-residential-care-homes-a-practitioner-inquiry
#17
Jenny Dudman, Julienne Meyer, Cheryl Holman, Wendy Moyle
Aim To explore the experiences and challenges for residential care home staff when managing the healthcare needs of their residents, in particular those living with dementia. BACKGROUND: Increasing number of older people, with complex health and social care needs are living in residential care homes. Yet there is limited appreciation of why staff sometimes struggle to manage residents' healthcare needs, or understanding of their working relationship with district nurses (DNs), whose responsibility it is to provide nursing support...
February 15, 2018: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/29433753/a-glutathione-responsive-sulfur-dioxide-polymer-prodrug-as-a-nanocarrier-for-combating-drug-resistance-in-cancer-chemotherapy
#18
Wei Shen, Wanguo Liu, Huailin Yang, Peng Zhang, Chunsheng Xiao, Xuesi Chen
Multidrug resistance (MDR) in cancer remains a significant challenge for curing cancer by chemotherapy. In this work, a kind of glutathione (GSH)-responsive polymer prodrug of SO2 was designed and synthesized, which presented synergistic effect with doxorubicin (DOX) for combating MCF-7 ADR human breast cancer cell. Firstly, a small molecular prodrug of SO2 , N-(3-azidopropyl)-2,4-dinitrobenzenesulfonamide (AP-DNs), was chemically conjugated onto the side chain of methoxy poly (ethylene glycol)-block-poly (γ-propargyl-l-glutamate) (mPEG-PPLG) block copolymer to generate an amphiphilic polymer prodrug of SO2 , mPEG-PLG (DNs)...
February 3, 2018: Biomaterials
https://www.readbyqxmd.com/read/29427322/comparison-of-risk-factors-and-outcomes-of-daptomycin-susceptible-and-nonsusceptible-vancomycin-resistant-enterococcus-faecium-infections-in-liver-transplant-recipients
#19
J D Lewis, A J Barros, C D Sifri
BACKGROUND: Vancomycin-resistant Enterococcus faecium (VRE) infections are common in liver transplant recipients (LTRs). Daptomycin (DAP) is an important treatment for such infections; however, DAP-nonsusceptible VRE (DNS-VRE) are increasingly frequent. The purpose of this study was to compare clinical characteristics and outcomes of LTRs with infections due to DNS-VRE and DAP-susceptible VRE (DS-VRE). METHODS: A single center, retrospective review of patients who underwent liver transplantation between January 1, 2010 and December 31, 2015 and developed infections due to DS-VRE or DNS-VRE post transplant was performed...
February 10, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29386633/a-peculiar-low-luminosity-short-gamma-ray-burst-from-a-double-neutron-star-merger-progenitor
#20
B-B Zhang, B Zhang, H Sun, W-H Lei, H Gao, Y Li, L Shao, Y Zhao, Y-D Hu, H-J Lü, X-F Wu, X-L Fan, G Wang, A J Castro-Tirado, S Zhang, B-Y Yu, Y-Y Cao, E-W Liang
Double neutron star (DNS) merger events are promising candidates of short gamma-ray burst (sGRB) progenitors as well as high-frequency gravitational wave (GW) emitters. On August 17, 2017, such a coinciding event was detected by both the LIGO-Virgo gravitational wave detector network as GW170817 and Gamma-Ray Monitor on board NASA's Fermi Space Telescope as GRB 170817A. Here, we show that the fluence and spectral peak energy of this sGRB fall into the lower portion of the distributions of known sGRBs. Its peak isotropic luminosity is abnormally low...
January 31, 2018: Nature Communications
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