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https://www.readbyqxmd.com/read/29143012/%C3%AE-alanine-and-n-terminal-cationic-substituents-affect-polyamide-dna-binding
#1
Beibei Liu, Shuo Wang, Karl Aston, Kevin J Koeller, Shahrzad Fanny Hakami Kermani, Carlos H Castañeda, M José Scuderi, Rensheng Luo, James K Bashkin, W David Wilson
Minor-groove binding hairpin polyamides (PAs) bind specific DNA sequences. Synthetic modifications can improve PA-DNA binding affinity and include flexible modules, such as β-alanine (β) motifs to replace pyrroles (Py), and increasing compound charge using N-terminal cationic substituents. To better understand the variations in kinetics and affinities caused by these modifications on PA-DNA interactions, a comprehensive set of PAs with different numbers and positions of β and different types of N-cationic groups was systematically designed and synthesized to bind their cognate sequence, the λB motif...
November 16, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29050873/comparing-the-sensation-of-common-donor-site-regions-for-autologous-breast-reconstruction-to-that-of-a-healthy-breast
#2
Anouk J M Cornelissen, Jop Beugels, Arno Lataster, Esther M Heuts, Shai M Rozen, Aldona J Spiegel, René R W J van der Hulst, Stefania M H Tuinder
INTRODUCTION: Autologous breast reconstruction has become the standard care for breast cancer patients. Although excellent cosmetic results can be achieved, most reconstructed breasts fail to regain normal sensation. Nerve coaptation of the flap has been suggested to improve sensation; the effect of the donor flap native sensory threshold on the degree of sensory restoration is yet to be determined. The aim of this study is to evaluate the differences in sensation between various potential donor site regions in comparison to the sensation of the healthy breast...
September 25, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/29046593/wavelength-selective-sequential-polymer-network-formation-controlled-with-a-two-color-responsive-initiation-system
#3
Xinpeng Zhang, Weixian Xi, Sijia Huang, Katelyn Long, Christopher N Bowman
We report a wavelength-selective polymerization process controlled by visible/UV light, whereby a base is generated for anion-mediated thiol-Michael polymerization reaction upon exposure at one wavelength (400-500 nm), while radicals are subsequently generated for a second stage radical polymerization at a second, independent wavelength (365 nm). Dual wavelength, light controlled sequential polymerization not only provides a relatively soft intermediate polymer that facilitates optimum processing and modification under visible light exposure but also enables a highly cross-linked, rigid final material after the UV-induced second stage radical polymerization...
August 8, 2017: Macromolecules
https://www.readbyqxmd.com/read/28989189/mechanistic-kinetic-modeling-of-thiol-michael-addition-photopolymerizations-via-photocaged-superbase-generators-an-analytical-approach
#4
Mauro Claudino, Xinpeng Zhang, Marvin D Alim, Maciej Podgórski, Christopher N Bowman
A kinetic mechanism and the accompanying mathematical framework are presented for base-mediated thiol-Michael photopolymerization kinetics involving a photobase generator. Here, model kinetic predictions demonstrate excellent agreement with a representative experimental system composed of 2-(2-nitrophenyl)propyloxycarbonyl-1,1,3,3-tetramethylguanidine (NPPOC-TMG) as a photobase generator that is used to initiate thiol-vinyl sulfone Michael addition reactions and polymerizations. Modeling equations derived from a basic mechanistic scheme indicate overall polymerization rates that follow a pseudo-first-order kinetic process in the base and coreactant concentrations, controlled by the ratio of the propagation to chain-transfer kinetic parameters (kp/kCT) which is dictated by the rate-limiting step and controls the time necessary to reach gelation...
November 8, 2016: Macromolecules
https://www.readbyqxmd.com/read/28987015/center-practice-drives-variation-in-choice-of-u-s-kidney-transplant-induction-therapy-a-retrospective-analysis-of-contemporary-practice
#5
V R Dharnidharka, A S Naik, D A Axelrod, M A Schnitzler, Z Zhang, S Bae, D L Segev, D C Brennan, T Alhamad, R Ouseph, N N Lam, M Nazzal, H Randall, B L Kasiske, M McAdams-Demarco, K L Lentine
To assess factors that influence the choice of induction regimen in contemporary kidney transplantation, we examined center-identified, national transplant registry data for 166,776 US recipients (2005-2014). Bi-level hierarchical models were constructed, wherein use of each regimen was compared pairwise with use of interleukin-2 receptor blocking antibodies (IL2rAb). Overall, 81.8% of patients received induction, including thymoglobulin (TMG, 46.0%), IL2rAb (21.9%), alemtuzumab (ALEM, 12.5%), and other agents (1...
October 7, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28973823/augmented-o-glcnacylation-of-amp-activated-kinase-promotes-the-proliferation-of-lovo-cells-a-colon-cancer-cell-line
#6
Emi Ishimura, Takatoshi Nakagawa, Kazumasa Moriwaki, Seiichi Hirano, Yoshinobu Matsumori, Michio Asahi
Increasing incidence of various cancers has been reported in diabetic patients. O-linked N-acetylglucosamine (O-GlcNAc) modification of proteins at serine/threonine residues (O-GlcNAcylation) is an essential post-translational modification that is upregulated in diabetic patients and has been implicated in tumor growth. However, the mechanisms by which O-GlcNAcylation promotes tumor growth remain unclear. Given that AMP-activated kinase (AMPK) has been thought to play important roles in suppressing tumor growth, we evaluated the involvement of AMPK O-GlcNAcylation on the growth of LoVo cells, a human colon cancer cell line...
October 3, 2017: Cancer Science
https://www.readbyqxmd.com/read/28973778/estimates-of-genetics-and-phenotypics-parameters-for-the-yield-and-quality-of-soybean-seeds
#7
E V Zambiazzi, A T Bruzi, S R Guilherme, D R Pereira, J G Lima, A M Zuffo, F O Ribeiro, A E S Mendes, S H M Godinho, M L M Carvalho
Estimating genotype x environment (GxE) parameters for quality and yield in soybean seed grown in different environments in Minas Gerais State was the goal of this study, as well as to evaluate interaction effects of GxE for soybean seeds yield and quality. Seeds were produced in three locations in Minas Gerais State (Lavras, Inconfidentes, and Patos de Minas) in 2013/14 and 2014/15 seasons. Field experiments were conducted in randomized blocks in a factorial 17 x 6 (GxE), and three replications. Seed yield and quality were evaluated for germination in substrates paper and sand, seedling emergence, speed emergency index, mechanical damage by sodium hypochlorite, electrical conductivity, speed aging, vigor and viability of seeds by tetrazolium test in laboratory using completely randomized design...
September 27, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28930871/reliability-and-measurement-error-of-tensiomyography-to-assess-mechanical-muscle-function-a-systematic-review
#8
Saúl Martín-Rodríguez, Irineu Loturco, Angus M Hunter, David Rodríguez-Ruiz, Diego Munguia-Izquierdo
Interest in studying mechanical skeletal muscle function through tensiomyography (TMG) has increased in recent years. This systematic review aimed to (a) report the reliability and measurement error of all TMG parameters [i.e., maximum radial displacement of the muscle belly (Dm), contraction time (Tc), delay time (Td), half-relaxation time (½ Tr), and sustained contraction time (Ts)] and (b) to provide critical reflection on how to perform accurate and appropriate measurements for informing clinicians, exercise professionals, and researchers...
September 11, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28830038/spectroscopic-studies-of-the-intramolecular-hydrogen-bonding-in-o-hydroxy-schiff-bases-derived-from-diaminomaleonitrile-and-their-deprotonation-reaction-products
#9
Anna Szady-Chełmieniecka, Beata Kołodziej, Maja Morawiak, Bohdan Kamieński, Wojciech Schilf
The structural study of five Schiff bases derived from diaminomaleonitrile (DAMN) and 2-hydroxy carbonyl compounds was performed using (1)H, (13)C and (15)N NMR methods in solution and in the solid state as well. ATR-FTIR and X-Ray spectroscopies were used for confirmation of the results obtained by NMR method. The imine obtained from DAMN and benzaldehyde was synthesized as a model compound which lacks intramolecular hydrogen bond. Deprotonation of all synthesized compounds was done by treating with tetramethylguanidine (TMG)...
August 12, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28828979/chronic-latent-magnesium-deficiency-in-obesity-decreases-positive-effects-of-vitamin-d-on-cardiometabolic-risk-indicators
#10
Edita Stokic, Andrea Romani, Branislava Ilincic, Aleksandar Kupusinac, Zoran Stosic, Esma R Isenovic
BACKGROUND: Obesity and micronutrient deficiencies contribute to the risk of cardiometabolic diseases such are type 2 diabetes mellitus and cardiovascular disease (CVD). OBJECTIVE: We examined the frequency of concomitant deficit of magnesium (Mg) and vitamin D in obese patients and evaluated the connection of these combined deficiencies with indicators of cardiometabolic risk in non-diabetic subjects. METHOD: Non-diabetic middle aged adults (n = 80; mean age 36 ± 4 years, 52% women) were recruited based on weight/adiposity parameters [i...
August 21, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28828075/baseline-mechanical-and-neuromuscular-profile-of-knee-extensor-and-flexor-muscles-in-professional-soccer-players-at-the-start-of-the-pre-season
#11
Oscar García-García, Virginia Serrano-Gómez, Antonio Hernández-Mendo, Verónica Morales-Sánchez
The aim of the study was to determine the mechanical and neuromuscular profile of knee extensor and flexor muscles in professional soccer players at the start of the pre-season, and to calculate percentages for symmetry, as well as examine differences according to the player's positional role. The vastus medialis (VM), vastus lateralis (VL), rectus femoris (RF) and biceps femoris (BF) of 16 professional soccer players were evaluated by means of tensiomyography (TMG) on the first day of the pre-season. A paired-samples t test (p < ...
September 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/28753281/tetrahedral-copper-ii-complexes-with-a-labile-coordination-site-supported-by-a-tris-tetramethylguanidinato-ligand
#12
Ikuma Shimizu, Yuma Morimoto, Dieter Faltermeier, Marion Kerscher, Sayantan Paria, Tsukasa Abe, Hideki Sugimoto, Nobutaka Fujieda, Kaori Asano, Takeyuki Suzuki, Peter Comba, Shinobu Itoh
A new tridentate N3 ligand (TMG3tach) consisting of cis,cis-1,3,5-triaminocyclohexane (tach) and three N,N,N',N'-tetramethylguanidino (TMG) groups has been developed to prepare copper complexes with a tetrahedral geometry and a labile coordination site. Treatment of the ligand with Cu(II)X2 (X = Cl and Br) gave copper(II)-halide complexes, [Cu(II)(TMG3tach)Cl](+) (2(Cl)) and [Cu(II)(TMG3tach)Br](+) (2(Br)), the structures of which have been determined by X-ray crystallographic analysis. The complexes exhibit a four-coordinate structure with C3v symmetry, where the labile halide ligand (X) occupies a position on the trigonal axis...
July 28, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28732494/the-effects-of-therapeutic-hip-exercise-with-abdominal-core-activation-on-recruitment-of-the-hip-muscles
#13
Mandy Ky Chan, Ka Wai Chow, Alfred Ys Lai, Noble Kc Mak, Jason Ch Sze, Sharon Mh Tsang
BACKGROUND: Core stabilization has been utilized for rehabilitation and prevention of lower limb musculoskeletal injuries. Previous studies showed that activation of the abdominal core muscles enhanced the hip muscle activity in hip extension and abduction exercises. However, the lack of the direct measurement and quantification of the activation level of the abdominal core muscles during the execution of the hip exercises affect the level of evidence to substantiate the proposed application of core exercises to promote training and rehabilitation outcome of the hip region...
July 21, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28704886/tensiomyographic-assessment-of-muscle-contractile-properties-in-9-to-14-year-old-children
#14
Bostjan Simunic, Hans Degens, Jernej Zavrsnik, Katja Koren, Tadeja Volmut, Rado Pisot
While there are numerous data on the skeletal muscle fiber type composition in adults, little is known about the changes in fiber type composition and contractile properties during maturational growth in children. Using noninvasive tensiomyography, we measured contraction time (Tc), an indirect estimate of the myosin heavy chain I (MHC-I) proportion, to assess the longitudinal changes of the biceps brachii (BB), biceps femois (BF), vastus lateralis (VL), and erector spinae (ES) muscles in 53 boys and 54 girls...
September 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28684973/total-synthesis-of-tmg-chitotriomycin-based-on-an-automated-electrochemical-assembly-of-a-disaccharide-building-block
#15
Yuta Isoda, Norihiko Sasaki, Kei Kitamura, Shuji Takahashi, Sujit Manmode, Naoko Takeda-Okuda, Jun-Ichi Tamura, Toshiki Nokami, Toshiyuki Itoh
The total synthesis of TMG-chitotriomycin using an automated electrochemical synthesizer for the assembly of carbohydrate building blocks is demonstrated. We have successfully prepared a precursor of TMG-chitotriomycin, which is a structurally-pure tetrasaccharide with typical protecting groups, through the methodology of automated electrochemical solution-phase synthesis developed by us. The synthesis of structurally well-defined TMG-chitotriomycin has been accomplished in 10-steps from a disaccharide building block...
2017: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28670284/tensiomyographic-markers-are-not-sensitive-for-monitoring-muscle-fatigue-in-elite-youth-athletes-a-pilot-study
#16
Thimo Wiewelhove, Christian Raeder, Rauno Alvaro de Paula Simola, Christoph Schneider, Alexander Döweling, Alexander Ferrauti
Objective: Tensiomyography (TMG) is an indirect measure of a muscle's contractile properties and has the potential as a technique for detecting exercise-induced skeletal muscle fatigue. Therefore, the aim of this study was to assess the sensitivity of tensiomyographic markers to identify reduced muscular performance in elite youth athletes. Methods: Fourteen male junior tennis players (age: 14.9 ± 1.2 years) with an international (International Tennis Federation) ranking position participated in this pre-post single group trial...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28638082/tandem-malonate-based-glucosides-tmgs-for-membrane-protein-structural-studies
#17
Hazrat Hussain, Jonas S Mortensen, Yang Du, Claudia Santillan, Orquidea Ribeiro, Juyeon Go, Parameswaran Hariharan, Claus J Loland, Lan Guan, Brian K Kobilka, Bernadette Byrne, Pil Seok Chae
High-resolution membrane protein structures are essential for understanding the molecular basis of diverse biological events and important in drug development. Detergents are usually used to extract these bio-macromolecules from the membranes and maintain them in a soluble and stable state in aqueous solutions for downstream characterization. However, many eukaryotic membrane proteins solubilized in conventional detergents tend to undergo structural degradation, necessitating the development of new amphiphilic agents with enhanced properties...
June 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28584122/an-exportin-1-dependent-microrna-biogenesis-pathway-during-human-cell-quiescence
#18
Ivan Martinez, Karen E Hayes, Jamie A Barr, Abby D Harold, Mingyi Xie, Syed I A Bukhari, Shobha Vasudevan, Joan A Steitz, Daniel DiMaio
The reversible state of proliferative arrest known as "cellular quiescence" plays an important role in tissue homeostasis and stem cell biology. By analyzing the expression of miRNAs and miRNA-processing factors during quiescence in primary human fibroblasts, we identified a group of miRNAs that are induced during quiescence despite markedly reduced expression of Exportin-5, a protein required for canonical miRNA biogenesis. The biogenesis of these quiescence-induced miRNAs is independent of Exportin-5 and depends instead on Exportin-1...
June 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28538312/skeletal-muscle-contraction-time-and-tone-decrease-after-8-weeks-of-plyometric-training
#19
RANDOMIZED CONTROLLED TRIAL
Damir Zubac, Boštjan Šimunič
The aim of the study was to examine whether an improvement in jumping performance after 8 weeks of plyometric training (PT) runs in parallel with changes in lower-limb skeletal muscle contractile properties. Using noninvasive tensiomyography (TMG), we assessed contraction time (Tc) and the maximal amplitude of radial displacement (Dm) in 20 subjects (50% men; age 22.4 ± 4.7 years of age), randomly divided in PT group (N = 10; PLYO) and a control group (N = 10; CTRL). The PLYO performed 8 weeks of PT. Tensiomyography was measured in 5 leg skeletal muscles: vastus lateralis (VL), biceps femoris (BF), tibialis anterior (TA), gastrocnemius medialis (GM), and gastrocnemius lateralis (GL)...
June 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28504178/tetramethylguanidine-based-gels-and-colloids-of-cellulose
#20
Gonçalo V S M Carrera, Anabela Raymundo, Francisco M Braz Fernandes, Noémi Jordão, Isabel Sousa, Manuel Nunes da Ponte, Luís C Branco
Novel and stable gels of cellulose were produced. These gels are prepared at room temperature by combination of cellulose and tetramethylguanidine (TMG) in different ratios (1:1, 1:2, 1:3 in equivalents of alcohol groups of cellulose per number of molecules of TMG). Detailed NMR, SEM, rheological and XRD studies of these gels were carried out. The concentration of cellulose in the gel, temperature, frequency of oscillation and shear rate were used as variables in order to understand the fundamentals and optimize operational conditions, considering their possible use as matrices for CO2 capture...
August 1, 2017: Carbohydrate Polymers
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