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https://www.readbyqxmd.com/read/27878171/fine-regulation-of-cellulose-dissolution-and-regeneration-by-low-pressure-co2-in-dmso-organic-base-dissolution-behavior-and-mechanism
#1
Jinfang Wang, Zhimin Xue, Chuanyu Yan, Zhonghao Li, Tiancheng Mu
In this study, the fine regulation of the dissolution and regeneration of microcrystalline cellulose (MCC) using very low pressure (0-0.2 MPa) CO2 in a mixed solvent of dimethyl sulfoxide (DMSO) and 1,8-diazabicyclo-[5.4.0]-undec-7-ene (DBU) at a very low temperature (30 °C) was achieved. The solubility of MCC in DMSO/DBU (weight ratio of DMSO WDMSO = 0.90) could reach 9.0% at 30 °C and under CO2 pressure of 0.2 MPa. A similar phenomenon was observed in the mixed solvent DMSO/1,1,3,3-tetramethylguanidine (TMG)...
November 23, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27864466/thiamet-g-mediates-neuroprotection-in-experimental-stroke-by-modulating-microglia-macrophage-polarization-and-inhibiting-nf-%C3%AE%C2%BAb-p65-signaling
#2
Yating He, Xiaofeng Ma, Daojing Li, Junwei Hao
Inflammatory responses are accountable for secondary injury induced by acute ischemic stroke (AIS). Previous studies indicated that O-GlcNAc modification (O-GlcNAcylation) is involved in the pathology of AIS, and increase of O-GlcNAcylation by glucosamine attenuated the brain damage after ischemia/reperfusion. Inhibition of β-N-acetylglucosaminidase (OGA) with thiamet G (TMG) is an alternative option for accumulating O-GlcNAcylated proteins. In this study, we investigate the neuroprotective effect of TMG in a mouse model of experimental stroke...
November 18, 2016: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27827318/isolation-of-t-cell-receptors-specifically-reactive-with-mutated-tumor-associated-antigens-from-tumor-infiltrating-lymphocytes-based-on-cd137-expression
#3
Maria R Parkhurst, Alena Gros, Anna Pasetto, Todd D Prickett, Jessica S Crystal, Paul F Robbins, Steven A Rosenberg
PURPOSE: The adoptive transfer of lymphocytes genetically modified to express tumor reactive T cell receptors (TCRs) can mediate tumor regression. Some tumor infiltrating lymphocytes (TIL) recognize somatic mutations expressed only in the patient's tumors, and evidence suggests that clinically effective TIL target tumor specific neoantigens. Here we attempted to isolate neoantigen reactive TCRs as a prelude to the treatment of patients with autologous T cells genetically modified to express such TCRs...
November 8, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27821527/left-right-analysis-of-mammary-gland-development-in-retinoid-x-receptor-%C3%AE-mice
#4
Jacqulyne P Robichaux, John W Fuseler, Shrusti S Patel, Steven W Kubalak, Adam Hartstone-Rose, Ann F Ramsdell
Left-right (L-R) differences in mammographic parenchymal patterns are an early predictor of breast cancer risk; however, the basis for this asymmetry is unknown. Here, we use retinoid X receptor alpha heterozygous null (RXRα(+/-)) mice to propose a developmental origin: perturbation of coordinated anterior-posterior (A-P) and L-R axial body patterning. We hypothesized that by analogy to somitogenesis-in which retinoic acid (RA) attenuation causes anterior somite pairs to develop L-R asynchronously-that RA pathway perturbation would likewise result in asymmetric mammary development...
December 19, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/27803853/gene-expression-and-histopathological-evaluation-of-thiamine-pyrophosphate-on-optic-neuropathy-induced-with-ethambutol-in-rats
#5
Emine Cinici, Nihal Cetin, Bahadir Suleyman, Durdu Altuner, Oguzhan Yarali, Hilal Balta, Ilknur Calik, Levent Tumkaya, Halis Suleyman
AIM: To compare the effects of thiamine pyrophosphate (TPP) and thiamine (TM) in oxidative optic neuropathy in rats induced by ethambutol. METHODS: The animals were divided into four groups: a control group (CG), an ethambutol control (ETC) group, TM plus ethambutol group (TMG), and TPP plus ethambutol group (TPPG). One hour after intraperitoneal administration of TM 20 mg/kg to the TMG group and TPP 20 mg/kg to TPPG group, 30 mg/kg ethambutol was given via gavage to all the groups but the CG...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/27803627/muscle-contraction-velocity-a-suitable-approach-to-analyze-the-functional-adaptations-in-elite-soccer-players
#6
Irineu Loturco, Lucas A Pereira, Ronaldo Kobal, Katia Kitamura, Rodrigo Ramírez-Campillo, Vinicius Zanetti, Cesar C Cal Abad, Fabio Y Nakamura
Tensiomyography (TMG) has been used as a simple and non-invasive tool to assess the mechanical properties of skeletal muscles. The TMG-derived velocity of contraction (Vc), which can be calculated from the ratio between maximal radial displacement and the sum of contraction time and delay time, has been proposed for evaluating athletes. However, its sensitivity to training effects and possible relation with changes in soccer players' neuromuscular performance have not yet been addressed. To test this possibility, twenty-two male Brazilian elite soccer players were assessed using TMG-derived Vc, unloaded squat jump, countermovement jump and drop jump at 45 cm, loaded jump squat and linear (20 m) and change of direction (COD) sprint tests, prior to and after an 8-week period, between two consecutive official tournaments, during which the concurrency between endurance and strength-power training commonly impairs neuromuscular capacities...
September 2016: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/27787977/synthesis-of-1-4-benzodiazepine-2-5-diones-by-base-promoted-ring-expansion-of-3-aminoquinoline-2-4-diones
#7
Filip Křemen, Martin Gazvoda, Stanislav Kafka, Karel Proisl, Anna Srholcová, Antonin Klasek, Damijana Urankar, Janez Košmrlj
An unprecedented reactivity of 3-aminoquinoline-2,4-diones is reported. Under basic conditions these compounds undergo molecular rearrangement to furnish 1,4-benzodiazepine-2,5-diones. The transformations take place under mild reaction conditions by using 1,1,3,3-tetramethylguanidine (TMG), NaOEt, or benzyltrimethylammonium hydroxide (Triton B) as a base. A proposed mechanism of the rearrangement and the conformational equilibrium of 1,4-benzodiazepine-2,5-dione rings are discussed.
October 27, 2016: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/27722545/enolate-mediated-1-3-dipolar-cycloaddition-reactions-of-allyl-ketones-with-nitrile-oxides-direct-access-to-3-5-disubstituted-isoxazolines
#8
Wenjun Li, Xiao Zhou, Zhenyan Shi, Yang Liu, Zhantao Liu, Hua Gao
TMG-promoted [3 + 2] organocatalytic 1,3-dipolar cycloaddition reactions of allyl ketones with in situ generated nitrile oxides have been developed. This strategy could generate 3,5-disubstituted isoxazolines in high yields and regioselectivities.
October 10, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27439472/-i-didn-t-really-understand-it-i-just-thought-it-d-help-exploring-the-motivations-understandings-and-experiences-of-patients-with-advanced-lung-cancer-participating-in-a-non-placebo-clinical-imp-trial
#9
Emily Harrop, Simon Noble, Michelle Edwards, Stephanie Sivell, Barbara Moore, Annmarie Nelson
BACKGROUND: Few studies have explored in depth the experiences of patients with advanced cancer who are participating in clinical investigational medicinal product trials. However, integrated qualitative studies in such trials are needed to enable a broader evaluation of patient experiences in the trial, with important ethical and practical implications for the design and conduct of similar trials and treatment regimes in the future. METHODS: Ten participants were recruited from the control and intervention arms of FRAGMATIC: a non-placebo trial for patients with advanced lung cancer...
2016: Trials
https://www.readbyqxmd.com/read/27434540/triphosphine-ligated-copper-hydrides-for-co2-hydrogenation-structure-reactivity-and-thermodynamic-studies
#10
Christopher M Zall, John C Linehan, Aaron M Appel
The copper(I) triphosphine complex LCu(MeCN)PF6 (L = 1,1,1-tris(diphenylphosphinomethyl)ethane), which we recently demonstrated is an active catalyst precursor for hydrogenation of CO2 to formate, reacts with H2 in the presence of a base to form a cationic dicopper hydride, [(LCu)2H]PF6. [(LCu)2H](+) is also an active precursor for catalytic CO2 hydrogenation, with equivalent activity to that of LCu(MeCN)(+), and therefore may be a relevant catalytic intermediate. The thermodynamic hydricity of [(LCu)2H](+) was determined to be 41...
August 10, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27402830/changes-in-o-linked-n-acetylglucosamine-o-glcnac-homeostasis-activate-the-p53-pathway-in-ovarian-cancer-cells
#11
Rafaela Muniz de Queiroz, Rashna Madan, Jeremy Chien, Wagner Barbosa Dias, Chad Slawson
O-GlcNAcylation is a dynamic post-translational modification consisting of the addition of a single N-acetylglucosamine sugar to serine and threonine residues in proteins by the enzyme O-linked β-N-acetylglucosamine transferase (OGT), whereas the enzyme O-GlcNAcase (OGA) removes the modification. In cancer, tumor samples present with altered O-GlcNAcylation; however, changes in O-GlcNAcylation are not consistent between tumor types. Interestingly, the tumor suppressor p53 is modified by O-GlcNAc, and most solid tumors contain mutations in p53 leading to the loss of p53 function...
September 2, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27354704/structure-function-analysis-and-genetic-interactions-of-the-luc7-subunit-of-the-saccharomyces-cerevisiae-u1-snrnp
#12
Radhika Agarwal, Beate Schwer, Stewart Shuman
Luc7 is an essential 261-amino acid protein subunit of the Saccharomyces cerevisiae U1 snRNP. To establish structure-function relations for yeast Luc7, we conducted an in vivo mutational analysis entailing N- and C-terminal truncations and alanine scanning of phylogenetically conserved amino acids, including two putative zinc finger motifs, ZnF1 and ZnF2, and charged amino acids within the ZnF2 module. We identify Luc7-(31-246) as a minimal functional protein and demonstrate that whereas mutations of the CCHH ZnF2 motif are lethal, mutations of the ZnF1 CCCH motif and the charged residues of the ZnF2 modules are not...
September 2016: RNA
https://www.readbyqxmd.com/read/27341918/computational-vibrational-spectroscopy-of-hdo-in-osmolyte-water-solutions
#13
Hochan Lee, Jun-Ho Choi, Pramod Kumar Verma, Minhaeng Cho
The IR absorption and time-resolved IR spectroscopy of the OD stretch mode of HDO in water was successfully used to study osmolyte effects on water H-bonding network. Protecting osmolytes such as sorbitol and trimethylglycine (TMG) make the vibrational OD stretch band red-shifted, whereas urea affects the OD band marginally. Furthermore, we recently showed that, even though sorbitol and TMG cause a slow-down of HDO rotation in their aqueous solutions, urea does not induce any change in the rotational relaxation of HDO in aqueous urea solutions even at high concentrations...
July 28, 2016: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/27317976/muscle-mechanical-properties-of-strength-and-endurance-athletes-and-changes-after-one-week-of-intensive-training
#14
Rauno Álvaro de Paula Simola, Christian Raeder, Thimo Wiewelhove, Michael Kellmann, Tim Meyer, Mark Pfeiffer, Alexander Ferrauti
The study investigates whether tensiomyography (TMG) is sensitive to differentiate between strength and endurance athletes, and to monitor fatigue after either one week of intensive strength (ST) or endurance (END) training. Fourteen strength (24.1±2.0years) and eleven endurance athletes (25.5±4.8years) performed an intensive training period of 6days of ST or END, respectively. ST and END groups completed specific performance tests as well as TMG measurements of maximal radial deformation of the muscle belly (Dm), deformation time between 10% and 90% Dm (Tc), rate of deformation development until 10% Dm (V10) and 90% Dm (V90) before (baseline), after training period (post1), and after 72h of recovery (post2)...
October 2016: Journal of Electromyography and Kinesiology
https://www.readbyqxmd.com/read/27231347/o-linked-n-acetylglucosamine-o-glcnac-transferase-and-o-glcnacase-interact-with-mi2%C3%AE-protein-at-the-a%C3%AE-globin-promoter
#15
Zhen Zhang, Flávia C Costa, Ee Phie Tan, Nathan Bushue, Luciano DiTacchio, Catherine E Costello, Mark E McComb, Stephen A Whelan, Kenneth R Peterson, Chad Slawson
One mode of γ-globin gene silencing involves a GATA-1·FOG-1·Mi2β repressor complex that binds to the -566 GATA site relative to the (A)γ-globin gene cap site. However, the mechanism of how this repressor complex is assembled at the -566 GATA site is unknown. In this study, we demonstrate that the O-linked N-acetylglucosamine (O-GlcNAc) processing enzymes, O-GlcNAc-transferase (OGT) and O-GlcNAcase (OGA), interact with the (A)γ-globin promoter at the -566 GATA repressor site; however, mutation of the GATA site to GAGA significantly reduces OGT and OGA promoter interactions in β-globin locus yeast artificial chromosome (β-YAC) bone marrow cells...
July 22, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27189432/high-performance-liquid-chromatography-ultraviolet-method-for-the-determination-of-total-specific-migration-of-nine-ultraviolet-absorbers-in-food-simulants-based-on-1-1-3-3-tetramethylguanidine-and-organic-phase-anion-exchange-solid-phase-extraction-to-remove
#16
Jianling Wang, Xiaofeng Xiao, Tong Chen, Tingfei Liu, Huaming Tao, Jun He
The glyceride in oil food simulant usually causes serious interferences to target analytes and leads to failure of the normal function of the RP-HPLC column. In this work, a convenient HPLC-UV method for the determination of the total specific migration of nine ultraviolet (UV) absorbers in food simulants was developed based on 1,1,3,3-tetramethylguanidine (TMG) and organic phase anion exchange (OPAE) SPE to efficiently remove glyceride in olive oil simulant. In contrast to the normal ion exchange carried out in an aqueous solution or aqueous phase environment, the OPAE SPE was performed in the organic phase environments, and the time-consuming and challenging extraction of the nine UV absorbers from vegetable oil with aqueous solution could be readily omitted...
June 17, 2016: Journal of Chromatography. A
https://www.readbyqxmd.com/read/27183893/enolate-mediated-1-3-dipolar-cycloaddition-reaction-of-%C3%AE-functionalized-ketones-with-nitrile-oxides-direct-access-to-3-4-5-trisubstituted-isoxazoles
#17
Xiao Zhou, Xianhong Xu, Zhenyan Shi, Kun Liu, Hua Gao, Wenjun Li
TMG-catalyzed [3 + 2] organocatalytic 1,3-dipolar cycloaddition reactions of β-functionalized ketones with nitrile oxides have been developed. This strategy could generate 3,4,5-trisubstituted isoxazoles in high yields and regioselectivities.
June 21, 2016: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/27131337/influence-of-blanketing-and-season-on-vitamin-d-and-parathyroid-hormone-calcium-phosphorus-and-magnesium-concentrations-in-horses-in-new-zealand
#18
S Azarpeykan, K E Dittmer, E K Gee, J C Marshall, J Wallace, P Elder, E Acke, K G Thompson
The aims of the study were to determine the effect of season and blanketing on vitamin D synthesis in horses and examine the interaction between vitamin D and other analytes involved in calcium homeostasis. Twenty-one healthy horses at pasture were included; 5 were covered with standard horse blankets including neck rugs. Blood samples were collected for 13 mo and analyzed for 25-hydroxyvitamin D2 (25OHD2) and 25-hydroxyvitamin D3 (25OHD3), 1,25-dihydroxyvitamin D (1,25[OH]2D), ionized calcium (iCa), total calcium (tCa), phosphorus (P), total magnesium (tMg), and parathyroid hormone (PTH)...
July 2016: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/27130929/comparing-breast-cancer-multiparameter-tests-in-the-optima-prelim-trial-no-test-is-more-equal-than-the-others
#19
John M S Bartlett, Jane Bayani, Andrea Marshall, Janet A Dunn, Amy Campbell, Carrie Cunningham, Monika S Sobol, Peter S Hall, Christopher J Poole, David A Cameron, Helena M Earl, Daniel W Rea, Iain R Macpherson, Peter Canney, Adele Francis, Christopher McCabe, Sarah E Pinder, Luke Hughes-Davies, Andreas Makris, Robert C Stein
BACKGROUND: Previous reports identifying discordance between multiparameter tests at the individual patient level have been largely attributed to methodological shortcomings of multiple in silico studies. Comparisons between tests, when performed using actual diagnostic assays, have been predicted to demonstrate high degrees of concordance. OPTIMA prelim compared predicted risk stratification and subtype classification of different multiparameter tests performed directly on the same population...
September 2016: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/27047776/the-microvascular-anastomotic-coupler-for-venous-anastomoses-in-free-flap-breast-reconstruction-improves-outcomes
#20
Edmund Fitzgerald O'Connor, Warren Matthew Rozen, Muhammad Chowdhry, Nakul Gamanlal Patel, Whitney T H Chow, Matthew Griffiths, Venkat V Ramakrishnan
BACKGROUND: Venous couplers are ubiquitous around the world and are a useful tool for the reconstructive microsurgeon. A systematic review of coupler performance studies demonstrated a thrombosis rate range of 0% to 3%, whilst the average time of using the device is 5 minutes. There is sparse published data on cost analysis and the impact of operator experience on the anastomotic coupler device success. Improvements in outcomes other than time benefits have also not been shown. This study aims to address these deficiencies in the literature...
April 2016: Gland Surgery
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