keyword
MENU ▼
Read by QxMD icon Read
search

Obsessive Compulsive Disorder

keyword
https://www.readbyqxmd.com/read/28104554/abnormalities-in-metabolite-concentrations-in-tourette-s-disorder-and-obsessive-compulsive-disorder-a-proton-magnetic-resonance-spectroscopy-study
#1
Siyan Fan, Danielle C Cath, Odile A van den Heuvel, Ysbrand D van der Werf, Caroline Schöls, Dick J Veltman, Petra J W Pouwels
INTRODUCTION: Abnormal glutamatergic transmission in cortico-striato-thalamo-cortical (CSTC) circuits is thought to be involved in the pathophysiology of Tourette's disorder (TD) and obsessive-compulsive disorder (OCD). Using proton magnetic resonance spectroscopy, the current study aimed to investigate regional concentrations of glutamatergic compounds in TD and OCD patients in comparison to healthy control subjects (HC). MATERIAL AND METHODS: Twenty-three TD patients, 20 OCD patients and 22 HC were included...
January 4, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28104431/abnormal-regional-spontaneous-neuronal-activity-associated-with-symptom-severity-in-treatment-naive-patients-with-obsessive-compulsive-disorder-revealed-by-resting-state-functional-mri
#2
Linlin Qiu, Xiangshuai Fu, Shuai Wang, Qunfeng Tang, Xingui Chen, Lin Cheng, Fuquan Zhang, Zhenhe Zhou, Lin Tian
A large number of neuroimaging studies have revealed the dysfunction of brain activities in obsessive-compulsive disorder (OCD) during various tasks. However, regional spontaneous activity abnormalities in OCD are gradually being revealed. In this current study, we aimed to investigate cerebral regions with abnormal spontaneous activity using resting-state functional magnetic resonance imaging (fMRI) and further explored the relationship between the spontaneous neuronal activity and symptom severity of patients with OCD...
January 16, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28103527/distinct-cortico-striatal-connections-with-subthalamic-nucleus-underlie-facets-of-compulsivity
#3
Laurel S Morris, Kwangyeol Baek, Valerie Voon
The capacity to flexibly respond to contextual changes is crucial to adapting to a dynamic environment. Compulsivity, or behavioural inflexibility, consists of heterogeneous subtypes with overlapping yet discrete neural substrates. The subthalamic nucleus (STN) mediates the switch from automatic to controlled processing to slow, break or stop behaviour when necessary. Rodent STN lesions or inactivation are linked with perseveration or repetitive, compulsive responding. However, there are few studies examining the role of latent STN-centric neural networks and compulsive behaviour in healthy individuals...
December 29, 2016: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28099183/memantine-as-an-adjuvant-treatment-for-obsessive-compulsive-symptoms-in-manic-phase-of-bipolar-disorder-a-randomized-double-blind-placebo-controlled-clinical-trial
#4
Ali Sahraian, Leila Razeghian Jahromi, Ahmad Ghanizadeh, Arash Mowla
PURPOSE/BACKGROUND: The aim of this study is to examine the effects of memantine as an adjuvant treatment for obsessive compulsive (OC) symptoms in patients with bipolar disorder (BD) type I, manic phase. METHODS/PROCEDURES: In this 16-week double-blind placebo-controlled randomized clinical trial, 58 patients in the manic phase of BD who had OC symptoms were randomly allocated to receive memantine or placebo plus their routine medications (lithium + olanzapine + clonazepam)...
January 18, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28099039/gilles-de-la-tourette-syndrome-depression-depressive-illness-and-correlates-in-a-child-and-adolescent-population
#5
Renata Rizzo, Mariangela Gulisano, Davide Martino, Mary May Robertson
OBJECTIVE: Gilles de la Tourette syndrome (GTS) and depression are both common disorders. It has been suggested that depression occurs in 13%-76% GTS patients. Despite this, there are few studies into the specific relationships and correlates between the two disorders. There is only some consensus as to the precise relationship between the two disorders. MATERIALS AND METHODS: We undertook the study to investigate the relationship between depressive symptomatology and the core clinical features of GTS in a well-characterized clinical population of youth with this disorder...
January 18, 2017: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/28096676/aripiprazole-augmentation-in-managing-comorbid-obsessive-compulsive-disorder-and-bipolar-disorder-a-case-with-suicidal-attempts
#6
Jianbo Lai, Qiaoqiao Lu, Peng Zhang, Tingting Xu, Yi Xu, Shaohua Hu
Comorbid obsessive-compulsive disorder (OCD) and bipolar disorder (BD) have long been an intractable problem in clinical practice. The increased risk of manic/hypomanic switch hinders the use of antidepressants for managing coexisting OCD symptoms in BD patients. We herein present a case of a patient with BD-OCD comorbidity, who was successfully treated with mood stabilizers and aripiprazole augmentation. The young female patient reported recurrent depressive episodes and aggravating compulsive behaviors before hospitalization...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28096674/alterations-of-white-matter-fractional-anisotropy-in-unmedicated-obsessive-compulsive-disorder
#7
Jiong Tao, Xianglan Wang, Zhiyong Zhong, Hongying Han, Sha Liu, Shenglin Wen, Nianhong Guan, Lingjiang Li
BACKGROUND: Abnormalities in white matter (WM) have previously been reported in patients with obsessive-compulsive disorder (OCD). However, there was some inconsistency in the results obtained for altered regions of WM. The aim of this study was to investigate fractional anisotropy (FA) in the WM of the whole brain in patients with OCD by using diffusion tensor imaging (DTI). METHODS: In total, 28 unmedicated patients with OCD and 28 healthy volunteers underwent DTI scan...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28095945/conflict-monitoring-and-adaptation-as-reflected-by-n2-amplitude-in-obsessive-compulsive-disorder
#8
A Riesel, J Klawohn, N Kathmann, T Endrass
BACKGROUND: Feelings of doubt and perseverative behaviours are key symptoms of obsessive-compulsive disorder (OCD) and have been linked to hyperactive error and conflict signals in the brain. While enhanced neural correlates of error monitoring have been robustly shown, far less is known about conflict processing and adaptation in OCD. METHOD: We examined event-related potentials during conflict processing in 70 patients with OCD and 70 matched healthy comparison participants, focusing on the stimulus-locked N2 elicited in a flanker task...
January 18, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28093822/the-role-of-guilt-sensitivity-in-ocd-symptom-dimensions
#9
Gabriele Melli, Claudia Carraresi, Andrea Poli, Donatella Marazziti, Antonio Pinto
: Although some studies have found that guilt may precede, motivate, or be a consequence of obsessive-compulsive disorder (OCD), the relationship between guilt and OCD has been under investigated. The studies that explored the role of trait guilt (guilt propensity) in OCD reported inconsistent findings and failed to support its predictive role. Since it has been suggested that OCD patients perceive guilt in a more threatening manner, it might also be relevant to test to what extent they negatively evaluate the experience of guilt (i...
January 16, 2017: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/28093790/a-case-series-of-family-based-treatment-for-adolescents-with-atypical-anorexia-nervosa
#10
Elizabeth K Hughes, Daniel Le Grange, Andrew Court, Susan M Sawyer
The aim of this case series was to examine engagement in and outcomes of family-based treatment (FBT) for adolescents with DSM-5 atypical AN, that is, adolescents who were not underweight at presentation. Consecutive referrals for FBT of adolescents with atypical AN to a specialist child and adolescent eating disorder program were examined. Engagement in treatment (i.e., dose of treatment, completion rate), and changes in psychological symptomatology (i.e., eating disorder symptoms, depressive symptoms, self-esteem, obsessive compulsiveness), weight, and menstrual function were examined...
January 17, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28090807/neurocognitive-function-in-pediatric-obsessive-compulsive-disorder
#11
Daniel A Geller, Amitai Abramovitch, Andrew Mittelman, Abigail Stark, Kesley Ramsey, Allison Cooperman, Lee Baer, S Evelyn Stewart
OBJECTIVES: The small body of neuropsychological research in pediatric OCD yields inconsistent results. A recent meta-analysis found small effect sizes, concluding that pediatric OCD may not be associated with cognitive impairments, stressing the need for more research. We investigated neuropsychological performance in a large sample of OCD youth, while assessing potential moderators. METHODS: Participants with OCD (n = 102), and matched controls (n = 161) were thoroughly screened and blindly evaluated for comorbidities, and completed a neuropsychological battery assessing processing-speed, visuospatial abilities (VSA), working memory (WM), nonverbal memory (NVM), and executive functions (EF)...
January 16, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28078209/cognitive-behavioural-therapy-for-obsessive-compulsive-disorder-co-occurring-with-psychosis-systematic-review-of-evidence
#12
Antonio Tundo, Roberta Necci
AIM: To review available evidence on the use of cognitive behavioural therapy (CBT) for treating obsessive compulsive disorder co-occurring with psychosis. METHODS: In this paper we present a detailed and comprehensive review of the current literature focusing on CBT treatment of obsessive compulsive disorder (OCD) co-occurring with schizophrenia or schizoaffective disorder. We identified relevant literature published between 2001 and May 2016 through MEDLINE/PubMed search using as search string ("obsessive compulsive disorders" or "obsessive compulsive symptoms") and ("schizophrenia" or "schizoaffective disorder" or "psychosis") and ("cognitive behavioural therapy")...
December 22, 2016: World Journal of Psychiatry
https://www.readbyqxmd.com/read/28076681/computational-modeling-of-neurotransmitter-release-evoked-by-electrical-stimulation-non-linear-approaches-to-predicting-stimulation-evoked-dopamine-release
#13
James K Trevathan, Ali Yousefi, Hyung Ook Park, John J Bartoletta, Kip A Ludwig, Kendall H Lee, J Luis Lujan
Neurochemical changes evoked by electrical stimulation of the nervous system have been linked to both therapeutic and undesired effects of neuromodulation therapies used to treat obsessive-compulsive disorder, depression, epilepsy, Parkinson's disease, stroke, hypertension, tinnitus, and many other indications. In fact, interest in better understanding the role of neurochemical signaling in neuromodulation therapies has been a focus of recent government- and industry-sponsored programs whose ultimate goal is to usher in an era of personalized medicine by creating neuromodulation therapies that respond to real-time changes in patient status...
January 11, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28076636/body-dysmorphic-symptoms-scale-for-patients-seeking-esthetic-surgery-cross-cultural-validation-study
#14
Tatiana Dalpasquale Ramos, Maria José Azevedo de Brito, Mônica Sarto Piccolo, Maria Fernanda Normanha da Silva Martins Rosella, Miguel Sabino, Lydia Masako Ferreira
CONTEXT AND OBJECTIVE: Rhinoplasty is one of the most sought-after esthetic operations among individuals with body dysmorphic disorder. The aim of this study was to cross-culturally adapt and validate the Body Dysmorphic Symptoms Scale. DESIGN AND SETTING: Cross-cultural validation study conducted in a plastic surgery outpatient clinic of a public university hospital. METHODS: Between February 2014 and March 2015, 80 consecutive patients of both sexes seeking rhinoplasty were selected...
November 2016: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28072701/pathophysiology-of-refractory-obsessive-compulsive-disorder-a-study-of-visual-search-combined-with-overactive-performance-monitoring
#15
Qingxiao Liu, Bo Tan, Jing Zhou, Zhong Zheng, Ling Li, Yanchun Yang
Based on both functional and structural studies of excessive activity, fronto-striatal-thalamic-cortical and cortico-striatal circuits have been hypothesized to underlie the pathophysiology of obsessive-compulsive disorder (OCD). However, the neurobiological underpinnings of OCD refractory to medication and therapy remain controversial. This study aimed to evaluate neuroanatomical abnormalities of the whole brain and to evaluate visual processing in patients with refractory OCD.This study was comprised of 2 experiments...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28071825/systematic-review-of-severity-scales-and-screening-instruments-for-tics-critique-and-recommendations
#16
Davide Martino, Tamara M Pringsheim, Andrea E Cavanna, Carlo Colosimo, Andreas Hartmann, James F Leckman, Sheng Luo, Alexander Munchau, Christopher G Goetz, Glenn T Stebbins, Pablo Martinez-Martin
BACKGROUND: Several clinician, informant, and self-report instruments for tics and associated phenomena have been developed that differ in construct, comprehensiveness, and ease of administration. OBJECTIVE: A Movement Disorders Society subcommittee aimed to rate psychometric quality of severity and screening instruments for tics and related sensory phenomena. METHODS: Following the methodology adopted by previous Movement Disorders Society subcommittee papers, a review of severity and screening instruments for tics was completed, applying a classification as "recommended," "suggested," or "listed" to each instrument...
January 10, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28070247/effectiveness-of-cognitive-behavioral-therapy-and-fluoxetine-on-sexual-function-of-women-with-obsessive-compulsive-disorder-a-double-blind-randomized-controlled-trial
#17
Zahra Sabetnejad, Fatemeh Assarian, Abdollah Omidi, Mohammad Reza Najarzadegan
BACKGROUND: Obsessive compulsive disorder (OCD) is a mental health concern due to its various negative consequences, especially in sexual function. Therefore, the treatment of sexual dysfunction in women with OCD is important in order to improve the patient's marital function and mental health. OBJECTIVES: To compare the sexual behavior and sexual and marital satisfaction in women with obsessive-compulsive disorder (OCD) before and after treatment with fluoxetine and cognitive behavior therapy...
November 2016: Electronic Physician
https://www.readbyqxmd.com/read/28070119/ocd-like-behavior-is-caused-by-dysfunction-of-thalamo-amygdala-circuits-and-upregulated-trkb-erk-mapk-signaling-as-a-result-of-spred2-deficiency
#18
M Ullrich, M Weber, A M Post, S Popp, J Grein, M Zechner, H Guerrero González, A Kreis, A G Schmitt, N Üçeyler, K-P Lesch, K Schuh
Obsessive-compulsive disorder (OCD) is a common neuropsychiatric disease affecting about 2% of the general population. It is characterized by persistent intrusive thoughts and repetitive ritualized behaviors. While gene variations, malfunction of cortico-striato-thalamo-cortical (CSTC) circuits, and dysregulated synaptic transmission have been implicated in the pathogenesis of OCD, the underlying mechanisms remain largely unknown. Here we show that OCD-like behavior in mice is caused by deficiency of SPRED2, a protein expressed in various brain regions and a potent inhibitor of Ras/ERK-MAPK signaling...
January 10, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28067006/addressing-reverse-inference-in-psychiatric-neuroimaging-meta-analyses-of-task-related-brain-activation-in-common-mental-disorders
#19
Emma Sprooten, Alexander Rasgon, Morgan Goodman, Ariella Carlin, Evan Leibu, Won Hee Lee, Sophia Frangou
Functional magnetic resonance imaging (fMRI) studies in psychiatry use various tasks to identify case-control differences in the patterns of task-related brain activation. Differently activated regions are often ascribed disorder-specific functions in an attempt to link disease expression and brain function. We undertook a systematic meta-analysis of data from task-fMRI studies to examine the effect of diagnosis and study design on the spatial distribution and direction of case-control differences on brain activation...
January 9, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28066002/management-of-obsessive-compulsive-disorder-comorbid-with-bipolar-disorder
#20
REVIEW
Firoz Kazhungil, E Mohandas
Obsessive-compulsive disorder (OCD) is one of the most common comorbidities in bipolar disorder (BD). Clinicians often get perplexed in making treatment decisions when encountering comorbid OCD and BD as treatment of OCD by pharmacotherapy may induce or exacerbate mood instability and psychotherapeutic approaches for OCD may not be feasible in acute manic or depressive state of BD. In this study, we reviewed literature, whether existing guideline-based treatments of BD may be effective in OCD and whether newer agents will be of use for treating this comorbidity...
July 2016: Indian Journal of Psychiatry
keyword
keyword
28714
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"