keyword
https://read.qxmd.com/read/38527659/successful-pregnancy-and-delivery-after-hiporfin-photodynamic-therapy-for-cervical-high-grade-squamous-intraepithelial-lesion
#1
JOURNAL ARTICLE
Yu Liu, Ruifang Wu, Changzhong Li, Lihui Wei, Ruizhen Li
OBJECTIVE: The study analyzed HiPorfin-Photodynamic therapy (PDT) for young women with cervial high-grade squamous intraepithelial lesion (HSIL) and evaluated the impact of PDT on their pregnancy and delivery. METHODS: Retrospective analysis of 4 patients (21-33 years old) were treated with HiPorfin® (2mg/kg) PDT in 2019-2022. 1 patient suffered from cervical intraepithelial neoplasia (CIN)Ⅱ and 3 patients from CIN Ⅲ. 630nm laser light irradiated the cervical surface and endocervical canal with light dose of 150 J/cm2 and 100-120J/cm2 respectively...
March 23, 2024: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/38401818/photodynamic-therapy-with-hiporfin-for-cervical-squamous-intraepithelial-lesion-at-childbearing-age
#2
JOURNAL ARTICLE
Yu Liu, Ruifang Wu, Changzhong Li, Lihui Wei, Ruizhen Li
OBJECTIVE: To evaluate the clinical efficacy and safety of HiPorfin® photodynamic therapy (PDT) in the treatment of young women at reproductive age with high-grade squamous intraepithelial lesion (HSIL) of the cervix. METHODS: Prospective study of 41 patients aged 28.8±4.6 years old with cervical intraepithelial neoplasia (CIN) Ⅱ-Ⅲ at Peking University Shenzhen Hospital from March 2019 to January 2023. HiPorfin® (2mg/kg) was infused intravenously, and 48-72h later, 630-nm laser irradiation was performed in cervical canal and cervical surface with an irradiation dose of 100-120J/cm2 and 150J/cm2 respectively...
February 22, 2024: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/38310827/glutaminolysis-inhibition-boosts-photodynamic-therapy-to-eliminate-cancer-stem-cells
#3
JOURNAL ARTICLE
Qiang Wang, Shiyou Li, Chen Xu, Xing Wang, Tian Yang, Chong Wang, Yuxuan Xiong, Zhijie Zhang, Xiangliang Yang, Zifu Li
High reactive oxygen species (ROS) levels provide a therapeutic opportunity to eradicate cancer stem cells (CSCs), a population of cells responsible for tumorigenesis, progression, metastasis, and recurrence. However, enhanced antioxidant systems in this population of cells attenuate ROS-inducing therapies. Here, we developed a nanoparticle-assisted combination therapy to eliminate CSCs by employing photodynamic therapy (PDT) to yield ROS while disrupting ROS defense with glutaminolysis inhibition. Specifically, we leveraged an oleic acid-hemicyanine conjugate (CyOA) as photosensitizer, a new entity molecule HYL001 as glutaminolysis inhibitor, and a biocompatible folic acid-hydroxyethyl starch conjugate (FA-HES) as amphiphilic surfactant to construct cellular and mitochondrial hierarchical targeting nanomedicine (COHF NPs)...
February 2, 2024: Biomaterials
https://read.qxmd.com/read/37680304/unimolecular-self-assembled-hemicyanine-oleic-acid-conjugate-acts-as-a-novel-succinate-dehydrogenase-inhibitor-to-amplify-photodynamic-therapy-and-eliminate-cancer-stem-cells
#4
JOURNAL ARTICLE
Qiang Wang, Tian Yang, Shiyou Li, Chen Xu, Chong Wang, Yuxuan Xiong, Xing Wang, Jiangling Wan, Xiangliang Yang, Zifu Li
Photodynamic therapy with reactive oxygen species production is a prospective treatment to combat cancer stem cells (CSCs). However, the innate drawbacks, including short lifetime and diffusion distance of reactive oxygen species and hypoxia within solid tumors, have become bottlenecks for clinical applications of photodynamic therapy. Here, we develop a mitochondria-targeting hemicyanine-oleic acid conjugate (CyOA), which can self-assemble into supramolecular nanoparticles (NPs) without any exogenous excipients...
2023: Research: a science partner journal
https://read.qxmd.com/read/35917911/porous-organic-polymer-overcomes-the-post-treatment-phototoxicity-of-photodynamic-agents-and-maintains-their-antitumor-efficiency
#5
JOURNAL ARTICLE
Yamin Liu, Ze-Kun Wang, Zhong-Zheng Gao, Yang Zong, Jian-Da Sun, Wei Zhou, Hui Wang, Da Ma, Zhan-Ting Li, Dan-Wei Zhang
Since 1995, photodynamic therapy (PDT) has been utilized as an effective method for cancer treatment. However, the residues of photosensitizers in the normal tissues after PDT can be activated by sunlight to cause severe skin phototoxicity, for which currently there are no clinical solutions. As a result, post-PDT patients need to remain out of sunlight for up to five weeks, which produces great living and mental burdens for patients. Herein, we report that a biocompatible porous organic polymer (POP) with average 3...
July 30, 2022: Acta Biomaterialia
https://read.qxmd.com/read/35338941/supramolecular-organic-frameworks-improve-the-safety-of-clinically-used-porphyrin-photodynamic-agents-and-maintain-their-antitumor-efficacy
#6
JOURNAL ARTICLE
Yamin Liu, Chuan-Zhi Liu, Ze-Kun Wang, Wei Zhou, Hui Wang, Yun-Chang Zhang, Dan-Wei Zhang, Da Ma, Zhan-Ting Li
Despite that photodynamic therapy (PDT) has been applied for the treatment of cancer and skin diseases for more than two decades, all clinically used photodynamic agents (PDAs) suffer the drawback of skin phototoxicity of PDAs, which requires patients to avoid exposure to natural light for weeks after treatment, but has so far lacked effective suppression methods. Here, we report that three-dimensional diamondoid supramolecular organic frameworks (SOFs), that possess well-defined 2.1-nm porosity, can be used to suppress the skin phototoxicity of Photofrin, HiPorfin and Talaporfin, three porphyrin-based PDAs which clinically receive the most wide applications by injecting SOF after PDT, via an adsorption and retention mechanism...
May 2022: Biomaterials
https://read.qxmd.com/read/34597833/bimodal-photodynamic-therapy-for-treatment-of-a-91-year-old-patient-with-locally-advanced-cutaneous-basal-cell-carcinoma-and-postoperative-scar-management
#7
JOURNAL ARTICLE
Caihe Liao, Lei Shi, Dixin Wang, Xiuli Wang
Locally advanced basal cell carcinoma (laBCC) is an uncommon cutaneous malignant tumor characterized by direct spread and extensive tissue destruction. The optimal therapy for laBCC remains a challenge, especially for elderly patients. Photodynamic therapy (PDT) has its advantage of better tumor selectivity, providing focal treatment for various non-melanoma carcinomas. We report that a new combination treatment of HiPorfin-photodynamic therapy (HiPorfin-PDT) and modified topical 5-aminolevulinic acid-photodynamic therapy (ALA-PDT), named bimodal PDT was successful to treat a 91-year-old patient with laBCC...
December 2021: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/34333147/quenching-effects-of-epigallocatechin-gallate-for-singlet-oxygen-production-and-its-protection-against-oxidative-damage-induced-by-ce6-mediated-photodynamic-therapy-in-vitro
#8
JOURNAL ARTICLE
Xianglian Liao, Chunxiu Yang, Huiyun Lin, Buhong Li
BACKGROUND: Singlet oxygen (1 O2 ) is highly reactive to biological components such as lipids, proteins and DNA, which induces oxidative damage to cells and tissues. Natural antioxidants may function as 1 O2 quencher to prevent 1 O2 involved photosensitized oxidation in biological system. METHODS: Time-resolved measurement of 1 O2 luminescence was employed to evaluate the 1 O2 quenching abilities of natural antioxidants in air-statured phosphate buffered saline (PBS), including (-)-Epigallocatechin gallate (EGCG), Proanthocyanidins, L-carnosine and Vitamin C...
December 2021: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/33708841/monitoring-perfusion-and-oxygen-saturation-in-port-wine-stains-during-vascular-targeted-photodynamic-therapy
#9
JOURNAL ARTICLE
Defu Chen, Ying Wang, Hongyou Zhao, Haixia Qiu, Yongtian Wang, Jian Yang, Ying Gu
BACKGROUND: Vascular targeted photodynamic therapy (V-PDT) is a safe and effective therapeutic modality for port-wine stains (PWS) by targetedly damaging the dilated and malformed blood vessels. This study aims to monitor and quantify the changes in oxygen saturation (StO2 ), blood volume fraction (BVF) and perfusion in PWS lesions before and during V-PDT. METHODS: Microvascular parameters (i.e., StO2 and BVF) and skin perfusion were measured noninvasively by using diffuse reflectance spectroscopy (DRS) and laser Doppler imaging (LDI), respectively...
February 2021: Annals of Translational Medicine
https://read.qxmd.com/read/32578508/clinical-efficacy-of-hiporfin-photodynamic-therapy-for-advanced-obstructive-esophageal-cancer
#10
JOURNAL ARTICLE
Ruifang Zeng, Chen Liu, Libo Li, Xiaojun Cai, Run Chen, Zhiwen Li
OBJECTIVE: To explore the clinical efficacy of HiPorfin photodynamic therapy for advanced esophageal cancer and evaluate its impact on survival. METHODS: Retrospective analysis of 32 patients with advanced obstructive esophageal cancer at our institution from September 2013 to December 2016. HiPorfin was infused as the photosensitizer at a dose of 5 mg/kg, and after 48 hours, 630-nm laser irradiation was subsequently performed through an optical fiber that passed through the biopsy channel of a flexible endoscope...
January 2020: Technology in Cancer Research & Treatment
https://read.qxmd.com/read/29575297/sonodynamic-therapy-assisted-immunotherapy-a-novel-modality-for-cancer-treatment
#11
JOURNAL ARTICLE
Qianyu Zhang, Cuixia Bao, Xiaojun Cai, Longwei Jin, Lingling Sun, Yuehong Lang, Libo Li
Sonodynamic therapy (SDT), which is based on photodynamic therapy (PDT), is a new cancer treatment modality. Unlike PDT, which has poor tissue penetration, ultrasound can penetrate deeply into tissues and largely target tumor tissue to mediate the cytotoxicity of sonosensitizers. We hypothesize that, similar to PDT, SDT may perform effectively as a cancer vaccine. Thus, we developed a therapeutic strategy to explore whether SDT can eliminate primary tumors, inhibit metastases, and prevent tumor relapse. In the present study, we found that HiPorfin (HPD)-induced SDT killed tumor cells, promoted calreticulin expression on the cell surface and elicited immune responses...
May 2018: Cancer Science
https://read.qxmd.com/read/25619546/hiporfin-mediated-photodynamic-therapy-in-preclinical-treatment-of-osteosarcoma
#12
JOURNAL ARTICLE
Mengxiong Sun, Chenghao Zhou, Hui Zeng, Nahum Puebla-Osorio, Elisabetta Damiani, Jian Chen, Hongsheng Wang, Guodong Li, Fei Yin, Liancheng Shan, Dongqing Zuo, Yuxin Liao, Zhuoying Wang, Longpo Zheng, Yingqi Hua, Zhengdong Cai
This study was carried out to investigate the anti-tumor effect and mechanism of hiporfin-mediated photodynamic therapy (hiporfin-PDT) in osteosarcoma. We found that hiporfin accumulated mainly in the cytoplasm of osteosarcoma cells in a time and concentration-dependent manner. Hiporfin-PDT inhibited the proliferation, induced apoptosis and produced cell cycle arrest at G2M in osteosarcoma cell lines. Hiporfin-PDT increased the expression of cleaved-caspase-3, cleaved PARP-1, Bax and RIP1 while it decreased the expression of Bcl-2; in addition, low concentration of hiporfin increased LC3 conversion...
May 2015: Photochemistry and Photobiology
https://read.qxmd.com/read/22369734/fluorescence-examination-and-photodynamic-therapy-of-facial-squamous-cell-carcinoma-a-case-report
#13
JOURNAL ARTICLE
Xiaona Zhang, Jinzhang Chen, Yuling Luo, Lanying Zhang, Rongcheng Luo, Libo Li
BACKGROUND AND OBJECTIVE: To evaluate the usefulness and feasibility of fluorescence examination and photodynamic therapy (PDT) for facial squamous cell carcinoma. METHODS: A 68-year-old male patient underwent 3 courses of PDT. The first treatment was carried out using topically applied 5-aminolevulinic acid (ALA) to the affected area (5.0 cm × 2.5 cm) 3h before light irradiation. ALA/PpIX-mediated fluorescence was used to visualize the lesion and its margin. The lesion was illuminated with a 630 nm laser at 120 J/cm²...
March 2012: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/19356672/an-update-on-the-regulatory-status-of-pdt-photosensitizers-in-china
#14
JOURNAL ARTICLE
Zheng Huang
Numerous photosensitizers have been developed and evaluated in China. HiPorfin, a hematoporphyrin derivative (HpD) received the first regulatory approval in the early 2000s. Aila, a topical formulation containing predrug 5-aminolevulinic acid, received the regulatory approval in 2007. Recently, new drug applications have been filed for several hematoporphyrin derivatives and a zinc phthalocyanine (ZnPc) derivative. This short report will summarize the current regulatory status of Chinese photosensitizers developed for photodynamic therapy (PDT)...
December 2008: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/19242772/treatment-of-perianal-paget-s-disease-using-photodynamic-therapy-with-assistance-of-fluorescence-examination-case-report
#15
JOURNAL ARTICLE
Libo Li, Yongjian Deng, Lanying Zhang, Wangjun Liao, Rongcheng Luo, Zheng Huang
Our aim was to determine the usefulness of fluorescence examination and photodynamic therapy (PDT) for the management of perianal extramammary Paget's disease. A 75-year-old woman underwent two courses of PDT. The first treatment was carried out with topically applied 5-aminolevulinic acid (ALA) to the affected area (2.5 x 2.5 cm(2)) 3 h before light treatment. We used ALA/protoporphyrin IX (PpIX)-mediated fluorescence to visualize the lesion and its margins. The lesion was treated with a 630 nm laser at 120 J/cm(2)...
November 2009: Lasers in Medical Science
1
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.