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https://www.readbyqxmd.com/read/29772692/insurance-coverage-policies-for-pharmacogenomic-and-multi-gene-testing-for-cancer
#1
Christine Y Lu, Stephanie Loomer, Rachel Ceccarelli, Kathleen M Mazor, James Sabin, Ellen Wright Clayton, Geoffrey S Ginsburg, Ann Chen Wu
Insurance coverage policies are a major determinant of patient access to genomic tests. The objective of this study was to examine differences in coverage policies for guideline-recommended pharmacogenomic tests that inform cancer treatment. We analyzed coverage policies from eight Medicare contractors and 10 private payers for 23 biomarkers (e.g., HER2 and EGFR ) and multi-gene tests. We extracted policy coverage and criteria, prior authorization requirements, and an evidence basis for coverage. We reviewed professional society guidelines and their recommendations for use of pharmacogenomic tests...
May 16, 2018: Journal of Personalized Medicine
https://www.readbyqxmd.com/read/29740220/attributing-diseases-to-multiple-pathways-a-causal-pie-modeling-approach
#2
Christine Chen, Wen-Chung Lee
Characterizing the relations between exposures and diseases is the central tenet of epidemiology. Researchers may want to evaluate exposure-disease causation by assessing whether the disease under concern is induced by the various exposures - the so-called "attribution". In this paper, the authors propose a method to attribute diseases to multiple pathways based on the causal-pie model. The method can also be used to evaluate the potential impact of an intervention strategy and to allocate responsibility in tort-law liability issues...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/29737846/design-of-conformationally-constrained-acyl-sulfonamide-isosteres-identification-of-n-1-2-4-triazolo-4-3-a-pyridin-3-yl-methane-sulfonamides-as-potent-and-selective-hnav1-7-inhibitors-for-the-treatment-of-pain
#3
Thilo Focken, Sultan Chowdhury, Alla Zenova, Michael E Grimwood, Christine Chabot, Tao Sheng, Ivan Hemeon, Shannon M Decker, Michael Wilson, Paul Bichler, Qi Jia, Shaoyi Sun, Clint Young, Sophia Lin, Samuel J Goodchild, Noah G Shuart, Elaine Chang, Zhiwei Xie, Bowen Li, Kuldip Khakh, Girish Bankar, Matthew Waldbrook, Rainbow Kwan, Karen Nelkenbrecher, Parisa Karimi Tari, Navjot Chahal, Luis Sojo, C Lee Robinette, Andrew D White, Chien-An Chen, Yi Zhang, Jodie Pang, Jae H Chang, David H Hackos, James P Johnson, Charles J Cohen, Daniel Fred Ortwine, Daniel P Sutherlin, Christoph M Dehnhardt, Brian Salvatore Safina
The sodium channel NaV1.7 has emerged as a promising target for the treatment of pain based on strong genetic validation of its role in nociception. In recent years, a number of aryl and acyl sulfonamides have been reported as potent inhibitors of NaV1.7, with high selectivity over the cardiac isoform NaV1.5. Herein, we report on the discovery of a novel series of N-([1,2,4]triazolo[4,3-a]pyridin-3-yl)methanesulfonamides as selective NaV1.7 inhibitors. Starting with the crystal structure of an acyl sulfonamide, we rationalized that cyclization to form a fused heterocycle would improve physicochemical properties, in particular lipophilicity...
May 8, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29726124/community-asthma-management-of-emergency-department-patients-a-pilot-study-of-adherence-with-national-consensus-guidelines
#4
Nicholas D Ross, David McD Taylor, Ashleigh J Sellar, Hayley H Chen, Luke D Plant, Daniel McLean, Paul Berlingeri, Rex Gavan, Tracey J Weiland, Jonathan C Knott, Christine F McDonald
We aimed to determine whether the outpatient management of ED patients with asthma adheres to Australia's Asthma Consensus Guidelines. Adult patients, under treatment for asthma, were administered a validated questionnaire. Data on their outpatient management were collected and analysed descriptively. Of 51 patients, 14 smoked and 35 did not undergo regular GP review. Twenty-one patients had a good understanding of a written asthma action plan although only 15 owned one. Fourteen patients used no preventer medication...
May 3, 2018: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/29718312/differences-in-silencing-of-mismatched-targets-by-sliced-versus-diced-sirnas
#5
Guihua Sun, Jinghan Wang, Yasheng Huang, Christine Wan-Yin Yuan, Keqiang Zhang, Shuya Hu, Linling Chen, Ren-Jang Lin, Yun Yen, Arthur D Riggs
It has been reported that the two major types of RNA interference triggers, the classical Dicer-generated small RNAs (siRNAs), which function with all members of the Argonaute (Ago) protein family in mammals, and the Ago2-sliced small RNAs (sli-siRNAs), which function solely through Ago2, have similar potency in target cleavage and repression. Here, we show that sli-siRNAs are generally more potent than siRNAs in silencing mismatched targets. This phenomenon is usually more apparent in targets that have mismatched nucleotides in the 3' supplementary region than in targets with mismatches in the seed region...
April 30, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29706172/effects-of-medication-assisted-treatment-mat-for-opioid-use-disorder-on-functional-outcomes-a-systematic-review
#6
Margaret A Maglione, Laura Raaen, Christine Chen, Gulrez Azhar, Nima Shahidinia, Mimi Shen, Ervant Maksabedian, Roberta M Shanman, Sydne Newberry, Susanne Hempel
This systematic review synthesizes evidence on the effects of Medication-Assisted Treatment (MAT) for opioid use disorder (OUD) on functional outcomes, including cognitive (e.g., memory), physical (e.g., fatigue), occupational (e.g., return to work), social/behavioral (e.g., criminal activity), and neurological (e.g., balance) function. Five databases were searched from inception to July 2017 to identify English-language controlled trials, case control studies, and cohort comparisons of one or more groups; cross-sectional studies were excluded...
June 2018: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/29706029/oncologist-provision-of-smoking-cessation-support-a-national-survey-of-australian-medical-and-radiation-oncologists
#7
Fiona L Day, Emma Sherwood, Tina Y Chen, Margaret Barbouttis, Megan Varlow, Jarad Martin, Marianne Weber, Freddy Sitas, Christine Paul
AIM: Continued smoking in patients diagnosed with cancer affects treatment outcomes and overall survival. With national surveys of Australian medical oncologists (MO) and radiation oncologists (RO) we sought to determine current clinical practices, preferences and barriers in providing patient smoking cessation support. METHODS: Oncologist members of the Medical Oncology Group of Australia (n = 452) and Trans-Tasman Radiation Oncology Group (n = 230) were invited to participate in a multiple choice survey exploring smoking cessation practices and beliefs...
April 29, 2018: Asia-Pacific Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29694882/cardiac-mtorc1-dysregulation-impacts-stress-adaptation-and-survival-in-huntington-s-disease
#8
Daniel D Child, John H Lee, Christine J Pascua, Yong Hong Chen, Alejandro Mas Monteys, Beverly L Davidson
Huntington's disease (HD) is a dominantly inherited neurological disorder caused by CAG-repeat expansion in exon 1 of Huntingtin (HTT). But in addition to the neurological disease, mutant HTT (mHTT), which is ubiquitously expressed, impairs other organ systems. Indeed, epidemiological and animal model studies suggest higher incidence of and mortality from heart disease in HD. Here, we show that the protein complex mTORC1 is dysregulated in two HD mouse models through a mechanism that requires intrinsic mHTT expression...
April 24, 2018: Cell Reports
https://www.readbyqxmd.com/read/29675171/diphosphine-protected-ultrasmall-gold-nanoclusters-opened-icosahedral-au-13-and-heart-shaped-au-8-clusters
#9
Shan-Shan Zhang, Lei Feng, Ravithree D Senanayake, Christine M Aikens, Xing-Po Wang, Quan-Qin Zhao, Chen-Ho Tung, Di Sun
Due to distinctive quantum confinement effects, ultrasmall gold nanoparticles usually exhibit interesting electronic structure and molecular-like properties. However, the lack of atomically-precise structural information makes the understanding of them almost impossible, such as understanding the relationships between their compositions and unique properties. Herein, by reducing a diphosphine AuI precursor (Au2 (dppm)2 Cl2 ; dppm = Ph2 PCH2 PPh2 ) with or without a S2- releasing reagent, we enriched our knowledge of the members in the families of Au13 and Au8 by the structural determinations of two new dppm-protected gold nanoclusters, [Au13 (dppm)6 ]5+ ( SD/Au1 ) and [Au8 (dppm)4 S2 ]2+ ( SD/Au2 ), respectively...
February 7, 2018: Chemical Science
https://www.readbyqxmd.com/read/29668571/evaluating-for-pseudoprogression-in-colorectal-and-pancreatic-tumors-treated-with-immunotherapy
#10
Christine M Parseghian, Madhavi Patnana, Priya Bhosale, Kenneth R Hess, Ya-Chen Tina Shih, Bumyang Kim, Scott Kopetz, Michael J Overman, Gauri R Varadhachary, Milind Javle, Aung Naing, Sarina Piha-Paul, David Hong, Hung Le, Vivek Subbiah, Shubham Pant
Pseudoprogression has been observed in patients with various tumor types treated with immunotherapy. However, the frequency of pseudoprogression is unknown in gastrointestinal malignancies. Metastatic colorectal cancer (mCRC) and advanced pancreatic ductal adenocarcinoma (PDAC) patients who progressed on treatment with immunotherapy beyond RECIST version 1.1 criteria were analyzed. Degree of progression, tumor markers, time to progression, overall survival, Eastern Cooperative Oncology Group Performance Status (ECOG PS), and costs were analyzed for patients treated beyond progression (TBP) and not treated beyond progression...
April 17, 2018: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29649236/predictive-value-for-cardiovascular-events-of-common-carotid-intima-media-thickness-and-its-rate-of-change-in-individuals-at-high-cardiovascular-risk-results-from-the-prog-imt-collaboration
#11
Matthias W Lorenz, Lu Gao, Kathrin Ziegelbauer, Giuseppe Danilo Norata, Jean Philippe Empana, Irene Schmidtmann, Hung-Ju Lin, Stela McLachlan, Lena Bokemark, Kimmo Ronkainen, Mauro Amato, Ulf Schminke, Sathanur R Srinivasan, Lars Lind, Shuhei Okazaki, Coen D A Stehouwer, Peter Willeit, Joseph F Polak, Helmuth Steinmetz, Dirk Sander, Holger Poppert, Moise Desvarieux, M Arfan Ikram, Stein Harald Johnsen, Daniel Staub, Cesare R Sirtori, Bernhard Iglseder, Oscar Beloqui, Gunnar Engström, Alfonso Friera, Francesco Rozza, Wuxiang Xie, Grace Parraga, Liliana Grigore, Matthieu Plichart, Stefan Blankenberg, Ta-Chen Su, Caroline Schmidt, Tomi-Pekka Tuomainen, Fabrizio Veglia, Henry Völzke, Giel Nijpels, Johann Willeit, Ralph L Sacco, Oscar H Franco, Heiko Uthoff, Bo Hedblad, Carmen Suarez, Raffaele Izzo, Dong Zhao, Thapat Wannarong, Alberico Catapano, Pierre Ducimetiere, Christine Espinola-Klein, Kuo-Liong Chien, Jackie F Price, Göran Bergström, Jussi Kauhanen, Elena Tremoli, Marcus Dörr, Gerald Berenson, Kazuo Kitagawa, Jacqueline M Dekker, Stefan Kiechl, Matthias Sitzer, Horst Bickel, Tatjana Rundek, Albert Hofman, Ellisiv B Mathiesen, Samuela Castelnuovo, Manuel F Landecho, Maria Rosvall, Rafael Gabriel, Nicola de Luca, Jing Liu, Damiano Baldassarre, Maryam Kavousi, Eric de Groot, Michiel L Bots, David N Yanez, Simon G Thompson
AIMS: Carotid intima media thickness (CIMT) predicts cardiovascular (CVD) events, but the predictive value of CIMT change is debated. We assessed the relation between CIMT change and events in individuals at high cardiovascular risk. METHODS AND RESULTS: From 31 cohorts with two CIMT scans (total n = 89070) on average 3.6 years apart and clinical follow-up, subcohorts were drawn: (A) individuals with at least 3 cardiovascular risk factors without previous CVD events, (B) individuals with carotid plaques without previous CVD events, and (C) individuals with previous CVD events...
2018: PloS One
https://www.readbyqxmd.com/read/29643249/neutralizing-antibody-responses-following-long-term-vaccination-with-hiv-1-env-gp140-in-guinea-pigs
#12
Christine A Bricault, James M Kovacs, Alexander Badamchi-Zadeh, Krisha McKee, Jennifer L Shields, Bronwyn M Gunn, George H Neubauer, Fadi Ghantous, Julia Jennings, Lindsey Gillis, James Perry, Joseph P Nkolola, Galit Alter, Bing Chen, Kathryn E Stephenson, Nicole Doria-Rose, John R Mascola, Michael S Seaman, Dan H Barouch
A vaccination regimen capable of eliciting potent and broadly neutralizing antibodies (bNAbs) remains an unachieved goal of the HIV-1 vaccine field. Here we report the immunogenicity of longitudinal prime/boost vaccination regimens over a period of 200 weeks in guinea pigs with a panel of HIV-1 envelope (Env) gp140 protein immunogens. We assessed vaccine regimens that included a monovalent clade C gp140 regimen (C97), a tetravalent regimen consisting of four clade C gp140s (4C), and a tetravalent regimen consisting of a clade A, B, C, and mosaic gp140 (ABCM)...
April 11, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29610072/automated-cell-segmentation-for-quantitative-phase-microscopy
#13
Nathan O Loewke, Sunil Pai, Christine Cordeiro, Dylan Black, Bonnie L King, Christopher H Contag, Bertha Chen, Thomas M Baer, Olav Solgaard
Automated cell segmentation and tracking is essential for dynamic studies of cellular morphology, movement, and interactions as well as other cellular behaviors. However, accurate, automated, and easy-to-use cell segmentation remains a challenge, especially in cases of high cell densities, where discrete boundaries are not easily discernable. Here, we present a fully automated segmentation algorithm that iteratively segments cells based on the observed distribution of optical cell volumes measured by quantitative phase microscopy...
April 2018: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/29600515/developing-drugs-for-treatment-of-atopic-dermatitis-in-children-%C3%A2-3-months-to-18-years-of-age-draft-guidance-for-industry
#14
REVIEW
Elaine C Siegfried, Jennifer C Jaworski, Lawrence F Eichenfield, Amy Paller, Adelaide A Hebert, Eric L Simpson, Emily Altman, Charles Arena, Andrew Blauvelt, Julie Block, Mark Boguniewicz, Suephy Chen, Kelly Cordoro, Diane Hanna, Kimberly Horii, Thomas Hultsch, James Lee, Donald Y Leung, Peter Lio, Joshua Milner, Theodore Omachi, Christine Schneider, Lynda Schneider, Robert Sidbury, Timothy Smith, Jeffrey Sugarman, Sharif Taha, Susan Tofte, Megha Tollefson, Wynnis L Tom, Dennis P West, Lucinda Whitney, Lee Zane
Atopic dermatitis is the most common chronic skin disease, and it primarily affects children. Although atopic dermatitis (AD) has the highest effect on burden of skin disease, no high-level studies have defined optimal therapy for severe disease. Corticosteroids have been used to treat AD since the 1950s and remain the only systemic medication with Food and Drug Administration approval for this indication in children, despite published guidelines of care that recommend against this option. Several clinical trials with level 1 evidence have supported the use of topical treatments for mild to moderate atopic dermatitis in adults and children, but these trials have had little consistency in protocol design...
March 30, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29599027/predictors-of-the-effect-of-bariatric-surgery-on-knee-osteoarthritis-pain
#15
Shannon X Chen, Fernando A Bomfim, Heekoung A Youn, Christine Ren-Fielding, Jonathan Samuels
INTRODUCTION: Bariatric surgery reduces obesity and knee osteoarthritis (OA) pain, but some patients improve more than others. We aimed to identify characteristics that predict this knee pain improvement. METHODS: We reviewed NYU Langone Health bariatrics records (2002-2015) and called eligible patients reporting pre-operative knee pain. Patients were asked to rate their pain on a 10-point scale at three time points: before surgery, one year post-surgery, and time of survey administration...
February 8, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29590749/discovery-of-a-potent-4r-5s-4-fluoro-5-methylproline-sulfonamide-transient-receptor-potential-ankyrin-1-trpa1-antagonist-and-its-methylene-phosphate-prodrug-guided-by-molecular-modeling
#16
Huifen Chen, Matthew Volgraf, Steven Do, Aleksandr Kolesnikov, Daniel G Shore, Vishal A Verma, Elisia Villemure, Lan Wang, Yong Chen, Baihua Hu, Ai-Jun Lu, Guosheng Wu, Xiaofeng Xu, Po-Wai Yuen, Yamin Zhang, Shawn D Erickson, Martin Dahl, Christine Brotherton-Pleiss, Suzanne Tay, Justin Q Ly, Lesley J Murray, Jun Chen, Desiree Amm, Wienke Lange, David H Hackos, Rebecca M Reese, Shannon D Shields, Joseph P Lyssikatos, Brian S Safina, Anthony A Estrada
TRPA1 is a non-selective cation channel expressed in sensory neurons where it functions as an irritant sensor for a plethora of electrophilic compounds and is implicated in pain, itch, and respiratory disease. To study its function in various disease contexts, we sought to identify novel, potent and selective small molecule TRPA1 antagonists. Herein we describe the evolution of an N-isopropyl glycine sulfonamide lead (1) to a novel and potent (4R,5S)-4-fluoro-5-methylproline sulfonamide series of inhibitors...
March 29, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29569017/a-review-of-preference-based-measures-for-the-assessment-of-quality-of-life-in-children-and-adolescents-with-cerebral-palsy
#17
REVIEW
Christine Mpundu-Kaambwa, Gang Chen, Elisabeth Huynh, Remo Russo, Julie Ratcliffe
PURPOSE: To examine the psychometric properties and suitability for use within the context of cerebral palsy research in children and adolescents of generic preference-based outcome measures (PROMs). METHODS: Nine electronic databases were searched in this systematic review. The consensus-based standards for the selection of health measurement instruments (COSMIN) checklist were used to measure the psychometric properties of the PROMs. A meta-analysis was used to pool correlation coefficients for convergent validity using the Schmidt-Hunter method...
March 22, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29556889/endoscopic-management-of-recalcitrant-marginal-ulcers-by-covering-the-ulcer-bed
#18
Sindhu Barola, Lea Fayad, Christine Hill, Thomas Magnuson, Michael Schweitzer, Vikesh Singh, Yen-I Chen, Saowanee Ngamruengphong, Mouen A Khashab, Anthony N Kalloo, Vivek Kumbhari
BACKGROUND: Management options for marginal ulcers (MU) vary from medical therapy to revision surgery. Medical therapy is often ineffective and revision surgery is associated with a high morbidity and possible recurrence. AIMS: To evaluate technical feasibility, efficacy, and safety of endoscopic management of MU by covering the ulcer bed using oversewing and/or deploying a fully covered self-expandable metallic stent (FCSEMS). METHODS: Medical records of consecutive patients who underwent endoscopic suturing and/or FCSEMS deployment for recalcitrant MU between August 2016 and June 2017 at a single academic center were reviewed...
March 19, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29550589/non-lytic-lymphocytes-engineered-to-express-virus-specific-t-cell-receptors-limit-hbv-infection-by-activating-apobec3
#19
Sarene Koh, Janine Kah, Christine Y L Tham, Ninghan Yang, Erica Ceccarello, Adeline Chia, Margaret Chen, Atefeh Khakpoor, Andrea Pavesi, Anthony T Tan, Maura Dandri, Antonio Bertoletti
BACKGROUND & AIMS: Strategies to develop virus-specific T cells against hepatic viral infections have been hindered by safety concerns. We engineered non-lytic human T cells to suppress replication of hepatitis B virus (HBV) and hepatitis C virus (HCV) without overt hepatotoxicity, and investigated their antiviral activity. METHODS: We electroporated resting T cells or T cells activated by anti-CD3 with mRNAs encoding HBV or HCV-specific T-cell receptors (TCRs) to create 2 populations of TCR-reprogrammed T cells...
March 14, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29544099/bacteroides-fragilis-toxin-coordinates-a-pro-carcinogenic-inflammatory-cascade-via-targeting-of-colonic-epithelial-cells
#20
Liam Chung, Erik Thiele Orberg, Abby L Geis, June L Chan, Kai Fu, Christina E DeStefano Shields, Christine M Dejea, Payam Fathi, Jie Chen, Benjamin B Finard, Ada J Tam, Florencia McAllister, Hongni Fan, Xinqun Wu, Sudipto Ganguly, Andriana Lebid, Paul Metz, Sara W Van Meerbeke, David L Huso, Elizabeth C Wick, Drew M Pardoll, Fengyi Wan, Shaoguang Wu, Cynthia L Sears, Franck Housseau
No abstract text is available yet for this article.
March 14, 2018: Cell Host & Microbe
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