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https://www.readbyqxmd.com/read/29691410/control-of-mechanical-pain-hypersensitivity-in-mice-through-ligand-targeted-photoablation-of-trkb-positive-sensory-neurons
#1
Rahul Dhandapani, Cynthia Mary Arokiaraj, Francisco J Taberner, Paola Pacifico, Sruthi Raja, Linda Nocchi, Carla Portulano, Federica Franciosa, Mariano Maffei, Ahmad Fawzi Hussain, Fernanda de Castro Reis, Luc Reymond, Emerald Perlas, Simone Garcovich, Stefan Barth, Kai Johnsson, Stefan G Lechner, Paul A Heppenstall
Mechanical allodynia is a major symptom of neuropathic pain whereby innocuous touch evokes severe pain. Here we identify a population of peripheral sensory neurons expressing TrkB that are both necessary and sufficient for producing pain from light touch after nerve injury in mice. Mice in which TrkB-Cre-expressing neurons are ablated are less sensitive to the lightest touch under basal conditions, and fail to develop mechanical allodynia in a model of neuropathic pain. Moreover, selective optogenetic activation of these neurons after nerve injury evokes marked nociceptive behavior...
April 24, 2018: Nature Communications
https://www.readbyqxmd.com/read/29690828/evidence-for-increased-mri-signal-intensity-and-morphological-changes-in-the-brachial-plexus-and-median-nerves-of-patients-with-chronic-arm-and-neck-pain-following-whiplash-injury
#2
Jane Greening, Kamakshi Anantharaman, Rupert Young, Andrew Dilley
Study Design Cross-sectional study. Background Whiplash following a motor vehicle accident can result in chronic neck and arm pain. Patients frequently present with cutaneous hypersensitivities and hypoesthesia but without obvious clinical sign of nerve injury. T2-weighted magnetic resonance imaging (MRI) has previously been used to identify nerve pathology. Objectives To determine whether there are signs of peripheral nerve pathology on MRI in patients with chronic arm and neck pain following whiplash injury...
April 24, 2018: Journal of Orthopaedic and Sports Physical Therapy
https://www.readbyqxmd.com/read/29689688/swimming-exercise-induced-reversed-expression-of-mir-96-and-its-target-gene-nav1-3-in-diabetic-peripheral-neuropathy-in-rats
#3
Amir Mahmoudi Aghdam, Parviz Shahabi, Elham Karimi-Sales, Rafigheh Ghiasi, Saeed Sadigh-Eteghad, Javad Mahmoudi, Mohammad Reza Alipour
Diabetes is a common metabolic disease which leads to diabetic peripheral neuropathy. Recently, the role of microRNA-96 (miR-96) in alleviating neuropathic pain by inhibiting the expression of NaV1.3, an isoform of voltage-gated sodium channels, has been shown. Peripheral nerve injuries result in NaV1.3 elevation. Exercise has beneficial role in diabetes management and peripheral neuropathy. However, the effects of exercise on miR-96 and its target gene NaV1.3 in diabetic rats are unknown. Therefore, the present study investigated the effects of exercise training on the expression of miR-96 and NaV1...
April 25, 2018: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/29688226/wide-field-corneal-subbasal-nerve-plexus-mosaics-in-age-controlled-healthy-and-type-2-diabetes-populations
#4
Neil S Lagali, Stephan Allgeier, Pedro Guimarães, Reza A Badian, Alfredo Ruggeri, Bernd Köhler, Tor Paaske Utheim, Beatrice Peebo, Magnus Peterson, Lars B Dahlin, Olov Rolandsson
A dense nerve plexus in the clear outer window of the eye, the cornea, can be imaged in vivo to enable non-invasive monitoring of peripheral nerve degeneration in diabetes. However, a limited field of view of corneal nerves, operator-dependent image quality, and subjective image sampling methods have led to difficulty in establishing robust diagnostic measures relating to the progression of diabetes and its complications. Here, we use machine-based algorithms to provide wide-area mosaics of the cornea's subbasal nerve plexus (SBP) also accounting for depth (axial) fluctuation of the plexus...
April 24, 2018: Scientific Data
https://www.readbyqxmd.com/read/29687564/clinical-spectrum-and-quality-of-life-qol-in-patients-with-chronic-polyneuropathy-a-cross-sectional-study
#5
M S Panduranga, Deepti Vibha, Kameshwar Prasad, Achal Kumar Srivastava, Garima Shukla
Chronic polyneuropathy is a disabling condition of the peripheral nerves, characterized by symmetrical sensory motor symptoms and signs. There is paucity of studies on the etiological spectrum of polyneuropathy and its impact on quality of life. The present cross sectional study in a referral based tertiary care center in North India found diabetic neuropathy as the commonest cause (25.5%) amongst 212 patients with chronic polyneuropathy. Idiopathic axonal polyneuropathy was present in 14.2% patients. Leprosy presenting as confluent mononeuritis multiplex constituted 11...
April 23, 2018: Journal of the Peripheral Nervous System: JPNS
https://www.readbyqxmd.com/read/29687307/up-regulation-of-cdc37-contributes-to-schwann-cell-proliferation-and-migration-after-sciatic-nerve-crush
#6
Yuxi Liu, Shuyao Wang, Dazhi Ding, Zhaohui Yu, Weiwei Sun, Youhua Wang
Cell division cycle protein 37 (Cdc37), a molecular chaperone takes part in a series of cellular processes including cell signal transduction, cell cycle progression, cell proliferation, cell motility, oncogenesis and malignant progression. It can not only recruit immature protein kinases to HSP90 but also work alone. Cdc37 was reported to be associated with neurogenesis, neurite outgrowth, axon guidance and myelination. However, the roles of Cdc37 on Schwann cells (SC) after peripheral nerve injury (PNI) remain unknown...
April 23, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29687021/myelin-protein-zero-mutations-and-the-unfolded-protein-response-in-charcot-marie-tooth-disease-type-1b
#7
Yunhong Bai, Xingyao Wu, Kathryn M Brennan, David S Wang, Maurizio D'Antonio, John Moran, John Svaren, Michael E Shy
Objective: To determine the prevalence of MPZ mutations that cause Charcot Marie Tooth neuropathy type 1B (CMT1B) and activate the unfolded protein Response (UPR). Background: CMT1B is caused by >200 heterozygous mutations in MPZ , the major protein in peripheral nerve myelin. Mutations Ser63del MPZ and Arg98Cys MPZ cause the mutant protein to be retained in the ER and activate the generally adaptive UPR. Treatments that modulate UPR activation have improved cellular and rodent models of CMT1B raising the possibility that other MPZ mutations that activate the UPR would also respond favorably to similar treatment...
April 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29686918/head-and-neck-schwannomas-a-surgical-challenge-a-series-of-5-cases
#8
Ishtyaque Ansari, Ashfaque Ansari, Arjun Antony Graison, Anuradha J Patil, Hitendra Joshi
Background: Schwannomas, also known as neurilemmomas, are benign peripheral nerve sheath tumors. They originate from any nerve covered with schwann cell sheath. Schwannomas constitute 25-45% of tumors of the head and neck. About 4% of head and neck schwannomas present as a sinonasal schwannoma. Brachial plexus schwannoma constitute only about 5% of schwannomas. Cervical vagal schwannomas constitute about 2-5% of neurogenic tumors. Methods: We present a case series of 5 patients of schwannomas, one arising from the maxillary branch of trigeminal nerve in the maxillary sinus, second arising from the brachial plexus, third arising from the cervical vagus, and two arising from cervical spinal nerves...
2018: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/29686668/emerging-concepts-of-adaptive-immunity-in-leprosy
#9
REVIEW
Soumi Sadhu, Dipendra Kumar Mitra
Leprosy is a chronic intracellular infection caused by the acid-fast bacillus, Mycobacterium leprae . The disease chiefly affects the skin, peripheral nerves, mucosa of the upper respiratory tract, and the eyes. The damage to peripheral nerves results in sensory and motor impairment with characteristic deformities and disability. Presently, the disease remains concentrated in resource-poor countries in tropical and warm temperate regions with the largest number of cases reported from India. Even though innate immunity influences the clinical manifestation of the disease, it is the components of adaptive immune system which seem to tightly correlate with the characteristic spectrum of leprosy...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29686181/the-effectiveness-of-aerobic-exercise-in-improving-peripheral-nerve-functions-in-type-2-diabetes-mellitus-an-evidence-based-case-report
#10
Listya Tresnanti Mirtha, Viandini Permatahati
BACKGROUND: peripheral neuropathy is known as one of most common complication in diabetes mellitus type 2 patient. This complication is caused by uncontrolled condition of blood glucose level in long periode. Regular physical activity in moderate to high intensity is beneficial in management of diabetes mellitus. This report aimed to know the effectiveness of aerobic exercise in causing improved peripheral functions in type 2 diabetes mellitus. METHODS: literature searching using several related keywords in Medline®, Pubmed®, and Cochrane library, following inclusion and exclusion criteria...
January 2018: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/29685912/eight-and-a-half-syndrome-one-and-a-half-syndrome-with-peripheral-facial-nerve-palsy
#11
Ahmad Almutlaq, Alby Richard
No abstract text is available yet for this article.
April 23, 2018: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/29685815/safety-and-efficacy-of-eculizumab-in-guillain-barr%C3%A3-syndrome-a-multicentre-double-blind-randomised-phase-2-trial
#12
Sonoko Misawa, Satoshi Kuwabara, Yasunori Sato, Nobuko Yamaguchi, Kengo Nagashima, Kanako Katayama, Yukari Sekiguchi, Yuta Iwai, Hiroshi Amino, Tomoki Suichi, Takanori Yokota, Yoichiro Nishida, Tadashi Kanouchi, Nobuo Kohara, Michi Kawamoto, Junko Ishii, Motoi Kuwahara, Hidekazu Suzuki, Koichi Hirata, Norito Kokubun, Ray Masuda, Juntaro Kaneko, Ichiro Yabe, Hidenao Sasaki, Ken-Ichi Kaida, Hiroshi Takazaki, Norihiro Suzuki, Shigeaki Suzuki, Hiroyuki Nodera, Naoko Matsui, Shoji Tsuji, Haruki Koike, Ryo Yamasaki, Susumu Kusunoki
BACKGROUND: Despite the introduction of plasmapheresis and immunoglobulin therapy, many patients with Guillain-Barré syndrome still have an incomplete recovery. Evidence from pathogenesis studies suggests the involvement of complement-mediated peripheral nerve damage. We aimed to investigate the safety and efficacy of eculizumab, a humanised monoclonal antibody against the complement protein C5, in patients with severe Guillain-Barré syndrome. METHODS: This study was a 24 week, multicentre, double-blind, placebo-controlled, randomised phase 2 trial done at 13 hospitals in Japan...
April 20, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/29685562/superficial-peroneal-nerve-to-deep-peroneal-nerve-transfer-with-allograft-conduit-for-neuroma-in-continuity
#13
Christopher Bibbo, Edgardo Rodrigues-Colazzo, Adam G Finzen
The anterior approach to the ankle for surgery can result in injury to the superficial peroneal nerve, resulting in a painful neuroma and significant patient morbidity. A paucity of data is available evaluating the role of the superficial peroneal nerve to deep peroneal nerve transfer as a method of treatment of neuromas in continuity after ankle arthrodesis. We describe 11 patients who underwent nerve transfer with nerve allograft and conduit repair to treat recalcitrant painful neuromas after ankle arthrodesis...
May 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29685535/imaging-cellularity-in-benign-and-malignant-peripheral-nerve-sheath-tumors-utility-of-the-target-sign-by-diffusion-weighted-imaging
#14
Shivani Ahlawat, Laura M Fayad
OBJECTIVE: To determine the utility of "target sign" on diffusion weighted imaging (DWI) and apparent diffusion coefficient (ADC) mapping for peripheral nerve sheath tumor (PNST) characterization. MATERIALS AND METHODS: This IRB-approved, HIPAA-compliant study retrospectively reviewed the MR imaging (comprised of T2- FS, DWI (b-values 50, 400, 800 s/mm2 and ADC mapping), and static contrast-enhanced (CE) T1-W imaging) of 42 patients (mean age: 40 years (range 8-68 years), 48% (20/42) females) with 15 malignant PNSTs (MPNSTs) and 33 benign PNSTs (BPNSTs)...
May 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29684504/schwann-cell-plasticity-is-regulated-by-a-weakened-intrinsic-antioxidant-defense-system-in-acute-peripheral-nerve-injury
#15
Wenjing Lv, Binbin Deng, Weisong Duan, Yuanyuan Li, Yakun Liu, Zhongyao Li, Wei Xia, Chunyan Li
The biological effects of the transcription factor NF-E2-related factor 2 (Nrf2) in acute peripheral nervous system (PNS) injury have not been adequately elucidated. By analyzing the results of Nrf2 knockout and Nrf2 activation experiments, we found the following: (1) The antioxidant system was rapidly inactivated after acute PNS injury in a partly Nrf2-dependent manner, giving rise to a temporary state of oxidative stress, and then slowly and partially recovered following regeneration. (2) Nrf2 knockout promoted the reprogramming and proliferation of Schwann cells and inhibited myelination, as well as the redifferentiation of repair Schwann cells...
April 20, 2018: Neuroscience
https://www.readbyqxmd.com/read/29684385/upregulation-of-ca-v-3-2-t-type-calcium-channels-in-adjacent-intact-l4-dorsal-root-ganglion-neurons-in-neuropathic-pain-rats-with-l5-spinal-nerve-ligation
#16
Qing-Ying Liu, Wen Chen, Shuang Cui, Fei-Fei Liao, Ming Yi, Feng-Yu Liu, You Wan
Besides the injured peripheral dorsal root ganglion (DRG) neurons, the adjacent intact DRG neurons also have important roles in neuropathic pain. Ion channels including Cav 3.2 T-type calcium channel in the DRG neurons are important in the development of neuropathic pain. In the present study, we aimed to examine the expression of Cav 3.2 T-type calcium channels in the intact DRG neurons in neuropathic pain. A neuropathic pain model of rat with lumbar 5 (L5) spinal nerve ligation (SNL) was established, in which the L4 DRG was separated from the axotomized L5 DRG, and the molecular, morphological and electrophysiological changes of Cav 3...
April 20, 2018: Neuroscience Research
https://www.readbyqxmd.com/read/29683959/malignant-peripheral-nerve-sheath-tumors-in-neurofibromatosis-impact-of-family-history
#17
Fatema Malbari, Menachem Spira, Pamela B Knight, Chong Zhu, Michael Roth, Jonathan Gill, Rick Abbott, Adam S Levy
OBJECTIVE: The main objective of this study was to determine if family history of malignant peripheral nerve sheath tumor (MPNST) increases risk of developing an MPNST in patients with neurofibromatosis-1 (NF-1). MATERIALS AND METHODS: Individuals with NF-1 registered with the Children's Tumor Foundation's Neurofibromatosis Registry were emailed an anonymous 15-minute survey with regard to personal and family history of NF-1, MPNST, ages of onset, and symptomatology...
April 20, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29682596/spared-nerve-injury-model-of-neuropathic-pain-in-mice
#18
Joseph Cichon, Linlin Sun, Guang Yang
Experimental models of peripheral nerve injury have been developed to study mechanisms of neuropathic pain in living animals. The spared nerve injury (SNI) model in rodents is a partial denervation model, in which the common peroneal and tibial nerves are injured, producing consistent and reproducible tactile hypersensitivity in the skin territory of the spared, intact sural nerve. SNI-operated mice require less force applied to the affected limb to elicit a withdrawal behavior as compared to sham mice. This effect is observed as early as 2 days after surgery and lasts for at least 1 month...
March 20, 2018: Bio-protocol
https://www.readbyqxmd.com/read/29682148/neuroembryology-of-the-acupuncture-principal-meridians-part-3-the-head-and-neck
#19
Peter T Dorsher, Poney Chiang
Background: Accumulating evidence from anatomical, physiologic, and neuroimaging research shows that Classical acupuncture points stimulate nerve trunks or their branches in the head, trunk, and extremities. The first part of this series revealed that phenomenon in the extremities. Principal meridian distributions mirror those of major peripheral nerves there and Classical acupuncture points are proximate to peripheral nerves there. These relationships were shown to be consistent with the linear neuroembryologic development of the extremities...
April 1, 2018: Medical Acupuncture
https://www.readbyqxmd.com/read/29681920/combination-of-heterologous-fibrin-sealant-and-bioengineered-human-embryonic-stem-cells-to-improve-regeneration-following-autogenous-sciatic-nerve-grafting-repair
#20
Roghayeh Mozafari, Sergiy Kyrylenko, Mateus Vidigal Castro, Rui Seabra Ferreira, Benedito Barraviera, Alexandre Leite Rodrigues Oliveira
Background: Peripheral nerve injury is a worldwide clinical problem, and the preferred surgical method for treating it is the end-to-end neurorrhaphy. When it is not possible due to a large nerve gap, autologous nerve grafting is used. However, these surgical techniques result in nerve regeneration at highly variable degrees. It is thus very important to seek complementary techniques to improve motor and sensory recovery. One promising approach could be cell therapy. Transplantation therapy with human embryonic stem cells (hESCs) is appealing because these cells are pluripotent and can differentiate into specialized cell types and have self-renewal ability...
2018: Journal of Venomous Animals and Toxins Including Tropical Diseases
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