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JOURNAL ARTICLE
Idalécia Cossa-Moiane, Clémentine Roucher, Maiza Campos-Ponce, Colleen Doak, Adilson Bauhofer, Assucênio Chissaque, António Prista, Nilsa de Deus, Katja Polman
Mozambique has one of the highest child undernutrition rates in Sub-Saharan Africa. The aim of this study was to characterize the profile of children from 1 to 14 years old hospitalized for undernutrition and to explore associated risk factors. Clinical, demographic, socioeconomic, and environmental data were collected. Anthropometric measurements and stool samples were collected from a child and their caretaker. The wealth index was determined using Principal Components Analysis. A total of 449 children and their caretakers were enrolled...
April 4, 2024: Nutrients
#2
JOURNAL ARTICLE
Determinants of Undernutrition among Children Admitted to a Pediatric Hospital in Port Sudan, Sudan.
Giulia Chiopris, Caterina Chiopris, Manuela Valenti, Susanna Esposito
Severe acute undernutrition (SAU) is still a crucial global health issue in the 0-59 months population, increasing the risk of mortality as well as of long-term consequences. In Sudan, 3.3 million children suffered from acute malnutrition between 2018 and 2019. This study was planned to evaluate, in the area of Port Sudan, the prevalence of acute undernutrition after the COVID-19 pandemic and to identify the most important factors favoring the development of acute undernutrition. The available clinical records of all the under-five children ( n = 1012) admitted to the Port Sudan Emergency Pediatric Hospital from 1 February 2021 to 31 January 2022 were analyzed...
March 10, 2024: Nutrients
#3
JOURNAL ARTICLE
Celine Bourdon, Abdoulaye Hama Diallo, Abu Sadat Mohammad Sayeem Bin Shahid, Md Alfazal Khan, Ali Faisal Saleem, Benson O Singa, Blaise Siézanga Gnoumou, Caroline Tigoi, Catherine Achieng Otieno, Chrisantus Odhiambo Oduol, Christina L Lancioni, Christine Manyasi, Christine J McGrath, Christopher Maronga, Christopher Lwanga, Daniella Brals, Dilruba Ahmed, Dinesh Mondal, Donna M Denno, Dorothy I Mangale, Emmanuel Chimwezi, Emmie Mbale, Ezekiel Mupere, Gazi Md Salauddin Mamun, Issaka Ouédraogo, James A Berkley, James M Njunge, Jenala Njirammadzi, John Mukisa, Johnstone Thitiri, Judd L Walson, Julie Jemutai, Kirkby D Tickell, Lubaba Shahrin, Macpherson Mallewa, Md Iqbal Hossain, Mohammod Jobayer Chisti, Molline Timbwa, Moses Mburu, Moses M Ngari, Narshion Ngao, Peace Aber, Philliness Prisca Harawa, Priya Sukhtankar, Robert H J Bandsma, Roseline Maïmouna Bamouni, Sassy Molyneux, Shalton Mwaringa, Shamsun Nahar Shaima, Syed Asad Ali, Syeda Momena Afsana, Sayera Banu, Tahmeed Ahmed, Wieger P Voskuijl, Zaubina Kazi
BACKGROUND: Growth faltering is well-recognized during acute childhood illness and growth acceleration during convalescence, with or without nutritional therapy, may occur. However, there are limited recent data on growth after hospitalization in low- and middle-income countries. METHODS: We evaluated growth following hospitalization among children aged 2-23 months in sub-Saharan Africa and South Asia. Between November 2016 and January 2019, children were recruited at hospital admission and classified as: not-wasted (NW), moderately-wasted (MW), severely-wasted (SW), or having nutritional oedema (NO)...
April 2024: EClinicalMedicine
#4
JOURNAL ARTICLE
Gaylord Ngaboyeka, Ghislain Bisimwa, Anouk Neven, Pacifique Mwene-Batu, Richard Kambale, Emmanuel Ongezi, Christine Chimanuka, Joseph Ntagerwa, Serge Balolebwami, Francis Mulume, Oreste Battisti, Michèle Dramaix, Philippe Donnen
BACKGROUND: Little is known about the use of mid-upper arm circumference for age (MUACZ) for diagnosing of severe acute malnutrition (SAM) and its correlation with WHZ (weight-for-height Z-score) in an area endemic for severe acute malnutrition (SAM) and with a high prevalence of kwashiorkor. Our study aims to analyze the concordance between the diagnostic criteria of SAM in a region presenting these characteristics. METHODS: We analyzed a database of children admitted from 1987 to 2008 for the management of SAM in Eastern Democratic Republic of Congo...
February 23, 2024: BMC Public Health
#5
JOURNAL ARTICLE
Jinfu Peng, Jie Huang, Hongyi Tan, Yun Kuang, Guoping Yang, Zhijun Huang
Monoclonal antibody drugs targeting proprotein convertase kwashiorkor type 9 (PCSK9) have recently demonstrated remarkable success in lipid-lowering therapies. Specifically, antibodies derived from immunoglobulin G1 (IgG1, alirocumab) and IgG2 (evolocumab) have been successfully utilized for this purpose. Recently, a novel recombinant fully human anti-PCSK9 monoclonal antibody, originally derived from IgG4 and designated as SAL003, was developed. This study aimed to explore the pharmacokinetics, efficacy, and safety of SAL003 in both single and multiple administrations...
February 9, 2024: ACS Pharmacology & Translational Science
#6
JOURNAL ARTICLE
Laura Vresk, Mary Flanagan, Allison I Daniel, Isabel Potani, Celine Bourdon, Carolyn Spiegel-Feld, Mehakpreet K Thind, Amber Farooqui, Catriona Ling, Emiliano Miraglia, Guanlan Hu, Bijun Wen, Stanley Zlotkin, Philip James, Marie McGrath, Robert H J Bandsma
Undernutrition remains a global struggle and is associated with almost 45% of deaths in children younger than 5 years. Despite advances in management of severe wasting (though less so for nutritional edema), full and sustained recovery remains elusive. Children with severe wasting and/or nutritional edema (also commonly referred to as severe acute malnutrition and part of the umbrella term "severe malnutrition") continue to have a high mortality rate. This suggests a likely multifactorial etiology that may include micronutrient deficiency...
February 13, 2024: Nutrition Reviews
#7
JOURNAL ARTICLE
Danièle Christiane Kedy Koum, Charlotte Eposse, Loick Pradel Kojom Foko, Ritha Mbono Betoko, Zeinabou Ismaila, Carine Laure Njanseb Nfanleu, Diomède Noukeu Njinkui, Calixte Ida Penda
BACKGROUND: Severe acute malnutrition (SAM) is a major public health concern responsible for paediatric hospitalizations and more than one-third of deaths across the world. In 2013, SAM caused ≥20% of deaths in severely malnourished infants in Douala, the economic capital of Cameroon. There is little data on SAM in economically, sanitary and socially disadvantaged Cameroonian regions including the North region. OBJECTIVES: To determine the prevalence and potential predictors of mortality among children with SAM in a reference health facility in Garoua, North region, Cameroon...
October 5, 2023: Journal of Tropical Pediatrics
#8
Thi-Phuong-Thao Pham, Maryam Tidjani Alou, Dipankar Bachar, Anthony Levasseur, Souleymane Brah, Daouda Alhousseini, Cheikh Sokhna, Aldiouma Diallo, Frank Wieringa, Matthieu Million, Didier Raoult
No abstract text is available yet for this article.
October 30, 2023: Scientific Reports
#9
REVIEW
Hannah Lee, Nathan Sim, Audrey Fotouhi, Steven Daveluy
Diet is known to play a role in the development of skin disorders. While a vegan diet is frequently described as a risk factor for skin disease secondary to nutritional deficiency, this risk may be overestimated. This review aims to debunk myths and provide information on skin disorders and inflammatory skin conditions that have associations with specific nutritional deficiencies in the context of a vegan diet. A literature search was performed for each nutrient and inflammatory skin disease using the PubMed/MEDLINE database and public health website pages concerning a vegan diet...
September 6, 2023: Journal of Clinical Medicine
#10
JOURNAL ARTICLE
Nazir Ahmed, Fehmida Umar, Fahad Saleem, Qaiser Iqbal, Sajjad Haider, Mohammad Bashaar
PURPOSE: Severe acute malnutrition (SAM) is the most prevalent reason for admission to a paediatric unit, and it is a leading cause of mortality in many countries, including Pakistan. This study aimed to assess treatment outcomes and associated factors among children aged 6-59 months with severe acute malnutrition. PATIENTS AND METHODS: A retrospective cohort study was conducted at the Outpatient Therapeutic Feeding Program Centre established at the Sheikh Khalifa bin Zayed Al Nahyan Medical Complex Quetta...
2023: Journal of Multidisciplinary Healthcare
#11
Thibault Vieille, Francois Feillet, Arnaud Wiedemann, Hadrien Winiszewski, Gael Piton
We describe a case of coma-related hyperammonemia in a woman presenting with severe edematous malnutrition (Kwashiorkor-like), without underlying hepatic disease. Our main hypothesis is that the patient developed a functional urea cycle disorder, due to the inability to synthesize N-acetylglutamate which is the activator of the first enzymes (carbamoyl phosphate synthetase) of urea cycle, in a context of severe deficiency of essential amino acids and of acetyl-CoA. Severe hyperammonemia is a medical emergency exposing to the risk of cerebral edema...
August 2023: Gastroenterology Research
#12
JOURNAL ARTICLE
Thaddaeus May, Esther Babirekere-Iriso, Mamady Traoré, Emmanuel Berbain, Maimuna Ahmed, Beatrice Amadi, André Briend, Mark Manary, Aminata Shamit Koroma, Neil Hanchard, Mette Frahm Olsen, Henrik Friis, George PrayGod, Tsinuel Girma, Moustapha Moussa, Aboubacar Mahamadou, Peter Hotez, Haoua Seini Sabo
No abstract text is available yet for this article.
August 25, 2023: Lancet Child & Adolescent Health
#13
Alexandre Bublitz, Christian Manirakiza, Katherine Whitehouse, Abdullahi Chara, Tumba Musa, Kirrily de Polnay, Engy Ali
The management of kwashiorkor disease (KD) in children is challenging in resource-limited settings, especially for those cases with severe skin lesions and its complications. There are no evidenced-based management protocols specific to KD. This article describes the clinical presentation and case management of two children with different presentations of complicated kwashiorkor skin lesions and explores kwashiorkor from the perspective of the children's caretakers in Maiduguri, Nigeria. Our experience shows that a well-structured approach and careful skin care are crucial...
July 2023: Oxford Medical Case Reports
#14
JOURNAL ARTICLE
Muhammad Sohail Arshad, Saadia Khan, Ibad Ali, Reema Arshad, Asad Abbas, Sundus Irshad
OBJECTIVE: To identify echocardiography-based myocardial changes in children with severe acute malnutrition. METHODS: The prospective study was conducted from January to November 2020 at a territory care paediatric hospital in Multan, Pakistan, and comprised severe acute malnutrition patients of either gender aged 1-60 months and an equal number of matching healthy controls. Malnutrition was categorised using the World Health Organisation criteria. Echocardiographic evaluation was done by expert cardiologists...
December 2022: JPMA. the Journal of the Pakistan Medical Association
#15
JOURNAL ARTICLE
Pallavi Dhulse, Archana Maurya, Mayur B Wanjari
Background Protein energy malnutrition (PEM) is a condition that results from inadequate intake of both macronutrients and micronutrients, leading to a lack of energy. The condition can manifest quickly or gradually, ranging from mild to severe. It predominantly affects children in low-income countries who do not receive enough calories and proteins. In developed nations, it is more prevalent among older individuals. PEM is more common in children as they consume less protein. In rare cases in developed countries, it may result from fad diets or a lack of knowledge about children's nutritional requirements, especially in cases of milk allergy...
April 2023: Curēus
#16
James J McCarthy, Sarah C Yale
INTRODUCTION: Kwashiorkor is a malnutrition syndrome most commonly seen in the United States among patients with malabsorptive conditions. While it is rare in otherwise healthy individuals, cases can develop where low nutritional literacy or unorthodox diets are a factor. CASE PRESENTATION: We present an 8-month-old infant who developed kwashiorkor after transitioning to homemade infant formula. DISCUSSION: This patient developed severe malnutrition due to consumption of homemade formula that did not meet nutritional standards...
March 2023: WMJ: Official Publication of the State Medical Society of Wisconsin
#17
JOURNAL ARTICLE
Francieli Fontana Sutile Tardetti Fantinato, Virginia Kagure Wachira, Victor Bertollo Gomes Porto, Henry Maia Peixoto, Elisabeth Carmen Duarte
INTRODUCTION: Considering that vaccination with yellow fever vaccine (YFV) is the most important method to prevent and control yellow fever (YF), this study synthesized evidence on factors associated with YFV failure. METHODS: A systematic review (SR) was performed in the PubMed, Cochrane CENTRAL, Embase, and LILACS databases up to November 2019. Observational and experimental analytical epidemiological studies that analyzed the failure of YFV were included. This review followed the guidelines of the Preferred Reporting Items for Systematic Reviews and meta-Analyses...
March 24, 2023: Vaccine
#18
Raelina S Howell, Shrey Shah, Saila Khan, Collin E M Brathwaite, Patrizio Petrone, Jun Levine
Gastric bypass has grown in popularity in recent years due to its high efficacy in achieving long-term weight loss in patients with morbid obesity. Gastric bypass has been described to further exacerbate baseline nutritional deficiencies due to reduced gastric capacity and malabsorption. In rare cases, when protein deficiency is severe, Kwashiorkor disease may arise. The incidence of Kwashiorkor specifically following gastric bypass is rare, with an incidence of 4.7%. We report a case of a female patient who underwent a gastric bypass and subsequently developed Kwashiorkor...
February 2023: Journal of Surgical Case Reports
#19
JOURNAL ARTICLE
Ganesh K Verma, Rajesh K Yadv, Ramesh Chand, Imran A Khan, Shashi Bhushan S Katiyar, Mukeshvir Singh
Background Malnutrition is a condition caused by defective nutrition in which either deficiency or excess of energy, protein, or micronutrients cause any measurable adverse effects on tissues/body form (body shape, size, composition), function, and clinical outcome. Children with a weight-for-height below -3 standard deviations (SD) of the mean based on the WHO standards have a high risk of death exceeding nine-fold that of children with a weight-for-height above 1 SD. In severe acute malnutrition (SAM) liver function tests, renal function tests, and serum electrolytes are deranged but their correlation with the prognosis is not well defined...
November 2022: Curēus
#20
REVIEW
Aysha Karim Kiani, Kristjana Dhuli, Kevin Donato, Barbara Aquilanti, Valeria Velluti, Giuseppina Matera, Amerigo Iaconelli, Stephen Thaddeus Connelly, Francesco Bellinato, Paolo Gisondi, Matteo Bertelli
Nutrition is the source of energy that is required to carry out all the processes of human body. A balanced diet is a combination of both macro- and micronutrients. "Nutritional inadequacy" involves an intake of nutrients that is lower than the estimated average requirement, whereas "nutritional deficiency" consists of severely reduced levels of one or more nutrients, making the body unable to normally perform its functions and thus leading to an increased risk of several diseases like cancer, diabetes, and heart disease...
June 2022: Journal of Preventive Medicine and Hygiene
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