Maryam Tidjani Alou, Matthieu Million, Sory I Traore, Donia Mouelhi, Saber Khelaifia, Dipankar Bachar, Aurelia Caputo, Jeremy Delerce, Souleymane Brah, Daouda Alhousseini, Cheikh Sokhna, Catherine Robert, Bouli A Diallo, Aldiouma Diallo, Philippe Parola, Michael Golden, Jean-Christophe Lagier, Didier Raoult
Severe acute malnutrition is the world-leading cause of children under-five's death. Recent metagenomics studies have established a link between gut microbiota and severe acute malnutrition, describing an immaturity with a striking depletion in oxygen-sensitive prokaryotes. Amoxicillin and therapeutic diet cure most of the children with severe acute malnutrition but an irreversible disruption of the gut microbiota is suspected in the refractory and most severe cases. In these cases, therapeutic diet may be unable to reverse the microbiota alteration leading to persistent impaired development or death...
2017: Frontiers in Microbiology