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https://www.readbyqxmd.com/read/27905352/-future-perspective-of-pharmacoepidemiology-in-the-big-data-era-and-the-growth-of-information-sources
#1
Diego Macías Saint-Gerons, César de la Fuente Honrubia, Fernando de Andrés Trelles, Ferrán Catalá-López Catalá-López
The arrival of new drug into the market requires many years of previous research along with the need of continuous evaluation throughout the lifetime of the drug. This warrants pharmacoepidemiological research which may be defined as the study of the use and the effects of drugs in large populations. Nowadays this type of research seems more feasible thanks to the massive expansion of the information sources and data (e.g: clinical patient registries, electronic medical records). However there is a risk of information overload, fragmented evidence and given the enthusiasm aroused by the "Big Data", it must be emphasized that its nature is mainly observational, and therefore subject to bias and confusion...
December 1, 2016: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/27903489/finding-important-terms-for-patients-in-their-electronic-health-records-a-learning-to-rank-approach-using-expert-annotations
#2
Jinying Chen, Jiaping Zheng, Hong Yu
BACKGROUND: Many health organizations allow patients to access their own electronic health record (EHR) notes through online patient portals as a way to enhance patient-centered care. However, EHR notes are typically long and contain abundant medical jargon that can be difficult for patients to understand. In addition, many medical terms in patients' notes are not directly related to their health care needs. One way to help patients better comprehend their own notes is to reduce information overload and help them focus on medical terms that matter most to them...
November 30, 2016: JMIR Medical Informatics
https://www.readbyqxmd.com/read/27899903/reading-touch-screen-storybooks-with-mothers-negatively-affects-7-year-old-readers-comprehension-but-enriches-emotional-engagement
#3
Kirsty M Ross, Rachel E Pye, Jordan Randell
Touch screen storybooks turn reading into an interactive multimedia experience, with hotspot-activated animations, sound effects, and games. Positive and negative effects of reading multimedia stories have been reported, but the underlying mechanisms which explain how children's learning is affected remain uncertain. The present study examined the effect of storybook format (touch screen and print) on story comprehension, and considered how level of touch screen interactivity (high and low) and shared reading behaviors (cognitive and emotional scaffolding, emotional engagement) might contribute to comprehension...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27898691/a-personalized-electronic-movie-recommendation-system-based-on-support-vector-machine-and-improved-particle-swarm-optimization
#4
Xibin Wang, Fengji Luo, Ying Qian, Gianluca Ranzi
With the rapid development of ICT and Web technologies, a large an amount of information is becoming available and this is producing, in some instances, a condition of information overload. Under these conditions, it is difficult for a person to locate and access useful information for making decisions. To address this problem, there are information filtering systems, such as the personalized recommendation system (PRS) considered in this paper, that assist a person in identifying possible products or services of interest based on his/her preferences...
2016: PloS One
https://www.readbyqxmd.com/read/27896572/identification-of-novel-mutations-in-hfe-hfe2-tfr2-and-slc40a1-genes-in-chinese-patients-affected-by-hereditary-hemochromatosis
#5
Yongwei Wang, Yali Du, Gang Liu, Shanshan Guo, Bo Hou, Xianyong Jiang, Bing Han, Yanzhong Chang, Guangjun Nie
Hereditary hemochromatosis (HH) is a group of inherited iron-overload disorders associated with pathogenic defects in the genes encoding hemochromatosis (HFE), hemojuvelin (HJV/HFE2), hepcidin (HAMP), transferrin receptor 2 (TfR2), and ferroportin (FPN1/SLC40A1) proteins, and the clinical features are well described. However, there have been only a few detailed reports of HH in Chinese populations. Thus, there is insufficient patient information for population-based analyses in Chinese populations or comparative studies among different ethical groups...
November 28, 2016: International Journal of Hematology
https://www.readbyqxmd.com/read/27885998/bi-ventricular-finite-element-model-of-right-ventricle-overload-in-the-healthy-rat-heart
#6
Fulufhelo Masithulela
BACKGROUND: The recognition of RV overpressure is critical to human life, as this may signify morbidity and mortality. Right ventricle (RV) dysfunction is understood to have an impact on the performance of the left ventricle (LV), but the mechanisms remain poorly understood. It is understood that ventricular compliance has the ability to affect cardiac performance. In this study, a bi-ventricular model of the rat heart was used in preference to other, single-ventricle models. Finite element analysis (FEA) of the bi-ventricular model provides important information on the function of the healthy heart...
November 25, 2016: Bio-medical Materials and Engineering
https://www.readbyqxmd.com/read/27882866/the-performance-of-community-health-workers-in-the-management-of-multiple-childhood-infectious-diseases-in-lira-northern-uganda-a-mixed-methods-cross-sectional-study
#7
Phillip Wanduru, Moses Tetui, Doreen Tuhebwe, Michael Ediau, Monica Okuga, Christine Nalwadda, Elizabeth Ekirapa-Kiracho, Peter Waiswa, Elizeus Rutebemberwa
BACKGROUND: Community health workers (CHWs) have the potential to reduce child mortality by improving access to care, especially in remote areas. Uganda has one of the highest child mortality rates globally. Moreover, rural areas bear the highest proportion of this burden. The optimal performance of CHWs is critical. In this study, we assess the performance of CHWs in managing malaria, pneumonia, and diarrhea in the rural district of Lira, in northern Uganda. DESIGNS: A cross-sectional mixed methods study was undertaken to investigate the performance of 393 eligible CHWs in the Lira district of Uganda...
2016: Global Health Action
https://www.readbyqxmd.com/read/27872033/a-review-of-visual-representations-of-physiologic-data
#8
REVIEW
Rishikesan Kamaleswaran, Carolyn McGregor
BACKGROUND: Physiological data is derived from electrodes attached directly to patients. Modern patient monitors are capable of sampling data at frequencies in the range of several million bits every hour. Hence the potential for cognitive threat arising from information overload and diminished situational awareness becomes increasingly relevant. A systematic review was conducted to identify novel visual representations of physiologic data that address cognitive, analytic, and monitoring requirements in critical care environments...
November 21, 2016: JMIR Medical Informatics
https://www.readbyqxmd.com/read/27860101/on-a-learning-curve-for-shared-decision-making-interviews-with-clinicians-using-the-knee-osteoarthritis-option-grid
#9
Glyn Elwyn, Julie Rasmussen, Katharine Kinsey, Jill Firth, Katy Marrin, Adrian Edwards, Fiona Wood
RATIONAL: Tools used in clinical encounters to illustrate to patients the risks and benefits of treatment options have been shown to increase shared decision making. However, we do not have good information about how these tools are viewed by clinicians and how clinicians think patients would react to their use. OBJECTIVE: Our aim was to examine clinicians' views about the possible and actual use of tools designed to support patients and clinicians to collaborate and deliberate about treatment options, namely, Option Grid decision aids...
November 16, 2016: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/27856087/hemodialysis-hospitalizations-and-readmissions-the-effects-of-payment-reform
#10
Kevin F Erickson, Wolfgang C Winkelmayer, Glenn M Chertow, Jay Bhattacharya
BACKGROUND: In 2004, the Centers for Medicare & Medicaid Services changed reimbursement for physicians and advanced practitioners caring for patients receiving hemodialysis from a capitated to a tiered fee-for-service system, encouraging increased face-to-face visits. This early version of a pay-for-performance initiative targeted a care process: more frequent provider visits in hemodialysis. Although more frequent provider visits in hemodialysis are associated with fewer hospitalizations and rehospitalizations, it is unknown whether encouraging more frequent visits through reimbursement policy also yielded these benefits...
November 14, 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/27849290/the-prevention-of-diabetic-foot-ulceration-how-biomechanical-research-informs-clinical-practice
#11
Frank E DiLiberto, Judith F Baumhauer, Deborah A Nawoczenski
Background: Implementation of interprofessional clinical guidelines for the prevention of neuropathic diabetic foot ulceration has demonstrated positive effects regarding ulceration and amputation rates. Current foot care recommendations are primarily based on research regarding the prevention of ulcer recurrence and focused on reducing the magnitude of plantar stress (pressure overload). Yet, foot ulceration remains to be a prevalent and debilitating consequence of Diabetes Mellitus...
November 16, 2016: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/27848180/iron-overload-patients-with-unknown-etiology-from-national-survey-in-japan
#12
Katsuya Ikuta, Mayumi Hatayama, Lynda Addo, Yasumichi Toki, Katsunori Sasaki, Yasuaki Tatsumi, Ai Hattori, Ayako Kato, Koichi Kato, Hisao Hayashi, Takahiro Suzuki, Masayoshi Kobune, Miyuki Tsutsui, Akihiko Gotoh, Yasuo Aota, Motoo Matsuura, Yuzuru Hamada, Takahiro Tokuda, Norio Komatsu, Yutaka Kohgo
Transfusion is believed to be the main cause of iron overload in Japan. A nationwide survey on post-transfusional iron overload subsequently led to the establishment of guidelines for iron chelation therapy in this country. To date, however, detailed clinical information on the entire iron overload population in Japan has not been fully investigated. In the present study, we obtained and studied detailed clinical information on the iron overload patient population in Japan. Of 1109 iron overload cases, 93.1% were considered to have occurred post-transfusion...
November 15, 2016: International Journal of Hematology
https://www.readbyqxmd.com/read/27833542/adaptive-automation-triggered-by-eeg-based-mental-workload-index-a-passive-brain-computer-interface-application-in-realistic-air-traffic-control-environment
#13
Pietro Aricò, Gianluca Borghini, Gianluca Di Flumeri, Alfredo Colosimo, Stefano Bonelli, Alessia Golfetti, Simone Pozzi, Jean-Paul Imbert, Géraud Granger, Raïlane Benhacene, Fabio Babiloni
Adaptive Automation (AA) is a promising approach to keep the task workload demand within appropriate levels in order to avoid both the under- and over-load conditions, hence enhancing the overall performance and safety of the human-machine system. The main issue on the use of AA is how to trigger the AA solutions without affecting the operative task. In this regard, passive Brain-Computer Interface (pBCI) systems are a good candidate to activate automation, since they are able to gather information about the covert behavior (e...
2016: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/27830226/new-unintended-adverse-consequences-of-electronic-health-records
#14
D F Sittig, A Wright, J Ash, H Singh
Although the health information technology industry has made considerable progress in the design, development, implementation, and use of electronic health records (EHRs), the lofty expectations of the early pioneers have not been met. In 2006, the Provider Order Entry Team at Oregon Health & Science University described a set of unintended adverse consequences (UACs), or unpredictable, emergent problems associated with computer-based provider order entry implementation, use, and maintenance. Many of these originally identified UACs have not been completely addressed or alleviated, some have evolved over time, and some new ones have emerged as EHRs became more widely available...
November 10, 2016: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/27823598/serum-potassium-levels-and-outcome-in-acute-heart-failure-data-from-the-protect-and-coach-trials
#15
Jasper Tromp, Jozine M Ter Maaten, Kevin Damman, Christopher M O'Connor, Marco Metra, Howard C Dittrich, Piotr Ponikowski, John R Teerlink, Gad Cotter, Beth Davison, John G F Cleland, Michael M Givertz, Daniel M Bloomfield, Martje H L van der Wal, Tiny Jaarsma, Dirk J van Veldhuisen, Hans L Hillege, Adriaan A Voors, Peter van der Meer
Serum potassium is routinely measured at admission for acute heart failure (AHF), but information on association with clinical variables and prognosis is limited. Potassium measurements at admission were available in 1,867 patients with AHF in the original cohort of 2,033 patients included in the Patients Hospitalized with acute heart failure and Volume Overload to Assess Treatment Effect on Congestion and Renal FuncTion trial. Patients were grouped according to low potassium (<3.5 mEq/l), normal potassium (3...
October 8, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27802256/parent-perspectives-on-their-mobile-technology-use-the-excitement-and-exhaustion-of-parenting-while-connected
#16
Jenny S Radesky, Caroline Kistin, Staci Eisenberg, Jamie Gross, Gabrielle Block, Barry Zuckerman, Michael Silverstein
OBJECTIVE: Parent use of mobile devices (e.g., smartphones, tablets) while around their young children may be associated with fewer or more negative parent-child interactions, but parent perspectives regarding this issue have not been explored. We aimed to understand parent views regarding their mobile device use to identify actionable targets of potential intervention. METHOD: We conducted 35 in-depth semi-structured group and individual interviews with English-speaking caregivers of children 0 to 8 years old, purposively sampled from diverse ethnic backgrounds, educational levels, and employment statuses...
November 2016: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/27786565/the-electromagnetic-basis-of-social-interactions
#17
A R Liboff
It has been established that living things are sensitive to extremely low-frequency magnetic fields at vanishingly small intensities, on the order of tens of nT. We hypothesize, as a consequence of this sensitivity, that some fraction of an individual's central nervous system activity can be magnetically detected by nearby individuals. Even if we restrict the information content of such processes to merely simple magnetic cues that are unconsciously received by individuals undergoing close-knit continuing exposure to these cues, it is likely that they will tend to associate these cues with the transmitting individual, no less than would occur if such signals were visual or auditory...
October 27, 2016: Electromagnetic Biology and Medicine
https://www.readbyqxmd.com/read/27783878/an-elephant-trunk-appearance-what-is-the-diagnosis
#18
Roopali Khanna, Deepchandh Raja, Pravin K Goel
Coronary cameral fistula is a rare congenital cardiac abnormality. An 18-year-old boy presented with features of right heart volume overload. Clinical examination was suggestive of hyperdynamic circulation with continuous murmur in precordium. 2D echocardiography showed dilated right coronary artery, and 3D echocardiography added information in tracing the track of the fistula which was consistent with the diagnosis of right coronary cameral fistula draining into the right ventricle. Coronary angiograms revealed an unusually dilated right coronary artery giving the appearance of an "elephant trunk" and with a fistulous tract into the right ventricle...
October 2016: Echocardiography
https://www.readbyqxmd.com/read/27783610/-vaccines-history-and-stories-between-reality-and-imagination
#19
Elisa Terracciano, Ermanno Zorzoli, Gian Loreto D'Alò, Laura Zaratti, Elisabetta Franco
Vaccinations and the controversy around them always go in parallel. We identified four categories blending in various amounts of truth and imagination: history, myths, shams and frauds. Over the years, they have alternated and sometimes transformed into one another. This sharp separation into categories is certainly academic and forced. In fact, the line between these aspects is not clear enough to allow a rigid and well-defined division. Our work starts from the category containing the most truthfulness: history, and goes on to analyze two categories that add fantasy to facts: myths and shams (or better, "old wives' tales")...
July 2016: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/27782781/co-creating-healthful-eating-behaviors-with-very-young-children-the-impact-of-information-overload-on-primary-caregivers
#20
Julie L Norton, Maria M Raciti
Primary caregivers of very young children are subject to excessive and often disparate information regarding the instilling of healthful eating behaviors. Our study focuses on the integration of the operant resources of primary caregivers (i.e., their knowledge and modeling skills) and that of their very young children (i.e., their self-regulation of energy intake and food preferences) to co-create healthful eating behaviors as a measure to curb overweight and obesity in adulthood. Our two-stage qualitative study makes original contributions demonstrating that primary caregivers' efforts to co-create healthful eating behaviors with their very young children are adversely affected by information overload...
October 26, 2016: Health Marketing Quarterly
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