Khairun I Abdul-Jalil, Katherine M Sheehan, Sinead Toomey, Jasmin Schmid, Jochen Prehn, Anthony O'Grady, Robert Cummins, Brian O'Neill, Deborah A McNamara, Joseph Deasy, Oscar Breathnach, Liam Grogan, Ailin Rogers, Glen Doherty, Des Winter, John Ryan, Sherif El-Masry, David Gibbons, Kieran Sheahan, Peter Gillen, Elaine W Kay, Bryan T Hennessy
BACKGROUND: Locally advanced rectal cancer (LARC: T3/4 and/or node-positive) is treated with preoperative/neoadjuvant chemoradiotherapy (CRT), but responses are not uniform. The phosphatidylinositol 3-kinase (PI3K), MAP kinase (MAPK), and related pathways are implicated in rectal cancer tumorigenesis. Here, we investigated the association between genetic mutations in these pathways and LARC clinical outcomes. METHODS: We genotyped 234 potentially clinically relevant nonsynonymous mutations in 33 PI3K and MAPK pathway-related genes, including PIK3CA, PIK3R1, AKT, STK11, KRAS, BRAF, MEK, CTNNB1, EGFR, MET, and NRAS, using the Sequenom platform...
August 2014: Annals of Surgical Oncology