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Trauma responses

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https://www.readbyqxmd.com/read/28742815/il33-mediated-ilc2-activation-and-neutrophil-il5-production-in-the-lung-response-after-severe-trauma-a-reverse-translation-study-from-a-human-cohort-to-a-mouse-trauma-model
#1
Jing Xu, Jesse Guardado, Rosemary Hoffman, Hui Xu, Rami Namas, Yoram Vodovotz, Li Xu, Mostafa Ramadan, Joshua Brown, Heth R Turnquist, Timothy R Billiar
BACKGROUND: The immunosuppression and immune dysregulation that follows severe injury includes type 2 immune responses manifested by elevations in interleukin (IL) 4, IL5, and IL13 early after injury. We hypothesized that IL33, an alarmin released early after tissue injury and a known regulator of type 2 immunity, contributes to the early type 2 immune responses after systemic injury. METHODS AND FINDINGS: Blunt trauma patients admitted to the trauma intensive care unit of a level I trauma center were enrolled in an observational study that included frequent blood sampling...
July 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28742799/the-new-survivors-and-a-new-era-for-trauma-research
#2
EDITORIAL
Karim Brohi, Martin Schreiber
Karim Brohi and Martin Schreiber, Guest Editors of the Special Issue on Trauma, describe a new era in exploration of the biology of injury response and translation of new opportunities into clinical practice.
July 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28741388/comparative-proteomic-analysis-of-the-effect-of-the-four-herb-chinese-medicine-anbp-on-promoting-mouse-skin-wound-healing
#3
Li Chen, Qian Hou, Zhong-Zhi Zhou, Mei-Rong Li, Ling-Zhi Zhong, Xiang-Dong Deng, Zi-Ying Zhu, Zhong-Yi Cheng, Jun Zhu, Cong-Lian Xiang, Wen-Jun He, Xiao-Bing Fu
Traditional Chinese medicine has great potential to improve wound healing. ANBP, the mixture of 4 Chinese herbs- Agrimoniapilosa, Nelumbonucifera, Boswelliacarteri, and Pollen typhae-is effective in trauma treatment while its mechanism is still elusive. In this study, quantitative proteomics and bioinformatics analyses were performed to decipher the possible roles of ANBP in accelerated wound healing of mouse skin. Among all 3171 identified proteins, 90, 71, 80, and 140 proteins were found to be differently expressed in 6 hours, 3 days, 7 days, and 14 days ANBP-treated tissues compared with corresponding control tissues, respectively...
July 1, 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28740457/perioperative-increase-in-neutrophil-cd64-expression-is-an-indicator-for-intra-abdominal-infection-after-colorectal-cancer-surgery
#4
Milena Kerin Povsic, Bojana Beovic, Alojz Ihan
BACKGROUND: Colorectal surgery is associated with a high incidence of postoperative infections. Early clinical signs are difficult to distinguish from the systemic inflammatory response related to surgical trauma. Timely diagnosis may significantly improve the outcome. The objective of this study was to compare a new biomarker index CD64 for neutrophils (iCD64n) with standard biomarkers, white blood cell (WBC) count, neutrophil/lymphocyte ratio (NLR), C-reactive protein (CRP) and procalcitonin (PCT) for the early detection of postoperative infection...
June 2017: Radiology and Oncology
https://www.readbyqxmd.com/read/28740438/availability-and-use-of-hemostatic-agents-in-prehospital-trauma-patients-in-pennsylvania-translation-from-the-military-to-the-civilian-setting
#5
Adam Sigal, Anthony Martin, Adrian Ong
OBJECTIVE: To understand the translation of one innovation in trauma care from the military to the civilian setting, the adoption of topical hemostatic agents in the Emergency Medical Services (EMS) community and in Trauma Centers in Pennsylvania. METHOD: We utilized an anonymous electronic survey of EMS Agency Administrative Officers and Trauma Center Coordinators. RESULTS: We received responses from 23% (93/402) Advanced Life Support and Air Medical agencies in the State...
2017: Open Access Emergency Medicine: OAEM
https://www.readbyqxmd.com/read/28738316/-what-kept-me-going-a-qualitative-study-of-avoidant-responses-to-war-related-adversity-and-perpetration-of-violence-by-former-forcibly-recruited-children-and-youth-in-the-acholi-region-of-northern-uganda
#6
Helle Harnisch, Edith Montgomery
This qualitative study investigates what, according to 36 former forcibly recruited women and men, enabled them to "keep on going" during and after their forced recruitment in the twenty-year-long civil war in northern Uganda. Furthermore, the study conveys the ways most of the former forcibly recruited kept on going and today cope with ongoing war-related adversity and difficult reintegration processes without relying on psycho-social intervention. Thirty-five of the 36 women and men were forcibly recruited when they were children by the Lord's Resistance Army (LRA) from the Acholi region of northern Uganda...
July 11, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28737767/sensitive-and-non-invasive-method-for-the-in-vivo-analysis-of-membrane-permeability-in-small-animals
#7
Andrea Fernandez-Carrera, Eva Vigo, Carla Regueiro-Rodríguez, África González-Fernández, David Olivieri, Luiz S Aroeira
Tissue membranes are boundaries that isolate organs or cavities in the body. These semi-permeable membranes are responsible for passive protection that acts through the regulation of nutrient absorption, secretion and filtration of small molecules. These functions could be altered as a consequence of inflammation or trauma, which in turn could lead to changes in permeability, allowing the entrance of toxins, antigens, proteins or facilitating the spread of tumors. Membrane permeability therefore plays an important role in numerous diseases...
July 24, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28737593/a-teachable-moment-after-orthopaedic-fracture-in-the-smoking-patient-a-randomized-controlled-trial
#8
Matthew D Baron, Christopher J DeFrancesco, Tiffany C Liu, Frank T Leone, Jaimo Ahn
OBJECTIVES: To assess whether education during hospitalization after an acute fracture changes patient attitudes toward smoking-related complications and to assess whether this change persists into the first outpatient follow-up visit. DESIGN: Prospective, randomized, controlled trial. SETTING: Level 1 trauma center. PATIENTS: Inpatients with fractures who identified as smokers: 40 assessed for inclusion and randomized, 30 completed inpatient assessments, and 20 completed outpatient follow-up...
August 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28736123/analysis-of-two-treatment-modalities-for-the-prevention-of-vomiting-after-trauma-orogastric-tube-or-anti-emetics
#9
H D Vermeijden, L P H Leenen, M van Polen, M G W Dijkgraaf, F Hietbrink
INTRODUCTION: Vomiting in the emergency department after trauma occurs frequently and might lead to aspiration of gastric content. An orogastric tube (OGT) is a way to prevent emesis. However, this is an inconvenient procedure and may actually trigger vomiting. Therefore, a change in policy was applied from preferably an OGT to the administration of anti-emetics in a selected population. The aim of this study was to analyse the prevention of vomiting in trauma patients after OGT or anti-emetics...
July 8, 2017: Injury
https://www.readbyqxmd.com/read/28734128/the-experience-of-initiating-injection-drug-use-and-its-social-context-a-qualitative-systematic-review-and-thematic-synthesis
#10
REVIEW
Andy Guise, Danielle Horyniak, Jason Melo, Ryan McNeill, Dan Werb
BACKGROUND AND AIM: Understanding the experience of initiating injection drug use and its social contexts is crucial to inform efforts to prevent transitions into this mode of drug consumption and support harm reduction. We systematically reviewed and synthesized existing qualitative scientific literature to identify the socio-structural contexts for, and experiences of, the initiation of injection drug use. METHODS: We systematically searched six databases (Medline, Embase, PsychINFO, CINAHL, IBSS, and SSCI), along with a manual search, including of key journals and subject experts...
July 22, 2017: Addiction
https://www.readbyqxmd.com/read/28734082/response-to-comment-on-moyron-et%C3%A2-al-differential-protein-expression-in-exosomal-samples-taken-from-trauma-patients-proteomics-clinical-application-2017-may-25
#11
Ron B Moyron, Nathan R Wall
No abstract text is available yet for this article.
July 22, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28730889/purposefulness-as-a-critical-factor-in-functioning-disability-and-health
#12
Joshua Y Lee, Emily A Ready, Eric N Davis, Philip C Doyle
Guided by theoretical frameworks of health and illness such as the International Classification of Functioning, Disability, and Health (ICF), we seek to describe the importance of purposefulness in the context of rehabilitation. We argue that ascribing meaning to life events, particularly changes in health, and acting in a manner that is driven by purpose is a universal characteristic of human beings. The ability to contextualize purposefulness within the broader biopsychosocial model of illness may provide a greater understanding of the relationship of purpose in the process of rehabilitation...
August 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28728875/the-use-and-uptake-of-pupillometers-in-the-intensive-care-unit
#13
Matthew Hao Lee, Biswadev Mitra, Jiun Kae Pui, Mark Fitzgerald
BACKGROUND: Traumatic brain injury (TBI) is a significant public health issue. Assessing pupil reactivity is a crucial aspect of its management and the pupillometer has been shown to be a more objective tool compared to the standard penlight. Its use, however, is not widespread. OBJECTIVE: To investigate the paucity in uptake, we examined the frequency of use of pupillometers (NeurOptics(®)NPi-100™) amongst Intensive Care Unit (ICU) doctors and nurses, evaluated its user-friendliness and explored barriers to its use...
July 17, 2017: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/28727662/paraphilic-thoughts-behaviors-and-sex-addiction-in-a-sample-of-persons-who-use-drugs-a-cross-sectional-study
#14
Jales Clemente, Sandra Cristina Pillon, Jair de Jesus Mari, Claudio Jeronimo da Silva, Paulo Roberto Henrique Santana, Alessandra Diehl
OBJECTIVE: The aim of this study was to evaluate the prevalence of paraphilic thoughts/behaviors (including paraphilic disorders) with and without sexual addiction and sexual-related conditions in a sample of substance disorder patients. METHODS: This was a cross-sectional study of substance-dependent individuals who sought outpatient treatment in São Paulo, Brazil. Data included sociodemographic information, drug of choice, responses to questions about sexual behavior, and to the following standardized questionnaires: (a) Sexual Addiction Screening Test, and (b) Childhood Trauma Questionnaire...
July 19, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28726543/differences-in-brain-architecture-in-remote-mild-traumatic-brain-injury
#15
Aishwarya Rajesh, Gillian E Cooke, Jim M Monti, Andrew Jahn, Ana M Daugherty, Arthur Kramer
Mild TBI (mTBI) is brain trauma from an external impact with a loss of consciousness less than 30 minutes. MTBI results in several biopsychosocial impairments with pronounced cognitive deficits, thought to resolve within three months of injury. Previous research suggests that these impairments are due to a temporary inability to appropriately allocate neural resources in response to cognitive demands. Our study questioned this assumption and instead hypothesized that mTBI was associated with long-term neural disruptions and compromised brain structure integrity...
July 20, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28726014/a-study-of-the-therapeutic-effects-of-resveratrol-on-blunt-chest-trauma-induced-acute-lung-injury-in-rats-and-the-potential-role-of-endocan-as-a-biomarker-of-inflammation
#16
Aysun Caglar Torun, Serife Tutuncu, Burcu Ustun, Hızır Ufuk Akdemir
The present study focused on the therapeutic effects of resveratrol in a rat model of blunt chest trauma-induced acute lung injury and the potential role of endocan as a biomarker of inflammation. They were randomly divided into the following four groups (n = 7 in each group): control group (no treatment or trauma); trauma group (trauma-induced group); resveratrol group (resveratrol [0.3 mg/kg] administered via the i.p. route group); and resveratrol + trauma group (resveratrol [0.3 mg/kg] administered via the i...
July 19, 2017: Inflammation
https://www.readbyqxmd.com/read/28725434/regression-of-multifocoal-in-transit-melanoma-metastases-after-palliative-resection-of-dominant-masses-and-2%C3%A2-years-after-treatment-with-ipilimumab
#17
Raphael B Moreira, Lana Hamieh, Evisa Gjini, Ana Lako, Katherine M Krajewski, Charles H Yoon, Patrick A Ott
BACKGROUND: Spontaneous regression of metastatic melanoma and delayed responses more than one year after treatment with ipilimumab are rarely seen. CASE PRESENTATION: Here, we present the case of a patient with in transit metastases from cutaneous melanoma on his right lower extremity who achieved complete regression of all metastatic lesions 13 months after the first of two consecutive palliative resections of dominant masses and more than two years after treatment with ipilimumab...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28722711/limiting-inflammation-the-negative-regulation-of-nf-%C3%AE%C2%BAb-and-the-nlrp3-inflammasome
#18
REVIEW
Inna S Afonina, Zhenyu Zhong, Michael Karin, Rudi Beyaert
A properly mounted immune response is indispensable for recognizing and eliminating danger arising from foreign invaders and tissue trauma. However, the 'inflammatory fire' kindled by the host response must be tightly controlled to prevent it from spreading and causing irreparable damage. Accordingly, acute inflammation is self-limiting and is normally attenuated after elimination of noxious stimuli, restoration of homeostasis and initiation of tissue repair. However, unresolved inflammation may lead to the development of chronic autoimmune and degenerative diseases and cancer...
July 19, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28720407/mechanical-properties-of-the-human-spinal-cord-under-the-compressive-loading
#19
Alireza Karimi, Ahmad Shojaei, Pedram Tehrani
The spinal cord as the most complex and critical part of the human body is responsible for the transmission of both motor and sensory impulses between the body and the brain. Due to its pivotal role any types of physical injury in that disrupts its function following by shortfalls, including the minor motor and sensory malfunctions as well as complicate quadriplegia and lifelong ventilator dependency. In order to shed light on the injuries to the spinal cord, the application of the computational models to simulate the trauma impact loading to that are deemed required...
July 15, 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/28719602/prehospital-immune-responses-and-development-of-multiple-organ-dysfunction-syndrome-following-traumatic-injury-a-prospective-cohort-study
#20
Jon Hazeldine, David N Naumann, Emma Toman, David Davies, Jonathan R B Bishop, Zhangjie Su, Peter Hampson, Robert J Dinsdale, Nicholas Crombie, Niharika Arora Duggal, Paul Harrison, Antonio Belli, Janet M Lord
BACKGROUND: Almost all studies that have investigated the immune response to trauma have analysed blood samples acquired post-hospital admission. Thus, we know little of the immune status of patients in the immediate postinjury phase and how this might influence patient outcomes. The objective of this study was therefore to comprehensively assess the ultra-early, within 1-hour, immune response to trauma and perform an exploratory analysis of its relationship with the development of multiple organ dysfunction syndrome (MODS)...
July 2017: PLoS Medicine
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