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https://www.readbyqxmd.com/read/27703788/personality-traits-in-adults-with-attention-deficit-hyperactivity-disorder-and-their-unaffected-first-degree-relatives
#1
Valentino Antonio Pironti, Meng-Chuan Lai, Ulrich Müller, Edward Thomas Bullmore, Barbara Jacquelyn Sahakian
BACKGROUND: Attention-deficit hyperactivity disorder (ADHD) shows clear, albeit heterogeneous, cognitive dysfunctions. However, personality traits are not well understood in adults with ADHD, and it is unclear whether they are predisposing factors or phenotypical facets of the condition. AIMS: To assess whether personality traits of impulsivity, sensation seeking and sensitivity to punishment and reward are predisposing factors for ADHD or aspects of the clinical phenotype...
July 2016: BJPsych Open
https://www.readbyqxmd.com/read/27703782/ketamine-stimulating-antidepressant-treatment
#2
Gin S Malhi, Yulisha Byrow, Frederick Cassidy, Andrea Cipriani, Koen Demyttenaere, Mark A Frye, Michael Gitlin, Sidney H Kennedy, Terence A Ketter, Raymond W Lam, Rupert McShane, Alex J Mitchell, Michael J Ostacher, Sakina J Rizvi, Michael E Thase, Mauricio Tohen
SUMMARY: The appeal of ketamine - in promptly ameliorating depressive symptoms even in those with non-response - has led to a dramatic increase in its off-label use. Initial promising results await robust corroboration and key questions remain, particularly concerning its long-term administration. It is, therefore, timely to review the opinions of mood disorder experts worldwide pertaining to ketamine's potential as an option for treating depression and provide a synthesis of perspectives - derived from evidence and clinical experience - and to consider strategies for future investigations...
May 2016: BJPsych Open
https://www.readbyqxmd.com/read/27703769/testing-the-social-competition-hypothesis-of-depression-using-a-simple-economic-game
#3
Aleksandra Kupferberg, Oliver M Hager, Urs Fischbacher, Laura S Brändle, Melanie Haynes, Gregor Hasler
BACKGROUND: Price's social competition hypothesis interprets the depressive state as an unconscious, involuntary losing strategy, which enables individuals to yield and accept defeat in competitive situations. AIMS: We investigated whether patients who suffer from major depressive disorder (MDD) would avoid competition more often than either patients suffering from borderline personality disorder (BPD) or healthy controls. METHOD: In a simple paper-folding task healthy participants and patiens with MDD and BPD were matched with two opponents, one with an unknown diagnosis and one who shared their clinical diagnosis, and they had to choose either a competitive or cooperative payment scheme for task completion...
March 2016: BJPsych Open
https://www.readbyqxmd.com/read/27703761/is-it-time-to-abandon-suicide-risk-assessment
#4
Declan Murray
SUMMARY: Suicide risk assessment includes estimating the likelihood of suicide in words such as 'low, medium or high'. A 'high suicide risk' rating can trigger a powerful urge to eliminate risk immediately. But it is far from clear what 'high suicide risk' actually means. In the current state of knowledge, suicide reduction measures should apply to all psychiatric patients, irrespective of an individual patient's perceived risk. For patients presenting with suicidal thoughts, feelings and behaviour, assessment and management should focus on reducing or tolerating emotional pain...
January 2016: BJPsych Open
https://www.readbyqxmd.com/read/27590221/cardiovascular-event-rates-and-mortality-according-to-achieved-systolic-and-diastolic-blood-pressure-in-patients-with-stable-coronary-artery-disease-an-international-cohort-study
#5
Emmanuelle Vidal-Petiot, Ian Ford, Nicola Greenlaw, Roberto Ferrari, Kim M Fox, Jean-Claude Tardif, Michal Tendera, Luigi Tavazzi, Deepak L Bhatt, Philippe Gabriel Steg
BACKGROUND: The optimum blood pressure target in hypertension remains debated, especially in coronary artery disease, given concerns for reduced myocardial perfusion if diastolic blood pressure is too low. We aimed to study the association between achieved blood pressure and cardiovascular outcomes in patients with coronary artery disease and hypertension. METHODS: We analysed data from 22 672 patients with stable coronary artery disease enrolled (from Nov 26, 2009, to June 30, 2010) in the CLARIFY registry (including patients from 45 countries) and treated for hypertension...
August 26, 2016: Lancet
https://www.readbyqxmd.com/read/27579829/budget-impact-of-adding-ivabradine-to-standard-of-care-in-patients-with-chronic-systolic-heart-failure-in-the-united-states
#6
Jeffrey S Borer, Anuraag R Kansal, Emily D Dorman, Stanimira Krotneva, Ying Zheng, Harshali K Patel, Luigi Tavazzi, Michel Komajda, Ian Ford, Michael Böhm, Adrian Kielhorn
BACKGROUND: Heart failure (HF) costs $21 billion annually in direct health care costs, 80% of which is directly attributable to hospitalizations. The SHIFT clinical study demonstrated that ivabradine plus standard of care (SoC) reduced HF-related and all-cause hospitalizations compared with SoC alone. OBJECTIVE: To estimate the budget impact of ivabradine from a U.S. commercial payer perspective. METHODS: A budget impact model estimated the per-member-per month (PMPM) impact of introducing ivabradine to existing formularies by comparing a reference scenario (SoC) and a new drug scenario (ivabradine + SoC) in hypothetical 1 million-member commercial and Medicare Advantage plans...
September 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27574749/budget-impact-of-adding-ivabradine-to-standard-of-care-in-patients-with-chronic-systolic-heart-failure-in-the-united-states
#7
Jeffrey S Borer, Anuraag R Kansal, Emily D Dorman, Stanimira Krotneva, Ying Zheng, Harshali K Patel, Luigi Tavazzi, Michel Komajda, Ian Ford, Michael Böhm, Adrian Kielhorn
BACKGROUND: Heart failure (HF) costs $21 billion annually in direct health care costs, 80% of which is directly attributable to hospitalizations. The SHIFT clinical study demonstrated that ivabradine plus standard of care (SoC) reduced HF-related and all-cause hospitalizations compared with SoC alone. OBJECTIVE: To estimate the budget impact of ivabradine from a U.S. commercial payer perspective. METHODS: A budget impact model estimated the per-member-per month (PMPM) impact of introducing ivabradine to existing formularies by comparing a reference scenario (SoC) and a new drug scenario (ivabradine + SoC) in hypothetical 1 million-member commercial and Medicare Advantage plans...
September 2016: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/27567348/availability-affordability-and-consumption-of-fruits-and-vegetables-in-18-countries-across-income-levels-findings-from-the-prospective-urban-rural-epidemiology-pure-study
#8
Victoria Miller, Salim Yusuf, Clara K Chow, Mahshid Dehghan, Daniel J Corsi, Karen Lock, Barry Popkin, Sumathy Rangarajan, Rasha Khatib, Scott A Lear, Prem Mony, Manmeet Kaur, Viswanathan Mohan, Krishnapillai Vijayakumar, Rajeev Gupta, Annamarie Kruger, Lungiswa Tsolekile, Noushin Mohammadifard, Omar Rahman, Annika Rosengren, Alvaro Avezum, Andrés Orlandini, Noorhassim Ismail, Patricio Lopez-Jaramillo, Afzalhussein Yusufali, Kubilay Karsidag, Romaina Iqbal, Jephat Chifamba, Solange Martinez Oakley, Farnaza Ariffin, Katarzyna Zatonska, Paul Poirier, Li Wei, Bo Jian, Chen Hui, Liu Xu, Bai Xiulin, Koon Teo, Andrew Mente
BACKGROUND: Several international guidelines recommend the consumption of two servings of fruits and three servings of vegetables per day, but their intake is thought to be low worldwide. We aimed to determine the extent to which such low intake is related to availability and affordability. METHODS: We assessed fruit and vegetable consumption using data from country-specific, validated semi-quantitative food frequency questionnaires in the Prospective Urban Rural Epidemiology (PURE) study, which enrolled participants from communities in 18 countries between Jan 1, 2003, and Dec 31, 2013...
October 2016: Lancet Global Health
https://www.readbyqxmd.com/read/27503672/providing-innovative-solutions-in-a-single-pill-servier-s-portfolio-in-hypertension
#9
Jean-Jacques Mourad, Jean-Christophe Guillerm
Jean-Jacques Mourad & Jean-Christophe Guillerm speak to Henry Ireland, Drug Evaluation Editor: Jean-Jacques Mourad talks about his vision of the current landscape and unmet medical needs in the field of hypertension. Jean-Christophe Guillerm describes the family of antihypertensive treatments from Servier, which were designed to address the current challenges in the management of hypertension by providing an adapted solution to doctors and to the specific needs of each patient. Jean-Jacques Mourad currently works as Professor of Medicine and is the Head of the Hypertension Unit at the Hôpital Avicenne in Bobigny, France...
September 2016: Future Cardiology
https://www.readbyqxmd.com/read/27488944/an-evaluation-of-the-effect-of-an-angiotensin-converting-enzyme-inhibitor-on-the-growth-rate-of-small-abdominal-aortic-aneurysms-a-randomised-placebo-controlled-trial-aardvark
#10
Gaia Kiru, Colin Bicknell, Emanuela Falaschetti, Janet Powell, Neil Poulter
BACKGROUND: Although data are inconsistent, angiotensin-converting enzyme inhibitors (ACE-Is) have been associated with a reduced incidence of abdominal aortic aneurysm (AAA) rupture in analysis of administrative databases. OBJECTIVES: (1) To investigate whether or not the ACE-I perindopril (Coversyl arginine, Servier) reduces small AAA growth rate and (2) to evaluate blood pressure (BP)-independent effects of perindopril on small AAA growth and to compare the repeatability of measurement of internal and external aneurysm diameters...
July 2016: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/27432382/effectiveness-and-tolerability-of-ivabradine-with-or-without-concomitant-beta-blocker-therapy-in-patients-with-chronic-stable-angina-in-routine-clinical-practice
#11
Stefan Perings, Georg Stöckl, Malte Kelm
INTRODUCTION: In the prospective, open-label, non-interventional, multicenter RESPONSIfVE study, the effectiveness, response rates and tolerability of ivabradine with or without beta blocker (BB) were evaluated in patients with chronic stable angina pectoris (AP) in daily clinical practice. METHODS: In patients with AP, ivabradine was given twice daily in flexible doses for 4 months. Resting heart rate (HR), number of angina attacks, short-acting nitrate use, severity of symptoms [by Canadian Cardiovascular Society (CCS) score] and tolerability with or without existing BB therapy were documented and analyzed using descriptive statistical methods...
September 2016: Advances in Therapy
https://www.readbyqxmd.com/read/27336342/-transitory-evening-venous-reflux-in-patients-with-intracutaneous-varicosity-and-medicamentous-correction-thereof
#12
Yu T Tsukanov, A I Nikolaichuk
The authors carried out a study aimed at revealing transitory refluxes along the great saphenous vein (GSV) in patients with intracutaneous varicosity, and at investigating the possibility of removing them by means of preparations of micronized purified flavonoid fraction (MPFF). The study included a total of one hundred and forty-seven 21-to-47-year-old (mean age 31±4.4 years) women presenting with cutaneous varicosity (class C1s). The duration of skin manifestations amounted to 9.4±3.9 years (varying from 4 to 24 years)...
2016: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/27290839/-physicians-conferences-a-viewpoint-to-consider
#13
EDITORIAL
Claudio Serviere Zaragoza
No abstract text is available yet for this article.
January 2016: Ginecología y Obstetricia de México
https://www.readbyqxmd.com/read/27061319/frontispiece-new-insights-on-the-mitochondrial-proteome-plasticity-in-parkinson-s-disease
#14
Miguel Aroso, Rita Ferreira, Ana Freitas, Rui Vitorino, Maria Gomez-Lazaro
DOI: 10.1002/prca.201500092 Mitochondria are central organelles for neuronal cell physiology and survival, which malfunction has been linked to Parkinson's disease. Proteomics of enriched mitochondrial fractions followed by data integration and network analysis, taking in consideration variables such as model of PD, cell line or tissue origin highlight the modulation of several biological processes. This image was produced using images modified from Servier Medical Art (Servier, www.servier.com, licensed under a Creative Commons Attribution 3...
April 2016: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/26794937/the-advantages-of-combination-therapy-on-hypertension-development-of-immediate-release-perindopril-indapamide-tablet-and-assessment-of-bioequivalence-studies
#15
A Ölçer, M Ölçer, I İnce, E Karasulu
Hypertension has a major associated risk for organ damage and mortality, which is further heightened in patients with prior cardiovascular events, comorbid diabetes mellitus, microalbuminuria and renal impairment. Convers Plus tablet including perindopril erbumine (PE), which is an angiotensin converting enzyme (ACE) inhibitor, and indapamide, which is diuretic, was designed as a combined tablet to succes in the treatment of hypertension. Physico-pharmaceutical properties and characterization studies were evaluated in vitro conditions...
March 2016: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/26764971/servier-s-pipeline-in-oncology-moving-from-research-to-patients
#16
Patrick Therasse, Jean-Pierre Abastado
No abstract text is available yet for this article.
March 2016: Future Oncology
https://www.readbyqxmd.com/read/26525390/effect-of-ivabradine-on-endothelial-function-in-patients-with-stable-angina-pectoris-assessment-with-the-endo-pat-2000-device
#17
Lucia Jedlickova, Lucia Merkovska, Lucia Jackova, Martin Janicko, Jan Fedacko, Bozena Novakova, Anna Chmelarova, Jaroslav Majernik, Daniel Pella
INTRODUCTION: Ivabradine has opened up new possibilities for treating stable angina and chronic heart failure by lowering heart rate. Ivabradine lowers heart rate by selectively inhibiting the I f current in the sinoatrial node. This study aimed to determine whether the decrease in heart rate achieved with ivabradine was accompanied by hemodynamic changes that might lead to an enhancement of endothelial function. METHODS: Thirty patients with stable angina pectoris were included in the study...
October 2015: Advances in Therapy
https://www.readbyqxmd.com/read/26521191/cardiac-and-hemodynamic-benefits-mode-of-action-of-ivabradine-in-heart-failure
#18
REVIEW
Antonio Carlos Pereira-Barretto
Heart failure has seen a number of therapeutic advances in recent years. Despite this, heart failure is still related to increasing rates of morbidity, repeated hospitalizations, and mortality. Ivabradine is a recent treatment option for heart failure. It has a mode of action that includes reduction in heart rate, and leads to improvement in outcomes related to heart failure mortality and morbidity, as demonstrated by the results of the SHIFT trial in patients with systolic heart failure, functional classes II and III on the New York Heart Association classification, and left ventricular ejection fraction ≤ 35%...
October 2015: Advances in Therapy
https://www.readbyqxmd.com/read/26418000/influence-of-cervical-muscle-fatigue-on-musculo-tendinous-stiffness-of-the-head-neck-segment-during-cervical-flexion
#19
Raphaël Portero, Franck Quaine, Violaine Cahouet, Marc Léouffre, Christine Servière, Pierre Portero
AIM: The aim of this study is to determine if the fatigue of cervical muscles has a significant influence on the head-neck segment musculo-tendinous stiffness. METHODS: Ten men (aged 21.2 ± 1.9 years) performed four quick-release trials of flexion at 30 and 50% MVC before and after the induction of muscular fatigue on cervical flexors. Electromyographic activity was recorded on the sternocleidomastoids (SCM) and spinal erectors (SE), bilaterally. Musculo-tendinous stiffness was calculated through the quick-release method adapted to the head-neck segment...
2015: PloS One
https://www.readbyqxmd.com/read/26386538/alcohol-consumption-and-cardiovascular-disease-cancer-injury-admission-to-hospital-and-mortality-a-prospective-cohort-study
#20
Andrew Smyth, Koon K Teo, Sumathy Rangarajan, Martin O'Donnell, Xiaohe Zhang, Punam Rana, Darryl P Leong, Gilles Dagenais, Pamela Seron, Annika Rosengren, Aletta E Schutte, Patricio Lopez-Jaramillo, Ayetkin Oguz, Jephat Chifamba, Rafael Diaz, Scott Lear, Alvaro Avezum, Rajesh Kumar, Viswanathan Mohan, Andrzej Szuba, Li Wei, Wang Yang, Bo Jian, Martin McKee, Salim Yusuf
BACKGROUND: Alcohol consumption is proposed to be the third most important modifiable risk factor for death and disability. However, alcohol consumption has been associated with both benefits and harms, and previous studies were mostly done in high-income countries. We investigated associations between alcohol consumption and outcomes in a prospective cohort of countries at different economic levels in five continents. METHODS: We included information from 12 countries participating in the Prospective Urban Rural Epidemiological (PURE) study, a prospective cohort study of individuals aged 35-70 years...
November 14, 2015: Lancet
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