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Li-Wei Zhou, Xue-Wei Wang, Josef Vlasák, Guang-Juan Ren
The family Nigrofomitaceae has been considered to be a member of Polyporales and a synonym of Polyporaceae for a long time. However, no molecular evidence supports this taxonomic opinion. For the first time, Nigrofomitaceae is included in a phylogenetic analysis, which shows that this family is separated from Polyporales and nested within Hymenochaetales as a distinct lineage from four well-known families, viz. Hymenochaetaceae, Neoantrodiellaceae, Oxyporaceae and Schizoporaceae. Therefore, Nigrofomitaceae is treated as the fifth family of Hymenochaetales...
2018: MycoKeys
Elena Sanchez, Emma Artuso, Chiara Lombardi, Ivan Visentin, Beatrice Lace, Wajeeha Saeed, Marco L Lolli, Piermichele Kobauri, Zahid Ali, Francesca Spyrakis, Pilar Cubas, Francesca Cardinale, Cristina Prandi
Strigolactones (SLs) are plant hormones with various functions in development, responses to stress and interaction with (micro)organisms in the rhizosphere, including seeds of parasitic plants. Their perception for hormonal functions requires an α,β-hydrolase belonging to the D14 clade in higher plants; perception of host-produced SLs in parasitic seeds relies on similar but phylogenetically distinct proteins (D14-like). D14 and D14-like proteins are peculiar receptors, because they cleave SLs before undergoing a conformational change that elicits downstream events...
March 15, 2018: Journal of Experimental Botany
Liliana L Cubas-Gaona, Elisabet Diaz-Beneitez, Marina Ciscar, José F Rodríguez, Dolores Rodríguez
Infectious bursal disease virus (IBDV) belongs to the Birnaviridae family and is the etiological agent of a highly contagious and immunosuppressive disease (IBD) that affects domestic chickens ( Gallus gallus ). IBD or Gumboro disease leads to high morbidity and mortality of infected animals, and is responsible for major economic losses to the poultry industry world-wide. IBD is characterized by a massive loss of IgM-bearing B lymphocytes and the destruction of the bursa of Fabricius. The molecular bases of the IBDV pathogenicity are still poorly understood, nonetheless, an exacerbated cytokine immune response and B cell depletion due to apoptosis are considered main factors contributing to the severity of the disease...
March 14, 2018: Journal of Virology
Ana Paula Cavalcante de Oliveira, Mario Roberto Dal Poz, Isabel Craveiro, Mariana Gabriel, Gilles Dussault
This study aims to analyze whether the process by which policies for human resources for health that aim to improve the geographic distribution of physicians have been informed by scientific evidence in Brazil and Portugal. This was a multiple case study on a decision-making process for human resources for health in Brazil and Portugal. The respective case studies were based on Brazil's More Doctors Program (Programa Mais Médicos - PMM) and Portugal's strategy of hiring foreign physicians through bilateral agreements, to work in the country's National Health Service (SNS)...
March 1, 2018: Cadernos de Saúde Pública
Alexis Sagastume Gutiérrez, Juan J Cabello Eras, Carlo Vandecasteele, Luc Hens
Assessing the biomass based electricity potential of developing nations like Cuba can help to reduce the fossil fuels dependency and the greenhouse gas emissions. The data included in this study present the evolution of electricity production and greenhouse gas emissions in Cuba. Additionally, the potentialities to produce biomass based electricity by using the most significant biomass sources in Cuba are estimated. Furthermore, estimations of the potential reductions of greenhouse gas emissions, resulting from implementing the biomass based electricity potential of the different sources discussed in the study, are included...
April 2018: Data in Brief
Dhammika D Siriwardhana, Sarah Hardoon, Greta Rait, Manuj C Weerasinghe, Kate R Walters
OBJECTIVE: To systematically review the research conducted on prevalence of frailty and prefrailty among community-dwelling older adults in low-income and middle-income countries (LMICs) and to estimate the pooled prevalence of frailty and prefrailty in community-dwelling older adults in LMICs. DESIGN: Systematic review and meta-analysis. PROSPERO registration number is CRD42016036083. DATA SOURCES: MEDLINE, EMBASE, AMED, Web of Science, CINAHL and WHO Global Health Library were searched from their inception to 12 September 2017...
March 1, 2018: BMJ Open
Janusz Springer, Wiesław Jerzy Cubała
Tianeptine is an atypical antidepressant approved in 25 countries for the treatment of depressive syndromes. Tianeptine abuse among psychiatric patients in the community and at inpatient wards has been increasingly reported in recent years. The purpose of this article is to alert clinicians to tianeptine abuse potential and identify any patterns in the literature. We searched the Academic Search Complete, Google Scholar, MEDLINE, Science Citation Index, Scopus, and the Social Sciences Citation Index for articles published between 1960-2017 in any language containing the keywords: "tianeptine abuse," "tianeptine misuse," "tianeptine dependence...
March 1, 2018: Journal of Psychoactive Drugs
Martin J Prince, Daisy Acosta, Mariella Guerra, Yueqin Huang, Ivonne Z Jimenez-Velazquez, Juan J Llibre Rodriguez, Aquiles Salas, Ana Luisa Sosa, Kia-Chong Chua, Michael E Dewey, Zhaorui Liu, Rosie Mayston, Adolfo Valhuerdi
BACKGROUND: Exposure to endogenous estrogen may protect against dementia, but evidence remains equivocal. Such effects may be assessed more precisely in settings where exogenous estrogen administration is rare. We aimed to determine whether reproductive period (menarche to menopause), and other indicators of endogenous estrogen exposure are inversely associated with dementia incidence. METHODS: Population-based cohort studies of women aged 65 years and over in urban sites in Cuba, Dominican Republic, Puerto Rico and Venezuela, and rural and urban sites in Peru, Mexico and China...
2018: PloS One
W Samir Cubas, Gerardo Jiménez, Juan Vega
The dermatological manifestations of disseminated histoplasmosis present in about 17% of the cases, is a challenge for its diagnosis. We report the case of a patient from the northern coast of Peru, who presented diffuse dermal lesions, erythema-violaceous nodules, and ulcers histopathologically compatible with the infection of the genus Histoplasma var. capsulatum.
December 2017: Revista Chilena de Infectología: órgano Oficial de la Sociedad Chilena de Infectología
Anne-Emanuelle Birn, Carles Muntaner
Latin American social medicine efforts are typically understood as national endeavours, involving health workers, policymakers, academics, social movements, unions, and left-wing political parties, among other domestic actors. But Latin America's social medicine trajectory has also encompassed considerable between-country solidarity, building on early twentieth century interchanges among a range of players who shared approaches for improving living and working conditions and instituting protective social policies...
February 22, 2018: Global Public Health
Kathrin Reetz, Roberto Rodríguez-Labrada, Imis Dogan, Shahram Mirzazade, Sandro Romanzetti, Jörg B Schulz, Edilia M Cruz-Rivas, Jose A Alvarez-Cuesta, Raul Aguilera Rodríguez, Yanetza Gonzalez Zaldivar, Georg Auburger, Luis Velázquez-Pérez
Objective: Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominantly inherited neurodegenerative disease mainly affecting the cerebellum and brainstem. In this Cuban-German research collaboration, we aimed to characterize atrophy patterns and associations with clinical measures in preclinical and manifest SCA2. Methods: In this study, 16 nonmanifest SCA2 mutation carriers, 26 manifest patients with SCA2, and 18 healthy control subjects underwent magnetic resonance imaging, as well as genetic and clinical characterization including assessment of ataxia (Scale for the Assessment and Rating of Ataxia) and saccade velocity in Cuba were enrolled...
February 2018: Annals of Clinical and Translational Neurology
Alexandra Arreola, Laura Beth Payne, Morgan H Julian, Aguirre A de Cubas, Anthony B Daniels, Sarah Taylor, Huaning Zhao, Jordan Darden, Victoria L Bautch, W Kimryn Rathmell, John C Chappell
Von Hippel-Lindau (VHL) gene mutations induce neural tissue hemangioblastomas, as well as highly vascularized clear cell renal cell carcinomas (ccRCCs). Pathological vessel remodeling arises from misregulation of HIFs and VEGF, among other genes. Variation in disease penetrance has long been recognized in relation to genotype. We show Vhl mutations also disrupt Notch signaling, causing mutation-specific vascular abnormalities, e.g., type 1 (null) vs. type 2B (murine G518A representing human R167Q). In conditional mutation retina vasculature, Vhl-null mutation (i...
February 22, 2018: JCI Insight
Annery Serrano, Miguel Ángel Morón, Alejandro Barro, Gabriela Molina
The Cuban archipelago has 79 Phyllophaga species with a 98.6 % of endemism, which makes the group ecologically and economically important, as some species are classified as crop pests. The aim of this study was to determine the relationship between the composition and structure of the Phyllophaga assemblages with their habitat type, considering both plant structure and level of human habitat disturbance. A total of 17 locations were sampled in Western Cuba during the rainy seasons of the period from 2011 to 2015; these differed in habitat types (forests and agroecosystems)...
March 2017: Revista de Biología Tropical
Elena de la Guardia, Dorka Cobián Rojas, Leonardo Espinosa, Zaimiuri Hernández, Lázaro García, Jesús Ernesto Arias González
The first lionfish sighting at the National Park "Cayos de San Felipe" was in 2009 and could be a threat to its marine ecosystem diversity and their capacity to generate services. To analyze the incidence of the lionfish invasion in the area, an annual sampling was conducted between 2013 and 2015. Lionfish abundance and size was investigated on mangroves through visual census on ten transects of 30x2 m/station, and on coral reefs (15 and 25 m deep) with stereo video on six transects of 50x2 m/station...
March 2017: Revista de Biología Tropical
José M Alvarez-Suarez, Francesca Giampieri, Massimiliano Gasparrini, Luca Mazzoni, Tamara Y Forbes-Hernández, Sadia Afrin, Maurizio Battino
We analyzed guava fruits (Psidium guajava L. cv. Red Suprema) from Cuba to determine their chemical composition, total antioxidant capacity, as well as their protective effect against oxidative damage using an in vitro model of human dermal fibroblasts. The guava fruit is a natural source of bioactive compounds, such as polyphenols, vitamin C, folates and beta carotenes with proven health benefits. Human dermal fibroblasts were pre-incubated with different concentrations of guava crude extract and then subjected to oxidative stress using the AAPH stressor...
February 17, 2018: Plant Foods for Human Nutrition
Angel A Noda, Linda Grillová, Reto Lienhard, Orestes Blanco, Islay Rodríguez, David Šmajs
OBJECTIVES: Bejel, caused by Treponema pallidum subsp. endemicum (TEN), was until now considered as a non-venereal disease endemic in areas with hot and dry climates. This study has identified TEN in clinical samples from Cuban patients previously diagnosed with syphilis. METHODS: We performed sequencing-based molecular typing on 92 samples from Cuban patients diagnosed with syphilis. Moreover, to differentiate T. pallidum subspecies, Multi-Locus Sequence Analysis (MLSA) was designed, and applied to suspicious samples...
February 15, 2018: Clinical Microbiology and Infection
Nora Bartolomé, Isabel Hilber, Dayana Sosa, Rainer Schulin, Philipp Mayer, Thomas D Bucheli
Assessing the bioaccessibility of organic pollutants in contaminated soils is considered a complement to measurements of total concentrations in risk assessment and legislation. Consequently, methods for its quantification require validation with historically contaminated soils. In this study, 35 such soils were obtained from various locations in Switzerland and Cuba. They were exposed to different pollution sources (e.g., pyrogenic and petrogenic) at various distance (i.e., urban to rural) and were subject to different land use (e...
February 3, 2018: Chemosphere
Christopher C Muth, Steven L Lewis
No abstract text is available yet for this article.
February 15, 2018: JAMA: the Journal of the American Medical Association
Randel L Swanson, Stephen Hampton, Judith Green-McKenzie, Ramon Diaz-Arrastia, M Sean Grady, Ragini Verma, Rosette Biester, Diana Duda, Ronald L Wolf, Douglas H Smith
Importance: From late 2016 through August 2017, US government personnel serving on diplomatic assignment in Havana, Cuba, reported neurological symptoms associated with exposure to auditory and sensory phenomena. Objective: To describe the neurological manifestations that followed exposure to an unknown energy source associated with auditory and sensory phenomena. Design, Setting, and Participants: Preliminary results from a retrospective case series of US government personnel in Havana, Cuba...
February 15, 2018: JAMA: the Journal of the American Medical Association
Sanjeev Mariathasan, Shannon J Turley, Dorothee Nickles, Alessandra Castiglioni, Kobe Yuen, Yulei Wang, Edward E Kadel Iii, Hartmut Koeppen, Jillian L Astarita, Rafael Cubas, Suchit Jhunjhunwala, Romain Banchereau, Yagai Yang, Yinghui Guan, Cecile Chalouni, James Ziai, Yasin Şenbabaoğlu, Stephen Santoro, Daniel Sheinson, Jeffrey Hung, Jennifer M Giltnane, Andrew A Pierce, Kathryn Mesh, Steve Lianoglou, Johannes Riegler, Richard A D Carano, Pontus Eriksson, Mattias Höglund, Loan Somarriba, Daniel L Halligan, Michiel S van der Heijden, Yohann Loriot, Jonathan E Rosenberg, Lawrence Fong, Ira Mellman, Daniel S Chen, Marjorie Green, Christina Derleth, Gregg D Fine, Priti S Hegde, Richard Bourgon, Thomas Powles
Therapeutic antibodies that block the programmed death-1 (PD-1)-programmed death-ligand 1 (PD-L1) pathway can induce robust and durable responses in patients with various cancers, including metastatic urothelial cancer. However, these responses only occur in a subset of patients. Elucidating the determinants of response and resistance is key to improving outcomes and developing new treatment strategies. Here we examined tumours from a large cohort of patients with metastatic urothelial cancer who were treated with an anti-PD-L1 agent (atezolizumab) and identified major determinants of clinical outcome...
February 14, 2018: Nature
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