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https://www.readbyqxmd.com/read/28445822/identification-of-the-inactivating-factors-and-mechanisms-exerted-on-ms2-coliphage-in-concentrated-synthetic-urine
#1
Wakana Oishi, Daisuke Sano, Loic Decrey, Syunsuke Kadoya, Tamar Kohn, Naoyuki Funamizu
Volume reduction (condensation) is a key for the practical usage of human urine as a fertilizer because it enables the saving of storage space and the reduction of transportation cost. However, concentrated urine may carry infectious disease risks resulting from human pathogens frequently present in excreta, though the survival of pathogens in concentrated urine is not well understood. In this study, the inactivation of MS2 coliphage, a surrogate for single-stranded RNA human enteric viruses, in concentrated synthetic urine was investigated...
April 23, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28445800/adjunctive-celecoxib-for-schizophrenia-a-meta-analysis-of-randomized-double-blind-placebo-controlled-trials
#2
Wei Zheng, Dong-Bin Cai, Xin-Hu Yang, Gabor S Ungvari, Chee H Ng, Norbert Müller, Yu-Ping Ning, Yu-Tao Xiang
Neuroinflammation has been implicated in the neurobiological pathways of schizophrenia. This meta-analysis evaluated the efficacy and tolerability of adjunctive celecoxib as a noncompetitive anti-inflammation drug in treating schizophrenia. Data were searched, extracted, checked and entered into the RevMan (version 5.3) software by two independent investigators. Standardized/weighted mean differences (SMDs/WMDs), risk ratio (RR) and their 95% confidence intervals (CIs) were calculated, as appropriate. Included were 8 randomized controlled trials (RCTs) with a total of 626 patients with schizophrenia including 316 (50...
April 14, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28445739/autophagy-associated-cytotoxicity-and-cellular-uptake-mechanisms-of-bismuth-nanoparticles-in-human-kidney-cells
#3
Yongming Liu, Jing Zhuang, Xihui Zhang, Cong Le, Ning Zhu, Liecheng Yang, Yong Wang, Tao Chen, Yangyun Wang, Leshuai W Zhang
Bismuth compounds have been used for treatment of bacterial infection, and recently bismuth nanoparticles (BiNP) were synthesized for imaging and diagnostic purpose, while safety concern of bismuth cannot be ignored. Here, we prepared ultrasmall BiNP and showed an enhanced tumor imaging, but BiNP revealed a differentiated cytotoxicity in human embryonic kidney 293 cells (HEK293) compared to other cell types. For the first time, we found that BiNP can induce autophagy, shown as the increase of monodansylcadaverine fluorescence staining and the amount of LC3II that can be inhibited by 3-MA...
April 23, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28445475/grhl3-binding-and-enhancers-rearrange-as-epidermal-keratinocytes-transition-between-functional-states
#4
Rachel Herndon Klein, Ziguang Lin, Amelia Soto Hopkin, William Gordon, Lam C Tsoi, Yun Liang, Johann E Gudjonsson, Bogi Andersen
Transcription factor binding, chromatin modifications and large scale chromatin re-organization underlie progressive, irreversible cell lineage commitments and differentiation. We know little, however, about chromatin changes as cells enter transient, reversible states such as migration. Here we demonstrate that when human progenitor keratinocytes either differentiate or migrate they form complements of typical enhancers and super-enhancers that are unique for each state. Unique super-enhancers for each cellular state link to gene expression that confers functions associated with the respective cell state...
April 26, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28445326/acceptance-in-chronic-neck-pain-associations-with-disability-and-fear-avoidance-beliefs
#5
Dave P Thompson, Steve R Woby
Chronic neck pain can result in significant levels of disability. Physiotherapy treatments often aim to modify cognitive factors and this approach benefits some, but not all, patients. Research from other pain conditions suggests that acceptance may be related to disability; however, it is unclear whether these associations exist in patients with neck pain. Moreover, it is unclear to what extent other cognitive factors are related to acceptance. Feasibly, if these factors are related, existing treatments may already be indirectly modifying acceptance...
April 25, 2017: International Journal of Rehabilitation Research. Revue Internationale de Recherches de Réadaptation
https://www.readbyqxmd.com/read/28445250/enteric-fever-in-children-in-western-sydney-australia-2003-2015
#6
Ameneh Khatami, Fouzia Khan, Kristine K Macartney
BACKGROUND: Enteric fever is a vaccine-preventable disease with cases in Australia predominantly acquired overseas. The aim of this study was to define the burden of enteric fever in children presenting to a pediatric hospital in Western Sydney between 2003 and 2015. METHODS: Cases between January 2003 and December 2013 were ascertained through medical records using ICD-coded discharge diagnoses, cross-referenced with microbiology laboratory data for all isolates of Salmonella enterica serovar Typhi (S...
April 25, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28444988/inhibitory-action-of-oxytocin-on-spontaneous-contraction-of-rat-distal-colon-by-nitrergic-mechanism-involvement-of-cyclic-gmp-and-apamin-sensitive-k-channels
#7
R Wang, M T Han, X L Lv, Y A Yu, S Q Chai, C M Qu, C Y Liu
AIM: The mechanisms underlying the inhibitory effects of oxytocin (OT) on colon tone are not totally understood. We explore the mechanisms of OT on spontaneous contractility in rat distal colon, and identify the mediators involved in this action. METHODS: In rat distal colon strips, mechanical activity was analyzed and the production of nitric oxide (NO) in tissue loaded with the fluorochrome DAF-FM was visualized by confocal microscopy. OT receptor (OTR) expression was determined by western blotting and immunofluorescence...
April 26, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/28444889/invasive-fungal-infections-in-paediatric-patients-treated-with-macromolecular-immunomodulators-other-than-tumour-necrosis-alpha-inhibitors
#8
REVIEW
Ioannis Kyriakidis, Athanasios Tragiannidis, Ilse Zündorf, Andreas H Groll
An expanding list of immunomodulatory or immunosuppressive monoclonal antibodies (mAbs) and biologic therapeutics is currently entering clinical practice, particularly in the areas of oncology, transplantation and autoimmune disorders. These agents are directed against molecules or cells involved in inflammation and immunity and may therefore be associated with serious and opportunistic infections. The purpose of this review was to critically analyse the literature on invasive fungal infections (IFIs) occurring in association with mAbs and fusion proteins other than tumour necrosis alpha (TNF-α) inhibitors, including therapeutics modulating T-cell-mediated pathologies (muromonab, abatacept, belatacept, ipilimumab, basiliximab, daclizumab), inducing lymphopenia (alemtuzumab), depleting CD20+ B cells (rituximab) and interfering with various targets (anakinra, natalizumab, blodalumab, ixekizumab and others) with a focus on children, and to provide a framework of evaluating the risk for IFIs in this population...
April 26, 2017: Mycoses
https://www.readbyqxmd.com/read/28444510/starvation-signals-in-yeast-are-integrated-to-coordinate-metabolic-reprogramming-and-stress-response-to-ensure-longevity
#9
REVIEW
Nianshu Zhang, Lu Cao
Studies on replicative and chronological aging in Saccharomyces cerevisiae have greatly advanced our understanding of how longevity is regulated in all eukaryotes. Chronological lifespan (CLS) of yeast is defined as the age-dependent viability of non-dividing cell populations. A number of nutrient sensing and signal transduction pathways (mainly TOR and PKA) have been shown to regulate CLS, yet it is poorly understood how the starvation signals transduced via these pathways lead to CLS extension. Using reporters whose expressions are induced by glucose starvation, we have screened the majority of the 'signaling' mutants in the yeast genome and identified many genes that are necessary for stress response...
April 25, 2017: Current Genetics
https://www.readbyqxmd.com/read/28444432/childhood-growth-predicts-higher-bone-mass-and-greater-bone-area-in-early-old-age-findings-among-a-subgroup-of-women-from-the-helsinki-birth-cohort-study
#10
T M Mikkola, M B von Bonsdorff, C Osmond, M K Salonen, E Kajantie, C Cooper, M J Välimäki, J G Eriksson
We examined the associations between childhood growth and bone properties among women at early old age. Early growth in height predicted greater bone area and higher bone mineral mass. However, information on growth did not improve prediction of bone properties beyond that predicted by body size at early old age. INTRODUCTION: We examined the associations between body size at birth and childhood growth with bone area, bone mineral content (BMC), and areal bone mineral density (aBMD) in early old age...
April 25, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28444363/sgh-stress-or-strain-gradient-hypothesis-insights-from-an-elevation-gradient-on-the-roof-of-the-world
#11
Pierre Liancourt, Yoann Le Bagousse-Pinguet, Christian Rixen, Jiri Dolezal
Background and Aims: The stress gradient hypothesis (SGH), the view that competition prevails in undisturbed and productive environments, and shifts to facilitation in disturbed or stressful environments, has become a central paradigm in ecology. However, an alternative view proposes that the relationship between biotic interactions and environmental severity should be unimodal instead of monotonic. Possible causes of discrepancies between these two views were examined in the high elevation desert of the arid Trans-Himalayas...
April 21, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28444240/non-specific-effects-of-oral-polio-vaccine-on-diarrheal-burden-and-etiology-among-bangladeshi-infants
#12
Alexander Upfill-Brown, Mami Taniuchi, James A Platts-Mills, Beth Kirkpatrick, Stacey L Burgess, M Steven Oberste, William Weldon, Eric Houpt, Rashidul Haque, K Zaman, William A Petri
Background: As the global polio eradication initiative prepares to cease use of oral polio vaccine (OPV) in 2020, there is increasing interest in understanding if oral vaccination provides non-specific immunity to other infections so that the consequences of this transition can be effectively planned for and mitigated. Methods: Data was collected from infants in an urban slum in Bangladesh (Mirpur, Dhaka) as part of the PROVIDE study. Following vaccination with tOPV at 6,10, and 14 weeks, infants were randomly assigned to receive tOPV (n=315) or IPV (n=299) at 39 weeks...
April 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28443678/outcomes-along-the-hiv-care-continuum-among-undocumented-immigrants-in-clinical-care
#13
Jonathan Ross, Uriel R Felsen, Chinazo O Cunningham, Viraj V Patel, David B Hanna
HIV-infected undocumented immigrants face unique barriers to care yet little is known about their clinical outcomes. We performed a retrospective cohort study of HIV-infected adults in clinical care from 2006-2014 at a large academic medical center in a setting where medical insurance is available to HIV-infected undocumented immigrants. Undocumented status was assessed based on Social Security number and insurance status and verified through medical chart review. Using Poisson regression models, we compared undocumented and documented patients with respect to retention in care (≥ 2 HIV-related lab tests ≥ 90 days apart), antiretroviral therapy (ART) prescription (≥ 3 active antiretroviral agents prescribed in a year) and viral suppression (HIV RNA <200 copies/ml for the last measured viral load) for each year in care...
April 26, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28443538/iohexol-clearance-for-determination-of-glomerular-filtration-rate-in-cynomolgus-monkeys-macaca-fascicularis
#14
Changqing Zhang, Shanshan Ding, Yupeng Fang, Li Zhang, Weimin Hu, Jinlian Lu, Tao Jing, Yi Tao, Xin Zhang
The purpose of this study was to validate a method for determine the glomerular filtration rate (GFR) in healthy cynomolgus monkeys by using iohexol. Eighteen healthy cynomolgus macaque monkeys (age, 4 to 6 y [mean, 5 y]; weight, 2 to 6 kg [mean, 4 kg]) were randomly entered into 3 different doses groups (3 male and 3 female macaques per group) of 30, 60, 90 mg I/kg to receive an intravenous bolus injection of iohexol. Serum iohexol concentrations were determined by using liquid chromatography-tandem mass spectrometry, and clearance rate were determined by using WinNonlin software...
April 25, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
https://www.readbyqxmd.com/read/28443086/complete-molecular-and-immunoprotective-characterization-of-babesia-microti-enolase
#15
Xiangye Liu, Chen Zheng, Xiaoge Gao, Jiaxu Chen, Kuiyang Zheng
The apicomplexan Babesia microti is the primary causative agent of human babesiosis, one of the most broadly distributed tick-borne diseases worldwide. B. microti undergoes a complex lifecycle within both the mammalian host and the tick vector, and employs several different specific molecular mechanisms to enter host cells. Enolase, the key glycolytic enzyme in intracellular glucose metabolism, can also be expressed on the parasite's outer surface, binds to human plasminogen, and coordinates apicomplexan parasite invasion of host cells, however, it lacks sorting sequences or lipoprotein anchor sites...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28443047/synchrony-in-joint-action-is-directed-by-each-participant-s-motor-control-system
#16
Lior Noy, Netta Weiser, Jason Friedman
In this work, we ask how the probability of achieving synchrony in joint action is affected by the choice of motion parameters of each individual. We use the mirror game paradigm to study how changes in leader's motion parameters, specifically frequency and peak velocity, affect the probability of entering the state of co-confidence (CC) motion: a dyadic state of synchronized, smooth and co-predictive motions. In order to systematically study this question, we used a one-person version of the mirror game, where the participant mirrored piece-wise rhythmic movements produced by a computer on a graphics tablet...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28442940/prevalence-of-anemia-and-its-associated-factors-among-pregnant-women-receiving-antenatal-care-at-aymiba-health-center-northwest-ethiopia
#17
Fikir Asrie
INTRODUCTION: Anemia is a global public health problem in both developing and developed countries; ~1.62 billion people suffer from anemia, and pregnant women are the most susceptible to it. The main aim of the present study was to assess the prevalence of anemia and associated risk factors among pregnant women receiving antenatal care at Aymiba Health Center, northwest Ethiopia. METHODS AND MATERIALS: An institution-based cross-sectional study was conducted at Aymiba Health Center from January to March 2015...
2017: Journal of Blood Medicine
https://www.readbyqxmd.com/read/28442909/tat-functionalized-liposomes-for-the-treatment-of-meningitis-an-in-vitro-study
#18
Caterina Bartomeu Garcia, Di Shi, Thomas J Webster
Bacterial meningitis has become a global concern, because of the emergence of antibiotic-resistant bacteria. It has been demonstrated that liposomes can enter bacteria, thus providing a possible treatment for numerous infections, including meningitis. Fusogenic liposomes are pH-sensitive with a high capacity to fuse with the bacteria membrane and promote intracellular drug release. Moreover, this ability can be improved by using cell-penetrating peptides (such as Tat47-57, which is a peptide derived from the Tat protein of HIV)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28442907/synthesis-of-magnetic-molecularly-imprinted-polymers-with-excellent-biocompatibility-for-the-selective-separation-and-inhibition-of-testosterone-in-prostate-cancer-cells
#19
Xiaoshuang Tang, Feng Li, Jing Jia, Chao Yang, Wei Liu, Ben Jin, Xinyang Wang, Ruixia Gao, Dalin He, Peng Guo
PURPOSE: Androgen plays an important role in the progression of prostate cancer. In the present study, novel magnetic molecularly imprinted polymers (MMIPs) with good biocompatibility were produced for the selective separation and inhibition of testosterone in prostate cancer cells. MATERIALS AND METHODS: MMIPs were prepared by using magnetic nanospheres, gelatin, and testosterone as the supporting materials, functional monomer, and the template molecule, respectively...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28442849/operative-management-of-enteroatmospheric-fistula-in-bj%C3%A3-rck-4-open-abdomen-patients-by-the-help-of-laparoscopic-lateral-approach
#20
Fahri Yetişir, A Ebru Sarer
As the open abdomen (OA) management increases, the number of fistula formation has also been increasing during the last two decades. These fistulas in OA have been defined as enteroatmospheric fistula (EAF). EAF occurring in a frozen OA is classified as Björck 4 OA. Management of Björck 4 OA patient is not easy and mortality of these patients is very high in spite of the presence of modern treatment modalities. There are a few surgical approaches for treatment of Björck 4 OA patients. One of them is excising the hostile segment by lateral abdominal approach from the healthy side or entering from lateral border of OA wound after enough time intervals for subsiding of the edematous intestine in acute inflammatory reaction in the hostile environment...
April 2017: Indian Journal of Surgery
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