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https://www.readbyqxmd.com/read/28634759/current-applications-of-high-resolution-mass-spectrometry-for-the-analysis-of-new-psychoactive-substances-a-critical-review
#1
REVIEW
Daniel Pasin, Adam Cawley, Sergei Bidny, Shanlin Fu
The proliferation of new psychoactive substances (NPS) in recent years has resulted in the development of numerous analytical methods for the detection and identification of known and unknown NPS derivatives. High-resolution mass spectrometry (HRMS) has been identified as the method of choice for broad screening of NPS in a wide range of analytical contexts because of its ability to measure accurate masses using data-independent acquisition (DIA) techniques. Additionally, it has shown promise for non-targeted screening strategies that have been developed in order to detect and identify novel analogues without the need for certified reference materials (CRMs) or comprehensive mass spectral libraries...
June 20, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28631433/forensic-radiology-pitfalls-ct-imaging-in-gunshot-wounds-of-the-head
#2
Mark A Giffen, Jason A Powell, Jerri McLemore
Computed tomography (CT) imaging is increasingly used in emergency departments and trauma services and is being offered as a supplemental tool with autopsy in coroner's and medical examiner's offices throughout the United States. The availability of CT images in lieu of traditional X-rays for medicolegal autopsies may lead to misinterpretation of images for forensic pathologists who are not familiar with these types of images. Forensic pathologists must become familiar with CT imaging, the basis of CT image formation and how to interpret CT images appropriately...
June 20, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28628783/automatic-retrieval-of-shoeprint-images-using-blocked-sparse-representation
#3
Sayyad Alizadeh, Cemal Kose
Shoe marks are regarded as remarkable clues which can be usually detected in crime scenes where forensic experts use them for investigating crimes and identifying the criminals. Hence, developing a robust method for matching shoeprints with one another is of critical significance which can be used for recognizing criminals. In this paper, a promising method is proposed for retrieving shoe marks by means of developing blocking sparse representation technique. In the proposed method, the queried image was divided into two blocks...
June 8, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28616810/accuracy-of-non-contrast-pmct-for-determining-cause-of-death
#4
Garyfalia Ampanozi, Yannick A Thali, Wolf Schweitzer, Gary M Hatch, Lars C Ebert, Michael J Thali, Thomas D Ruder
The aim of this study was (1) to compare levels of accuracy regarding the categorization of causes of death between non-contrast post-mortem computed tomography (PMCT) and the final forensic report as well as between autopsy and the final forensic report, and (2) to assess levels of confidence regarding the categorization of causes of death after non-contrast PMCT and after autopsy. This prospective study was conducted over a 5 month period during which 221 cases were admitted to our institute for forensic investigations...
June 15, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/28614757/the-diagnostic-value-of-anthropometric-indices-of-maxillary-sinuses-for-sex-determination-using-ct-scan-images-in-iranian-adults-a-cross-sectional-study
#5
Mitra Akhlaghi, Khadijeh Bakhtavar, Artin Kamali, Jaleh Maarefdoost, Ardeshir Sheikhazadi, Farinaz Mousavi, Seyed Hossein Saberi Anary, Elham Sheikhazadi
BACKGROUND: The identification of human remains is an essential part of forensic science. Studying paranasal sinuses is very useful in identification of mutilated or burnt bodies from accidents such as plane crashes. We aimed to assess the diagnostic value of anthropometric indices of maxillary sinuses for sex determination using CT-scan images in Iranian adults. METHODS: CT-scan slices of 228 maxillary sinuses (from 144 men and 144 women) were studied. The maximum height, maximum anterior-posterior diameter, maximum width, and maximum distance between the sinuses were measured in both sexes...
July 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28612206/temperature-corrected-postmortem-3-t-mr-quantification-of-histopathological-early-acute-and-chronic-myocardial-infarction-a-feasibility-study
#6
Anders Persson, John Baeckmann, Johan Berge, Christian Jackowski, Marcel Warntjes, Wolf-Dieter Zech
The goal of the present study was to evaluate if quantitative postmortem cardiac 3-T magnetic resonance (QPMCMR) T1 and T2 relaxation times and proton density values of histopathological early acute and chronic myocardial infarction differ to the quantitative values of non-pathologic myocardium and other histopathological age stages of myocardial infarction with regard to varying corpse temperatures. In 60 forensic corpses (25 female, 35 male), a cardiac 3-T MR quantification sequence was performed prior to autopsy and cardiac dissection...
June 13, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28606334/an-investigation-into-the-cause-of-the-inner-dark-areas-and-outer-lighter-areas-ghosting-seen-in-dynamically-created-two-dimensional-bare-footprints
#7
Wesley Vernon Obe, Neil Simmonite, Sarah Reel, Selina Reidy
Dynamic bare footprints differ from static bare footprints through the presence of additional, lighter markings around the rear of the heel print and apices of the toe print areas. These images can appropriately be described as inner dark and outer ghosting features. To date, the functional cause of both features has not been understood. To gain such an understanding could potentially allow the further development and use of these features in forensic identification. The aim of this project was to investigate the causes of the inner dark and outer ghosting features seen in dynamic bare footprints through an observational, practice-based action research approach within a gait laboratory...
July 2017: Science & Justice: Journal of the Forensic Science Society
https://www.readbyqxmd.com/read/28597948/identification-of-a-carbonized-body-using-implanted-surgical-plates-the-importance-of-computed-tomography
#8
Vanessa Moreira Andrade, Christian Abreu Stibich, Paulo Maurício de Santa Martha, Casimiro Abreu Possante de Almeida, Andrea de Castro Domingos Vieira
In addition to clinical examination, forensic odontologists can use diagnostic imaging as an auxiliary method for identification. This paper reports a case where forensic odontologists from the Afrânio Peixoto Legal Medicine Institute in Rio de Janeiro (Brazil) positively identified a carbonized and partially calcined body using oral and maxillofacial imaging. The cadaver showed several metallic plates fixed with metallic screws on bones of the neurocranium and viscerocranium. Family members provided spiral computed tomography scans of the skull and a panoramic radiograph that were acquired after an accident that required surgical procedures...
June 9, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28589523/unexpected-brain-finding-in-pre-autopsy-postmortem-ct
#9
Vasiliki Chatzaraki, Stephan A Bolliger, Michael J Thali, Sebastian Eggert, Thomas D Ruder
A case is presented in which pre-autopsy postmortem computed tomography (PMCT) revealed an unexpected brain abscess with a related frontal sinusitis and an erosion of the posterior wall of the frontal sinus. PMCT findings enabled the forensic pathologists to adapt protective measures during autopsy and protect their health from infection. Pre-autopsy PMCT has been also useful in the early differential diagnosis procedure. The complementary use of postmortem imaging and autopsy can improve the quality of forensic death investigations...
June 7, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/28586732/the-virtual-approach-to-the-assessment-of-skeletal-injuries-in-human-skeletal-remains-of-forensic-importance
#10
Petra Urbanová, Ann H Ross, Mikoláš Jurda, Ivana Šplíchalová
While assessing skeletal injuries in human skeletal remains, forensic anthropologists are frequently presented with fractured, fragmented, or otherwise modified skeletal remains. The examination of evidence and the mechanisms of skeletal injuries often require that separate osseous elements be permanently or temporarily reassembled or reconstructed. If not dealt with properly, such reconstructions may impede accurate interpretation of the evidence. Nowadays, routine forensic examinations increasingly incorporate digital imaging technologies...
July 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28584483/can-dead-man-tooth-do-tell-tales-tooth-prints-in-forensic-identification
#11
Vineetha Christopher, Sarvani Murthy, S R Ashwinirani, Kulkarni Prasad, Suragimath Girish, Shashikanth Patil Vinit
BACKGROUND: We know that teeth trouble us a lot when we are alive, but they last longer for thousands of years even after we are dead. Teeth being the strongest and resistant structure are the most significant tool in forensic investigations. Patterns of enamel rod end on the tooth surface are known as tooth prints. AIM: This study is aimed to know whether these tooth prints can become a forensic tool in personal identification such as finger prints. A study has been targeted toward the same...
January 2017: Journal of Forensic Dental Sciences
https://www.readbyqxmd.com/read/28584482/age-and-gender-assessment-through-three-dimensional-morphometric-analysis-of-maxillary-sinus-using-magnetic-resonance-imaging
#12
Sanda Usha Rani, Guttikonda Venkateswara Rao, Dumpala Rakesh Kumar, Taneeru Sravya, Yeluri Sivaranjani, Manchikatla Praveen Kumar
BACKGROUND: Age and sex determinations are important tools in forensic odontology which help in the identification of an individual. Radiographic method of sex and age estimation is a noninvasive simple technique. Measurements of the maxillary sinuses can be used for the estimation of age and gender when other methods are inconclusive. Maxillary sinus dimensions were used as an important tool in the identification of unknown. AIM: This study aims to estimate age and sex using the dimensions and volume of the maxillary sinus in magnetic resonance imaging (MRI)...
January 2017: Journal of Forensic Dental Sciences
https://www.readbyqxmd.com/read/28584475/virtopsy-touch-free-autopsy
#13
REVIEW
Raj Kumar Badam, Triekan Sownetha, D B Gandhi Babu, Shefali Waghray, Lavanya Reddy, Komali Garlapati, Sunanda Chavva
The word "autopsy" denotes "to see with own eyes." Autopsy (postmortem) is a process that includes a thorough examination of a corpse noting everything related to anatomization, surface wounds, histological and culture studies. Virtopsy is a term extracted from two words "virtual" and "autopsy." It employs imaging methods that are routinely used in clinical medicine such as computed tomography and magnetic resonance imaging in the field of autopsy, to find the reason for death. Virtopsy is a multi-disciplinary technology that combines forensic medicine and pathology, roentgenology, computer graphics, biomechanics, and physics...
January 2017: Journal of Forensic Dental Sciences
https://www.readbyqxmd.com/read/28580230/the-use-of-long-acting-injectable-antipsychotics-in-schizophrenia
#14
REVIEW
Seiya Miyamoto, W Wolfgang Fleischhacker
Schizophrenia is a mostly chronic mental disorder, and symptomatic relapse is frequently observed. It is often associated with social and/or occupational decline that can be difficult to reverse. Most patients with the illness need long-term pharmacological treatment, and antipsychotic drugs represent the mainstay of clinical care. Long-acting injectable antipsychotics (LAIs) are an important alternative to oral medication, particularly advantageous in the context of compliance management. Several new-generation antipsychotics (NGAs), including risperidone, olanzapine, paliperidone, and aripiprazole, have become available as long-acting formulations, and new evidence has been accumulating...
2017: Current Treatment Options in Psychiatry
https://www.readbyqxmd.com/read/28574998/expertise-with-unfamiliar-objects-is-flexible-to-changes-in-task-but-not-changes-in-class
#15
Rachel A Searston, Jason M Tangen
Perceptual expertise is notoriously specific and bound by familiarity; generalizing to novel or unfamiliar images, objects, identities, and categories often comes at some cost to performance. In forensic and security settings, however, examiners are faced with the task of discriminating unfamiliar images of unfamiliar objects within their general domain of expertise (e.g., fingerprints, faces, or firearms). The job of a fingerprint expert, for instance, is to decide whether two unfamiliar fingerprint images were left by the same unfamiliar finger (e...
2017: PloS One
https://www.readbyqxmd.com/read/28552305/matrix-assisted-laser-desorption-ionization-mass-spectrometric-imaging-for-the-rapid-segmental-analysis-of-methamphetamine-in-a-single-hair-using-umbelliferone-as-a-matrix
#16
Hang Wang, Ying Wang
Segmental hair analysis offers a longer period for retrospective drug detection than blood or urine. Hair is a keratinous fiber and is strongly hydrophobic. The embedding of drugs in hydrophobic hair at low concentrations makes it difficult for extraction and detection with matrix-assisted laser desorption/ionization (MALDI) coupled with mass spectrometric imaging (MSI). In this study, a single scalp hair was longitudinally cut with a cryostat section to a length of 4 mm and fixed onto a stainless steel MALDI plate...
July 4, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28550762/forensic-age-estimation-by-morphometric-analysis-of-the-manubrium-from-3d-mr-images
#17
Naira P Martínez Vera, Johannes Höller, Thomas Widek, Bernhard Neumayer, Thomas Ehammer, Martin Urschler
Forensic age estimation research based on skeletal structures focuses on patterns of growth and development using different bones. In this work, our aim was to study growth-related evolution of the manubrium in living adolescents and young adults using magnetic resonance imaging (MRI), which is an image acquisition modality that does not involve ionizing radiation. In a first step, individual manubrium and subject features were correlated with age, which confirmed a statistically significant change of manubrium volume (Mvol:p<0...
May 12, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28535429/high-speed-video-analysis-of-forward-and-backward-spattered-blood-droplets
#18
P M Comiskey, A L Yarin, D Attinger
High-speed videos of blood spatter due to a gunshot taken by the Ames Laboratory Midwest Forensics Resource Center (MFRC) [1] are analyzed. The videos used in this analysis were focused on a variety of targets hit by a bullet which caused either forward, backward, or both types of blood spatter. The analysis process utilized particle image velocimetry (PIV) and particle analysis software to measure drop velocities as well as the distributions of the number of droplets and their respective side view area. The results of this analysis revealed that the maximal velocity in the forward spatter can be about 47±5m/s and for the backward spatter - about 24±8m/s...
May 1, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28526949/antemortem-identification-by-fusion-of-mr-and-ct-of-the-paranasal-sinuses
#19
Jakob Heimer, Dominic Gascho, Simon Gentile, Gary M Hatch, Michael J Thali, Thomas D Ruder
Radiologic forensic identification is usually performed by comparing antemortem and postmortem radiographs. While computed tomography (CT) has become a valuable addition to radiologic identification, magnetic resonance (MR) imaging has only rarely been used for this purpose. In our case, identification was accomplished using fused MR- and CT images in a survivor of a gunshot injury to the head. This case supports and highlights the possibility to perform intermodality radiologic identification comparing preexisting MR imaging to subsequently aquired CT data in living (or deceased) humans as long as manual modifications of windowing, color and contrast enable differentiation of the two modalities in the fused image...
May 20, 2017: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/28525774/development-and-validation-of-a-physical-model-to-investigate-the-biomechanics-of-infant-head-impact
#20
M Jones, D Darwall, G Khalid, R Prabhu, A Kemp, Owen J Arthurs, P Theobald
Head injury in childhood is the single most common cause of death or permanent disability from injury. However, despite its frequency and significance, there is little understanding of the response of a child's head to injurious loading. This is a significant limitation when making early diagnoses, informing clinical and/or forensic management or injury prevention strategies. With respect to impact vulnerability, current understanding is predominantly based on a few post-mortem-human-surrogate (PMHS) experiments...
July 2017: Forensic Science International
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