Ping Wang, Zhiyun Ren, Weiwan Wang, Mingda Liu, Yutao Jia, Mingzhuo Zhang, Ying Xue, Chenyang Zhang, Jianteng Xu, Cheng Wang, Xiaoyan Wang
Candesartan is a common angiotensin-II receptor-1 blocker used for patients with cardiovascular and renal diseases. Angiotensin-converting enzyme 2 (ACE2) is a negative regulator of blood pressure (BP), and also a major receptor for coronaviruses. To determine whether and how candesartan upregulates ACE2, we examined BP and ACE2 in multi-organs from male and female C57BL/6J mice treated with candesartan (1 mg/kg, i.p.) for 7 days. Relative to the vehicle, candesartan lowered BP more in males than females; ACE2 protein abundances were increased in kidneys, not lungs, hearts, aorta, liver, spleen, brain, or serum, only from males...
March 31, 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology