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https://www.readbyqxmd.com/read/28414674/a-clot-possibly-due-to-loss-of-tnf-%C3%AE-supression
#1
J Broussard, M Berlinger, D Lauret
INTRODUCTION: Inflammation and venous thrombosis enjoy a close Relationship. We present a patient who had multiple DVTs following the discontinuation of anti- TNF-α therapy. CASE: A 34 year old African American female with a history of multiple DVT's, miscarriages, and reported Crohn's disease presented with shortness of breath. In the Emergency Department, CTA showed bilateral pulmonary emboli. The patient had been off adalimumab for one year and reported abdominal pain with 6-7 non-bloody bowel movements daily...
March 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28338207/evaluation-of-failed-immunotherapy-among-patients-with-negative-apla-recurrent-spontaneous-abortion-by-serum-anticardiolipin-antibodies-and-mononuclear-cell-of-tim-1
#2
J Li, D Xu, H-L Li
OBJECTIVE: The present study is aimed to analyze the expression of serum anticardiolipin antibody (ACA) and mononuclear cells of Tim-1 among the patients with negative anti paternal lymphocyte antibody (APLA) recurrent spontaneous abortion conducted by lymphocyte immunotherapy resulting in failure. PATIENTS AND METHODS: 58 patients with negative APLA recurrent spontaneous abortion (RSA) who was diagnosed for the first time and received lymphocyte immunotherapy in our hospital were selected continuously...
March 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28116653/classical-and-additional-antiphospholipid-antibodies-in-blood-samples-of-ischemic-stroke-patients-and-healthy-controls
#3
Narin-Nard Carmel-Neiderman, David Tanne, Idan Goren, Pnina Rotman-Pikielny, Yair Levy
Classical antiphospholipid antibodies (aPLa) are found in 6-25% of blood samples from stroke patients. The frequency of novel aPLa antibodies in blood samples of CVA patients is not known. Enzyme-linked immunosorbent assays (ELISA) were performed on blood samples from 209 CVA patients (170 samples were obtained during the acute phase and 39 samples were from patients with complete carotid stenosis) and compared to 54 healthy controls. Subjects were tested for the presence of the classical aPL antibodies anticardiolipin (aCL) and anti-beta2-glycoprotein (aβ2gI), in addition to antiphosphatidylethanolamine (aPE), anti-phosphatidylserine (aPS), and Annexin V...
January 23, 2017: Immunologic Research
https://www.readbyqxmd.com/read/28064294/primary-versus-secondary-immune-thrombocytopenia-in-adults-a-comparative-analysis-of-clinical-and-laboratory-attributes-in-newly-diagnosed-patients-in-southern-pakistan
#4
S Sultan, S J Ahmed, S Murad, S M Irfan
BACKGROUND: Immune thrombocytopenic purpura (ITP) is a hemorrhagic diathesis, characterized by platelets destruction alongside impaired production. Patients from Asian regions often exhibit distinctive characteristics in comparison to the western patients. We accomplished this study to evaluate the prevalence of primary versus secondary ITP along with the comparative analysis between them. The secondary objective was to determine the etiological spectrum of secondary ITP. METHODS: We illustrate the results of a large cohort of newly diagnosed adults ITP from southern Pakistan...
October 2016: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28063132/evaluation-of-role-of-fv-fviii-and-aplas-in-the-pathogenesis-of-apcr-in-fv-leiden-negative-dvt-patients-a-study-in-india
#5
Amit Sharma, Kanwaljeet Singh, Arijit Biswas, Ravi Ranjan, Kamal Kishor, Ravi Kumar, Hareram Pandey, Vineet Kumar Kamal, Renu Saxena
Resistance to APC (APCR) is a very important cause of thrombophilia and most frequently caused by the Leiden mutation. APCR is also seen in the absence of FV Leiden and associated with elevated levels of factor V (FV), factor VIII (FVIII) and antiphospholipid antibodies (APLAs). The aim of this prospective case control study was to find out the frequency and role of FV, FVIII and APLAs in the pathogenesis of APCR in FV Leiden negative deep vein thrombosis (DVT) patients in India. A total 30 APCR positive and FV Leiden negative patients with DVT and similar number of age and sex matched healthy controls were recruited...
February 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/27728350/is-it-apla-causing-portal-vein-thrombosis-with-portal-cavernoma
#6
Sivaji Patibandla, Jaya Singh K, Tumbanatham, Appikatla
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27728089/is-it-apla-causing-portal-vein-thrombosis-with-portal-cavernoma
#7
Sivaji Patibandla, Jaya Singh K, Tumbanatham Appikatla
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27678386/synthesis-of-polylactide-based-core-shell-interface-cross-linked-micelles-for-anticancer-drug-delivery
#8
Chih-Kuang Chen, Wei-Jen Lin, Yu Hsia, Leu-Wei Lo
Well-defined poly(ethylene glycol)-b-allyl functional polylactide-b-polylactides (PEG-APLA-PLAs) are synthesized through sequential ring-opening polymerization. PEG-APLA-PLAs that have amphiphilic properties and reactive allyl side chains on their intermediate blocks are successfully transferred to core-shell interface cross-linked micelles (ICMs) by micellization and UV-initiated irradiation. ICMs have demonstrated enhanced colloidal stability in physiological-mimicking media. Hydrophobic molecules such as Nile Red or doxorubicin (Dox) are readily loaded into ICMs; the resulting drug-ICM formulations possess slow and sustained drug release profiles under physiological-mimicking conditions...
March 2017: Macromolecular Bioscience
https://www.readbyqxmd.com/read/27127741/clinical-significance-of-nonspecificity-of-antiphospholipid-antibodies-in-recurrent-abortions-and-unexplained-infertility
#9
Priyanka Malik, Maninder Kaur, Gurdeep Kaur Bedi, Khushpreet Kaur
BACKGROUND: Antiphospholipid antibodies (APLA) are acquired autoantibodies directed to phospholipids which are associated with slow progressive thrombosis and infarction of placenta. Infertility and recurrent pregnancy loss may occur because of impaired trophoblast function, placental infarction, and abnormal blood clotting. AIM: To evaluate APLA (IgG and IgM) in cases of infertility and recurrent abortions. MATERIALS AND METHODS: A prospective study comprising 70 subjects was carried out...
April 2016: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/27067744/incidence-of-antiphospholipid-antibodies-in-patients-with-immune-thrombocytopenia-and-correlation-with-treatment-with-steroids-in-north-indian-population
#10
Aniruddha Dayama, Jasmita Dass, Manoranjan Mahapatra, Renu Saxena
INTRODUCTION: Antiphospholipid antibodies (APLAs) have been variably reported in 14% to 75% of patients with immune thrombocytopenia (ITP). There is lack of Indian data on incidence of APLA in ITP. OBJECTIVE: We studied the incidence of APLA in patients with pediatric and adult Indian ITP. MATERIALS AND METHODS: We prospectively studied 100 patients including acute (n = 37), persistent (n = 13), and chronic (n = 50) ITP. Male to female ratio was 1...
January 1, 2016: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/26969522/development-of-an-in-process-uv-crosslinked-electrospun-pcl-apla-co-tmc-composite-polymer-for-tubular-tissue-engineering-applications
#11
I Stefani, J J Cooper-White
UNLABELLED: Cardiovascular diseases remain the largest cause of death worldwide, and half of these deaths are the result of failure of the vascular system. Tissue engineering promises to provide new, and potentially more effective therapeutic strategies to replace damaged or degenerated vessels with functional vessels. However, these engineered vessels have substantial performance criteria, including vessel-like tubular shape, structure and mechanical property slate. Further, whether implanted without or with prior in vitro culture, such tubular scaffolds must provide a suitable environment for cell adhesion and growth and be of sufficient porosity to permit cell colonization...
May 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/26939208/extended-antiphospholipid-antibodies-screening-in-systemic-lupus-erythematosus-patients
#12
Alina Dima, Simona Caraiola, C Jurcut, Eugenia Balanescu, P Balanescu, Doina Ramba, Camelia Badea, V Pompilian, R Ionescu, Anda Baicus, C Baicus, G A Dan
BACKGROUND: The antiphospholipid syndrome (APS) is one of the most encountered autoimmunity in systemic lupus erythematosus (SLE) patients and pathogenesis of these two seems to be intricate. AIM: To investigate the association of antiphospholipid antibodies (APLAs) titer with the presence of secondary APS diagnosis in SLE patients. METHODS: 65 patients fulfilling the 2012 Systemic Lupus Collaborating International Clinics (SLICC) SLE's criteria were included...
October 2015: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/26820623/ldlr-and-pcsk9-are-associated-with-the-presence-of-antiphospholipid-antibodies-and-the-development-of-thrombosis-in-apla-carriers
#13
Eguzkine Ochoa, Mikel Iriondo, Carmen Manzano, Asier Fullaondo, Irama Villar, Guillermo Ruiz-Irastorza, Ana M Zubiaga, Andone Estonba
INTRODUCTION: The identification of the genetic risk factors that could discriminate non- thrombotic from thrombotic antiphospholipid antibodies (aPLA) carriers will improve prognosis of these patients. Several human studies have shown the presence of aPLAs associated with atherosclerotic plaque, which is a known risk factor for thrombosis. Hence, in order to determine the implication of atherosclerosis in the risk of developing thrombosis in aPLA positive patients, we performed a genetic association study with 3 candidate genes, APOH, LDLR and PCSK9...
2016: PloS One
https://www.readbyqxmd.com/read/26712985/anesthetic-management-in-a-case-of-antiphospholipid-antibody-syndrome
#14
Venkata Rama Rao Mikkiliineni, Nagarjuna Panidapu, Mrunalini Parasa, Mastan Saheb Shaik
Antiphospholipid antibody (APLA) syndrome is one of the most common thrombocytophilias but, unfortunately, goes unrecognized most often. It is an auto-immune disorder in which thrombotic events and a recurrent fetal loss occur in the presence of antibodies to phospholipids. It is the most common acquired hyper-coagulable state. There is a limited literature on peroperative management of patients with this syndrome. We report a case of APLA syndrome in a parturient due to its rarity and complexity.
September 2015: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/26264622/a-novel-pathway-of-cellular-activation-mediated-by-antiphospholipid-antibody-induced-extracellular-vesicles
#15
M Wu, J Barnard, S Kundu, K R McCrae
BACKGROUND: Elevated levels of endothelial cell (EC)-derived extracellular vesicles (EVs) circulate in patients with antiphospholipid antibodies (APLAs), and APLAs, particularly those against β2 -glycoprotein I (β2 GPI), stimulate EV release from ECs. However, the effects of EC-derived EVs have not been characterized. OBJECTIVE: To determine the mechanism by which EVs released from ECs by anti-β2 GPI antibodies activate unstimulated ECs. PATIENTS/METHODS: We used interleukin (IL)-1 receptor inhibitors, small interfering RNA (siRNA) against Toll-like receptors (TLRs) and microRNA (miRNA) profiling to assess the mechanism(s) by which EVs released from ECs exposed to anti-β2 GPI antibodies activated unstimulated ECs...
October 2015: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/26078573/prevalence-significance-and-predictive-value-of-antiphospholipid-antibodies-in-crohn-s-disease
#16
Nora Sipeki, Laszlo Davida, Eszter Palyu, Istvan Altorjay, Jolan Harsfalvi, Peter Antal Szalmas, Zoltan Szabo, Gabor Veres, Zakera Shums, Gary L Norman, Peter L Lakatos, Maria Papp
AIM: To assess the prevalence and stability of different antiphospholipid antibodies (APLAs) and their association with disease phenotype and progression in inflammatory bowel diseases (IBD) patients. METHODS: About 458 consecutive patients [Crohn's disease (CD): 271 and ulcerative colitis (UC): 187] were enrolled into a follow-up cohort study in a tertiary IBD referral center in Hungary. Detailed clinical phenotypes were determined at enrollment by reviewing the patients' medical charts...
June 14, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26020758/effects-of-anti-phospholipase-a-2-antibody-supplementation-on-dry-matter-intake-feed-efficiency-acute-phase-response-and-blood-differentials-of-steers-fed-forage-and-grain-based-diets
#17
COMPARATIVE STUDY
V R G Mercadante, K M Waters, G H L Marquezini, D D Henry, F M Ciriaco, J D Arthington, N DiLorenzo, G C Lamb
To determine whether supplementation of anti-phospholipase A antibody (aPLA) would alter voluntary DMI, feed efficiency (FE), acute-phase protein concentration, and blood differentials (BD) due to a change in diet from a forage-based to a grain-based diet, individual daily DMI was measured on 80 cross-bred steers during a 141-d period. On d 0, steers were blocked by BW and randomly assigned to receive a growing forage diet containing 1) no additive (CON; = 20), 2) inclusion of 30 mg of monensin and 8.8 mg of tylosin per kg of diet DM (MT; = 20), 3) inclusion of an aPLA supplement at 0...
February 2015: Journal of Animal Science
https://www.readbyqxmd.com/read/25918850/antiphospholipid-antibody-and-risk-of-retinal-vein-occlusion-a-systematic-review-and-meta-analysis
#18
REVIEW
Wei Zhu, Yan Wu, Ming Xu, Jin-Yu Wang, Yi-Fang Meng, Zheng Gu, Jiong Lu
BACKGROUND: Retinal vein occlusion (RVO) is a common retinal vascular disease and it is one of the most frequently reported causes of visual damage and blindness in the elderly. The current study investigated the potential association between antiphospholipid antibodies (APLA) and RVO risk by conducting a meta-analysis of case-control studies. METHODS: A systematic literature search of Pubmed and Embase databases was conducted in August 1st, 2014. Odds ratios (ORs) were used to evaluate the associations between APLA and the incidence of RVO...
2014: PloS One
https://www.readbyqxmd.com/read/25891605/cortical-venous-sinus-thrombosis-after-lp-and-high-dose-steroid-in-a-case-clinically-isolated-syndrome
#19
M Thakre, J Inshasi
UNLABELLED: Role of lumbar puncture and high dose steroids have been implicated previously in causing cerebral venous sinus thrombosis in multiple sclerosis. We report a case of clinically isolated syndrome who developed cerebral venous sinus thrombosis after Lumbar puncture and high dose steroids. Forty two years old gentleman presented with right hand numbness and weakness over 1 week. MRI brain and spine showed periventricular and cerebellar white matter lesions suggestive of multiple sclerosis...
November 2014: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/25862984/oxidative-stress-and-treg-depletion-in-lupus-patients-with-anti-phospholipid-syndrome
#20
Zhi-wei Lai, Ivan Marchena-Mendez, Andras Perl
Anti-phospholipid antibodies (APLA) represent a diagnostic criterion of systemic lupus erythematosus (SLE) and cause morbidity, termed anti-phospholipid syndrome (APS). Activation of the mechanistic target of rapamycin (mTOR) has been recently associated with APS. mTOR is a sensor of oxidative stress. Therefore, we examined mitochondrial mass, superoxide production, mTOR activity and FoxP3 expression in 72 SLE patients, twelve of whom also had APS, and 54 healthy controls by flow cytometry. Mitochondrial mass was increased in CD4(-)CD8(-) double-negative (DN) T cells of SLE patients with APS (2...
June 2015: Clinical Immunology: the Official Journal of the Clinical Immunology Society
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