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https://www.readbyqxmd.com/read/27728350/is-it-apla-causing-portal-vein-thrombosis-with-portal-cavernoma
#1
Sivaji Patibandla, Jaya Singh K, Tumbanatham, Appikatla
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27728089/is-it-apla-causing-portal-vein-thrombosis-with-portal-cavernoma
#2
Sivaji Patibandla, Jaya Singh K, Tumbanatham Appikatla
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27678386/synthesis-of-polylactide-based-core-shell-interface-cross-linked-micelles-for-anticancer-drug-delivery
#3
Chih-Kuang Chen, Wei-Jen Lin, Yu Hsia, Leu-Wei Lo
Well-defined poly(ethylene glycol)-b-allyl functional polylactide-b-polylactides (PEG-APLA-PLAs) are synthesized through sequential ring-opening polymerization. PEG-APLA-PLAs that have amphiphilic properties and reactive allyl side chains on their intermediate blocks are successfully transferred to core-shell interface cross-linked micelles (ICMs) by micellization and UV-initiated irradiation. ICMs have demonstrated enhanced colloidal stability in physiological-mimicking media. Hydrophobic molecules such as Nile Red or doxorubicin (Dox) are readily loaded into ICMs; the resulting drug-ICM formulations possess slow and sustained drug release profiles under physiological-mimicking conditions...
September 28, 2016: Macromolecular Bioscience
https://www.readbyqxmd.com/read/27127741/clinical-significance-of-nonspecificity-of-antiphospholipid-antibodies-in-recurrent-abortions-and-unexplained-infertility
#4
Priyanka Malik, Maninder Kaur, Gurdeep Kaur Bedi, Khushpreet Kaur
BACKGROUND: Antiphospholipid antibodies (APLA) are acquired autoantibodies directed to phospholipids which are associated with slow progressive thrombosis and infarction of placenta. Infertility and recurrent pregnancy loss may occur because of impaired trophoblast function, placental infarction, and abnormal blood clotting. AIM: To evaluate APLA (IgG and IgM) in cases of infertility and recurrent abortions. MATERIALS AND METHODS: A prospective study comprising 70 subjects was carried out...
April 2016: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/27067744/incidence-of-antiphospholipid-antibodies-in-patients-with-immune-thrombocytopenia-and-correlation-with-treatment-with-steroids-in-north-indian-population
#5
Aniruddha Dayama, Jasmita Dass, Manoranjan Mahapatra, Renu Saxena
INTRODUCTION: Antiphospholipid antibodies (APLAs) have been variably reported in 14% to 75% of patients with immune thrombocytopenia (ITP). There is lack of Indian data on incidence of APLA in ITP. OBJECTIVE: We studied the incidence of APLA in patients with pediatric and adult Indian ITP. MATERIALS AND METHODS: We prospectively studied 100 patients including acute (n = 37), persistent (n = 13), and chronic (n = 50) ITP. Male to female ratio was 1...
April 10, 2016: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/26969522/development-of-an-in-process-uv-crosslinked-electrospun-pcl-apla-co-tmc-composite-polymer-for-tubular-tissue-engineering-applications
#6
I Stefani, J J Cooper-White
UNLABELLED: Cardiovascular diseases remain the largest cause of death worldwide, and half of these deaths are the result of failure of the vascular system. Tissue engineering promises to provide new, and potentially more effective therapeutic strategies to replace damaged or degenerated vessels with functional vessels. However, these engineered vessels have substantial performance criteria, including vessel-like tubular shape, structure and mechanical property slate. Further, whether implanted without or with prior in vitro culture, such tubular scaffolds must provide a suitable environment for cell adhesion and growth and be of sufficient porosity to permit cell colonization...
May 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/26939208/extended-antiphospholipid-antibodies-screening-in-systemic-lupus-erythematosus-patients
#7
Alina Dima, Simona Caraiola, C Jurcut, Eugenia Balanescu, P Balanescu, Doina Ramba, Camelia Badea, V Pompilian, R Ionescu, Anda Baicus, C Baicus, G A Dan
BACKGROUND: The antiphospholipid syndrome (APS) is one of the most encountered autoimmunity in systemic lupus erythematosus (SLE) patients and pathogenesis of these two seems to be intricate. AIM: To investigate the association of antiphospholipid antibodies (APLAs) titer with the presence of secondary APS diagnosis in SLE patients. METHODS: 65 patients fulfilling the 2012 Systemic Lupus Collaborating International Clinics (SLICC) SLE's criteria were included...
October 2015: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/26820623/ldlr-and-pcsk9-are-associated-with-the-presence-of-antiphospholipid-antibodies-and-the-development-of-thrombosis-in-apla-carriers
#8
Eguzkine Ochoa, Mikel Iriondo, Carmen Manzano, Asier Fullaondo, Irama Villar, Guillermo Ruiz-Irastorza, Ana M Zubiaga, Andone Estonba
INTRODUCTION: The identification of the genetic risk factors that could discriminate non- thrombotic from thrombotic antiphospholipid antibodies (aPLA) carriers will improve prognosis of these patients. Several human studies have shown the presence of aPLAs associated with atherosclerotic plaque, which is a known risk factor for thrombosis. Hence, in order to determine the implication of atherosclerosis in the risk of developing thrombosis in aPLA positive patients, we performed a genetic association study with 3 candidate genes, APOH, LDLR and PCSK9...
2016: PloS One
https://www.readbyqxmd.com/read/26712985/anesthetic-management-in-a-case-of-antiphospholipid-antibody-syndrome
#9
Venkata Rama Rao Mikkiliineni, Nagarjuna Panidapu, Mrunalini Parasa, Mastan Saheb Shaik
Antiphospholipid antibody (APLA) syndrome is one of the most common thrombocytophilias but, unfortunately, goes unrecognized most often. It is an auto-immune disorder in which thrombotic events and a recurrent fetal loss occur in the presence of antibodies to phospholipids. It is the most common acquired hyper-coagulable state. There is a limited literature on peroperative management of patients with this syndrome. We report a case of APLA syndrome in a parturient due to its rarity and complexity.
September 2015: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/26264622/a-novel-pathway-of-cellular-activation-mediated-by-antiphospholipid-antibody-induced-extracellular-vesicles
#10
M Wu, J Barnard, S Kundu, K R McCrae
BACKGROUND: Elevated levels of endothelial cell (EC)-derived extracellular vesicles (EVs) circulate in patients with antiphospholipid antibodies (APLAs), and APLAs, particularly those against β2 -glycoprotein I (β2 GPI), stimulate EV release from ECs. However, the effects of EC-derived EVs have not been characterized. OBJECTIVE: To determine the mechanism by which EVs released from ECs by anti-β2 GPI antibodies activate unstimulated ECs. PATIENTS/METHODS: We used interleukin (IL)-1 receptor inhibitors, small interfering RNA (siRNA) against Toll-like receptors (TLRs) and microRNA (miRNA) profiling to assess the mechanism(s) by which EVs released from ECs exposed to anti-β2 GPI antibodies activated unstimulated ECs...
October 2015: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/26078573/prevalence-significance-and-predictive-value-of-antiphospholipid-antibodies-in-crohn-s-disease
#11
Nora Sipeki, Laszlo Davida, Eszter Palyu, Istvan Altorjay, Jolan Harsfalvi, Peter Antal Szalmas, Zoltan Szabo, Gabor Veres, Zakera Shums, Gary L Norman, Peter L Lakatos, Maria Papp
AIM: To assess the prevalence and stability of different antiphospholipid antibodies (APLAs) and their association with disease phenotype and progression in inflammatory bowel diseases (IBD) patients. METHODS: About 458 consecutive patients [Crohn's disease (CD): 271 and ulcerative colitis (UC): 187] were enrolled into a follow-up cohort study in a tertiary IBD referral center in Hungary. Detailed clinical phenotypes were determined at enrollment by reviewing the patients' medical charts...
June 14, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/26020758/effects-of-anti-phospholipase-a-2-antibody-supplementation-on-dry-matter-intake-feed-efficiency-acute-phase-response-and-blood-differentials-of-steers-fed-forage-and-grain-based-diets
#12
COMPARATIVE STUDY
V R G Mercadante, K M Waters, G H L Marquezini, D D Henry, F M Ciriaco, J D Arthington, N DiLorenzo, G C Lamb
To determine whether supplementation of anti-phospholipase A antibody (aPLA) would alter voluntary DMI, feed efficiency (FE), acute-phase protein concentration, and blood differentials (BD) due to a change in diet from a forage-based to a grain-based diet, individual daily DMI was measured on 80 cross-bred steers during a 141-d period. On d 0, steers were blocked by BW and randomly assigned to receive a growing forage diet containing 1) no additive (CON; = 20), 2) inclusion of 30 mg of monensin and 8.8 mg of tylosin per kg of diet DM (MT; = 20), 3) inclusion of an aPLA supplement at 0...
February 2015: Journal of Animal Science
https://www.readbyqxmd.com/read/25918850/antiphospholipid-antibody-and-risk-of-retinal-vein-occlusion-a-systematic-review-and-meta-analysis
#13
REVIEW
Wei Zhu, Yan Wu, Ming Xu, Jin-Yu Wang, Yi-Fang Meng, Zheng Gu, Jiong Lu
BACKGROUND: Retinal vein occlusion (RVO) is a common retinal vascular disease and it is one of the most frequently reported causes of visual damage and blindness in the elderly. The current study investigated the potential association between antiphospholipid antibodies (APLA) and RVO risk by conducting a meta-analysis of case-control studies. METHODS: A systematic literature search of Pubmed and Embase databases was conducted in August 1st, 2014. Odds ratios (ORs) were used to evaluate the associations between APLA and the incidence of RVO...
2014: PloS One
https://www.readbyqxmd.com/read/25891605/cortical-venous-sinus-thrombosis-after-lp-and-high-dose-steroid-in-a-case-clinically-isolated-syndrome
#14
M Thakre, J Inshasi
UNLABELLED: Role of lumbar puncture and high dose steroids have been implicated previously in causing cerebral venous sinus thrombosis in multiple sclerosis. We report a case of clinically isolated syndrome who developed cerebral venous sinus thrombosis after Lumbar puncture and high dose steroids. Forty two years old gentleman presented with right hand numbness and weakness over 1 week. MRI brain and spine showed periventricular and cerebellar white matter lesions suggestive of multiple sclerosis...
November 2014: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/25862984/oxidative-stress-and-treg-depletion-in-lupus-patients-with-anti-phospholipid-syndrome
#15
Zhi-wei Lai, Ivan Marchena-Mendez, Andras Perl
Anti-phospholipid antibodies (APLA) represent a diagnostic criterion of systemic lupus erythematosus (SLE) and cause morbidity, termed anti-phospholipid syndrome (APS). Activation of the mechanistic target of rapamycin (mTOR) has been recently associated with APS. mTOR is a sensor of oxidative stress. Therefore, we examined mitochondrial mass, superoxide production, mTOR activity and FoxP3 expression in 72 SLE patients, twelve of whom also had APS, and 54 healthy controls by flow cytometry. Mitochondrial mass was increased in CD4(-)CD8(-) double-negative (DN) T cells of SLE patients with APS (2...
June 2015: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/25821728/association-of-anti-phospholipid-antibodies-with-connective-tissue-diseases
#16
Reena Rai, T Swetha
BACKGROUND: The antiphospholipid antibodies (APLA) are directed against phospholipids and their binding proteins and are frequently found in association with connective tissue disorders. Systemic lupus erythematoses (SLE) with APLA may cause a diagnostic dilemma as there are several manifestations like haemolytic anemia, thrombocytopenia, neurologic manifestations, leg ulcerations, serositis proteinuria which overlap in both these conditions. We conducted a study to find out the association of antiphospholipid antibodies with connective tissue diseases and compared the clinical and laboratory parameters between antiphoshpolipid antibody positive and antiphoshpolipid antibody negative group...
March 2015: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/25787579/-228-pos-a-complicated-pregnancy-with-preeclampsia-hellp-syndrome-and-thrombotic-microangiopathy-in-a-woman-with-lupus-and-antiphospholipid-syndrome
#17
Amy E Lin, Nadine Shehata, Heather Reich, David Barth, Carl Laskin, Stephen Lapinsky, Shital Gandhi
OBJECTIVES: We outline a case of a woman with lupus (SLE) and antiphospholipid syndrome (APLA) at 26 weeks' gestation who develops a complex multiorgan condition with a broad differential. METHODS: Case report. RESULTS: A 34 year old woman, G1P0, presented at 26 weeks gestation with a 5 day history of epigastric pain and emesis. She has a history of lupus anticoagulant (LAC), anticardiolipin (ACL) and anti-dsDNA (ADD) positive SLE and APLA syndrome diagnosed at age 13 with multiple small cerebral infarcts...
January 2015: Pregnancy Hypertension
https://www.readbyqxmd.com/read/25526601/frequency-of-vascular-and-pregnancy-morbidity-in-patients-with-low-vs-moderate-to-high-titers-of-antiphospholipid-antibodies
#18
COMPARATIVE STUDY
Shachaf Ofer-Shiber, Yair Molad
Antiphospholipid syndrome (APLS) is an autoimmune hypercoagulable syndrome characterized by thrombotic and obstetric manifestations. We sought to determine the rate of APLS feature in patients tested positive for antiphospholipid antibodies (APLA) regardless of the serum level of anticardiolipin (ACL) and/or anti-β2-glycoprotein I (β2GPI) antibodies. An inception cohort of individuals who were tested positive for ACL and/or β2GPI IgG/IgM antibody, and/or lupus anticoagulant (LAC) on two occasions of at least 12 weeks apart...
April 2015: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/25378850/bilateral-pleural-effusion-with-apla-positivity-in-a-case-of-rhupus-syndrome
#19
Kaushik Saha, Arnab Saha, Mrinmoy Mitra, Prabodh Panchadhyayee
Rhupus syndrome is a rare syndrome characterized by overlap of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Our patient was a diagnosed case of RA and developed SLE 2 years after. She was a middle-aged woman, presented with bilateral pleural effusion with exacerbation of skin and joint symptoms of SLE. We diagnosed the case as tubercular pleural effusion by positive Mycobacterium tuberculosis in bactec 460 culture. She had also anti-phospholipid antibody positivity without any symptoms and signs of thrombosis...
October 2014: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/25201005/lupus-anticoagulant-and-thrombosis-in-splenic-marginal-zone-lymphoma
#20
J Gebhart, K Lechner, C Skrabs, T Sliwa, E Müldür, H Ludwig, T Nösslinger, K Vanura, K Stamatopoulos, I Simonitsch-Klupp, A Chott, P Quehenberger, G Mitterbauer-Hohendanner, I Pabinger, U Jäger, K Geissler
INTRODUCTION: Splenic marginal zone lymphoma (SMZL) is a rare low-malignant Non-Hodgkin lymphoma (NHL), in which immune mediated paraneoplastic phenomena such as autoimmune hemolytic anemia (AIHA), autoimmune thrombocytopenia (ITP) and C1 esterase inhibitor deficiency are relatively common. MATERIALS AND METHODS: We performed a multicenter retrospective study in 70 patients on the prevalence and clinical features of antiphospholipid antibodies (aPLA) in SMZL. RESULTS AND CONCLUSIONS: Nine patients (13%) had the diagnosis of a lupus anticoagulant (LA)...
November 2014: Thrombosis Research
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