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https://www.readbyqxmd.com/read/28526913/mapping-qtls-controlling-kernel-dimensions-in-a-wheat-inter-varietal-ril-mapping-population
#1
Ruiru Cheng, Zhongxin Kong, Liwei Zhang, Quan Xie, Haiyan Jia, Dong Yu, Yulong Huang, Zhengqiang Ma
Seven kernel dimension QTLs were identified in wheat, and kernel thickness was found to be the most important dimension for grain weight improvement. Kernel morphology and weight of wheat (Triticum aestivum L.) affect both yield and quality; however, the genetic basis of these traits and their interactions has not been fully understood. In this study, to investigate the genetic factors affecting kernel morphology and the association of kernel morphology traits with kernel weight, kernel length (KL), width (KW) and thickness (KT) were evaluated, together with hundred-grain weight (HGW), in a recombinant inbred line population derived from Nanda2419 × Wangshuibai, with data from five trials (two different locations over 3 years)...
May 19, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/28526669/development-of-an-evidence-informed-blog-to-promote-healthy-eating-among-mothers-use-of-the-intervention-mapping-protocol
#2
Audrée-Anne Dumas, Simone Lemieux, Annie Lapointe, Véronique Provencher, Julie Robitaille, Sophie Desroches
BACKGROUND: Low adherence to dietary guidelines and a concurrent rise of obesity-related chronic diseases emphasize the need for effective interventions to promote healthy eating. There is growing recognition that behavior change interventions should draw on theories of behavior change. Online interventions grounded in theory lead to increased effectiveness for health behavior change; however, few theory-driven social media-based health promotion interventions have been described in the literature...
May 19, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28522182/hodotopy-neuroplasticity-and-diffuse-gliomas
#3
H Duffau
BACKGROUND AND PURPOSE: The historical approach in neurooncology is used to mainly investigate the tumor, with very few considerations regarding the brain itself. Nonetheless, to select the best personalized therapeutic management for each patient with a diffuse glioma, i.e. to optimize the "onco-functional balance", the brain reaction induced by glioma growth and migration should be studied. Indeed, due to strong interactions between the glioma and the brain, cerebral adaptive phenomena often occur in order to maintain neurological and cognitive functions, as well as to compensate glioma spreading...
May 15, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28521756/rethinking-physical-activity-communication-using-focus-groups-to-understand-women-s-goals-values-and-beliefs-to-improve-public-health
#4
Michelle Segar, Jennifer M Taber, Heather Patrick, Chan L Thai, April Oh
BACKGROUND: Communication about physical activity (PA) frames PA and influences what it means to people, including the role it plays in their lives. To the extent that PA messages can be designed to reflect outcomes that are relevant to what people most value experiencing and achieving in their daily lives, the more compelling and effective they will be. Aligned with self-determination theory, this study investigated proximal goals and values that are salient in everyday life and how they could be leveraged through new messaging to better support PA participation among women...
May 18, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28517952/dna-methylation-and-transcription-onset-in-the-brain
#5
Renaud Massart, Matthew Suderman, Valerie Mongrain, Moshe Szyf
AIM: The goal of this study was to test the state of methylation of transcription start positions in DNA that are actively involved in transcription. MATERIALS & METHODS: We used sequential ChIP-bisulfite-sequencing with an antibody to RNpolII-PS5 to map the state of methylation of actively transcribing transcription start sites (TSS). RESULTS: TSS that RNApolII-PS5 physically bind to, are ubiquitously unmethylated. TSS that appear to be both heavily methylated and transcriptionally active are truly a mixture of unmethylated TSS with bound RNApolII-PS5 in some nuclei and unbound methylated TSS in other nuclei...
May 18, 2017: Epigenomics
https://www.readbyqxmd.com/read/28516087/dna-sequence-analysis-in-clinical-medicine-proceeding-cautiously
#6
REVIEW
Moyra Smith
Delineation of underlying genomic and genetic factors in a specific disease may be valuable in establishing a definitive diagnosis and may guide patient management and counseling. In addition, genetic information may be useful in identification of at risk family members. Gene mapping and initial genome sequencing data enabled the development of microarrays to analyze genomic variants. The goal of this review is to consider different generations of sequencing techniques and their application to exome sequencing and whole genome sequencing and their clinical applications...
2017: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/28511666/barriers-and-facilitators-of-access-to-maternal-services-for-women-with-disabilities-scoping-review-protocol
#7
Doreen Mheta, Tivani P Mashamba-Thompson
BACKGROUND: The Sustainable Development Goals (SDGs) emphasises the increasing equitable coverage of quality health care and provision of integrated services as means of reducing maternal mortality. Despite so much effort being placed on improved access to maternity health care, studies show that women with disabilities are being systemically excluded from the mainstream maternal health services. The proposed scoping review aims to map literature on the barriers and facilitators of access to maternal services for women with disabilities...
May 16, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28508800/electronic-health-records-in-prehospital-care
#8
Katharina Rohrer
Documentation is an essential part and duty in all clinical settings. "ELGA" (short for "Elektronische Gesundheitsakte") is the Austrian Electronic Health Record and aims to support the process of clinical decision-making. However the use case of integrating ELGA to an out-of-hospital setting is not defined yet. This work explores the special requirements in prehospital care. The aim of research is to identify needed information and processes at the emergency scene to establish appropriate decisions about diagnosis, treatments and transport...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28506523/integration-of-population-census-and-water-point-mapping-data-a-case-study-of-cambodia-liberia-and-tanzania
#9
Weiyu Yu, Nicola A Wardrop, Robert Bain, Jim A Wright
Sustainable Development Goal (SDG) 6 has expanded the Millennium Development Goals' focus from improved drinking-water to safely managed water services. This expanded focus to include issues such as water quality requires richer monitoring data and potentially integration of datasets from different sources. Relevant data sets include water point mapping (WPM), the survey of boreholes, wells and other water points, census and household survey data. This study examined inconsistencies between population census and WPM datasets for Cambodia, Liberia and Tanzania, and identified potential barriers to integrating the two datasets to meet monitoring needs...
May 4, 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28500916/valuing-urban-open-space-using-the-travel-cost-method-and-the-implications-of-measurement-error
#10
Merlin M Hanauer, John Reid
Urbanization has placed pressure on open space within and adjacent to cities. In recent decades, a greater awareness has developed to the fact that individuals derive multiple benefits from urban open space. Given the location, there is often a high opportunity cost to preserving urban open space, thus it is important for both public and private stakeholders to justify such investments. The goals of this study are twofold. First, we use detailed surveys and precise, accessible, mapping methods to demonstrate how travel-cost methods can be applied to the valuation of urban open space...
May 10, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28500558/natural-peer-leaders-as-substance-use-prevention-agents-the-teens-life-choice-project
#11
Megan M Golonka, Kristen F Peairs, Patrick S Malone, Christina L Grimes, Philip R Costanzo
In adolescent social groups, natural peer leaders have been found to engage in more frequent experimentation with substance use and to possess disproportionate power to affect the behavior and social choices of their associated peer followers. In the current exploratory study, we used sociometrics and social cognitive mapping to identify natural leaders of cliques in a seventh grade population and invited the leaders to develop anti-drug presentations for an audience of younger peers. The program employed social-psychological approaches directed at having leaders proceed from extrinsic inducements to intrinsic identification with their persuasive products in the context of the group intervention process...
May 12, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/28496560/transmodal-learning-of-functional-networks-for-alzheimer-s-disease-prediction
#12
Mehdi Rahim, Bertrand Thirion, Claude Comtat, Gaël Varoquaux
Functional connectivity describes neural activity from resting-state functional magnetic resonance imaging (rs-fMRI). This noninvasive modality is a promising imaging biomarker of neurodegenerative diseases, such as Alzheimer's disease (AD), where the connectome can be an indicator to assess and to understand the pathology. However, it only provides noisy measurements of brain activity. As a consequence, it has shown fairly limited discrimination power on clinical groups. So far, the reference functional marker of AD is the fluorodeoxyglucose positron emission tomography (FDG-PET)...
October 2016: IEEE Journal of Selected Topics in Signal Processing
https://www.readbyqxmd.com/read/28493232/anthracycline-induced-cardiotoxicity-biomarkers-and-omics-technology-in-the-era-of-patient-specific-care
#13
REVIEW
Shayan Moazeni, Martin Cadeiras, Eric H Yang, Mario C Deng, Kim-Lien Nguyen
Anthracyclines are highly effective against a variety of malignancies. However, their dose-dependent cardiotoxic effects can potentially limit their use. In the past decade, serum biomarkers have been used to diagnose, monitor, predict, and prognosticate disease. Biomarkers such as cardiac troponin and natriuretic peptides have some predictive value, but still lack reliability in this patient population. Novel biomarkers such as galectin-3, soluble ST-2 proteins, myeloperoxidase, and fibrocytes are being explored as potential biomarkers to reliably predict the onset of cardiotoxicity...
December 2017: Clinical and Translational Medicine
https://www.readbyqxmd.com/read/28489900/scanning-double-sided-documents-without-incurring-show-through-by-learning-to-fuse-two-complementary-images-using-multilayer-perceptron
#14
Yuzhong Chen
This paper presents a novel method for scanning duplex-printed documents without incurring the unwanted show-through artifact. The proposed method achieves the goal of eliminating the leaked-out reverse-side content by fusing a white backed scan image with a black backed scan image of the document. The fusion is accomplished using a multilayer perceptron having learned a fusion mapping from manually corrected document images. The main novel contributions of this work include (1) being the first to propose to accomplish the goal of show through free scanning by fusing a white backed scan image with a black backed scan image of the document; (2) proposing a learning approach using a multilayer perceptron to learn the fusion mapping from manually corrected scan images; and (3) proposing to use the pixel value histogram of reverse-side-printed area as well as the pixel value histogram of duplex-printed area to quantitatively indicate show through severity to facilitate objective comparison of the methods in consideration...
2017: PloS One
https://www.readbyqxmd.com/read/28484827/-hot-rods-in-the-icu-what-is-the-antibiotic-mileage-of-your-renal-replacement-therapy
#15
REVIEW
J T Kielstein, A K Kruse, N Anderson, H Vaitiekunas, S Scherneck
We would neither be disappointed nor upset if the gas mileage on the sticker of a car didn't match our personal, real-life fuel consumption. Depending on our daily route to work, our style of accelerating and the number of passengers in our carpool, the gas mileage will vary. As soon as the falcon wing door of our car is closed and entrance to the ICU is granted, we tend to forget all of this, even though another hot rod is waiting there for us. Renal replacement therapy is like a car; it fulfills goals, such as the removal of uremic toxins and accumulated fluids, but it also "consumes" (removes) antibiotics...
May 8, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://www.readbyqxmd.com/read/28483888/alignment-of-canadian-primary-care-with-the-patient-medical-home-model-a-qualico-pc-study
#16
Alan Katz, Nicole Herpai, Glenys Smith, Kris Aubrey-Bassler, Mylaine Breton, Antoine Boivin, William Hogg, Baukje Miedema, Jocelyn Pang, Walter P Wodchis, Sabrina T Wong
PURPOSE: The patient medical home (PMH) model aims to improve patient satisfaction and health outcomes in Canada, but since its introduction in 2009, there has been no evaluation of the extent to which primary care conforms with PMH attributes. Our objective was to compare current primary care across Canada with the 10 goals of the PMH model. METHODS: A cross-sectional survey of primary care organization and delivery was conducted in Canadian provinces to evaluate the PMH-based attributes of primary care practices...
May 2017: Annals of Family Medicine
https://www.readbyqxmd.com/read/28483703/next-generation-sequencing-analysis-of-soy-glyceollins-and-17-%C3%AE-estradiol-effects-on-transcript-abundance-in-the-female-mouse-brain
#17
REVIEW
Sanaya F Bamji, Eric Rouchka, Yan Zhang, Xiaohong Li, Ted Kalbfleisch, Cynthia Corbitt
Glyceollins (Glys) are produced by soy plants in response to stress and are known for their anti-estrogenic activity both in vivo and in vitro in cancer cell lines as well as peripheral tissues. Glys can also exhibit non-estrogen receptor (ER) mediated effects. The effects of Glys on gene expression in the brain are still unclear. For this study, 17-β estradiol (E2) or placebo slow-release pellets were implanted into ovariectomized CFW mice followed by 11 days of exposure to either Glys or vehicle i.p. injections...
May 5, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28480617/comparison-of-arterial-spin-labeling-registration-strategies-in-the-multi-center-genetic-frontotemporal-dementia-initiative-genfi
#18
Henri J M M Mutsaerts, Jan Petr, David L Thomas, Enrico de Vita, David M Cash, Matthias J P van Osch, Xavier Golay, Paul F C Groot, Sebastien Ourselin, John van Swieten, Robert Laforce, Fabrizio Tagliavini, Barbara Borroni, Daniela Galimberti, James B Rowe, Caroline Graff, Francesca B Pizzini, Elizabeth Finger, Sandro Sorbi, Miguel Castelo Branco, Jonathan D Rohrer, Mario Masellis, Bradley J MacIntosh
PURPOSE: To compare registration strategies to align arterial spin labeling (ASL) with 3D T1-weighted (T1w) images, with the goal of reducing the between-subject variability of cerebral blood flow (CBF) images. MATERIALS AND METHODS: Multi-center 3T ASL data were collected at eight sites with four different sequences in the multi-center GENetic Frontotemporal dementia Initiative (GENFI) study. In a total of 48 healthy controls, we compared the following image registration options: (I) which images to use for registration (perfusion-weighted images [PWI] to the segmented gray matter (GM) probability map (pGM) (CBF-pGM) or M0 to T1w (M0-T1w); (II) which transformation to use (rigid-body or non-rigid); and (III) whether to mask or not (no masking, M0-based FMRIB software library Brain Extraction Tool [BET] masking)...
May 8, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28478896/osteochondritis-dissecans-of-the-capitellum-lesion-size-and-pattern-analysis-using-quantitative-3-dimensional-computed-tomography-and-mapping-technique
#19
Rens Bexkens, Jacobien H Oosterhoff, Tsung-Yuan Tsai, Job N Doornberg, Michel P J van den Bekerom, Denise Eygendaal, Luke S Oh
BACKGROUND: The goals of this study were to evaluate the reliability of a quantitative 3-dimensional computed tomography (Q3DCT) technique for measurement of the capitellar osteochondritis dissecans (OCD) surface area, to analyze OCD distribution using a mapping technique, and to investigate associations between Q3DCT lesion quantification and demographic characteristics and/or clinical examination findings. METHODS: We identified patients with capitellar OCD who presented to our orthopedic sports medicine practice between January 2001 and January 2016 and who had undergone a preoperative computed tomography scan (slice thickness ≤1...
May 3, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28476618/identification-of-repaglinide-as-a-therapeutic-drug-for-glioblastoma-multiforme
#20
Zui Xuan Xiao, Ruo Qiao Chen, Dian Xing Hu, Xiao Qiang Xie, Shang Bin Yu, Xiao Qian Chen
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with a median survival time of only 14 months after treatment. It is urgent to find new therapeutic drugs that increase survival time of GBM patients. To achieve this goal, we screened differentially expressed genes between long-term and short-term survived GBM patients from Gene Expression Omnibus database and found gene expression signature for the long-term survived GBM patients. The signaling networks of all those differentially expressed genes converged to protein binding, extracellular matrix and tissue development as revealed in BiNGO and Cytoscape...
June 17, 2017: Biochemical and Biophysical Research Communications
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