Kaixi Ren, Songwang Hou, Steven E Johnson, Jon Lomasney, Chad R Haney, Jungwha Lee, Zhi-Dong Ge, Daniel C Lee, Jeffrey J Goldberger, Rishi Arora, Ming Zhao
BACKGROUND: The goal was to determine the feasibility of mapping the injured-but-not-infarcted myocardium using 99m Tc-duramycin in the postischemic heart, with spatial information for its characterization as a pathophysiologically intermediate tissue, which is neither normal nor infarcted. METHODS AND RESULTS: Coronary occlusion was conducted in Sprague Dawley rats with preconditioning and 30-minute ligation. In vivo single-photon emission computed tomography was acquired after 3 hours (n=6) using 99m Tc-duramycin, a phosphatidylethanolamine-specific radiopharmaceutical...
April 19, 2024: Journal of the American Heart Association