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https://www.readbyqxmd.com/read/29166516/proteus-syndrome
#1
Ritha de Cássia Capelato Rocha, Mariani Paulino Soriano Estrella, Danielle Mechereffe do Amaral, Angela Marques Barbosa, Marilda Aparecida Milanez Morgado de Abreu
Proteus syndrome is a rare syndrome characterized by disproportionate overgrowth of limbs, multiple hamartomas, and vascular malformations. The cerebriform connective tissue nevi, also called cerebriform plantar hyperplasia, are present in most patients, and is the main characteristic of the syndrome. If present, even alone, they can be considered as a pathognomonic sign. This article reports a classic case of Proteus syndrome in a 2-year-old male patient who began to show a discrete asymmetry of the right hemibody in relation to the left one after birth, which increased over the months...
September 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29164348/delineation-of-inheritance-pattern-of-aleurone-layer-colour-through-chemical-tests-in-rice
#2
Chandu Singh, Sripathy K V, Jeevan Kumar S P, Bhojaraja Naik K, Govind Pal, Udaya Bhaskar K, Ramesh K V, Somasundaram G
BACKGROUND: Rice aleurone layer develops different colours with various chemical tests that may help to develop some rapid tests for identification/grouping of rice varieties. Understanding the colour inheritance pattern could enable to develop chemical clues that may help for genetic purity analysis along with grow-out-test. RESULTS: In this study, inheritance pattern of aleurone layer colour was studied in parents, F1 and F2 progenies derived from the crosses IR 36 × Acc...
November 21, 2017: Rice
https://www.readbyqxmd.com/read/29163587/global-dna-methylation-patterns-can-play-a-role-in-defining-terroir-in-grapevine-vitis-vinifera-cv-shiraz
#3
Huahan Xie, Moumouni Konate, Na Sai, Kiflu G Tesfamicael, Timothy Cavagnaro, Matthew Gilliham, James Breen, Andrew Metcalfe, John R Stephen, Roberta De Bei, Cassandra Collins, Carlos M R Lopez
Understanding how grapevines perceive and adapt to different environments will provide us with an insight into how to better manage crop quality. Mounting evidence suggests that epigenetic mechanisms are a key interface between the environment and the genotype that ultimately affect the plant's phenotype. Moreover, it is now widely accepted that epigenetic mechanisms are a source of useful variability during crop varietal selection that could affect crop performance. While the contribution of DNA methylation to plant performance has been extensively studied in other major crops, very little work has been done in grapevine...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29163566/cultivar-diversity-of-grape-skin-polyphenol-composition-and-changes-in-response-to-drought-investigated-by-lc-ms-based-metabolomics
#4
Lucie Pinasseau, Anna Vallverdú-Queralt, Arnaud Verbaere, Maryline Roques, Emmanuelle Meudec, Loïc Le Cunff, Jean-Pierre Péros, Agnès Ageorges, Nicolas Sommerer, Jean-Claude Boulet, Nancy Terrier, Véronique Cheynier
Phenolic compounds represent a large family of plant secondary metabolites, essential for the quality of grape and wine and playing a major role in plant defense against biotic and abiotic stresses. Phenolic composition is genetically driven and greatly affected by environmental factors, including water stress. A major challenge for breeding of grapevine cultivars adapted to climate change and with high potential for wine-making is to dissect the complex plant metabolic response involved in adaptation mechanisms...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29163494/reproducibility-and-reuse-of-adaptive-immune-receptor-repertoire-data
#5
Felix Breden, Eline T Luning Prak, Bjoern Peters, Florian Rubelt, Chaim A Schramm, Christian E Busse, Jason A Vander Heiden, Scott Christley, Syed Ahmad Chan Bukhari, Adrian Thorogood, Frederick A Matsen Iv, Yariv Wine, Uri Laserson, David Klatzmann, Daniel C Douek, Marie-Paule Lefranc, Andrew M Collins, Tania Bubela, Steven H Kleinstein, Corey T Watson, Lindsay G Cowell, Jamie K Scott, Thomas B Kepler
High-throughput sequencing (HTS) of immunoglobulin (B-cell receptor, antibody) and T-cell receptor repertoires has increased dramatically since the technique was introduced in 2009 (1-3). This experimental approach explores the maturation of the adaptive immune system and its response to antigens, pathogens, and disease conditions in exquisite detail. It holds significant promise for diagnostic and therapy-guiding applications. New technology often spreads rapidly, sometimes more rapidly than the understanding of how to make the products of that technology reliable, reproducible, or usable by others...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29163459/crispr-cas9-system-as-a-valuable-genome-editing-tool-for-wine-yeasts-with-application-to-decrease-urea-production
#6
Ileana Vigentini, Marinella Gebbia, Alessandra Belotti, Roberto Foschino, Frederick P Roth
An extensive repertoire of molecular tools is available for genetic analysis in laboratory strains of S. cerevisiae. Although this has widely contributed to the interpretation of gene functionality within haploid laboratory isolates, the genetics of metabolism in commercially-relevant polyploid yeast strains is still poorly understood. Genetic engineering in industrial yeasts is undergoing major changes due to Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) and CRISPR-associated protein (Cas) engineering approaches...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29163451/non-saccharomyces-yeasts-nitrogen-source-preferences-impact-on-sequential-fermentation-and-wine-volatile-compounds-profile
#7
Antoine Gobert, Raphaëlle Tourdot-Maréchal, Christophe Morge, Céline Sparrow, Youzhong Liu, Beatriz Quintanilla-Casas, Stefania Vichi, Hervé Alexandre
Nitrogen sources in the must are important for yeast metabolism, growth, and performance, and wine volatile compounds profile. Yeast assimilable nitrogen (YAN) deficiencies in grape must are one of the main causes of stuck and sluggish fermentation. The nitrogen requirement of Saccharomyces cerevisiae metabolism has been described in detail. However, the YAN preferences of non-Saccharomyces yeasts remain unknown despite their increasingly widespread use in winemaking. Furthermore, the impact of nitrogen consumption by non-Saccharomyces yeasts on YAN availability, alcoholic performance and volatile compounds production by S...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29163412/different-non-saccharomyces-yeast-species-stimulate-nutrient-consumption-in-s-cerevisiae-mixed-cultures
#8
Jose A Curiel, Pilar Morales, Ramon Gonzalez, Jordi Tronchoni
The growing interest of the winemaking industry on the use of non-Saccharomyces starters has prompted several studies about the physiological features of this diverse group of microorganisms. The fact that the proposed use of these new starters will almost invariably involve either simultaneous or sequential inoculation with Saccharomyces cerevisiae has also driven the attention to the potential biological interactions between different starters during wine fermentation. Our current understanding is that alternative yeast starters will affect wine features by both direct and indirect mechanisms (through metabolic or other types of interactions with S...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29162708/lactobacillus-acidophilus-metabolizes-dietary-plant-glucosides-and-externalizes-their-bioactive-phytochemicals
#9
Mia C Theilmann, Yong Jun Goh, Kristian Fog Nielsen, Todd R Klaenhammer, Rodolphe Barrangou, Maher Abou Hachem
Therapeutically active glycosylated phytochemicals are ubiquitous in the human diet. The human gut microbiota (HGM) modulates the bioactivities of these compounds, which consequently affect host physiology and microbiota composition. Despite a significant impact on human health, the key players and the underpinning mechanisms of this interplay remain uncharacterized. Here, we demonstrate the growth of Lactobacillus acidophilus on mono- and diglucosyl dietary plant glycosides (PGs) possessing small aromatic aglycones...
November 21, 2017: MBio
https://www.readbyqxmd.com/read/29160960/risk-of-past-year-injury-related-to-hours-of-exposure-to-an-elevated-bac-and-average-monthly-alcohol-volume-data-from-four-national-alcohol-surveys-2000-2015
#10
Cheryl J Cherpitel, Yu Ye, William C Kerr
BACKGROUND: While a strong association exists between alcohol and injury in emergency department (ED) studies, these studies are not representative of the general population. OBJECTIVE: The association of injury with the number of hours of exposure to a BAC ≥ 0.05 and average monthly volume in drinks, both based on self-report of quantity and frequency of drinking in the last year, in a merged sample of respondents (n=29,571) from four U.S. National Alcohol Surveys (2000-2015) is analyzed...
November 21, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29160564/functional-differences-in-transport-properties-of-natural-hkt1-1-variants-influence-shoot-na-exclusion-in-grapevine-rootstocks
#11
Sam W Henderson, Jake D Dunlevy, Yue Wu, Deidre H Blackmore, Rob R Walker, Everard J Edwards, Matthew Gilliham, Amanda R Walker
Under salinity, Vitis spp. rootstocks can mediate salt (NaCl) exclusion from grafted V. vinifera scions enabling higher grapevine yields and production of superior wines with lower salt content. Until now, the genetic and mechanistic elements controlling sodium (Na(+) ) exclusion in grapevine were unknown. Using a cross between two Vitis interspecific hybrid rootstocks, we mapped a dominant quantitative trait locus (QTL) associated with leaf Na(+) exclusion (NaE) under salinity stress. The NaE locus encodes six high-affinity potassium transporters (HKT)...
November 21, 2017: New Phytologist
https://www.readbyqxmd.com/read/29159315/l-arginine-biosensors-a-comprehensive-review
#12
REVIEW
Neelam Verma, Ashish Kumar Singh, Minni Singh
Arginine has been considered as the most potent nutraceutics discovered ever, due to its powerful healing property, and it's been known to scientists as the Miracle Molecule. Arginine detection in fermented food products is necessary because, high level of arginine in foods forms ethyl carbamate (EC) during the fermentation process. Therefore, L-arginine detection in fermented food products is very important as a control measure for quality of fermented foods, food supplements and beverages including wine. In clinical analysis arginine detection is important due to their enormous inherent versatility in various metabolic pathways, topmost in the synthesis of Nitric oxide (NO) and tumor growth...
December 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/29158427/do-emotions-related-to-alcohol-consumption-differ-by-alcohol-type-an-international-cross-sectional-survey-of-emotions-associated-with-alcohol-consumption-and-influence-on-drink-choice-in-different-settings
#13
Kathryn Ashton, Mark A Bellis, Alisha R Davies, Karen Hughes, Adam Winstock
OBJECTIVES: To examine the emotions associated with drinking different types of alcohol, explore whether these emotions differ by sociodemographics and alcohol dependency and whether the emotions associated with different drink types influence people's choice of drinks in different settings. DESIGN: International cross-sectional opportunistic survey (Global Drug Survey) using an online anonymous questionnaire in 11 languages promoted through newspapers, magazines and social media from November 2015 to January 2016...
November 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/29156939/phenolic-compounds-as-natural-and-multifunctional-anti-obesity-agents-a-review
#14
Celia Rodríguez-Pérez, Antonio Segura-Carretero, María Del Mar Contreras
Prevalence of obesity worldwide has reached pandemic proportions. Despite the increasing evidence in the implication of phenolic compounds in obesity management, the real effect is not completely understood. The available in vitro and in vivo studies have demonstrated the implication of phenolic compounds in: lowering food intake, decreasing lipogenesis, increasing lipolysis, stimulating fatty acids β-oxidation, inhibiting adipocyte differentiation and growth, attenuating inflammatory responses and suppress oxidative stress...
November 20, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29156243/isolation-identification-and-selection-of-antagonistic-yeast-against-alternaria-alternata-infection-and-tenuazonic-acid-production-in-wine-grapes-from-argentina
#15
Luciana P Prendes, María G Merín, Ariel R Fontana, Rubén A Bottini, María L Ramirez, Vilma I Morata de Ambrosini
Epiphytic isolates with yeast characteristics from grapes of the Malbec cultivar were obtained in order to find antagonists against Alternaria alternata. From a total of 111 isolates, 82% corresponded to the yeast-like organism Aureobasidium pullulans and the rest to the non-Saccharomyces yeasts Hanseniaspora uvarum (6.3%), Metschnikowia pulcherrima or spp. (5.4%), Cryptoccocus laurentti II (2.7%), Starmerella bacilaris or Candida zemplinina (2.7%) and Rhodotorula spp. (0.9%). The 22.4% (15 out of 67) of epiphytic yeasts and yeast-like organisms evaluated were able to reduce A...
November 8, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29155356/refined-assessment-and-perspectives-on-the-cumulative-risk-resulting-from-the-dietary-exposure-to-pesticide-residues-in-the-danish-population
#16
Martin Olof Larsson, Vibe Sloth Nielsen, Niels Bjerre, Frank Laporte, Nina Cedergreen
Relatively few studies are available on realistic cumulative risk assessments for dietary pesticide exposure. Despite available studies showing low risk, public concern remains. A method to estimate realistic residue levels based on information from spraying journals and supervised residue trials was described in a previous publication. The present article proposes a new method to estimate average residue levels in imported foods based on residue monitoring data and knowledge about agronomic practices. The two methods were used in combination to estimate average pesticide residue levels in 47 commodities on the Danish market...
November 16, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29154003/tracing-the-role-of-endogenous-carbon-in-denitrification-using-wine-industry-by-product-as-an-external-electron-donor-coupling-isotopic-tools-with-mathematical-modeling
#17
R Carrey, P Rodríguez-Escales, A Soler, N Otero
Nitrate removal through enhanced biological denitrification (EBD), consisting of the inoculation of an external electron donor, is a feasible solution for the recovery of groundwater quality. In this context, liquid waste from wine industries (wine industry by-products, WIB) may be feasible for use as a reactant to enhance heterotrophic denitrification. To address the feasibility of WIB as electron donor to promote denitrification, as well as to evaluate the role of biomass as a secondary organic C source, a flow-through experiment was carried out...
November 16, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29153090/chiral-analysis-of-3-sulfanylhexan-1-ol-and-3-sulfanylhexyl-acetate-in-wine-by-high-performance-liquid-chromatography-tandem-mass-spectrometry
#18
Liang Chen, Dimitra L Capone, David W Jeffery
A number of polyfunctional thiols are well-recognised as some of the most potent aroma compounds in nature and have been identified in various foods, and beverages such as wine. These potent character impact compounds are present at nanogram-per-litre levels and are particularly challenging to measure. Where present, enantiomeric forms having different odour qualities further complicate the analysis. In this work, a chiral high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) method using stable isotope dilution analysis (SIDA) has been developed and validated for the individual enantiomers of 3-sulfanylhexan-1-ol (3-SH, 1) and its O-acetate, 3-sulfanylhexyl acetate (3-SHA, 2), in wine after extraction as their 4-thiopyridine derivatives...
January 15, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29150706/application-of-directed-evolution-to-develop-ethanol-tolerant-oenococcus-oeni-for-more-efficient-malolactic-fermentation
#19
Alice L Betteridge, Krista M Sumby, Joanna F Sundstrom, Paul R Grbin, Vladimir Jiranek
Malolactic fermentation (MLF) is an important step in winemaking, which can be notoriously unreliable due to the fastidious nature of Oenococcus oeni. This study aimed to use directed evolution (DE) to produce a more robust strain of O. oeni having the ability to withstand high ethanol concentrations. DE involves an organism mutating and potentially adapting to a high stress environment over the course of extended cultivation. A continuous culture of O. oeni was established and exposed to progressively increasing ethanol content such that after approximately 330 generations, an isolate from this culture was able to complete MLF in high ethanol content medium earlier than its parent...
November 17, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29150586/megan-brannigan
#20
Leigh-Anne Brown
An unconventional boss with an astonishing sense of humour, Megan welcomed a diverse team into her practices. She was a humanist, feminist and connoisseur of fine food and wine.
November 18, 2017: Veterinary Record
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