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pediatric nephro

Pierre-Hugues Vivier, Thomas A Augdal, Fred E Avni, Justine Bacchetta, Rolf Beetz, Anna K Bjerre, Johan Blickman, Pierre Cochat, Rosana Coppo, Beatrice Damasio, Kassa Darge, Alaa El-Ghoneimi, Piet Hoebeke, Göran Läckgren, Marc-David Leclair, Maria-Luisa Lobo, Gianantonio Manzoni, Stephen D Marks, Girolamo Mattioli, Hans-Joachim Mentzel, Pierre Mouriquand, Tryggve Nevéus, Aikaterini Ntoulia, Lil-Sofie Ording-Muller, Josef Oswald, Frederica Papadopoulou, Gabriella Porcellini, Ekkehard Ring, Wolfgang Rösch, Ana F Teixeira, Michael Riccabona
To promote the standardization of nephro-uroradiological terms used in children, the European Society of Paediatric Radiology uroradiology taskforce wrote a detailed glossary. This work has been subsequently submitted to European experts in pediatric urology and nephrology for discussion and acceptance to improve the quality of radiological reports and communication between different clinicians involved in pediatric urology and nephrology.
November 15, 2017: Pediatric Radiology
Iosif Mendichovszky, Bernardita Troncoso Solar, Naima Smeulders, Marina Easty, Lorenzo Biassoni
In the context of ante-natally diagnosed hydronephrosis, the vast majority of children with a dilated renal pelvis do not need any surgical treatment, as the dilatation resolves spontaneously with time. Slow drainage demonstrated at Tc-99m-mercaptoacetyltriglycine (MAG3) renography does not necessarily mean obstruction. Obstruction is defined as resistance to urinary outflow with urinary stasis at the level of the pelvic-ureteric junction (PUJ) which, if left untreated, will damage the kidney. Unfortunately this definition is retrospective and not clinically helpful...
May 2017: Seminars in Nuclear Medicine
Kanishka Das, Srinivas Raju Rajkiran
AIM: A solitary functioning renal unit in high anorectal malformation may harbor anomalies in the upper/lower urinary tract that further compromise renal function and accelerate hyperfiltration injury. We aimed to analyze the clinical course, management, and outcome of children with a solitary renal unit and high anorectal malformation. MATERIALS AND METHODS: A cohort of solitary renal units in anorectal malformation managed between 2000 and 2015 with a defined protocol at a pediatric nephro-urology clinic are included in the study...
April 2017: Journal of Indian Association of Pediatric Surgeons
Monika Miklaszewska, Przemysław Korohoda, Katarzyna Zachwieja, Michał Wolnicki, Małgorzata Mizerska-Wasiak, Dorota Drożdż, Jacek A Pietrzyk
Myelomeningocele (MMC) results from a failure of normal neural tube fusion in early fetal development. Retrospective, observational study of medical data of 54 children treated in Pediatric Nephrology and Urology Clinics for five years was performed. The following data were analyzed: serum creatinine, eGFR, urine analysis, renal scintigraphy (RS), renal ultrasound, and urodynamics. Mean age of studied population: 12.3 years, median of eGFR at the beginning and at the end of survey was 110.25 and 116.5 mL/min/1...
September 1, 2016: International Journal of Environmental Research and Public Health
Vered Shkalim-Zemer, Shifra Ash, Helen Toledano, Yehuda Kollender, Josephine Issakov, Isaac Yaniv, Ian J Cohen
PURPOSE: Aggressive chemotherapy protocols for non-metastatic limb osteosarcoma have improved histological response without affecting prognosis. This study evaluated the toxicity and outcome of a dose-intensive, high-dose 3- to 5-drug pilot protocol, SCOS 89. METHODS: The cohort included 26 patients (14 male; ages 6.5-22 years) with non-metastatic limb osteosarcoma treated at a tertiary pediatric medical center between 1989 and 2013. Preoperatively, patients received two courses of once-weekly pulses of high-dose methotrexate (12-30 g/m(2)) for 2 weeks; doxorubicin (90 mg/m(2)) with dexrazoxane, combined with cisplatin (200 mg/m(2)), was added in week 3...
November 2015: Cancer Chemotherapy and Pharmacology
Srivandana Akshintala, Leigh Marcus, Katherine E Warren, Robert F Murphy, Tristan M Sissung, Anjali Srivastava, Wendy J Goodspeed, Anne Goodwin, Carmen C Brewer, Christopher Zalewski, Kelly A King, AeRang Kim, William D Figg, Brigitte C Widemann
BACKGROUND: Based on pre-clinical and clinical activity in adult refractory tumors, and absence of significant neuro-, nephro-, or oto-toxicity, we conducted a pediatric phase 1 trial to determine the toxicities, maximum tolerated dose (MTD), and pharmacokinetics of satraplatin, an oral platinum analogue, in children and young adults with refractory solid tumors. PROCEDURE: Satraplatin was administered orally once daily on days 1-5 of a 28-day cycle at dose level (DL) 1 (60 mg/m(2) /dose), and DL2 (80 mg/m(2) /dose)...
April 2015: Pediatric Blood & Cancer
C Montalvo Avalos, A Gómez Farpón, N Vega Mata, A López López, M Oviedo Gutiérrez, J A Alvarez Zapico
OBJECTIVES: To determine clinical, epidemiological and therapeutic characteristics of pediatric urolithiasis in our institution. MATERIAL AND METHODS: We reviewed retrospectively patients diagnosed with urolithiasis between 1998 and 2010 in our hospital. RESULTS: A total of 32 patients (19 males and 13 females) with a mean age of 4.5 years (SD 1.9) were studied. 72% had a history of metabolic or nephro-urological malformations. The most common presentation was urinary tract infection (53%) and abdominal pain (21%)...
July 2013: Cirugía Pediátrica: Organo Oficial de la Sociedad Española de Cirugía Pediátrica
Dorota Drozdz, Kalina Kawecka-Jaszcz
It is well established that elevated blood pressure constitutes a major risk factor for coronary heart disease, arrythmias, heart failure, cerebrovascular disease, peripheral artery disease and renal failure. Blood pressure level and the duration of arterial hypertension (HTN) impact target organ damage. Many studies in adults have demonstrated the role of antihypertensive therapy in preventing cardiovascular (CV) events. The so-called hard end-points, such as death, myocardial infarction (MI) or stroke, are rarely seen in children, but intermediate target organ damage, including left ventricular hypertrophy, increased intima-media thickness and microalbuminuria, is already detectable during childhood...
September 2014: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Surasak Sangkhathat, Samornmas Kanngurn, Welawee Chaiyapan, Podchanaporn Gridist, Wanwisa Maneechay
Wilms' tumor 1 gene (WT1) is known to be a tumor suppressor gene in the subset of nephroblastomas that harbors WT1 mutations. However, its role in nephroblastomas without mutations remains unclear. This study aimed to evaluate the expression of WT1 and its potential oncogenic role in pediatric nephroblastoma with wild-type WT1. A total of 24 nephroblastomas were studied for WT1 mRNA expression by quantitative reverse-transcription polymerase chain reaction. The expression levels were compared between nephro-blastomas with and without WT1 mutations, as well as to normal kidney tissue, other pediatric renal tumors and neuroblastomas...
July 2010: Oncology Letters
Filipa Caldeira, Carla Juvandes, Margarida Pinto, Manuela Braga, Paulo Calhau
INTRODUCTION: Multicystic dysplastic kidney (MDK) is one of the most common congenital anomalies of the urinary tract and the main cystic renal disease in children. Our institution follow-up protocol of MDK uses, as has been performed more widely in the last two decades, a conservative attitude. OBJECTIVES: To characterize MDK cases followed in our Outpatient Clinic of Pediatric Nephrology, evaluate their progress and reflect on the protocol adopted. METHODS: 36 MDK patients observed between January 1995 and December 2009 were included in this retrospective study and followed-up...
December 2011: Acta Médica Portuguesa
Marta Hegyi, Agnes Gulácsi, Edit Cságoly, Katalin Csordás, Olivér T Eipel, Dániel J Erdélyi, Judit Müller, Karolina Nemes, Orsolya Lautner-Csorba, Gábor T Kovács
PURPOSE: High-dose methotrexate (HD-MTX) with leucovorin rescue is widely used to treat osteosarcoma. Our objectives were to assess correlations between pharmacokinetic parameters and the outcome of osteosarcoma and to analyze the relation between HD-MTX exposure and toxicity. METHODS: Pharmacokinetic data of 105 patients with osteosarcoma treated with 989 HD-MTX courses were evaluated. Pharmacokinetic parameters (clearance, half-life and AUC) were calculated based on methotrexate (MTX) serum levels measured at 6, 24, 36, 48 h after the initiation of the infusion...
October 2012: Journal of Cancer Research and Clinical Oncology
Alex M Barnacle, Derek J Roebuck, John M Racadio
Nephro-urological interventions developed in adult practice are highly transferable to the pediatric setting, and their use has widened the role of interventional radiology in the management of renal tract pathology in spheres such as oncology and urolithiasis. The emerging evidence is that these procedures are safe and effective in children and their use should be encouraged. Many of the techniques are similar to those used in adults. There are, however, subtle but important pediatric tips and tricks available that serve to minimize risk to the child and increase the chances of technical success...
December 2010: Techniques in Vascular and Interventional Radiology
Jameela A Kari, Manal Halawani, Ghadeer Mokhtar, Sawsan M Jalalah, Wasim Anshasi
Steroid resistant nephrotic syndrome (SRNS) remains a challenge facing pediatric nephrologists. The underlying histopathology usually affects the course of the disease and the response to treatment. We studied the pattern of histopathology in children with SRNS who presented to the King Abdul Aziz University Hospital (KAUH), Jeddah, Saudi Arabia. The records of all children with primary SRNS, who were seen between 2002 and 2007 were reviewed. Only patients who had undergone a renal biopsy were included in the study...
September 2009: Saudi Journal of Kidney Diseases and Transplantation
Piotr Czarniak, Aleksandra Zurowska, Przemysław Szcześniak, Magdalena Drozyńska-Duklas, Michał Maternik, Andrzej Gołebiewski, Leszek Komasara, Krzysztof Preis, Iwona Domzalska, Alicja Sowa
UNLABELLED: Antenatal hydronephrosis is one of the most frequently diagnosed congenital abnormalities in the fetus. The aim of the study is to present the preliminary results of a newly launched Pommeranian Program for Early Management of CAKUT in Children. MATERIAL AND METHODS: 105 neonates and infants with hydronephrosis were assessed between Jan and Dec 2007 (27 girls and 78 boys). All patients had postnatal ultrasound performed. Static and dynamic scyntigraphy and cystography were performed according to set indications...
April 2009: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Piotr Czarniak, Aleksandra Zurowska, Andrzej Gołebiewski, Leszek Komasara, Krzysztof Preis, Iwona Domzalska-Popadiuk, Alicja Sowa
Congenital anomalies of kidney and urinary tract (CAKUT) are the main cause of end stage renal disease in childhood. Early prenatal detection with planned postnatal diagnosis and therapy are the mainstay of management of neonates with CAKUT which is aimed at the conservation of renal tissue. The above assumptions led to the establishment of the Pommeranian Program for Management of Children with CAKUT. The strategy of the program is to coordinate prenatal diagnosis performed by obstetricians, postnatal care by neonatologists and early management by pediatric nephrologists and urologists...
April 2009: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Cristina M Bouissou Soares, José Silvério S Diniz, Eleonora M Lima, Jose M Penido Silva, Gilce R Oliveira, Monica R Canhestro, Enrico A Colosimo, Ana Cristina Simoes e Silva, Eduardo A Oliveira
The purpose of this retrospective cohort study was to describe the outcome of 107 patients with chronic kidney disease (CKD) admitted to a pre-dialysis interdisciplinary management program from 1990 to 2006. The events of interest were progression to CKD stage 5 (renal survival), patient survival, hypertension, and somatic growth. Survival was studied by the Kaplan-Meier method. Patients were classified into four groups according to their primary renal disease: congenital nephro-uropathies; glomerular diseases; cystic disease, and miscellaneous...
November 2008: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Ibasdin Okoeguale Michael, Ofovwe Egberue Gabriel
To document the pattern of childhood renal diseases in the mid-western zone of Nigeria, we evaluated 195 children in the pediatric in-patient service at the University of Benin Teaching Hospital (UBTH) from 1997-2002. There were 250 renal disease episodes that occurred in 195 children. Renal disease accounted for 4.5% of total pediatric admissions. Urinary tract infection (UTI) was found in 82 (32.8%) cases caused largely by Escherichia coli in 39 (47.6%) followed by Staphylococcus aureus in 21 (25.6%). Other morbidities were nephrotic syndrome 61(24...
October 2003: Saudi Journal of Kidney Diseases and Transplantation
Amela Begić
Urinary tract diseases are common problem that, if untraeted may lead to progressive renal damage. Interpretation of a dynamic renal study includes evaluation of the parenchimal phase, the cortical transit time and the urine drainage phase. The diagnosis and management of urinary tract obstruction is an important problem in both pediatric and adult urology. For the study of urinary tract obstruction, conventional radionuclide renography has been modified to include, the administration of a potent diuretic. Dynamic renal study accurately reflect the functional status of each kidney...
2006: Medicinski Arhiv
Amy Piepsz, Hamphrey R Ham
This review should be regarded as an opinion based on personal experience, clinical and experimental studies, and many discussions with colleagues. It covers the main radionuclide procedures for nephro-urological diseases in children. Glomerular filtration rate can be accurately determined using simplified 2- or 1-blood sample plasma clearance methods. Minor controversies related to the technical aspects of these methods concern principally some correction factors, the quality control, and the normal values in children...
January 2006: Seminars in Nuclear Medicine
K Weisser, K Bauer, P Volkers, B Keller-Stanislawski
Thiomersal was used in the 1930s for the first time for the preservation of vaccines to prevent bacterial and fungal contamination. Thiomersal is an organic compound containing 49% mercury (Hg) by weight. It is generally well known that mercury and its compounds, including thiomersal, ethylmercury, and methylmercury, act as nephro- and neurotoxicants, however, at much higher doses than used in vaccines. In the 1990s the question of toxicity of thiomersal in vaccines was reassessed since the numbers of vaccines recommended for routine administration to infants and children, and therefore the cumulative thiomersal dose in children, increased in some countries...
December 2004: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
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