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https://www.readbyqxmd.com/read/29352744/crystal-structure-of-adp-dependent-glucokinase-from-methanocaldococcus-jannaschii-in-complex-with-5-iodotubercidin-reveals-phosphoryl-transfer-mechanism
#1
Piotr Tokarz, Magdalena Wiśniewska, Marcin M Kamiński, Grzegorz Dubin, Przemysław Grudnik
ADP-dependent glucokinase (ADPGK) is an alternative novel glucose phosphorylating enzyme in a modified glycolysis pathway of hyperthermophilic Archaea. In contrast to classical ATP-dependent hexokinases, ADPGK utilizes ADP as a phosphoryl group donor. Here we present a crystal structure of archaeal ADPGK from Methanocaldococcus jannaschii in complex with an inhibitor, 5-iodotubercidin, D-glucose, inorganic phosphate and a magnesium ion. Detailed analysis of the architecture of the active site allowed for confirmation of the previously proposed phosphorylation mechanism and the crucial role of the invariant arginine residue (Arg197)...
January 20, 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29352610/neural-representation-of-octave-illusion-in-the-human-cortex-revealed-with-functional-magnetic-resonance-imaging
#2
Keita Tanaka, Hiroki Kurasaki, Shinya Kuriki
The auditory "octave illusion" arises when dichotic tones, presented one octave apart, alternate rapidly between the ears. This study aimed to explore the link between the perception of illusory pitches and brain activity during presentation of dichotic tones. We conducted a behavioral study of how participants perceived binaural dichotic tones of octave illusions and classified them, based on the reported percepts, in an illusion (ILL) group, without an illusion (non-ILL) group, and others. We recorded brain activity using functional magnetic resonance imaging and analyzed the activation due to dichotic illusion tones...
January 8, 2018: Hearing Research
https://www.readbyqxmd.com/read/29352511/draft-genome-and-reference-transcriptomic-resources-for-the-urticating-pine-defoliator-thaumetopoea-pityocampa-lepidoptera-notodontidae
#3
B Gschloessl, F Dorkeld, H Berges, G Beydon, O Bouchez, M Branco, A Bretaudeau, C Burban, E Dubois, P Gauthier, E Lhuillier, J Nichols, S Nidelet, S Rocha, L Sauné, R Streiff, M Gautier, C Kerdelhué
The pine processionary moth Thaumetopoea pityocampa (Lepidoptera: Notodontidae) is the main pine defoliator in the Mediterranean region. Its urticating larvae cause severe human and animal health concerns in the invaded areas. This species shows a high phenotypic variability for various traits, such as phenology, fecundity, and tolerance to extreme temperatures. This study presents the construction and analysis of extensive genomic and transcriptomic resources, which are an obligate prerequisite to understand their underlying genetic architecture...
January 20, 2018: Molecular Ecology Resources
https://www.readbyqxmd.com/read/29352127/structural-covariance-of-gray-matter-volume-in-hiv-vertically-infected-adolescents
#4
Jielan Li, Lei Gao, Zhi Wen, Jing Zhang, Panying Wang, Ning Tu, Hao Lei, Fuchun Lin, Xi'en Gui, Guangyao Wu
Human immunodeficiency virus (HIV) infection significantly affect neurodevelopmental and behavioral outcomes. We investigated whether alterations of gray matter organization and structural covariance networks with vertical HIV infection adolescents exist, by using the GAT toolbox. MRI data were analysed from 25 HIV vertically infected adolescents and 33 HIV-exposed-uninfected control participants. The gray matter volume (GMV) was calculated, and structural brain networks were reconstructed from gray matter co-variance...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352126/role-of-subcortical-structures-on-cognitive-and-social-function-in-schizophrenia
#5
Daisuke Koshiyama, Masaki Fukunaga, Naohiro Okada, Fumio Yamashita, Hidenaga Yamamori, Yuka Yasuda, Michiko Fujimoto, Kazutaka Ohi, Haruo Fujino, Yoshiyuki Watanabe, Kiyoto Kasai, Ryota Hashimoto
Subcortical regions have a pivotal role in cognitive, affective, and social functions in humans, and the structural and functional abnormalities of the regions have been associated with various psychiatric disorders. Although previous studies focused on the neurocognitive and socio-functional consequences of prefrontal and tempolo-limbic abnormalities in psychiatric disorders, those of subcortical structures remain largely unknown. Recently, MRI volume alterations in subcortical structures in patients with schizophrenia have been replicated in large-scale meta-analytic studies...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29352073/right-ventricular-myofilament-functional-differences-in-humans-with-systemic-sclerosis-associated-versus-idiopathic-pulmonary-arterial-hypertension
#6
Steven Hsu, Kristen M Kokkonen-Simon, Jonathan A Kirk, Todd M Kolb, Rachel L Damico, Stephen C Mathai, Monica Mukherjee, Ami A Shah, Fredrick M Wigley, Kenneth B Margulies, Paul M Hassoun, Marc K Halushka, Ryan J Tedford, David A Kass
Background -Patients with systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH) have a far worse prognosis than those with idiopathic PAH (IPAH). In the intact heart, SSc-PAH exhibits depressed rest and reserve right ventricular (RV) contractility as compared to IPAH. We tested whether this disparity involves underlying differences in myofilament function. Methods -Cardiac myocytes were isolated from RV septal endomyocardial biopsies from patients with SSc-PAH, IPAH, or SSc with exertional dyspnea but no resting PAH (SSc-d); control RV septal tissue was obtained from non-diseased donor hearts (6-7/group)...
January 19, 2018: Circulation
https://www.readbyqxmd.com/read/29351467/from-ionic-to-cellular-variability-in-human-atrial-myocytes-an-integrative-computational-and-experimental-study
#7
Anna Muszkiewicz, Xing Liu, Alfonso Bueno-Orovio, Brodie A J Lawson, Kevin Burrage, Barbara Casadei, Blanca Rodriguez
Variability refers to differences in physiological function between individuals, which may translate into different disease susceptibility and treatment efficacy. Experiments in human cardiomyocytes face wide variability and restricted tissue access; under these conditions computational models are a useful complementary tool. We conducted a computational and experimental investigation in cardiomyocytes isolated from samples of the right atrial appendage of patients undergoing cardiac surgery to evaluate the impact of variability in action potentials (APs) and sub-cellular ionic densities on calcium transient dynamics...
December 22, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29351431/feasibility-of-phase-contrast-cine-magnetic-resonance-imaging-for-measuring-blood-flow-in-the-sheep-fetus
#8
An Qi Duan, Jack R T Darby, Jia Yin Soo, Mitchell C Lock, Meng Yuan Zhu, Lucy V Flynn, Sunthara Rajan Perumal, Christopher K Macgowan, Joseph B Selvanayagam, Janna L Morrison, Mike Seed
Phase-contrast cine MRI (PC-MRI) is the gold-standard non-invasive technique for measuring vessel blood flow and has previously been applied in the human fetal circulation. We aimed to assess the feasibility of using PC-MRI to define the distribution of the fetal circulation in sheep. Fetuses were catheterized at 119-120 days gestation (term, 150 days) and underwent MRI at 123 days gestation under isoflurane anesthesia, ventilated at a FiO2 of 1.0. PC-MRI was performed using a fetal arterial blood pressure catheter signal for cardiac triggering...
December 13, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29351369/heparin-but-not-tissue-plasminogen-activator-improves-outcomes-in-dcd-liver-transplantation-in-a-porcine-model
#9
Amelia J Hessheimer, Marina Vendrell, Javier Muñoz, Ángel Ruíz, Alba Díaz, Luís Flores Sigüenza, Jorge Rodríguez Lanzilotta, Eduardo Delgado Oliver, Jose Fuster, Miquel Navasa, Juan Carlos García-Valdecasas, Pilar Taurá, Constantino Fondevila
BACKGROUND: Ischemic type biliary lesions arise most frequently after DCD liver transplantation and result in high morbidity and graft loss. Many DCD grafts are discarded out of fear for this complication. In theory, microvascular thrombi deposited during donor warm ischemia might be implicated in ITBL pathogenesis. Herein, we aim to evaluate the effects of the administration of either heparin or the fibrinolytic drug TPA as means to improve DCD liver graft quality and potentially avoid ITBL...
January 19, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29351262/imu-to-segment-assignment-and-orientation-alignment-for-the-lower-body-using-deep-learning
#10
Tobias Zimmermann, Bertram Taetz, Gabriele Bleser
Human body motion analysis based on wearable inertial measurement units (IMUs) receives a lot of attention from both the research community and the and industrial community. This is due to the significant role in, for instance, mobile health systems, sports and human computer interaction. In sensor based activity recognition, one of the major issues for obtaining reliable results is the sensor placement/assignment on the body. For inertial motion capture (joint kinematics estimation) and analysis, the IMU-to-segment (I2S) assignment and alignment are central issues to obtain biomechanical joint angles...
January 19, 2018: Sensors
https://www.readbyqxmd.com/read/29350887/species-specific-clinical-characteristics-of-human-coronavirus-infection-among-otherwise-healthy-adolescents-and-adults
#11
Monique Bouvier, Wei-Ju Chen, John C Arnold, Mary P Fairchok, Patrick J Danaher, Tahaniyat Lalani, Leslie Malone, Deepika Mor, Michelande Ridoré, Timothy H Burgess, Eugene V Millar
Human coronavirus (HCoV) is a known cause of influenza-like illness (ILI). In a multi-site, observational, longitudinal study of ILI among otherwise healthy adolescents and adults, 12% of subjects were PCR-positive for HCoV. The distribution of species was as follows: HCoV-OC43 (34%), HCoV-229E (28%), HCoV-NL63 (22%), and HCoV-HKU1 (16%). We did not observe species-specific differences in the clinical characteristics of HCoV infection, with the exception of HCoV-HKU1, for which the severity of gastrointestinal symptoms trended higher on the fourth day of illness...
January 19, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29350881/interferon-induced-protein-35-ifi35-inhibits-endothelial-cell-proliferation-migration-and-re-endothelialization-of-injured-arteries-by-inhibiting-the-nuclear-factor-kappa-b-nf-kb-pathway
#12
Dongdong Jian, Weina Wang, Xinmiao Zhou, Zhen Jia, Jing Wang, Mei Yang, Wenting Zhao, Zhen Jiang, Xiaotong Hu, Jianhua Zhu
AIM: Endothelial recovery, or re-endothelialization, plays an important role in intimal hyperplasia and atherosclerosis after endothelial injury. Studying the mechanisms of re-endothelialization and strategies to promote efficient endothelial recovery are still needed. Interferon-induced protein 35 (IFI35) is an IFN-γ-induced protein that plays important roles in the anti-virus-related immune-inflammatory response. In this study, we tested whether overexpression IFI35 affects the proliferation and migration of endothelial cells (ECs) and re-endothelialization...
January 19, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29350877/effects-of-human-rhinovirus-on-epithelial-barrier-integrity-and-function-in-children-with-asthma
#13
Kevin Looi, Alysia G Buckley, Paul J Rigby, Luke W Garratt, Thomas Iosifidis, Graeme R Zosky, Alexander N Larcombe, Francis J Lannigan, Kak-Ming Ling, Kelly M Martinovich, Elizabeth Kicic-Starcevich, Nicole C Shaw, Erika N Sutanto, Darryl A Knight, Anthony Kicic, Stephen M Stick
BACKGROUND: Bronchial epithelial tight junctions (TJ) have been extensively assessed in healthy airway epithelium. However, no studies have yet assessed the effect of human rhinovirus (HRV) infection on the expression and resultant barrier function in epithelial tight junctions (TJ) in childhood asthma. OBJECTIVES: To investigate the impact of HRV infection on airway epithelial TJ expression and barrier function in airway epithelial cells (AEC) of children with and without asthma...
January 19, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29350833/platelets-kill-bacteria-by-bridging-innate-and-adaptive-immunity-via-pf4-and-fc%C3%AE-riia
#14
R Palankar, T P Kohler, K Krauel, J Wesche, S Hammerschmidt, A Greinacher
BACKGROUND: Activated platelets release the chemokine platelet factor 4 (PF4) stored in their granules. PF4 binds to polyanions (P) on bacteria, undergoes a conformational change and exposes neoepitopes. These neoepitopes induce production of anti-PF4/P antibodies. As PF4 binds to a variety of bacteria, anti-PF4/P IgG can bind and opsonize several bacterial species. OBJECTIVE: Here we investigated whether platelets are able to kill bacteria directly after recognizing anti-PF4/P IgG opsonized bacteria in the presence of PF4 via their FcγRIIA...
January 19, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29350807/mait-cells-and-viruses
#15
James E Ussher, Christian B Willberg, Paul Klenerman
Mucosal associated invariant T cells (MAIT cells) bear a T cell receptor (TCR) that specifically targets microbially-derived metabolites. Functionally they respond to bacteria and yeasts, which possess the riboflavin pathway, essential for production of such metabolites and which are presented on MR1. Viruses cannot generate these ligands, so a priori, they should not be recognized by MAIT cells and indeed this is true when considering recognition through the TCR. However, MAIT cells are distinctive in another respect, since they respond quite sensitively to non-TCR signals, especially in the form of inflammatory cytokines...
January 19, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29350771/recombinant-relaxin-protects-liver-transplants-from-ischemia-damage-via-hepatocyte-glucocorticoid-receptor-from-bench-to-bedside
#16
Shoichi Kageyama, Kojiro Nakamura, Takehiro Fujii, Bibo Ke, Rebecca A Sosa, Elaine F Reed, Nakul Datta, Ali Zarrinpar, Ronald W Busuttil, Jerzy W Kupiec-Weglinski
Hepatic ischemia-reperfusion injury (IRI) represents a major risk factor of early graft dysfunction and acute/chronic rejection as well as a key obstacle to expanding the donor pool in orthotopic liver transplantation (OLT). Although glucocorticoid receptor (GR) signaling may enhance cytoprotective programs, clinical use of glucocorticoid is limited due to adverse effects, while clinical relevance of GR-facilitated cytoprotection in OLT remains unknown. We aimed to evaluate the significance of hepatic GR in clinical OLT and verify the impact of recombinant human relaxin (rhRLX), which may function as GR agonist in tissue/disease-specific manner...
January 19, 2018: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29350763/molecular-allergen-profiling-in-horses-by-microarray-reveals-fag-e-2-from-buckwheat-as-a-frequent-sensitizer
#17
L Einhorn, G Hofstetter, S Brandt, E K Hainisch, I Fukuda, K Kusano, A Scheynius, I Mittermann, Y Resch-Marat, S Vrtala, R Valenta, E Marti, C Rhyner, R Crameri, R Satoh, R Teshima, A Tanaka, H Sato, H Matsuda, I Pali-Schöll, E Jensen-Jarolim
BACKGROUND: Companion animals are also affected by IgE-mediated allergies, but the eliciting molecules are largely unknown. We aimed at refining an allergen microarray to explore sensitization in horses and compare it to the human IgE reactivity profiles. METHODS: Custom-designed allergen microarray was produced on the basis of the IimmunoCAP ISAC technology containing 131 allergens. Sera from 51 horses derived from Europe or Japan were tested for specific IgE reactivity...
January 19, 2018: Allergy
https://www.readbyqxmd.com/read/29350756/cytocompatibility-of-biodentine-and-iroot-fs-with-human-periodontal-ligament-cells-an-in-vitro-study
#18
T Luo, J Liu, Y Sun, Y Shen, L Zou
AIM: To evaluate the cytocompatibility of Biodentine and iRoot FS with human periodontal ligament cells (hPDLCs). METHODOLOGY: hPDLCs were characterized by flow cytometry and immunocytochemical analysis. hPDLC adhesion was assessed by scanning electron microscopy at day 3; proliferation by live/dead assay at day 1, 3 and 7; and osteogenic differentiation by alkaline phosphatase (ALP) activity staining, ALP quantification analysis and qRT-PCR at day 7 and 14. Data were analysed with ANOVA and independent sample t-tests with SPSS 21...
January 19, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29350418/species-differences-in-circulation-and-inflammatory-responses-in-children-with-common-respiratory-adenovirus-infections
#19
Haruna Nakamura, Takao Fujisawa, Shigeru Suga, Kiyosu Taniguchi, Mizuho Nagao, Masahiro Ito, Hitoshi Ochiai, Masami Konagaya, Nozomu Hanaoka, Tsuguto Fujimoto
BACKGROUND: Human adenoviruses (HAdVs) cause severe inflammatory respiratory infections, but previous epidemiological studies lacked analysis of the characteristics of the inflammation. METHODS: Consecutive patients <13 years old with acute febrile illness during a 2-year period were tested. HAdV strains were isolated from nasopharyngeal swabs, and molecular identification was performed by hexon, fiber and species-specific PCR methods. Blood inflammatory markers, including the white blood cell (WBC) count, CRP and 29 cytokines, were measured...
January 19, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29350399/biological-functions-of-elabela-a-novel-endogenous-ligand-of-apj-receptor
#20
REVIEW
Jin Xu, Linxi Chen, Zhisheng Jiang, Lanfang Li
The G protein-coupled receptor APJ and its cognate ligand, apelin, are widely expressed throughout human body. They are implicated in different key physiological processes such as angiogenesis, cardiovascular functions, fluid homeostasis and energy metabolism regulation. Recently, a new endogenous peptidic ligand of APJ, named Elabela, has been identified and shown to play a crucial role in embryonic development. In addition, increasing evidences show that Elabela is also intimate associated with a large number of physiological processes in adulthood...
January 19, 2018: Journal of Cellular Physiology
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