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https://www.readbyqxmd.com/read/29783254/-legal-bases-of-vaccination-in-ukraine
#1
Olena O Terzi
OBJECTIVE: Introduction: Despite the extraordinary progress made in the field of vaccination, a large number of children in the last decade, 24 million children, or nearly 20% of children born every year, do not receive a full plan for vaccination during their first year of life. The aim: The purpose of the article is to analyze the legal framework of vaccination in Ukraine, comparing the approach of the domestic legislator to the vaccination with foreign experience. PATIENTS AND METHODS: Materials and methods: Methods of research are selected based on the goal of the study...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29782576/self-represented-witnessing-the-use-of-social-media-by-asylum-seekers-in-australia-s-offshore-immigration-detention-centres
#2
Maria Rae, Rosa Holman, Amy Nethery
The act of witnessing connects audiences with distant suffering. But what happens when bearing witness becomes severely restricted? External parties, including the mainstream news media, are constrained from accessing Australia's offshore immigration detention centres. The effect is that people seeking asylum are hidden from the public and excluded from national debates. Some detainees have adopted social media as a platform to communicate their stories of flight, and their experiences of immigration detention, to a wider audience...
May 2018: Media, culture, and society
https://www.readbyqxmd.com/read/29782490/an-optimized-digital-watermarking-algorithm-in-wavelet-domain-based-on-differential-evolution-for-color-image
#3
Xinchun Cui, Yuying Niu, Xiangwei Zheng, Yingshuai Han
In this paper, a new color watermarking algorithm based on differential evolution is proposed. A color host image is first converted from RGB space to YIQ space, which is more suitable for the human visual system. Then, apply three-level discrete wavelet transformation to luminance component Y and generate four different frequency sub-bands. After that, perform singular value decomposition on these sub-bands. In the watermark embedding process, apply discrete wavelet transformation to a watermark image after the scrambling encryption processing...
2018: PloS One
https://www.readbyqxmd.com/read/29782041/meta-analysis-of-brain-mechanisms-of-chewing-and-clenching-movements
#4
Chia-Shu Lin
BACKGROUND: Functional magnetic resonance imaging (fMRI) is widely used for investigating brain activation patterns associated with chewing and clenching movements. Whether studies consistently identify similar brain loci engaged in these movements remains unknown. OBJECTIVE: We investigated the consistency with which specific brain loci were reported to be activated during teeth-occluding movements, using the activation likelihood estimation (ALE) meta-analysis...
May 21, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29781972/human-trafficking-how-nurses-can-make-a-difference
#5
Meredith Scannell, Andrea E MacDonald, Amanda Berger, Nichole Boyer
Human trafficking is a human rights violation and a global health problem. Victims of human trafficking have medical and mental health sequelae requiring specific healthcare interventions. Healthcare professionals may be the initial contact that these victims make outside the world of trafficking. Healthcare professionals are key agents in the identification of human trafficking, which is essential in eliminating this public health problem. Unfortunately, healthcare professionals are not always able to detect signs of human trafficking...
April 2018: Journal of Forensic Nursing
https://www.readbyqxmd.com/read/29781971/sexual-assault-nurse-examiner-forensic-examinations-for-immigrant-victims-a-case-study
#6
Amanda Payne
This case study examines how sexual assault nurse examiners (SANEs) in the United States are in a unique position to provide valuable medical forensic documentation for immigrant victims. In addition to providing evidence to solve crimes domestically, SANEs may help victims of persecution and human rights violations receive legally protected immigration status. Incorporating The Istanbul Protocol into practice provides SANEs with a tool to advocate for and protect the rights of immigrant victims both domestically and abroad...
April 2018: Journal of Forensic Nursing
https://www.readbyqxmd.com/read/29781969/an-ecological-approach-toward-prevention-and-care-of-victims-of-domestic-minor-sex-trafficking
#7
Rosario V Sanchez, Dula F Pacquiao
Sex trafficking is a widespread form of human trafficking that exists globally. The forced sexual exploitation of young women for profit at the hands of traffickers is a human rights violation. Sex trafficking is a form of modern-day slavery where youths are sold as a commodity. It is difficult to determine the wide range of negative health outcomes associated with domestic minor sex trafficking due to the hidden nature of the crime and its lack of statistical data to determine prevalence. Viewing domestic minor sex trafficking through an ecological lens assists in the understanding of the multiple complex interactions between victims, their relationships, and environments that influence their health...
April 2018: Journal of Forensic Nursing
https://www.readbyqxmd.com/read/29781692/significance-of-mental-health-legislation-for-successful-primary-care-for-mental-health-and-community-mental-health-services-a-review
#8
Getinet Ayano
BACKGROUND:  Mental health legislation (MHL) is required to ensure a regulatory framework for mental health services and other providers of treatment and care, and to ensure that the public and people with a mental illness are afforded protection from the often-devastating consequences of mental illness. AIMS:  To provide an overview of evidence on the significance of MHL for successful primary care for mental health and community mental health servicesMethod: A qualitative review of the literature on the significance of MHL for successful primary care for mental health and community mental health services was conducted...
March 29, 2018: African Journal of Primary Health Care & Family Medicine
https://www.readbyqxmd.com/read/29781582/sphingosine-1-phosphate-receptor-1-signaling-maintains-endothelial-cell-barrier-function-and-protects-against-immune-complex-induced-vascular-injury
#9
Nathalie Burg, Steven Swendeman, Stefan Worgall, Timothy Hla, Jane E Salmon
OBJECTIVE: Immune complex (IC) deposition activates neutrophils (PMN), increases vascular permeability and leads to organ damage in SLE and RA. The bioactive lipid sphingosine-1-phosphate (S1P), acting via S1P receptor 1 (S1P1 ), is a key regulator of endothelial cell (EC) barrier function. We hypothesized that augmenting EC integrity via S1P1 signaling would attenuate inflammatory injury mediated by ICs. METHODS: In vitro barrier function was assessed in human umbilical vein endothelial cells (HUVECs) by Electric Cell-substrate Impedance Sensing (ECIS)...
May 21, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29781574/melanocyte-development-in-the-mouse-tail-epidermis-requires-the-adamts9-metalloproteinase
#10
Grace Tharmarajah, Ulrich Eckhard, Fagun Jain, Giada Marino, Anna Prudova, Oscar Urtatiz, Helmut Fuchs, Martin Hrabe de Angelis, Christopher M Overall, Catherine D Van Raamsdonk
The mouse tail has an important role in the study of melanogenesis, because mouse tail skin can be used to model human skin pigmentation. To better understand the development of melanocytes in the mouse tail, we cloned two dominant ENU-generated mutations of the Adamts9 gene, Und3 and Und4, which cause an unpigmented ring of epidermis in the middle of the tail, but do not alter pigmentation in the rest of the mouse. Adamts9 encodes a widely expressed zinc metalloprotease with thrombospondin type 1 repeats with few known substrates...
May 21, 2018: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29781566/the-5-ht7-receptor-is-up-regulated-in-onuf-s-nucleus-in-rats-with-chronic-spinal-cord-injury
#11
Jianshu Ni, Nailong Cao, Xiaohu Wang, Changsheng Zhan, Jiemin Si, Baojun Gu, Karl-Erik Andersson
OBJECTIVES: To examine the effect of intrathecal 5-HT7 agonist administration on voiding function in urethane-anesthetized rat, and the change of 5-HT7 receptor expression in lumbosacral cord Onuf's nucleus after SCI. MATERIALS AND METHODS: Thirty-two female Sprague-Dawley (SD) rats were divided into spinally intact (SI) group and SCI group (n=16 each). Eight weeks after transection, half of the rats underwent continuous cystometry under urethane anesthetization, and the 5-HT7 selective agonist LP44 was given intrathecally...
May 21, 2018: BJU International
https://www.readbyqxmd.com/read/29781547/altered-expression-of-matrix-remodeling-associated-7-mxra7-in-psoriatic-epidermis-evidence-for-a-protective-role-in-the-psoriasis-imiquimod-mouse-model
#12
Jinling Ning, Ying Shen, Ting Wang, Mengru Wang, Wei Liu, Yonghu Sun, Furen Zhang, Lingling Chen, Yiqiang Wang
Preliminary datamining performed with Gene Expression Omnibus datasets implied that psoriasis may involve the matrix remodeling associated 7 (MXRA7), a gene with little function information yet. To test that hypothesis, studies were performed in human samples and murine models. Immunohistochemistry in normal human skin showed that MXRA7 proteins were present across the full epidermal layer, with highest expression level detected in the basal layer. In psoriatic samples, MXRA7 proteins were absent in the basal stem cells layer while suprabasal keratinocytes stained at a higher level than in normal tissues...
May 21, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29781531/down-regulation-of-kif2a-inhibits-gastric-cancer-cell-invasion-via-suppressing-mt1-mmp
#13
Peng Zhao, Fei Lan, Hui Zhang, Guangwei Zeng, Dong Liu
Gastric cancer accounts for a sizeable proportion of global cancer mortality with high morbidity and poor prognosis. Kinesin superfamily proteins (KIFs) are microtubule-dependent motor proteins that function as oncogenes in cancer cells, it has been discovered in recent years. Kinesin family member 2a (KIF2A), a member of KIFs, has received attention for its role in carcinogenesis and its prognostic value in several human cancers such as breast cancer, colorectal cancer, and squamous cell carcinoma. However, the role of KIF2A in human gastric cancer remains unknown...
May 21, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29781517/a-homozygous-scn5a-mutation-associated-with-atrial-standstill-and-sudden-death
#14
Reina Bianca Tan, Ivan Gando, Lei Bu, Frank Cecchin, William Coetzee
BACKGROUND: Atrial standstill is an arrhythmogenic condition characterized by the absence of spontaneous electrical and mechanical atrial activity or in response to stimulation. There are few reported familial cases which have been associated with SCN5A mutations co-segregating with GJA5 or RYR2 however isolated SCN5A mutations are rare. OBJECTIVE: The purpose of this study was to determine the clinical and biophysical consequence of a novel SCN5A mutation identified in a family with progressive atrial standstill and sudden death...
May 21, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29781233/fit-guts-reduced-models-online-from-theory-to-practice
#15
Virgile Baudrot, Philippe Veber, Guillaume Gence, Sandrine Charles
Mechanistic modelling approaches, as the toxicokinetic-toxicodynamic (TKTD) framework, are promoted by international institutions as EFSA and OECD to assess the environmental risk of chemical products generated by human activities. TKTD models can encompass a large set of mechanisms describing the kinetics of compounds inside organisms (e.g. uptake and elimination) and their effect at the level of individuals (e.g. damage accrual, recovery and death mechanism). Compared to classical dose-response models, TKTD approaches have many advantages as taking into account temporal aspects of exposure and toxicity, considering data-points all along the experiment and not only at the end, and making predictions for untested situations as realistic exposure scenarios...
May 20, 2018: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/29781185/helper-t-cell-responses-and-pulmonary-fungal-infections
#16
REVIEW
Andrew J McDermott, Bruce S Klein
The mucosal surface of the respiratory tract encounters microbes, such as fungal particles, with every inhaled breath. When pathogenic fungi breach the physical barrier and innate immune system within the lung to establish an infection, adaptive immunity is engaged often in the form of helper CD4 T-cell responses. Type 1 responses, characterized by IFNγ production from CD4 cells, promote clearance of Histoplasma capsulatum and Cryptococcus neoformans infection. Likewise, IL-17A production from Th17 cells promotes immunity to Blastomyces dermatitidis and Coccidiodes species infection by recruiting neutrophils...
May 20, 2018: Immunology
https://www.readbyqxmd.com/read/29781179/pigmentation-is-associated-with-stemness-hierarchy-of-progenitor-cells-within-cultured-limbal-epithelial-cells
#17
Lei Liu, Frederik Mølgaard Nielsen, Jeppe Emmersen, Chris Bath, Jesper Østergaard Hjortdal, Simone Riis, Trine Fink, Cristian Pablo Pennisi, Vladimir Zachar
Ex-vivo cultured human limbal epithelial stem/progenitor cells (hLESCs) are the main source for regenerative therapy of limbal stem cell deficiency (LSCD), which is worldwide one of the major causes of corneal blindness. Despite many stemness-associated markers have been identified within the limbal niche, the phenotype of the earliest hLESCs has not been hitherto identified. We sought to confirm or refute the use of tumor protein p63 (p63) and ATP binding cassette subfamily B member 5 (ABCB5) as surrogate markers for hLESCs early within the limbal differentiation hierarchy...
May 20, 2018: Stem Cells
https://www.readbyqxmd.com/read/29780866/molecular-imaging-what-is-right-and-what-is-an-illusion
#18
William E Klunk
Over the past 40 years, brain molecular imaging has evolved from measuring cerebral metabolism with fluorodeoxyglucose, to neuroreceptor imaging, to imaging pathological protein deposits. In the early going, the characteristics of successful molecular imaging radiotracers were defined, and a detailed "Process" was developed for the collection of basic pharmacodynamic and pharmacokinetic data. These data are essential for the interpretation of in vivo imaging data and for defining the strengths, weaknesses, and limitations of new tracers...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29780832/collagen-type-iii-metabolism-evaluation-in-patients-with-malignant-head-and-neck-cancer-treated-with-radiotherapy
#19
Klaudia Mazurek, Krzysztof Siemianowicz, Wirginia Likus, Ewa Pierzchała, Robert Kwiatkowski, Jarosław Markowski
Ionizing radiation affects the metabolism of key proteins of extracellular matrix including type III collagen, an important component of human skin. The aim of the work is an analysis of the impact of radical and palliative radiotherapy on collagen type III synthesis in patients with head and neck cancer. The test group consisted of 56 males with histopathologically confirmed head and neck cancer, for whom radiotherapy was applied as a form of radical or palliative treatment. The level of procollagen III aminoterminal propeptide (PIIINP), which is a marker of collagen type III synthesis, was determined in blood serum before radiotherapy, immediately following radiotherapy, and 3 months after it was finished...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29780607/renal-cell-carcinoma-in-a-cat-with-polycystic-kidney-disease-undergoing-renal-transplantation
#20
Daniel J Adams, Jolie A Demchur, Lillian R Aronson
Case summary: A 10-year-old spayed female American Shorthair cat underwent renal transplantation due to worsening chronic kidney disease secondary to polycystic kidney disease. During transplantation, the right kidney grossly appeared to be more diseased than the left and was firmly adhered to the surrounding tissues. An intraoperative fine-needle aspirate of the right native kidney revealed inflammatory cells but no evidence of neoplasia. To create space for the allograft, a right nephrectomy was performed...
January 2018: JFMS Open Reports
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