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https://www.readbyqxmd.com/read/28651365/cathepsin-k-inhibitors-for-osteoporosis-biology-potential-clinical-utility-and-lessons-learned
#1
Matthew T Drake, Bart L Clarke, Merry Jo Oursler, Sundeep Khosla
Cathepsin K is a cysteine protease member of the cathepsin lysosomal protease family. While cathepsin K is highly expressed in osteoclasts, lower levels of cathepsin K are also found in a variety of other tissues. Secretion of cathepsin K from the osteoclast into the sealed osteoclast-bone cell interface results in efficient degradation of type I collagen. The absence of cathepsin K activity in humans results in pycnodysostosis, characterized by increased bone mineral density and fractures. Pharmacological cathepsin K inhibition leads to continuous increases in BMD for up to five years of treatment and improves bone strength at the spine and hip...
June 23, 2017: Endocrine Reviews
https://www.readbyqxmd.com/read/28651178/the-influence-of-impact-direction-and-axial-loading-on-the-bone-fracture-pattern
#2
Haim Cohen, Chen Kugel, Hila May, Bahaa Medlej, Dan Stein, Viviane Slon, Tamar Brosh, Israel Hershkovitz
The effect of the direction of the impact and the presence of axial loading on fracture patterns have not yet been established in experimental 3-point bending studies. PURPOSE: To reveal the association between the direction of the force and the fracture pattern, with and without axial loading. MATERIAL AND METHODS: A Dynatup Model POE 2000 (Instron Co.) low energy pendulum impact machine was utilized to apply impact loading on fresh pig femoral bones (n=50). The bone clamp shaft was adjusted to position the bone for three-point bending with and without additional bone compression...
May 22, 2017: Forensic Science International
https://www.readbyqxmd.com/read/28651092/role-of-proteoglycans-on-the-biochemical-and-biomechanical-properties-of-dentin-organic-matrix
#3
Cristina de Mattos Pimenta Vidal, Ariene Arcas Leme-Kraus, Momina Rahman, Ana Paula Farina, Ana K Bedran-Russo
OBJECTIVE: Proteoglycans (PGs) are multifunctional biomacromolecules of the extracellular matrix of collagen-based tissues. In teeth, besides a pivotal regulatory role on dentin biomineralization, PGs provide mechanical support to the mineralized tissue and compressive strength to the biosystem. This study assessed enzymatic protocols for selective PGs removal from demineralized dentin to determine the roles of these biomacromolecules in the bulk mechanical properties and biostability of type I collagen...
June 16, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28650949/efficacy-and-safety-of-tranexamic-acid-in-orthopedic-fracture-surgery-a-meta-analysis-and-systematic-literature-review
#4
Kamil Amer, Saqib Rehman, Christopher Haydel
BACKGROUND: Tranexamic acid (TXA) is an anti-fibrinolytic drug that has been shown to be effective in reducing blood loss and the need for transfusions after several orthopedic surgeries. However, the effectiveness of TXA use in orthopedic fracture surgeries still remains unclear. The purpose of this meta-analysis was to review existing literature with interest in the effectiveness and safety of TXA treatment in reducing total blood loss and transfusion rates for patients who underwent surgery for fracture repairs...
June 12, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28650948/hip-fracture-treatment-at-orthopaedic-teaching-hospitals-better-care-at-a-lower-cost
#5
Sanjit R Konda, Ariana Lott, Arthur Manoli, Karan Patel, Kenneth A Egol
OBJECTIVE: To compare the cost and outcomes of patients treated at orthopaedic teaching hospitals (OTH) compared to those treated at non-teaching hospitals (NTH) DESIGN:: Retrospective study SETTING:: The Statewide Planning and Research Cooperative Systems (SPARCS) database, which includes all admissions to New York State hospitals from 2000-2011. PATIENTS/PARTICIPANTS: 165,679 isolated closed hip fracture patients aged 65 and older met inclusion criteria. Of these, 57,279 were treated at OTH and 108,400 were treated at NTH...
June 12, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28650947/three-dimensional-deformities-of-non-operative-midshaft-clavicle-fractures-a-surface-matching-analysis
#6
Satoshi Oki, Noboru Matsumura, Yoshimori Kiriyama, Takuji Iwamoto, Kazuki Sato, Takeo Nagura
OBJECTIVE: The purpose of this study was to describe the three-dimensional deformities of midshaft clavicle fractures, which had been treated nonoperatively, using computed tomography (CT) surface matching. METHODS: Twenty-one patients with unilateral midshaft clavicle fracture, who had been treated nonoperatively, were enrolled and evaluated retrospectively. The three-dimensional deformity of the fractured clavicle was evaluated by CT surface matching. CT scans of 21 age- and sex-matched patients with initial traumatic shoulder dislocation or proximal humeral fracture were enrolled as a control group, and the differences in three-dimensional deformities and lengths of the clavicles between the fracture group and the control group were evaluated...
June 15, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28650946/the-hyperextension-tibial-plateau-fracture-pattern-a-predictor-of-poor-outcome
#7
Leah J Gonzalez, Ariana Lott, Sanjit Konda, Kenneth A Egol
OBJECTIVES: To assess the outcome of patients with hyperextension bicondylar tibial plateau fractures (HEBTP) to those with other complex tibial plateau fractures DESIGN:: Retrospective cohort design SETTING:: Academic Medical Center PATIENTS:: A total of 84 patients were included in the study. There were 69 patients with 69 knees (82%) that had sustained non-hyperextension bicondylar tibial plateau fractures and 15 patients with 15 knees (18%) that had hyperextension bicondylar tibial plateau fractures (HEBTP) INTERVENTION:: Surgical repair of bicondylar tibial plateau fracture MAIN OUTCOME MEASURES:: Clinical and functional outcomes included knee range of motion, post-operative alignment, NRS pain scores and Short Musculoskeletal Functional Assessment (SMFA) scores at long-term follow-up...
June 15, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28650945/treatment-approach-for-infection-of-healed-fractures-after-internal-fixation
#8
Joshua M Lawrenz, Salvatore J Frangiamore, Ajinkya A Rane, W Alex Cantrell, Heather A Vallier
OBJECTIVE: To review the efficacy of a treatment approach for patients with infection and colonized implants after open reduction and internal fixation of fractures. DESIGN: Retrospective case series. SETTING: Level one trauma center. PATIENTS: Twenty patients were treated for wound infection with colonized implants after open reduction and internal fixation. INTERVENTION: Surgical debridement, removal of implants and a short post-operative oral antibiotic course...
June 15, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28650944/intramedullary-implant-choice-and-cost-in-the-treatment-of-pediatric-diaphyseal-forearm-fractures
#9
Austin Heare, Dawn Goral, Matthew Belton, Corey Beebe, Anastasiya Trizno, Jason Stoneback
OBJECTIVES: The aim of this study was to compare outcomes and costs between titanium elastic nails (TENs), stainless steel elastic nails (SENs), and Kirschner wires (K-wires) in the treatment of pediatric diaphyseal forearm fractures with intramedullary fixation. DESIGN: Retrospective cohort study. SETTING: Level 1 Pediatric Trauma Center. PATIENTS/PARTICIPANTS: A total of 100 patients (65 male and 35 female) under 18 years of age with diaphyseal forearm fractures treated with intramedullary fixation were included in the study...
June 15, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28650943/intramedullary-fixation-with-minimally-invasive-clamp-assisted-reduction-for-the-treatment-of-ipsilateral-femoral-neck-and-subtrochanteric-fractures-a-technical-trick
#10
Qi Sun, Wei Ge, RenLong Li, ShaoHua Li, Ming Cai
No abstract text is available yet for this article.
June 15, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28650942/open-supracondylar-intercondylar-fractures-of-the-femur-treatment-with-taylor-spatial-frame
#11
Francesco Sala, Ahmed M Thabet, Paolo Capitani, Federico Bove, Amr A Abdelgawad, Giovanni Lovisetti
OBJECTIVES: Evaluate the Taylor spatial frame (TSF) for primary and definitive fixation of open supracondylar-intracondylar femoral (SIF) fractures. DESIGN: Retrospective. SETTING: Level I trauma center. PATIENTS: Subset of 20 SIF open fractures treated with TSF extracted from a consecutive series of 80 SIF fractures treated between 2007 and 2013. INTERVENTION: Eighteen (90%) fractures underwent definitive fixation with the TSF; 2 were treated primarily within 24 hours of injury...
June 15, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28650940/surgical-fixation-of-periprosthetic-humerus-fractures-using-an-extension-plate-a-technical-trick
#12
Bradley Schoch, Samir Mehta, Surena Namdari
No abstract text is available yet for this article.
June 19, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28650892/the-2017-hormone-therapy-position-statement-of-the-north-american-menopause-society
#13
(no author information available yet)
The 2017 Hormone Therapy Position Statement of The North American Menopause Society (NAMS) updates the 2012 Hormone Therapy Position Statement of The North American Menopause Society and identifies future research needs. An Advisory Panel of clinicians and researchers expert in the field of women's health and menopause was recruited by NAMS to review the 2012 Position Statement, evaluate new literature, assess the evidence, and reach consensus on recommendations, using the level of evidence to identify the strength of recommendations and the quality of the evidence...
June 22, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28650869/the-2017-hormone-therapy-position-statement-of-the-north-american-menopause-society
#14
(no author information available yet)
The 2017 Hormone Therapy Position Statement of The North American Menopause Society (NAMS) updates the 2012 Hormone Therapy Position Statement of The North American Menopause Society and identifies future research needs. An Advisory Panel of clinicians and researchers expert in the field of women's health and menopause was recruited by NAMS to review the 2012 Position Statement, evaluate new literature, assess the evidence, and reach consensus on recommendations, using the level of evidence to identify the strength of recommendations and the quality of the evidence...
July 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28650786/alveolar-fracture-caused-by-tooth-extraction-at-home
#15
Fabrício Kitazono de Carvalho, Thaís Aparecida Xavier, Nicole Gonçalves Lima, Alexandra Mussolino de Queiroz, Marcilene Coelho Vinhorte, Paulo Nelson-Filho
Injuries to the teeth and surrounding structures are relatively common. Although traumatic injuries caused by falls or activities related to sports are widely discussed, the same cannot be said regarding accidents arising from non-professional extraction of primary teeth. The present study reports a 6-year-old male child who underwent mandibular alveolar bone fracture during non-professional extraction of his central lower left incisor at home, performed by his 30-year-old aunt. The root of the tooth was with an irregular physiological resorption, which acted as a lever component for the mechanical force applied, leading to bone fracture...
2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28650764/dorsal-fracture-dislocation-of-the-tarsal-navicularcase-report-and-review-of-a-rare-injury
#16
Isidro Jimenez, Juan Pedro Rodriguez-Alvarez, Ricardo Navarro-Navarro
Fracture-dislocations of the tarsal navicular are rare and highly complex injuries to the midfoot. The only published data on this type of fracture are clinical case reports. These injuries are normally caused by high-energy trauma, and their pathophysiology and most appropriate treatment remain unclear. We report a clinical case of a dorsal fracture-dislocation of the tarsal navicular bone associated with a medial swivel dislocation of the Chopart joint caused by a bicycle fall in a 20-year-old healthy man...
May 2017: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/28650589/immediate-initiation-of-antiretroviral-therapy-for-hiv-infection-accelerates-bone-loss-relative-to-deferring-therapy-findings-from-the-start-bone-mineral-density-substudy-a-randomized-trial
#17
Jennifer F Hoy, Birgit Grund, Mollie Roediger, Ann V Schwartz, John Shepherd, Anchalee Avihingsanon, Sharlaa Badal-Faesen, Stephane de Wit, Simone Jacoby, Alberto La Rosa, Sanjay Pujari, Mauro Schechter, David White, Nicole Wyman Engen, Kristine Ensrud, Peer D Aagaard, Andrew Carr
Both HIV infection and antiretroviral therapy (ART) are associated with lower bone mineral density (BMD) and increased fracture risk. Because the relative contributions of ART and untreated HIV to BMD loss are unclear, it is important to quantify the effect of ART on bone. We compared the effect of early ART initiation (CD4 >500 cells/μL) with deferred ART on change in BMD in the START Bone Mineral Density substudy, a randomized trial evaluating the effect of immediate ART initiation versus deferring ART (to CD4 <350 cells/μL)...
June 26, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28650253/diagnosis-and-treatment-of-osteoporosis-before-and-after-fracture-a-side-by-side-analysis-of-commercially-insured-and-medicare-advantage-osteoporosis-patients
#18
Jessica Weaver, Shiva Sajjan, E Michael Lewiecki, Steven T Harris
BACKGROUND: Although treatment for osteoporosis is recommended by U.S. clinical guidelines, a lack of diagnosis and treatment is common among patients with osteoporotic fractures. OBJECTIVE: To determine the rates of osteoporosis diagnosis and treatment before and after various types of fractures. METHODS: This was a retrospective claims analysis using data from the Humana Medicare Advantage claims (Medicare group) and Optum Insight Clinformatics Data Mart commercial claims (Commercial group)...
July 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28650214/distinct-dna-methylation-profiles-in-bone-and-blood-of-osteoporotic-and-healthy-postmenopausal-women
#19
Sjur Reppe, Tonje G Lien, Yi-Hsiang Hsu, Vigdis T Gautvik, Ole K Olstad, Rona Yu, Hege G Bakke, Robert Lyle, Marianne K Kringen, Ingrid K Glad, Kaare M Gautvik
DNA methylation affects expression of associated genes and may contribute to the missing genetic effects from genome-wide association studies of osteoporosis. To improve insight into the mechanisms of postmenopausal osteoporosis, we combined transcript profiling with DNA methylation analyses in bone. RNA and DNA were isolated from 84 bone biopsies of postmenopausal donors varying markedly in bone mineral density (BMD). In all, 2529 CpGs in the top 100 genes most significantly associated with BMD were analyzed...
June 26, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28649980/mid-term-outcomes-of-stent-overlap-in-long-total-occluded-lesions-of-superficial-femoral-artery
#20
Ulas Bildirici, Mujdat Aktas, Emir Dervis, Umut Celikyurt
BACKGROUND Superficial femoral artery chronic total occlusion (SCTO) is a common type of peripheral arterial disease (PAD). Endovascular therapy is a treatment approach that has a poor long-term success rate in this group. The aim of this study was to compare the mid-term results of two different uses of nitinol stents in long SCTO lesions (>100 mm): the use of one long stent or two shorter stents. MATERIAL AND METHODS Of 154 patients who underwent percutaneous infrainguinal interventions from 2011 to 2014, a total of 170 CTO lesions were selected for this retrospective study analysis...
June 26, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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