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https://www.readbyqxmd.com/read/29668069/the-direct-synthesis-of-imines-benzimidazoles-and-quinoxalines-from-nitroarenes-and-carbonyl-compounds-via-selective-nitroarene-hydrogenation-employing-a-reusable-iron-catalyst
#1
Rhett Kempe, Christoph Bäumler
The "replacement" of noble metals by earth abundant metals is a desirable aim in catalysis and a possible way of conserving rare elements. The "replacement" is especially attractive if novel selectivity patterns are observed permitting the development of novel coupling reactions. Herein, we report on a novel, robust and reusable iron catalyst, which permits the selective hydrogenation of nitroarenes in the presence of hydrogenation-sensitive functional groups. Based on the selectivity pattern observed, the direct iron catalyzed synthesis of imines and benzimidazoles from nitroarenes and aldehydes becomes feasible...
April 18, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29668061/ligand-tuneable-red-emitting-iridium-iii-complexes-for-efficient-triplet-triplet-annihilation-upconversion-performance
#2
Simon J Pope, Thomas Stonelake, Kaitlin Phillips, Simon Coles, Peter Horton, Shannon Keane, Emily Stokes, Ian Fallis, Joseph Beames, Jianzhang Zhao, Kepeng Chen, Yuqi Hou, Andrew Hallett, Sean O'Kell
A series of substituted 2-phenylquinoxaline ligands have been explored to finely tune the visible emission properties of a corresponding set of cationic, cyclometalated iridium(III) complexes. The electronic and redox properties of the complexes were investigated using experimental (including time-resolved luminescence and transient absorption spectroscopy) and theoretical methods. The complexes display absorption and phosphorescent emission in the visible region attributed to MLCT transitions. The different substitution patterns of the ligands induce variations in these parameters...
April 18, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29668058/i-introduction-understanding-medicines-and-medical-interventions
#3
Kristi L Lockhart, Frank C Keil
We live in an increasingly pharmacological and medical world, where children and adults frequently encounter alleged treatments for an enormous range of illnesses. How do we come to understand what heals and why? Here, 15 studies explore how 1,414 children (ages 5-11) and 882 adults construe the efficacies of different kinds of cures. Developmental patterns in folk physics, psychology, and biology lead to predictions about which expectations about cures will remain relatively constant across development and which will change...
June 2018: Monographs of the Society for Research in Child Development
https://www.readbyqxmd.com/read/29668052/iv-agency-and-spatial-patterns-of-illnesses-and-treatments
#4
Kristi L Lockhart, Frank C Keil
No abstract text is available yet for this article.
June 2018: Monographs of the Society for Research in Child Development
https://www.readbyqxmd.com/read/29668046/black-cohosh-extracts-and-powders-induce-micronuclei-a-biomarker-of-genetic-damage-in-human-cells
#5
Stephanie L Smith-Roe, Carol D Swartz, Kim G Shepard, Steven M Bryce, Stephen D Dertinger, Suramya Waidyanatha, Grace E Kissling, Scott S Auerbach, Kristine L Witt
Black cohosh extract (BCE) is a widely used dietary supplement marketed to women to alleviate symptoms of gynecological ailments, yet its toxicity has not been well characterized. The National Toxicology Program (NTP) previously reported significant increases in micronucleated erythrocytes in peripheral blood of female Wistar Han rats and B6C3F1/N mice administered 15-1,000 mg BCE/kg/day by gavage for 90 days. These animals also developed a dose-dependent nonregenerative macrocytic anemia characterized by clinical changes consistent with megaloblastic anemia...
April 18, 2018: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/29668032/presence-of-meniscus-tear-alters-gene-expression-profile-of-anterior-cruciate-ligament-tears
#6
Robert H Brophy, Marcus A Rothermich, Eric D Tycksen, Lei Cai, Muhammad Farooq Rai
Anterior cruciate ligament (ACL) tears occur in isolation or in tandem with other intra-articular injuries such as meniscus tears. The impact of injury pattern on the molecular biology of the injured ACL is unknown. Here, we tested the hypothesis that the biological response of the ACL to injury varies based on the presence or absence of concomitant meniscus tear. We performed RNA-seq on 28 ACL tears remnants (12 isolated, 16 combined). In total, 16,654 transcripts were differentially-expressed between isolated and combined injury groups at false-discovery-rate of 0...
April 18, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29668017/phylogeographic-analyses-of-the-pampas-cat-leopardus-colocola-carnivora-felidae-reveal-a-complex-demographic-history
#7
Anelisie da Silva Santos, Tatiane Campos Trigo, Tadeu Gomes de Oliveira, Leandro Silveira, Eduardo Eizirik
The pampas cat is a small felid that occurs in open habitats throughout much of South America. Previous studies have revealed intriguing patterns of morphological differentiation and genetic structure among its populations, as well as molecular evidence for hybridization with the closely related L. tigrinus. Here we report phylogeographic analyses encompassing most of its distribution (focusing particularly on Brazilian specimens, which had been poorly sampled in previous studies), using a novel dataset comprising 2,143 bp of the mitogenome, along with previously reported mtDNA sequences...
2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29668016/genetic-and-ecological-niche-modeling-of-calydorea-crocoides-iridaceae-an-endemic-species-of-subtropical-highland-grasslands
#8
Juliana Lustosa Matos de Alencar, Eliane Kaltchuk-Santos, Juliana Fachinetto, Luana Olinda Tacuatiá, Eliana Regina Forni-Martins, Eudes Maria Stiehl-Alves, Tatiana Teixeira de Souza-Chies
Evolutionary analyses have been widely used for evaluation of genetic diversity of natural populations and correlate these data to the fitness of the species, especially in the case of threatened species. Calydorea crocoides occurs in a restricted area at altitudes from 800 to 1500 m in southern Brazil and is considered endangered. A study assessing genetic diversity, cytogenetic features and ecological niche was performed aiming to characterize C. crocoides by multidisciplinary approaches. Molecular data highlighted that most of the total variation (76%; p < 0...
2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29668014/oxytocin-and-arginine-vasopressin-systems-in-the-domestication-process
#9
Bibiana S O Fam, Pamela Paré, Aline B Felkl, Pedro Vargas-Pinilla, Vanessa R Paixão-Côrtes, Lucas Henriques Viscardi, Maria Cátira Bortolini
Domestication is of unquestionable importance to the technological revolution that has given rise to modern human societies. In this study, we analyzed the DNA and protein sequences of six genes of the oxytocin and arginine vasopressin systems (OXT-OXTR; AVP-AVPR1a, AVPR1b and AVPR2) in 40 placental mammals. These systems play an important role in the control of physiology and behavior. According to our analyses, neutrality does not explain the pattern of molecular evolution found in some of these genes. We observed specific sites under positive selection in AVPR1b (ω = 1...
2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29668013/drosophila-relics-hobo-and-hobo-mites-transposons-as-raw-material-for-new-regulatory-networks
#10
Elgion L S Loreto, Maríndia Deprá, José F Diesel, Yanina Panzera, Vera Lucia S Valente-Gaiesky
Hypermutable strains of Drosophila simulans have been studied for 20 years. Several mutants were isolated and characterized, some of which had phenotypes associated with alteration in development; for example, showing ectopic legs with eyes being expressed in place of antennae. The causal agent of this hypermutability is a non-autonomous hobo-related sequence (hoboVA). Around 100 mobilizable copies of this element are present in the D. simulans genome, and these are likely mobilized by the autonomous and canonical hobo element...
2018: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/29667937/structural-properties-of-templated-ge-quantum-dot-arrays-impact-of-growth-and-pre-pattern-parameters
#11
Jenny Tempeler, Serhiy Danylyuk, Sascha Brose, Peter Loosen, Larissa Juschkin
In this study we analyze the impact of process and growth parameters on the structural properties of germanium (Ge) quantum dot arrays. The arrays were deposited by molecular beam epitaxy on pre-patterned silicon (Si) substrates. Periodic arrays of pits with diameters between 120 nm to 20 nm and pitches ranging from 200 nm down to 40 nm were etched into the substrate prior to growth. The structural perfection of the 2-dimensional quantum dot (QD) arrays was evaluated based on SEM images. The impact of two processing steps on the directed self-assembly of Ge QD arrays is investigated...
April 18, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29667936/automated-algorithms-for-detecting-sleep-period-time-using-a-multi-sensor-pattern-recognition-activity-monitor-from-24-h-free-living-data-in-older-adults
#12
Veronica Cabanas-Sanchez, Sara Higueras-Fresnillo, Miguel Ángel De La Camara, Oscar L Veiga, David Martinez-Gomez
The aims of the present study were: (i) to develop automated algorithms to identify the sleep period time in 24-h data from the Intelligent Device for Energy Expenditure and Activity (IDEEA) in older adults, and (ii) to analyze the agreement of these algorithms to identify the sleep period time as compared to self-reported data and expert visual analysis of accelerometer raw data.&#13; Approach. This study comprised 50 participants, aged 65 to 85 years. Fourteen automated algorithms were developed. Participants reported their bedtime and wake time in the days wearing the device...
April 18, 2018: Physiological Measurement
https://www.readbyqxmd.com/read/29667927/biophysics-of-object-segmentation-in-a-collision-detecting-neuron
#13
Richard Burkett Dewell, Fabrizio Gabbiani
Collision avoidance is critical for survival, including in humans, and many species possess visual neurons exquisitely sensitive to objects approaching on a collision course. Here, we demonstrate that a collision-detecting neuron can detect the spatial coherence of a simulated impending object, thereby carrying out a computation akin to object segmentation critical for proper escape behavior. At the cellular level, object segmentation relies on a precise selection of the spatiotemporal pattern of synaptic inputs by dendritic membrane potential-activated channels...
April 18, 2018: ELife
https://www.readbyqxmd.com/read/29667924/telomerase-may-paradoxically-accelerate-aging-of-the-dna-methylome
#14
Andrew R Mendelsohn, James W Larrick
DNA methylation (DNAm) clocks such as the Horvath DNAm clock provide the most accurate biological determination of biological age relative to chronological age available today. However, there is little correlation between DNAm clocks, telomere-based aging clocks, and transcriptomic-based aging clocks. Recently, a genome-wide association study identified single-nucleotide polymorphism variants of TERT, the gene that encodes telomerase, as accelerating intrinsic aging in the Horvath DNAm clock. These same variants have been previously associated with long telomeres in leukocytes, suggesting that TERT acts paradoxically on telomere-associated aging and DNAm-associated aging...
April 2018: Rejuvenation Research
https://www.readbyqxmd.com/read/29667915/chronic-lithium-treatment-induces-novel-patterns-of-pendrin-localization-and-expression
#15
Nathaniel J Himmel, Yirong Wang, Daniel A Rodriguez, Michael A Sun, Mitsi A Blount
Prolonged lithium treatment is associated with various renal side effects and is known to induce inner medullary collecting duct (IMCD) remodeling. In animals treated with lithium, the fraction of intercalated cells (ICs), which are responsible for acid-base homeostasis, increases as compared to renal principal cells (PCs). In order to investigate the intricacies of lithium-induced IMCD remodeling, male Sprague Dawley rats were fed a lithium-enriched diet for 0,1, 2, 3, 6, 9, or 12 weeks. Urine osmolality was decreased at 1 week, and from 2-12 weeks, animals were severely polyuric...
April 18, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29667897/narrative-roles-among-contact-versus-noncontact-sexual-offenders
#16
Emma Hamilton, Delida Sanchez
The current study explored narrative roles among individuals convicted of a sexual offense. Narrative roles in a criminal context are defined as specific personal accounts utilized by offenders to justify illegal behavior. The chosen theoretical framework recognized four primary offender roles: Revengeful Mission/Romantic Quest, Professional, Victim, and Tragic Hero. A total of 23 interviews were conducted with individuals convicted of a sexual offense ( n = 11 contact, n = 12 noncontact) to explore and compare narrative roles between contact and noncontact offenders...
April 1, 2018: Sexual Abuse: a Journal of Research and Treatment
https://www.readbyqxmd.com/read/29667888/liver-calcifications-and-calcified-liver-masses-pattern-recognition-approach-on-ct
#17
Madhavi Patnana, Christine O Menias, Perry J Pickhardt, Mohamed Elshikh, Sanaz Javadi, Ayman Gaballah, Akram M Shaaban, Brinda Rao Korivi, Naveen Garg, Khaled M Elsayes
OBJECTIVE: Because of the ubiquitous use of radiologic imaging, particularly with CT, the detection of focal hepatic calcifications has increased. Calcifications can be seen in cystic and solid masses associated with both benign and malignant causes, pseudomasses, and miscellaneous pathologic abnormalities. CONCLUSION: These calcifications can manifest in various patterns, recognition of which can increase specificity for various diagnoses. In this article, we review a wide range of calcified hepatic pathologic abnormalities at CT and propose an approach for diagnosis...
April 18, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29667882/new-doppler-imaging-technique-for-assessing-angiogenesis-in-breast-tumors-correlation-with-immunohistochemically-analyzed-microvessels-density
#18
Sewha Kim, Hye Jin Lee, Kyung Hee Ko, Ah Young Park, Jieun Koh, Hae Kyoung Jung
Background Microvessel density (MVD) is associated with grade and prognosis in breast tumors. However, conventional color Doppler flow (CDF) imaging has been limited to represent MVD of breast tumors. Purpose To evaluate whether a new Doppler imaging technique (AngioPLUS) can represent MVD of breast tumors. Material and Methods The institutional review board approved this retrospective study, and patients' informed consent was waived. CDF and AngioPLUS were available in pathologically confirmed 55 breast tumors of 53 women...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29667860/educational-needs-in-the-diagnosis-and-management-of-pediatric-functional-constipation-a-us-survey-of-specialist-and-primary-care-clinicians
#19
Justin Barnes, Brandon Coleman, Sharon Hwang, Aleksandra Stolic, Athos Bousvaros, Samuel Nurko, Gregory D Salinas
OBJECTIVES: The goal of this study was to identify opportunities among gastroenterologists and gastroenterology nurse practitioners (NPs)/physician assistants (PAs) for continuing medical education (CME) related to functional constipation. METHODS: An online, case-vignette survey was designed to identify and quantify practice patterns of pediatric gastroenterology clinicians. Case vignettes are a validated method for assessing clinician practice patterns. The survey consisted of three patient cases: a 3-year-old female with a 6-month history of constipation; a 6-year-old male with a 1-year history of constipation refractory to treatment and a sacral dimple with nearby tuft of hair; and a 16-year-old male with a 10-year history of constipation, and a sullen, depressed mood...
April 18, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29667852/determination-of-the-position-of-the-knee-at-the-time-of-an-anterior-cruciate-ligament-rupture-for-male-versus-female-patients-by-an-analysis-of-bone-bruises
#20
Kwadwo A Owusu-Akyaw, Sophia Y Kim, Charles E Spritzer, Amber T Collins, Zoë A Englander, Gangadhar M Utturkar, William E Garrett, Louis E DeFrate
BACKGROUND: The incidence of anterior cruciate ligament (ACL) ruptures is 2 to 4 times higher in female athletes as compared with their male counterparts. As a result, a number of recent studies have addressed the hypothesis that female and male patients sustain ACL injuries via different mechanisms. The efficacy of prevention programs may be improved by a better understanding of whether there are differences in the injury mechanism between sexes. Hypothesis/Purpose: To compare knee positions at the time of a noncontact ACL injury between sexes...
April 1, 2018: American Journal of Sports Medicine
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