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https://www.readbyqxmd.com/read/28813931/making-neurorehabilitation-fun-multiplayer-training-via-damping-forces-balancing-differences-in-skill-levels
#1
Kilian Baur, Peter Wolf, Robert Riener, Jaime E Duarte
Multiplayer environments are thought to increase the training intensity in robot-aided rehabilitation therapy after stroke. We developed a haptic-based environment to investigate the dynamics of two-player training performing time-constrained reaching movements using the ARMin rehabilitation robot. We implemented a challenge level adaptation algorithm that controlled a virtual damping coefficient to reach a desired success rate. We tested the algorithm's effectiveness in regulating the success rate during game play in a simulation with computer-controlled players, in a feasibility study with six unimpaired players, and in a single session with one stroke patient...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813762/the-impact-of-a-rural-training-track-on-medical-students-specialty-choice
#2
Brooke Jensen, Susan M Anderson, Edward Simanton
BACKGROUND: Compare the expectations and outcomes of students involved in rural medical training versus those of urban trainees. METHODS: Survey items relating to primary care interest were added to program evaluation surveys already being sent at the beginning and end of the primary clinical year. Students from the graduating class of 2016 and the class of 2017 responded to the surveys (N=115). Responses from students trained in rural sites were compared with students trained in medium or large communities...
June 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28813541/reflections-on-medical-tourism-from-the-2016-global-healthcare-policy-and-management-forum
#3
Valorie A Crooks, Meghann Ormond, Ki Nam Jin
In October 2016, the Global Healthcare Policy and Management Forum was held at Yonsei University, Seoul, South Korea. The goal of the forum was to discuss the role of the state in regulating and supporting the development of medical tourism. Forum attendees came from 10 countries. In this short report article, we identify key lessons from the forum that can inform the direction of future scholarly engagement with medical tourism. In so doing, we reference on-going scholarly debates about this global health services practice that have appeared in multiple venues, including this very journal...
2017: BMC Proceedings
https://www.readbyqxmd.com/read/28813507/comparison-of-homologous-and-heterologous-prime-boost-vaccine-approaches-using-modified-vaccinia-ankara-and-soluble-protein-to-induce-neutralizing-antibodies-by-the-human-cytomegalovirus-pentamer-complex-in-mice
#4
Flavia Chiuppesi, Felix Wussow, Louise Scharf, Heidi Contreras, Han Gao, Zhuo Meng, Jenny Nguyen, Peter A Barry, Pamela J Bjorkman, Don J Diamond
Since neutralizing antibodies (NAb) targeting the human cytomegalovirus (HCMV) pentamer complex (PC) potently block HCMV host cell entry, anti-PC NAb induction is thought to be important for a vaccine formulation to prevent HCMV infection. By developing a vaccine strategy based on soluble PC protein and using a previously generated Modified Vaccinia Ankara vector co-expressing all five PC subunits (MVA-PC), we compared HCMV NAb induction by homologous immunization using prime-boost vaccine regimen employing only PC protein or MVA-PC and heterologous immunization using prime-boost combinations of PC protein and MVA-PC...
2017: PloS One
https://www.readbyqxmd.com/read/28813460/mechanisms-for-pattern-specificity-of-deep-brain-stimulation-in-parkinson-s-disease
#5
Osvaldo Matías Velarde, Germán Mato, Damián Dellavale
Deep brain stimulation (DBS) has become a widely used technique for treating advanced stages of neurological and psychiatric illness. In the case of motor disorders related to basal ganglia (BG) dysfunction, several mechanisms of action for the DBS therapy have been identified which might be involved simultaneously or in sequence. However, the identification of a common key mechanism underlying the clinical relevant DBS configurations has remained elusive due to the inherent complexity related to the interaction between the electrical stimulation and the neural tissue, and the intricate circuital structure of the BG-thalamocortical network...
2017: PloS One
https://www.readbyqxmd.com/read/28813415/cdk4-6-inhibition-triggers-anti-tumour-immunity
#6
Shom Goel, Molly J DeCristo, April C Watt, Haley BrinJones, Jaclyn Sceneay, Ben B Li, Naveed Khan, Jessalyn M Ubellacker, Shaozhen Xie, Otto Metzger-Filho, Jeremy Hoog, Matthew J Ellis, Cynthia X Ma, Susanne Ramm, Ian E Krop, Eric P Winer, Thomas M Roberts, Hye-Jung Kim, Sandra S McAllister, Jean J Zhao
Cyclin-dependent kinases 4 and 6 (CDK4/6) are fundamental drivers of the cell cycle and are required for the initiation and progression of various malignancies. Pharmacological inhibitors of CDK4/6 have shown significant activity against several solid tumours. Their primary mechanism of action is thought to be the inhibition of phosphorylation of the retinoblastoma tumour suppressor, inducing G1 cell cycle arrest in tumour cells. Here we use mouse models of breast carcinoma and other solid tumours to show that selective CDK4/6 inhibitors not only induce tumour cell cycle arrest, but also promote anti-tumour immunity...
August 16, 2017: Nature
https://www.readbyqxmd.com/read/28813303/stress-and-its-associations-with-relationship-satisfaction
#7
REVIEW
Ashley K Randall, Guy Bodenmann
Stress is an all too common experience for people around the world. In the past 30 years, researchers have built upon traditional models of stress, which have focused on the individual, to explore stress' systemic effects. As such, the once thought individual experience of stress can now be conceptualized as a dyadic construct that affects both individuals within an interdependent dyad. Reviewing a selection of the literature published after Randall and Bodenmann's [1] seminal review on the impact of stress on close relationships, this review conceptualizes the associations between different types of stressors-particularly those that originate outside (external) and inside (internal) the relationship-and relationship satisfaction within romantic relationships...
February 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28813286/effects-of-job-stress-on-family-relationships
#8
REVIEW
Rena Repetti, Shu-Wen Wang
In the short-term, daily job stressors influence family interactions through their impact on the employed person's mood, thoughts, and coping behaviors. In the long-term, family relationships can be shaped by those experiences in both positive and negative ways. Some spouse 'cross-over' effects appear to represent accommodations of the employed partner under stress-for instance, a spouse's increased provision of social support and involvement with children-and are evidence of dynamics that go beyond a simple and direct transfer of stress from work to home...
February 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28813249/neuroendocrine-mechanisms-for-parental-sensitivity-overview-recent-advances-and-future-directions
#9
REVIEW
James E Swain, Shao-Hsuan Shaun Ho
Early parent-infant relationships play important roles in infants' development. New parents adapt to the developing relationship with their infants to coordinate parenting behaviors in the milieu of infant needs, hormones, moods, and stress. This review highlights research from the past two years, using non-invasive brain-imaging techniques and naturalistic tasks in mothers and fathers in relation to psychological, and endocrine measures. Recent work also connects parental brain physiology with parental sensitive behavior, parent/child outcomes and parent psychotherapy...
June 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/28813204/prefrontal-cortex-and-neurological-impairments-of-active-thought
#10
Tim Shallice, Lisa Cipolotti
This article reviews the effects of lesions to the frontal cortex on the ability to carry out active thought, namely, to reason, think flexibly, produce strategies, and formulate and realize plans.Wediscuss how and why relevant neuropsychological studies should be carried out. The relationships between active thought and both intelligence and language are considered. The following basic processes necessary for effective active thought are reviewed: concentration, set switching, inhibiting potentiated responses, and monitoring and checking...
August 16, 2017: Annual Review of Psychology
https://www.readbyqxmd.com/read/28813175/qualitative-analysis-of-registered-nurses-perceptions-of-lactation-assessment-tools-why-and-how-they-are-completed
#11
Joan Esper Kuhnly, Donna J Chapman
BACKGROUND: Although lactation assessment tools are consistently used in clinical practice, there is no evidence describing registered nurses' perspectives regarding the purpose and thought processes involved when conducting a breastfeeding assessment. Research aim: This study aimed to explore registered nurses' perceptions on the purpose of lactation assessment tools and the thought processes involved in completing one. METHODS: Seven focus groups were held from April 2015 through July 2015, in coordination with regional and international lactation and perinatal conferences...
August 1, 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28812983/a-microfluidic-platform-for-modeling-metastatic-cancer-cell-matrix-invasion
#12
Laura Blaha, Chentian Zhang, Mario Cabodi, Joyce Y Wong
Invasion of the extracellular matrix is a critical step in the colonization of metastatic tumors. The invasion process is thought to be driven by both chemokine signaling and interactions between invading cancer cells and physical components of the metastatic niche, including endothelial cells that line capillary walls and serve as a barrier to both diffusion and invasion of the underlying tissue. Transwell chambers, a tool for generating artificial chemokine gradients to induce cell migration, have facilitated recent work to investigate the chemokine contributions to matrix invasion...
August 16, 2017: Biofabrication
https://www.readbyqxmd.com/read/28812969/functional-expression-of-bmp7-receptors-in-oral-epithelial-cells-interleukin-17f-production-in-response-to-bmp7
#13
Kensuke Nishio, Yasumasa Ozawa, Hisanori Ito, Takashi Kifune, Tatsuya Narita, Toshimitsu Iinuma, Nobuhito Gionhaku, Masatake Asano
BACKGROUND: Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β (TGF-β) superfamily. Recently, BMP7 has been demonstrated to be produced by salivary glands and contribute to embryonic branching in mice. The BMP7 in saliva is thought to be delivered to the oral cavity and is expected to contact with stratified squamous epithelial cells which line the surface of oral mucosa. In this study, we attempted to investigate the effects of BMP7 on oral epithelial cells...
October 2017: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/28812948/age-related-resistance-in-arabidopsis-thaliana-involves-the-mads-domain-transcription-factor-short-vegetative-phase-and-direct-action-of-salicylic-acid-on-pseudomonas-syringae
#14
Daniel C Wilson, Christine J Kempthorne, Philip Carella, David K Liscombe, Robin Cameron
Arabidopsis thaliana exhibits a developmentally regulated disease-resistance response known as Age-Related Resistance (ARR), a process that requires intercellular accumulation of salicylic acid (SA), which is thought to act as an antimicrobial agent. ARR is characterized by enhanced resistance to some pathogens at the late adult-vegetative and reproductive stages. While the transition to flowering does not cause the onset of ARR, both processes involve the MADS-domain transcription factor SHORT VEGETATIVE PHASE (SVP)...
August 16, 2017: Molecular Plant-microbe Interactions: MPMI
https://www.readbyqxmd.com/read/28812808/history-structure-and-agency-in-global-health-governance-comment-on-global-health-governance-challenges-2016-are-we-ready
#15
Stephen Gill, Solomon R Benatar
Ilona Kickbusch's thought provoking editorial is criticized in this commentary, partly because she fails to refer to previous critical work on the global conditions and policies that sustain inequality, poverty, poor health and damage to the biosphere and, as a result, she misreads global power and elides consideration of the fundamental historical structures of political and material power that shape agency in global health governance. We also doubt that global health can be improved through structures and processes of multilateralism that are premised on the continued reproduction of the ecologically myopic and socially unsustainable market civilization model of capitalist development that currently prevails in the world economy...
August 29, 2016: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28812776/labelled-sunscreen-spfs-may-overestimate-protection-in-natural-sunlight
#16
Brian Diffey, Uli Osterwalder
Limited evidence exists to indicate that sunscreen protection factors determined in the laboratory are higher than those in natural sunlight. In this article we propose an explanation for this difference and estimate the expected SPFs of sunscreen products in natural sunlight and those expected from laboratory testing. Our results indicate that the labelled SPF, determined by in vivo assay using a UV solar simulator, overestimates the SPF that would be expected in natural sunlight to the extent that for products labelled SPF50+, it may not be possible to achieve a protection against sunlight of more than 25-fold...
August 16, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28812648/fungus-like-mycelial-fossils-in-2-4-billion-year-old-vesicular-basalt
#17
Stefan Bengtson, Birger Rasmussen, Magnus Ivarsson, Janet Muhling, Curt Broman, Federica Marone, Marco Stampanoni, Andrey Bekker
Fungi have recently been found to comprise a significant part of the deep biosphere in oceanic sediments and crustal rocks. Fossils occupying fractures and pores in Phanerozoic volcanics indicate that this habitat is at least 400 million years old, but its origin may be considerably older. A 2.4-billion-year-old basalt from the Palaeoproterozoic Ongeluk Formation in South Africa contains filamentous fossils in vesicles and fractures. The filaments form mycelium-like structures growing from a basal film attached to the internal rock surfaces...
April 24, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28812624/perceptive-costs-of-reproduction-drive-ageing-and-physiology-in-male-drosophila
#18
Zachary M Harvanek, Yang Lyu, Christi M Gendron, Jacob C Johnson, Shu Kondo, Daniel E L Promislow, Scott D Pletcher
Costs of reproduction are thought to result from natural selection optimizing organismal fitness within putative physiological constraints. Phenotypic and population genetic studies of reproductive costs are plentiful across taxa, but an understanding of their mechanistic basis would provide important insight into the diversity in life-history traits, including reproductive effort and ageing. Here, we dissect the causes and consequences of specific costs of reproduction in male Drosophila melanogaster. We find that key survival and physiological costs of reproduction arise from perception of the opposite sex, and they are reversed by the act of mating...
May 15, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28812568/gene-expression-plasticity-as-a-mechanism-of-coral-adaptation-to-a-variable-environment
#19
Carly D Kenkel, Mikhail V Matz
Local adaptation is ubiquitous, but the molecular mechanisms that give rise to this ecological phenomenon remain largely unknown. A year-long reciprocal transplant of mustard hill coral (Porites astreoides) between a highly environmentally variable inshore habitat and a more stable offshore habitat demonstrated that populations exhibit phenotypic signatures that are consistent with local adaptation. We characterized the genomic basis of this adaptation in both coral hosts and their intracellular symbionts (Symbiodinium sp...
November 7, 2016: Nature ecology & evolution
https://www.readbyqxmd.com/read/28812563/multicopy-plasmids-potentiate-the-evolution-of-antibiotic-resistance-in-bacteria
#20
Alvaro San Millan, Jose Antonio Escudero, Danna R Gifford, Didier Mazel, R Craig MacLean
Plasmids are thought to play a key role in bacterial evolution by acting as vehicles for horizontal gene transfer, but the role of plasmids as catalysts of gene evolution remains unexplored. We challenged populations of Escherichia coli carrying the blaTEM-1 β-lactamase gene on either the chromosome or a multicopy plasmid (19 copies per cell) with increasing concentrations of ceftazidime. The plasmid accelerated resistance evolution by increasing the rate of appearance of novel TEM-1 mutations, thereby conferring resistance to ceftazidime, and then by amplifying the effect of TEM-1 mutations due to the increased gene dosage...
November 7, 2016: Nature ecology & evolution
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