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Robert Bissonnette, Kim Papp, Catherine Maari, Yihong Yao, Gabriel Robbie, Wendy I White, Chenxiong Le, Barbara White
BACKGROUND: Interferon-alfa (IFN-alpha) has been implicated in the pathogenesis of psoriasis. OBJECTIVE: To evaluate the safety profile of MEDI-545, a fully human anti-IFN-alpha monoclonal antibody and to explore its effect on the involvement of type I IFN-alpha activity in the maintenance of established plaque psoriasis. METHODS: We conducted an 18-week, randomized, double-blind, placebo-controlled, dose-escalating study in 36 subjects with chronic plaque psoriasis...
March 2010: Journal of the American Academy of Dermatology
Shigeki Murakami, Takashi Emoto, Hiroshige Mori, Katsuhisa Fujita, Naoki Kubo
A syringe-type radiopharmaceutical being supplied by a manufacturer has a syringe shield and a plunger shield, whereas an in-hospital labeling radiopharmaceutical is administered by a disposable plastic syringe without the plunger shield. In cooperation with Nihon Medi-Physics Co. Ltd., we have produced a new experimental plunger shield for the disposable plastic syringe. In order to evaluate this shielding effect, we compared the leaked radiation doses of our plunger shield with those of the syringe-type radiopharmaceutical (Medi shield type)...
August 20, 2008: Nihon Hoshasen Gijutsu Gakkai Zasshi
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