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https://www.readbyqxmd.com/read/29684881/source-specific-speciation-profiles-of-pm-2-5-for-heavy-metals-and-their-anthropogenic-emissions-in-china
#1
Yayong Liu, Jia Xing, Shuxiao Wang, Xiao Fu, Haotian Zheng
Heavy metals are concerned for its adverse effect on human health and long term burden on biogeochemical cycling in the ecosystem. In this study, a provincial-level emission inventory of 13 kinds of heavy metals including V, Cr, Mn, Co, Ni, Cu, Zn, As, Cd, Sn, Sb, Ba and Pb from 10 anthropogenic sources was developed for China, based on the 2015 national emission inventory of primary particulate matters and source category-specific speciation profiles collected from 50 previous studies measured in China. Uncertainties associated with the speciation profiles were also evaluated...
April 20, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29684873/seabird-colonies-as-relevant-sources-of-pollutants-in-antarctic-ecosystems-part-1-trace-elements
#2
C V Z Cipro, P Bustamante, M V Petry, R C Montone
Global distillation is classically pointed as the biggest responsible for contaminant inputs in Polar ecosystems. Mercury (Hg) and other trace elements (TEs) also present natural sources, whereas the biologically mediated input is typically ignored. However, bioaccumulation and biomagnification combined with the fact that seabirds gather in large numbers into large colonies and excrete on land might represent an important local TEs input. A previous work suggested these colonies as sources of not only nutrients, but also organic contaminants...
March 24, 2018: Chemosphere
https://www.readbyqxmd.com/read/29684640/three-invariant-hi-c-interaction-patterns-applications-to-genome-assembly
#3
Sivan Oddes, Aviv Zelig, Noam Kaplan
Assembly of reference-quality genomes from next-generation sequencing data is a key challenge in genomics. Recently, we and others have shown that Hi-C data can be used to address several outstanding challenges in the field of genome assembly. This principle has since been developed in academia and industry, and has been used in the assembly of several major genomes. In this paper, we explore the central principles underlying Hi-C-based assembly approaches, by quantitatively defining and characterizing three invariant Hi-C interaction patterns on which these approaches can build: Intrachromosomal interaction enrichment, distance-dependent interaction decay and local interaction smoothness...
April 20, 2018: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29684621/setd7-and-its-contribution-to-boron-induced-bone-regeneration-in-b-mbg-scaffolds
#4
Chengcheng Yin, Xiaoshi Jia, Richard J Miron, Qiaoyun Long, Hudi Xu, Yan Wei, Min Wu, Yufeng Zhang, Zubing Li
Boron (B), a trace element found in the human body, plays an important role for health of bone by promoting the proliferation and differentiation of osteoblasts. Our research group previously fabricated B-mesoporous bioactive glass (MBG) scaffolds, which successfully promoted osteogenic differentiation of osteoblasts when compared to pure MBG scaffolds without boron. However, the mechanisms of the positive effect of B-MBG scaffolds on osteogenesis remains unknown. Therefore, we performed in-vivo experiments in an OVX rat models with pure MBG scaffolds and compared them to B-MBG scaffold...
April 20, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29684313/breathing-and-coding-a-bit-easier-changes-to-international-classification-of-disease-coding-for-pulmonary-hypertension
#5
REVIEW
Stephen C Mathai, Sherin Mathew
International Classification of Disease (ICD) coding system is broadly utilized by healthcare providers, hospitals, healthcare payers, and governments to track health trends and statistics at the global, national, and local levels and to provide a reimbursement framework for medical care based upon diagnosis and severity of illness. The current iteration of the ICD system, ICD-10, was implemented in 2015. While many changes to the prior ICD-9 system were included in the ICD-10 system, the newer revision failed to adequately reflect advances in the clinical classification of certain diseases such as pulmonary hypertension (PH)...
April 20, 2018: Chest
https://www.readbyqxmd.com/read/29684292/elevated-blood-pressure-and-its-predictors-among-secondary-school-students-in-sarawak-a-cross-sectional-study
#6
Woei Feng Grace Kho, Whye Lian Cheah, Helmy Hazmi
OBJECTIVES: Hypertension is a health issue affecting adolescents. Accumulating evidence affirms that elevated blood pressure begins in childhood and tracks into adulthood. This cross-sectional study was conducted to determine the prevalence of elevated blood pressure and its predictors among secondary school students in Sarawak, Malaysia. METHODS: A total of 2,461 secondary school students aged 12-17 years from 19 schools in Sarawak participated in the study. Questionnaire was used to obtain socio-demographic data, parental history of hypertension, and self-reported physical activity...
March 2018: Central European Journal of Public Health
https://www.readbyqxmd.com/read/29684278/thermal-superinsulating-materials-made-from-nanofibrillated-cellulose-stabilized-pickering-emulsions
#7
Clara Jiménez-Saelices, Bastien Seantier, Yves Grohens, Isabelle Capron
Thermal superinsulating properties of biobased-materials are investigated via the structuration of aerogels through a biphasic system. Highly stable Pickering emulsions are produced using TEMPO-oxidized cellulose nanofibrils (NFC) adsorbed at an oil/water interface. NFCs form an entangled system of clusters of droplets that lead to excellent mechanical properties. The emulsions produced are strong gels that are further used as template to form aerogels. The freeze-dried emulsions result in porous bioaerogels with extremely low densities (0...
April 23, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29684257/reliability-of-neurometabolite-detection-with-two-dimensional-localized-correlation-spectroscopy-at-3t
#8
Jameen Arm, Oun Al-Iedani, Scott Quadrelli, Karen Ribbons, Rod Lea, Jeannette Lechner-Scott, Saadallah Ramadan
BACKGROUND: Two-dimensional localized correlational spectroscopy (2D L-COSY) has been applied in vivo to investigate metabolic profiles in many disorders due to its ability to detect several metabolites simultaneously. Successful application of this technique depends on the reliability of the detection and understanding of the variability result from test-retest measurements. PURPOSE: To evaluate the test-retest repeatability/reliability of 2D L-COSY in detecting brain metabolites in a phantom and healthy subjects in a 3T scanner...
April 23, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29684240/external-laryngeal-nerve-landmarks-revisited
#9
Consuelo Ortega, Eva Maranillo, Steve McHanwell, Jose Sañudo, Teresa Vázquez-Osorio
BACKGROUND: Because external laryngeal nerve (ELN) iatrogenic damage is frequent during neck surgery, its precise localization has been highly recommended. This study analyzes the different surgical landmarks previously proposed and the anatomy of the collateral and terminal branches of the ELN. METHODS: The necks of 157 (77 men and 80 women) human adult embalmed cadavers were examined. The ELN origin, length, and relationship to different landmarks were recorded and results statistically compared with those previously reported...
April 23, 2018: Head & Neck
https://www.readbyqxmd.com/read/29684187/non-invasive-epicardial-and-endocardial-electrocardiographic-imaging-for-scar-related-ventricular-tachycardia
#10
Linwei Wang, Omar A Gharbia, Saman Nazarian, B Milan Horácek, John L Sapp
Aims: Contact mapping is currently used to guide catheter ablation of scar-related ventricular tachycardia (VT) but usually provides incomplete assessment of 3D re-entry circuits and their arrhythmogenic substrates. This study investigates the feasibility of non-invasive electrocardiographic imaging (ECGi) in mapping scar substrates and re-entry circuits throughout the epicardium and endocardium. Methods and results: Four patients undergoing endocardial and epicardial mapping and ablation of scar-related VT had computed tomography scans and a 120-lead electrocardiograms, which were used to compute patient-specific ventricular epicardial and endocardial unipolar electrograms (CEGMs)...
April 18, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29684161/impact-of-heat-stress-during-the-follicular-phase-on-porcine-ovarian-steroidogenic-and-phosphatidylinositol-3-signaling
#11
M J Dickson, C L Hager, A Al-Shaibi, P Q Thomas, L H Baumgard, J W Ross, A F Keating
Environmental conditions that impede heat dissipation and increase body temperature cause heat stress (HS). The study objective was to evaluate impacts of HS on the follicular phase of the estrous cycle. Post-pubertal gilts (126.0 ± 21.6 kg) were orally administered altrenogest to synchronize estrus, and subjected to either 5 d of thermal neutral (TN; 20.3 ± 0.5°C; n = 6) or cyclical HS (25.4 - 31.9°C; n = 6) conditions during the follicular phase preceding behavioral estrus. On d 5, blood samples were obtained, gilts were euthanized, and ovaries collected...
April 19, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29684084/local-and-systemic-inflammatory-lipid-profiling-in-a-rat-model-of-osteoarthritis-with-metabolic-dysregulation
#12
H M de Visser, S C Mastbergen, S Ravipati, P M J Welsing, F C Pinto, F P J G Lafeber, V Chapman, D A Barrett, H Weinans
OBJECTIVE: Bioactive oxidised lipids (oxylipins) are important signalling mediators, capable of modulating the inflammatory state of the joint and anticipated to be of importance in joint homeostasis and status of osteoarthritis. The aim of this study was to quantify oxylipin levels in plasma and synovial fluid from rats with experimentally induced osteoarthritis to investigate the potential role of oxylipins as a marker in the disease process of early osteoarthritis. DESIGN: Forty rats were randomly allocated to a standard or high-fat diet group...
2018: PloS One
https://www.readbyqxmd.com/read/29684020/black-boxing-and-cause-effect-power
#13
William Marshall, Larissa Albantakis, Giulio Tononi
Reductionism assumes that causation in the physical world occurs at the micro level, excluding the emergence of macro-level causation. We challenge this reductionist assumption by employing a principled, well-defined measure of intrinsic cause-effect power-integrated information (Φ), and showing that, according to this measure, it is possible for a macro level to "beat" the micro level. Simple systems were evaluated for Φ across different spatial and temporal scales by systematically considering all possible black boxes...
April 23, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29684009/switchable-slow-cellular-conductances-determine-robustness-and-tunability-of-network-states
#14
Guillaume Drion, Julie Dethier, Alessio Franci, Rodolphe Sepulchre
Neuronal information processing is regulated by fast and localized fluctuations of brain states. Brain states reliably switch between distinct spatiotemporal signatures at a network scale even though they are composed of heterogeneous and variable rhythms at a cellular scale. We investigated the mechanisms of this network control in a conductance-based population model that reliably switches between active and oscillatory mean-fields. Robust control of the mean-field properties relies critically on a switchable negative intrinsic conductance at the cellular level...
April 23, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29683988/case-report-ocular-myasthenia-gravis-associated-with-in-vitro-fertilization-procedures
#15
Yung Ju Yoo, Sang Beom Han, Hee Kyung Yang, Jeong-Min Hwang
SIGNIFICANCE: Ocular myasthenia gravis is a localized form of myasthenia gravis, which is a postsynaptic disorder of the neuromuscular junction that causes fluctuating weakness of extraocular muscles resulting from autoimmune mechanisms. In women with myasthenia, changes in sex hormone levels and administration of corticosteroids can trigger or worsen symptoms of myasthenia gravis. PURPOSE: To describe a case of seronegative ocular myasthenia gravis whose first symptom appeared a day after in vitro fertilization procedure...
April 20, 2018: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/29683683/sequentially-responsive-therapeutic-peptide-assembling-nanoparticles-for-dual-targeted-cancer-immunotherapy
#16
Keman Cheng, Yanping Ding, Ying Zhao, Shefang Ye, Xiao Zhao, Yinlong Zhang, Tianjiao Ji, Huanhuan Wu, Bin Wang, Gregory J Anderson, Lei Ren, Guangjun Nie
Combination therapeutic regimen is becoming a primary direction for current cancer immunotherapy to broad the antitumor response. Functional nanomaterials offer great potential for steady co-delivery of various drugs, especially small molecules, therapeutic peptides, and nucleic acids, thereby realizing controllable drug release, increase of drug bioavailability and reduction of adverse effects. Herein, a therapeutic peptide assembling nanoparticle that can sequentially respond to dual stimuli in the tumor extracellular matrix was designed for tumor-targeted delivery and on-demand release of a short D-peptide antagonist of programmed cell death-ligand 1 (D PPA-1) and an inhibitor of idoleamine 2, 3-dioxygenase (NLG919)...
April 23, 2018: Nano Letters
https://www.readbyqxmd.com/read/29683382/public-health-system-delivered-mental-health-preventive-care-links-to-significant-reduction-of-health-care-costs
#17
Jie Chen, Priscilla Novak, Howard Goldman
The objective was to estimate the association between health care expenditures and implementation of preventive mental health programs by local health departments (LHDs). Multilevel nationally representative data sets were linked to test the hypothesis that LHDs' provision of preventive mental health programs was associated with cost savings. A generalized linear model with log link and gamma distribution and state-fixed effects was used to estimate the association between LHDs' mental illness prevention services and total health care expenditures per person per year for adults aged 18 years and older...
April 23, 2018: Population Health Management
https://www.readbyqxmd.com/read/29683059/wind-power-and-the-situatedness-of-community-engagement
#18
Hyomin Kim, Seung Hee Cho, Sungsoo Song
Jeju, an island in Korea, became a place to site wind turbines with an unusually high level of public acceptance. Based on interviews, media analyses, and policy research, we found that the collective memory of socio-economic deprivation enabled community engagement to matter to residents, the provincial government, and environmental activists. It was within socio-historically contextualized processes of articulating the vision of a "good" society that an actual form of community engagement, however inadequate it might appear to some, became relevant to stakeholders in a particular locality...
April 1, 2018: Public Understanding of Science
https://www.readbyqxmd.com/read/29682903/cataract-frequency-and-subtypes-involved-in-workers-assessed-for-their-solar-radiation-exposure-a-systematic-review
#19
REVIEW
Alberto Modenese, Fabriziomaria Gobba
Cataract is currently the primary cause of blindness worldwide, and one of its main risk factors is solar ultraviolet radiation exposure. According to the localization of lens opacities, three main subtypes of cataract are recognized: nuclear, cortical and posterior subcapsular cataract. One of the main determinants of individual long-term solar radiation exposure is outdoor work. We systematically reviewed scientific literature from the last 20 years to update the recent development of research on the risk of cataract in outdoor workers and on the specific subtypes involved, also investigating the methods applied to evaluate the occupational risk...
April 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29682764/how-confident-are-physicians-in-deprescribing-for-the-elderly-and-what-barriers-prevent-deprescribing
#20
L Djatche, S Lee, D Singer, S E Hegarty, M Lombardi, V Maio
WHAT IS KNOWN AND OBJECTIVE: Deprescribing is the process of discontinuing or reducing the dosage of medications that are no longer appropriate or aligned with goals of care, which is paramount in elderly patients with multiple comorbidities and polypharmacy. The objective of this study was to assess the perceptions of primary care physicians on deprescribing for elderly patients and potential barriers to deprescribing that physicians experience in the Local Health Authority (LHA) of Parma, Emilia-Romagna, Italy...
April 22, 2018: Journal of Clinical Pharmacy and Therapeutics
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