keyword
MENU ▼
Read by QxMD icon Read
search

Local levels

keyword
https://www.readbyqxmd.com/read/29908515/an-altered-state-emergent-changes-to-illicit-drug-markets-and-distribution-networks-in-scotland
#1
James Densley, Robert McLean, Ross Deuchar, Simon Harding
BACKGROUND: Many efforts have been undertaken to construct an overview of various aspects of illicit drug distribution in the United Kingdom. Yet given that national, regional, and local differences can be profound, this has proven difficult, to the extent that Scotland has been largely excluded from the conversation. In addition, the level of supply being examined, the drug type, and the actors involved only add to confusion and vast differences between some findings. METHOD: The current study aims to provide a holistic account, as best as possible considering variations of illegal drug supply in illicit networks, by focusing in on a particular geographical context (Scotland) and addressing drug supply at all levels...
June 13, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29908514/sdvsrm-a-new-ssrm-based-technique-featuring-dynamically-adjusted-scanner-synchronized-sample-voltages-for-measurement-of-actively-operated-devices
#2
Stefan Doering, Andre Wachowiak, Hagen Roetz, Stefan Eckl, Thomas Mikolajick
Scanning spreading resistance microscopy (SSRM) with its high spatial resolution and high dynamic signal range is a powerful tool for two-dimensional characterization of semiconductor dopant areas. However, the application of the method is limited to devices in equilibrium condition, as the investigation of actively operated devices would imply potential differences within the device, whereas SSRM relies on a constant voltage difference between sample surface and probe tip. Furthermore, the standard preparation includes short circuiting of all device components, limiting applications to devices in equilibrium condition...
June 1, 2018: Ultramicroscopy
https://www.readbyqxmd.com/read/29908501/review-of-modelling-air-pollution-from-traffic-at-street-level-the-state-of-the-science
#3
REVIEW
H Forehead, N Huynh
Traffic emissions are a complex and variable cocktail of toxic chemicals. They are the major source of atmospheric pollution in the parts of cities where people live, commute and work. Reducing exposure requires information about the distribution and nature of emissions. Spatially and temporally detailed data are required, because both the rate of production and the composition of emissions vary significantly with time of day and with local changes in wind, traffic composition and flow. Increasing computer processing power means that models can accept highly detailed inputs of fleet, fuels and road networks...
June 13, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29908499/characterization-of-polycyclic-aromatic-hydrocarbons-pahs-in-vegetables-near-industrial-areas-of-shanghai-china-sources-exposure-and-cancer-risk
#4
Jinpu Jia, Chunjuan Bi, Junfeng Zhang, Xiaopei Jin, Zhenlou Chen
Dietary consumption of contaminated vegetables may contribute to polycyclic aromatic hydrocarbon (PAH) exposure in humans; however, this exposure pathway has not been examined thoroughly. This study aims to characterize the concentrations of PAHs in six types of vegetables grown near industrial facilities in Shanghai, China. We analyzed 16 individual PAHs on the US EPA priority list, and the total concentration in vegetables ranged from 65.7 to 458.0 ng g-1 in the following order: leafy vegetables (romaine lettuce, Chinese cabbage and Shanghai green cabbage) > stem vegetables (lettuce) > seed and pod vegetables (broad bean) > rhizome vegetables (daikon)...
June 13, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29908347/aging-related-functional-and-structural-changes-in-the-heart-and-aorta-mitotempo-improves-aged-cardiovascular-performance
#5
Yusuf Olgar, Sinan Degirmenci, Aysegul Durak, Deniz Billur, Belgin Can, Gizem Kayki Mutlu, Ebru Arioglu Inan, Belma Turan
Aging in humans represents declining in cardio-protective systems, however its mechanisms are not known yet. We aimed to analyse how aging affects key mechanisms responsible for contractile dysfunction via comparing the improperly synchrony between electrical and mechanical activities in male aged-rats (24-month old) comparison to those of adult-rats (6-month old). We determined significantly increased systemic oxidative stress with decreased antioxidant capacity, clear insulin resistance and hypertrophy in aged-rats with normal fasting blood glucose...
June 13, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29908149/a-hexokinase-2-modulator-for-field-directed-treatment-of-experimental-actinic-keratoses
#6
Vered Behar, Hadas Pahima, Adi Kozminsky-Atias, Nir Arbel, Emmanuel Loeb, Max Herzberg, Oren M Becker
Overexpression of hexokinase 2 (HK2), and its binding to VDAC1 on the outer mitochondrial membrane of cancer cells, is key to their metabolic reprogramming to aerobic glycolysis, which enables them to proliferate. We describe Comp-1, an allosteric small molecule that selectively detaches HK2 from the mitochondria. Detachment of HK2 reduces glycolysis and triggers apoptosis in cancer cells, without affecting HK1 expressing normal cells. The anti-cancer activity of Comp-1 was demonstrated in the UVB-damaged skin model in SKH-1 mice...
June 13, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29907928/trends-in-the-incidence-of-retinopathy-of-prematurity-over-a-10-year-period
#7
Prudence P C Chow, Wilson W K Yip, Mary Ho, Julie Y C Lok, Henry H W Lau, Alvin L Young
AIM: To describe and evaluate the trends in the incidence of retinopathy of prematurity over a 10-year period in a tertiary hospital in Hong Kong. METHODS: A retrospective review was performed on all preterm infants screened and/or treated for retinopathy of prematurity from January 2006 to December 2015 at Prince of Wales Hospital, Hong Kong. Preterm infants with incomplete records or transferred-in from other hospitals/region solely for treatment of ROP were excluded...
June 16, 2018: International Ophthalmology
https://www.readbyqxmd.com/read/29907871/c3a-receptor-antagonism-as-a-novel-therapeutic-target-for-chronic-rhinosinusitis
#8
Jennifer K Mulligan, Kunal Patel, Tucker Williamson, Nicholas Reaves, William Carroll, Sarah E Stephenson, Peng Gao, Richard R Drake, Benjamin A Neely, Stephen Tomlinson, Rodney J Schlosser, Carl Atkinson
Chronic rhinosinusitis with nasal polyps (CRSwNP) is an inflammatory disease with an unknown etiology. Recent studies have implicated the complement system as a potential modulator of disease immunopathology. We performed proteomic pathway enrichment analysis of differentially increased proteins, and found an enrichment of complement cascade pathways in the nasal mucus of individuals with CRSwNP as compared to control subjects. Sinonasal mucus levels of complement 3 (C3) correlated with worse subjective disease severity, whereas no significant difference in systemic C3 levels could be determined in plasma samples...
June 15, 2018: Mucosal Immunology
https://www.readbyqxmd.com/read/29907735/identification-of-proteins-potentially-associated-with-renal-aging-in-rats
#9
Diangeng Li, Delong Zhao, Weiguang Zhang, Qian Ma, Dong Liu, Qi Huang, Ying Zheng, Xueyuan Bai, Xuefeng Sun, Xiangmei Chen
We established a young (Y)-old (O) rat kidney transplantation model. With this model, we detected no age-related differences in renal structure between Y→Y and Y→O kidneys or O→O and O→Y kidneys. However, we did detect differences in levels of the senescence markers β-gal and p16 as well as the inflammatory cytokines TNF-α and IL-1β. Using proteomics analysis we detected 66 proteins associated with suppression of aging and 73 proteins associated with enhancement of aging. After construction of a protein-protein interaction network, a total of 73 nodes and 99 edges were analyzed using MCODE, and three significant modules were selected...
June 14, 2018: Aging
https://www.readbyqxmd.com/read/29907698/selective-activation-of-retinoic-acid-%C3%AE-2-receptors-exerts-cardioprotective-effects
#10
Alice Marino, Takuya Sakamoto, Xiao-Han Tang, Lorraine J Gudas, Roberto Levi
We previously discovered that oral treatment with AC261066, a synthetic selective agonist for the retinoic acid β2-receptor (RARβ2), decreases oxidative stress in the liver, pancreas, and kidney of mice fed a high-fat diet (HFD). Since hyperlipidemic states are causally associated with myocardial ischemia and oxidative stress, we have now investigated the effects of AC261066 in an ex-vivo ischemia/reperfusion (I/R) injury model in hearts of two prototypic dysmetabolic mice. We found that a 6-week oral treatment with AC261066 in both genetically hypercholesterolemic (ApoE-/-) and obese (HFD-fed) wild-type mice exerts protective effects when their hearts are subsequently subjected to I/R ex vivo in the absence of added drug...
June 15, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29907536/methicillin-resistant-staphylococcus-aureus-nasal-carriage-and-infection-among-patients-with-diabetic-foot-ulcer
#11
Shin-Yi Lin, Nai-Yu Lin, Yu-Yao Huang, Chi-Chun Hsieh, Yhu-Chering Huang
PURPOSE: To evaluate the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) nasal carriage in patients with diabetic foot ulcer (DFU) in Taiwan, and to assess the concordance between colonizing and clinical MRSA isolates from the patients. METHOD: A total of 354 nasal specimens were collected from 112 to 242 diabetic patients with and without foot ulcer, respectively. MRSA clinical isolates from DFU wound cultures were collected for comparison. RESULTS: Nasal carriage rate of S...
June 4, 2018: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/29907326/fgf21-protects-human-umbilical-vein-endothelial-cells-against-high-glucose-induced-apoptosis-via-pi3k-akt-fox3a-signaling-pathway
#12
Dongmin Guo, Lele Xiao, Huijun Hu, Mihua Liu, Lu Yang, Xiaolong Lin
AIMS: Diabetic macroangiopathy is the main cause of morbidity and mortality in patients with diabetes. Endothelial cell injury is a pathological precondition for diabetic macroangiopathy. Fibroblast growth factor 21 (FGF21) is a key metabolic regulator which has recently been suggested to protect cardiac myocytes and vascular cells against oxidative stress-induced injury in vitro and vivo. In this study, we aimed to investigate the protective capacity of FGF21 in human umbilical vein endothelial cells (HUVECs) against high glucose (HG)-induced apoptosis via phosphatidylinositol-3-kinase/protein kinase B (PI3K/Akt)/FoxO3a pathway...
May 25, 2018: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/29907200/effect-of-time-to-operation-on-outcomes-in-adults-who-underwent-emergency-general-surgery-procedure
#13
Trevor Wood, Arash Azin, Fayez A Quereshy
BACKGROUND: Patients who undergo an emergency procedure have an increase in postoperative morbidity and mortality. Emergency procedures constitute 14.2% of all general surgery procedures and account for 53.5% of deaths. Among this population, time to surgery from arrival to the emergency department (ED) has not been evaluated as an independent risk factor for morbidity and mortality. MATERIAL AND METHODS: Patients who underwent an emergency general surgery procedure from 2013 to 2015 were identified using a local American College of Surgeons National Surgical Quality Improvement Project (ACS-NSQIP) database...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29907185/density-measurement-of-demodex-canis-by-qpcr-and-analysis-of-serum-cytokine-levels-in-dogs-with-different-clinical-forms-of-demodicosis
#14
Naiani Domingos Gasparetto, Arleana do Bom Parto Ferreira Almeida, Luciano Nakazato, Eduardo Luzía França, Adenilda Cristina Honorio França, Danny Laura Gomes Fagundes, Juliano Bortolini, Valéria Régia Franco Sousa
OBJECTIVES: To quantify (by qPCR) the density of Demodex canis mites in the skin of dogs with demodicosis and in healthy dogs, as well as measuring the serum concentrations of interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-12, and tumour necrosis factor-alfa (TNF-α). METHODS: Fifty-four dogs were divided into three groups: localized demodicosis (LD, n = 16), generalized demodicosis (GD, n = 22), and control group (CG, n = 16). All dogs were subjected to skin scraping, blood collection, and skin biopsy...
June 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29907086/potential-risk-factors-and-prevalence-of-helicobacter-pylori-infection-among-adult-patients-with-dyspepsia-symptoms-in-cameroon
#15
Laure Brigitte Kouitcheu Mabeku, Michelle Larissa Noundjeu Ngamga, Hubert Leundji
BACKGROUND: Helicobacter pylori is a Gram negative bacterium that colonizes the stomach of approximately two-thirds of the human population and it is involved in the pathogenesis of gastroduodenal diseases. This study sought to determine potential risk factors associated with seroprevalence of H. pylori among dyspepsia patients in Cameroon for a better management of the disease. METHODS: The study was carried out from August to December 2014 at Laquintinie Hospital and District Hospital of Bonassama in Douala metropolis...
June 15, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29907080/decadal-stability-in-genetic-variation-and-structure-in-the-intertidal-seaweed-fucus-serratus-heterokontophyta-fucaceae
#16
Alexander Jueterbock, James A Coyer, Jeanine L Olsen, Galice Hoarau
BACKGROUND: The spatial distribution of genetic diversity and structure has important implications for conservation as it reveals a species' strong and weak points with regard to stability and evolutionary capacity. Temporal genetic stability is rarely tested in marine species other than commercially important fishes, but is crucial for the utility of temporal snapshots in conservation management. High and stable diversity can help to mitigate the predicted northward range shift of seaweeds under the impact of climate change...
June 15, 2018: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/29907027/variation-of-optical-spectra-of-water-clusters-with-size-from-many-body-green-s-function-theory
#17
Min Wei, Fan Jin, Tingwei Chen, Yuchen Ma
Water clusters are an important species in the environment and atmosphere and take part in various chemical and biological reactions. How their optical properties vary with size is still an open question. Using the GW method and Bethe-Salpeter equation within the ab initio many-body Green's function theory, we study the electronic excitations in a series of water clusters (H2 O)n with n = 1-48. We find that their absorption peaks blueshift with increasing cluster size due to the reducing electron-hole binding energy which arises from the enhanced electronic screening and gradually delocalized excitonic spatial distribution...
June 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29906970/crystallization-process-of-a-three-dimensional-complex-plasma
#18
Benjamin Steinmüller, Christopher Dietz, Michael Kretschmer, Markus H Thoma
Characteristic timescales and length scales for phase transitions of real materials are in ranges where a direct visualization is unfeasible. Therefore, model systems can be useful. Here, the crystallization process of a three-dimensional complex plasma under gravity conditions is considered where the system ranges up to a large extent into the bulk plasma. Time-resolved measurements exhibit the process down to a single-particle level. Primary clusters, consisting of particles in the solid state, grow vertically and, secondarily, horizontally...
May 2018: Physical Review. E
https://www.readbyqxmd.com/read/29906818/cooperation-dynamics-of-generalized-reciprocity-in-state-based-social-dilemmas
#19
Viktor Stojkoski, Zoran Utkovski, Lasko Basnarkov, Ljupco Kocarev
We introduce a framework for studying social dilemmas in networked societies where individuals follow a simple state-based behavioral mechanism based on generalized reciprocity, which is rooted in the principle "help anyone if helped by someone." Within this general framework, which applies to a wide range of social dilemmas including, among others, public goods, donation, and snowdrift games, we study the cooperation dynamics on a variety of complex network examples. By interpreting the studied model through the lenses of nonlinear dynamical systems, we show that cooperation through generalized reciprocity always emerges as the unique attractor in which the overall level of cooperation is maximized, while simultaneously exploitation of the participating individuals is prevented...
May 2018: Physical Review. E
https://www.readbyqxmd.com/read/29906729/atmospheric-particle-bound-organophosphate-ester-flame-retardants-and-plasticizers-in-a-north-african-mediterranean-coastal-city-bizerte-tunisia
#20
Javier Castro-Jiménez, Richard Sempéré
Organophosphate ester (OPE) flame retardants and plasticizers have been detected at generally high frequencies (70-98%) for the first time in the atmosphere over the NW African coastal Mediterranean. Results from sixty air samples (total suspended particles, TSP) collected between March 2015 and January 2016 in an urban coastal site (Bizerte, Tunisia) revealed ∑9 OPE concentrations of ~100-1060 pg m-3 (470 pg m-3 , median) with TCPPs, EHDPP and TiBP exhibiting the higher median concentrations (~110, 100 and 85 pg m-3 , respectively)...
June 12, 2018: Science of the Total Environment
keyword
keyword
28642
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"