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https://www.readbyqxmd.com/read/29236364/intraflagellar-transporter-protein-140-ift140-a-component-of-ift-a-complex-is-essential-for-male-fertility-and-spermiogenesis-in-mice
#1
Yong Zhang, Hong Liu, Wei Li, Zhengang Zhang, Shiyang Zhang, Maria E Teves, Courtney Stevens, James A Foster, Gregory E Campbell, Jolene J Windle, Rex A Hess, Gregory J Pazour, Zhibing Zhang
Intraflagellar transport (IFT) is a conserved mechanism essential for the assembly and maintenance of most eukaryotic cilia and flagella. However, little is known about its role in sperm flagella formation and male fertility. IFT140 is a component of IFT-A complex. In mouse, it is highly expressed in the testis. Ift140 gene was inactivated specifically in mouse spermatocytes/spermatids. The mutant mice did not show any gross abnormalities, but all were infertile associated with significantly reduced sperm number and motility...
December 13, 2017: Cytoskeleton
https://www.readbyqxmd.com/read/29236199/caspase-cleavage-of-transcription-factor-sp1-enhances-apoptosis
#2
Behzad Torabi, Samuel Flashner, Kate Beishline, Aislinn Sowash, Kelly Donovan, Garrett Bassett, Jane Azizkhan-Clifford
Sp1 is a ubiquitous transcription factor that regulates many genes involved in apoptosis and senescence. Sp1 also has a role in the DNA damage response; at low levels of DNA damage, Sp1 is phosphorylated by ATM and localizes to double-strand break sites where it facilitates DNA double-strand-break repair. Depletion of Sp1 increases the sensitivity of cells to DNA damage, whereas overexpression of Sp1 can drive cells into apoptosis. In response to a variety of stimuli, Sp1 can be regulated through proteolytic cleavage by caspases and/or degradation...
December 13, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/29236125/-laser-treatment-of-basal-cell-carcinoma
#3
REVIEW
C Salavastru, G S Tiplica, K Fritz
With a clear increase in the incidence and a continuously earlier onset, the main risk factors for the development of basal cell carcinoma are still exposure to sunlight, fair skin, immunosuppression, carcinogens such as arsenic, chronic irritations and certain genodermatoses. Treatment options for localized resectionable basal cell carcinoma include micrographically controlled surgery, simple excision, curettage, laser ablation, cryosurgery, imiquimod, 5‑fluorouracil, photodynamic treatment and radiotherapy...
December 13, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29236067/how-well-do-health-mediation-programs-address-the-determinants-of-the-poor-health-status-of-roma-a-longitudinal-case-study
#4
Andrej Belak, Zuzana Dankulincova Veselska, Andrea Madarasova Geckova, Jitse P van Dijk, Sijmen A Reijneveld
In Central and Eastern Europe (CEE), health-mediation programs (HMPs) have become central policy instruments targeting health inequities between segregated Roma and general populations. Social determinants of health (SDH) represent the root causes behind health inequities. We therefore evaluated how an HMP based in Slovakia addressed known SDH in its agenda and its everyday implementation. To produce descriptive data on the HMP's agenda and everyday implementation we observed and consulted 70 program participants across organizational levels and 30 program recipients over the long-term...
December 13, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29236042/single-channel-eeg-artifact-identification-using-two-dimensional-multi-resolution-analysis
#5
Mojtaba Taherisadr, Omid Dehzangi, Hossein Parsaei
As a diagnostic monitoring approach, electroencephalogram (EEG) signals can be decoded by signal processing methodologies for various health monitoring purposes. However, EEG recordings are contaminated by other interferences, particularly facial and ocular artifacts generated by the user. This is specifically an issue during continuous EEG recording sessions, and is therefore a key step in using EEG signals for either physiological monitoring and diagnosis or brain-computer interface to identify such artifacts from useful EEG components...
December 13, 2017: Sensors
https://www.readbyqxmd.com/read/29236014/identification-of-potential-sewer-mining-locations-a-monte-carlo-based-approach
#6
I K Tsoukalas, C K Makropoulos, S N Michas
Rapid urbanization affecting demand patterns, coupled with potential water shortages due to supply side impacts of climatic changes, has led to the emergence of new technologies for water and wastewater reuse. Sewer mining (SM) is a novel decentralized option that could potentially provide non-potable water for urban uses, including for example the irrigation of urban green spaces, providing a mid-scale solution to effective wastewater reuse. SM is based on extracting wastewater from local sewers and treatment at the point of demand and entails in some cases the return of treatment residuals back to the sewer system...
December 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29236013/characteristics-distribution-and-sources-of-polychlorinated-biphenyls-pcbs-in-coastal-sediments-from-the-heavily-industrialized-area-of-asalouyeh-iran
#7
Hossein Arfaeinia, Zahra Asadgol, Ehsan Ahmadi, Morteza Seifi, Masoud Moradi, Sina Dobaradaran
In this research, the levels of polychlorinated biphenyls (PCBs) were investigated in the marine sediments of Asaluyeh harbor, in the Persian Gulf. The samples were taken from industrial, semi-industrial and urban regions. The mean concentration levels of total (Σ) 18 detected PCBs were 514.32, 144.67 and 31.6 pg/g dw for the industrial, semi-industrial and urban sampling stations, respectively. Based on a multivariate statistical analysis, it was found that high contamination levels of PCBs in sediments collected along the Persian Gulf were associated with releases from local industries...
December 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29235541/biodegradable-bisvinyl-sulfonemethyl-crosslinked-gelatin-conduit-promotes-regeneration-after-peripheral-nerve-injury-in-adult-rats
#8
Chien-Hsin Ko, Ming-You Shie, Jia-Horng Lin, Yi-Wen Chen, Chun-Hsu Yao, Yueh-Sheng Chen
In our previous study, we found that gelatin-based materials exhibit good conductivity and are non-cytotoxic. In this study, gelatin was cross-linked with bisvinyl sulfonemethyl (BVSM) to fabricate a biodegradable conduit for peripheral nerve repair. First, BVSM on the prepared conduit was characterized to determine its mechanical properties and contact angle. The maximum tensile strength and water contact angle of the gelatin-BVSM conduits were 23 ± 4.8 MPa and 74.7 ± 9°, which provided sufficient mechanical strength to resist muscular contraction; additionally, the surface was hydrophilic...
December 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29235462/atomic-resolution-three-dimensional-hydration-structures-on-a-heterogeneously-charged-surface
#9
Kenichi Umeda, Lidija Zivanovic, Kei Kobayashi, Juha Ritala, Hiroaki Kominami, Peter Spijker, Adam S Foster, Hirofumi Yamada
Local hydration structures at the solid-liquid interface around boundary edges on heterostructures are key to an atomic-level understanding of various physical, chemical and biological processes. Recently, we succeeded in visualising atomic-scale three-dimensional hydration structures by using ultra-low noise frequency-modulation atomic force microscopy. However, the time-consuming three-dimensional-map measurements on uneven heterogeneous surfaces have not been achieved due to experimental difficulties, to the best of our knowledge...
December 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/29235261/interferon-%C3%AE-2-and-interferon-%C3%AE-induce-the-degranulation-independent-production-of-vegf-a-and-il-1-receptor-antagonist-and-other-mediators-from-human-mast-cells
#10
Sharon A Oldford, Suzanne P Salsman, Liliana Portales-Cervantes, Raidan Alyazidi, Robert Anderson, Ian D Haidl, Jean S Marshall
BACKGROUND: Mast cells are resident immune effector cells, often studied in the context of allergic disease. Found in substantial numbers at sites of potential infection they are increased at sites of angiogenesis and can be pivotal for the sensing and clearance of a variety of pathogens. Interferons (IFNs) are cytokines that are critical for host defence against intracellular pathogens. Increased levels of IFNs are observed during viral infection and in autoimmune diseases. IFNs are also widely used therapeutically and have been examined in the therapy of severe asthma...
December 13, 2017: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/29235237/community-based-preventive-activities-in-the-public-dental-service-in-norway
#11
E Widström, A Tillberg, L I Byrkjeflot, L Stein, R Skudutyte-Rysstad
OBJECTIVES: The purpose of this study was to describe community-based preventive interventions undertaken by the dental team outside the dental clinics in Norway, from the dental hygienists' and the dentists' perspective, with the main focus on target groups and existing guidelines and routines for these activities. A secondary aim was to identify the personnel responsible for developing the local guidelines and the knowledge sources for the guidelines. METHODS: With the assistance of the Chief Dental Officers in 15 Public Dental Service (PDS) regions, questionnaires were emailed to the local clinics (n = 421)...
December 13, 2017: International Journal of Dental Hygiene
https://www.readbyqxmd.com/read/29235095/immune-cells-regulate-vegf-signaling-via-release-of-vegf-and-antagonistic-soluble-vegf-receptor-1
#12
Timm Hoeres, Martin Wilhelm, Manfred Smetak, Elisabeth Holzmann, Gundula Schulze-Tanzil, Josef Birkmann
Vascular endothelial growth factor (VEGF) is an important regulator of physiological and pathological angiogenesis. Beside malignant and stromal cells, local immune cells shape VEGF signaling in the tumor microenvironment. Aminobisphosphonates like zoledronic acid (Zol) are drugs known to inhibit osteoclast activity and bone resorption, but also have immunomodulatory and anti-tumor effects. These properties have previously been linked to the downregulation of VEGF and interference with tumor neo-angiogenesis...
December 13, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29234666/technical-advances-to-study-extracellular-vesicles
#13
REVIEW
Paula Carpintero-Fernández, Juan Fafián-Labora, Ana O'Loghlen
Extracellular vesicles are a heterogeneous and dynamic group of lipid bilayer membrane nanoparticles that can be classified into three different groups depending on their cellular origin: exosomes, microvesicles, and apoptotic bodies. They are produced by different cell types and can be isolated from almost all body fluids. EVs contain a variety of proteins, lipids, nucleic acids, and metabolites which regulate a number of biological and pathological scenarios both locally and systemically. Different techniques have been described in order to determine EV isolation, release, uptake, and cargo...
2017: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29234569/a-case-of-localized-pulmonary-calcification-presenting-as-a-persistent-mass-lesion-in-an-immunosuppressed-patient-following-treatment-of-a-pseudomonas-pneumonia
#14
Matthew J Cecchini, Dominic L Shepherd, Jessica G Shepherd
We report a case of a persistent right upper lobe opacity following treatment for a Pseudomonas infection in an immunosuppressed patient with a recent renal transplantation. The patient underwent a surgical lung biopsy for definitive diagnosis of the mass. The lesion was composed of extensive calcifications deposited throughout the lung with associated fibrosis. The patient had a history of a remote parathyroidectomy for hyperparathyroidism; however, the parathyroid hormone (PTH) and the calcium levels were still mildly elevated...
October 11, 2017: Curēus
https://www.readbyqxmd.com/read/29234512/new-models-of-care-a-liaison-psychiatry-service-for-medically-unexplained-symptoms-and-frequent-attenders-in-primary-care
#15
Janine Bestall, Najma Siddiqi, Suzanne Heywood-Everett, Charlotte Freeman, Paul Carder, Mick James, Brendan Kennedy, Angela Moulson, Allan House
Aims and method This paper describes the process of setting up and the early results from a new liaison psychiatry service in primary care for people identified as frequent general practice attenders with long-term conditions or medically unexplained symptoms. Using a rapid evidence synthesis, we identified existing service models, mechanisms to identify and refer patients, and outcomes for the service. Considering this evidence, with local contingencies we defined options and resources. We agreed a model to set up a service in three diverse general practices...
December 2017: BJPsych Bulletin
https://www.readbyqxmd.com/read/29234498/evaluation-of-the-national-return-of-unwanted-medicines-rum-program-in-australia-a-study-protocol
#16
Amanda J Wheeler, Jean Spinks, Emilie Bettington, Fiona Kelly
Background: The National Return of Unwanted Medicines (NatRUM) program in Australia is one of the few nationally coordinated, free-to-consumer schemes to dispose of unwanted medicines globally. This scheme has been in operation since 1996, however, little is known about public awareness of the scheme and its effectiveness in reducing unsafe disposal practices. The study objectives are to undertake a review of (1) the current use of the NatRUM scheme by consumers; and (11) to investigate disposal practices and beliefs of the general population...
2017: Journal of Pharmaceutical Policy and Practice
https://www.readbyqxmd.com/read/29234259/simultaneous-measurements-of-follicle-stimulating-hormone-and-total-testosterone-and-associations-in-clinically-localized-prostate-cancer
#17
Antonio B Porcaro, Salvatore Siracusano, Nicolò de Luyk, Paolo Corsi, Marco Sebben, Alessandro Tafuri, Tania Processali, Davide Inverardi, Giovanni Cacciamani, Daniele Mattevi, Maria A Cerruto, Matteo Brunelli, Claudio Ghimenton, Carmelo Monaco, Walter Artibani
Objectives: To evaluate the potential relations of simultaneous measurements of basal levels of follicle stimulating hormone (FSH) and total testosterone (TT) in clinically localized prostate cancer (PCa). Materials and Methods: The study included 126 patients who had simultaneous measurements of prostate specific antigen (PSA), FSH, and TT before undergoing radical prostatectomy for clinically localized PCa. Correlations and independent associations between clinical and pathological factors were investigated by statistical methods...
November 2017: Current Urology
https://www.readbyqxmd.com/read/29234182/interleukin-10-and-interferon-%C3%AE-levels-in-patients-with-cutaneous-leishmaniasis-treated-with-cryotherapy
#18
Farhad Handjani, Saeed Reza Yousef, Nasrin Saki, Nasrin Hamidizadeh
Pentavalent antimonials, as the 1st choice for the treatment of cutaneous leishmaniasis (CL), have various side effects. Also, there are some reports of drug resistance. Due to its safety, cryotherapy can be a good alternative or complementary treatment in CL. The aim of this study was to explore the possible systemic immunological mechanisms of cryotherapy besides its local effects in the treatment of CL. Twenty patients with CL were selected. The disease was confirmed via a direct smear. A venous blood sample was collected to determine IL-10 and IFN-γ levels before starting cryotherapy...
September 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29234079/a-genetic-screen-to-discover-sumoylated-proteins-in-living-mammalian-cells
#19
Maki Komiya, Akihiro Ito, Mizuki Endo, Daisuke Hiruma, Mitsuru Hattori, Hisato Saitoh, Minoru Yoshida, Takeaki Ozawa
Post-translational modification by the Small Ubiquitin-related Modifier (SUMO) is indispensable for diverse biological mechanisms. Although various attempts have been made to discover novel SUMO substrate proteins to unveil the roles of SUMOylation, the reversibility of SUMOylation, and the differences in the SUMOylation level still makes it difficult to explore infrequently-SUMOylated proteins in mammalian cells. Here, we developed a method to screen for mammalian SUMOylated proteins using the reconstitution of split fluorescent protein fragments in living mammalian cells...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29233983/endocytosis-regulates-tdp-43-toxicity-and-turnover
#20
Guangbo Liu, Alyssa N Coyne, Fen Pei, Spencer Vaughan, Matthew Chaung, Daniela C Zarnescu, J Ross Buchan
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron degenerative disease. ALS-affected motor neurons exhibit aberrant localization of a nuclear RNA binding protein, TDP-43, into cytoplasmic aggregates, which contributes to pathology via unclear mechanisms. Here, we demonstrate that TDP-43 turnover and toxicity depend in part upon the endocytosis pathway. TDP-43 inhibits endocytosis, and co-localizes strongly with endocytic proteins, including in ALS patient tissue. Impairing endocytosis increases TDP-43 toxicity, aggregation, and protein levels, whereas enhancing endocytosis reverses these phenotypes...
December 12, 2017: Nature Communications
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