keyword
MENU ▼
Read by QxMD icon Read
search

P selectin

keyword
https://www.readbyqxmd.com/read/29050464/anti-platelet-effects-of-epigallocatechin-3-gallate-in-addition-to-the-concomitant-aspirin-clopidogrel-or-ticagrelor-treatment
#1
Hyung Joon Joo, Ji-Young Park, Soon Jun Hong, Kyoung-Ah Kim, Seung Hoon Lee, Jae-Young Cho, Jae Hyoung Park, Cheol Woong Yu, Do-Sun Lim
Background/Aims: Although epigallocatechin-3-gallate (EGCG), which is found in high contents in the dried leaves of green tea, has been reported to have an anti-platelet effect, synergistic effects of EGCG in addition to current anti-platelet medications remains to be elucidated. Methods: Blood samples were obtained from 40 participants who took aspirin (ASA, n = 10), clopidogrel (CPD, n = 10), ticagrelor (TCG, n = 10) and no anti-platelet medication (Control, n = 10)...
October 19, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29037856/platelet-cd40-mediates-leukocyte-recruitment-and-neointima-formation-after-arterial-denudation-injury-in-atherosclerosis-prone-mice
#2
Rong Jin, Adam Y Xiao, Zifang Song, Shiyong Yu, Jarvis Li, Mei-Zhen Cui, Guohong Li
The role of platelets in the development of thrombosis and abrupt closure after angioplasty is well recognized. However, the direct impact of platelets on neointima formation after arterial injury remains undetermined. Here we show that neointima formation after carotid artery wire injury reduces markedly in CD40(-/-)apoE(-/-) mice but only slightly in CD40L(-/-)apoE(-/-) mice, compared with apolipoprotein E-deficient (apoE(-/-)) mice. Wild-type and CD40-deficient platelets were isolated from blood of apoE(-/-) and CD40(-/-)apoE(-/-) mice, respectively...
October 13, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29032524/patterns-and-levels-of-platelet-glycosylation-in-patients-with-coronary-heart-disease-and-type-2-diabetes-mellitus
#3
Liping Li, Chenxue Qu, Xuelian Wu, Juhua Dai, Yao Lu, Yan Gong, Ran You, Yaqi Liu
Coronary heart disease (CHD) and diabetes mellitus (DM) have high reactivity of platelets and an increased risk of thrombosis. Platelet glycosylation is closely related to platelet function and survival. However, the alteration of platelet glycosylation in CHD and T2DM still remains unknown. Platelet samples were obtained from 55 healthy controls and 102 patients, including 33 CHD, 30 T2DM and 39 CHD complicated with T2DM (CHD + T2DM). Platelet glycosylation was detected using eight-lectin based assay by flow cytometry...
October 14, 2017: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29030501/enzymatic-synthesis-of-core-2-o-glycans-governs-the-tissue-trafficking-potential-of-memory-cd8-t-cells
#4
Jossef F Osborn, Jana L Mooster, Samuel J Hobbs, Michael W Munks, Conrad Barry, John T Harty, Ann B Hill, Jeffrey C Nolz
Trafficking of memory CD8(+) T cells out of the circulation is essential to provide protective immunity against intracellular pathogens in nonlymphoid tissues. However, the molecular mechanisms that dictate the trafficking potential of diverse memory CD8(+) T cell populations are not completely defined. We show that after infection or inflammatory challenge, central memory (TCM) CD8(+) T cells rapidly traffic into nonlymphoid tissues, whereas most effector memory cells remain in the circulation. Furthermore, we demonstrate that cellular migration of memory CD8(+) T cells into nonlymphoid tissues is driven by interleukin-15 (IL-15)-stimulated enzymatic synthesis of core 2 O-glycans, which generates functional ligands for E- and P-selectins...
October 13, 2017: Science Immunology
https://www.readbyqxmd.com/read/29020675/increased-platelet-monocyte-interaction-in-stable-copd-in-the-absence-of-platelet-hyper-reactivity
#5
Floor E Aleva, Godfrey Temba, Quirijn de Mast, Sami O Simons, Philip G de Groot, Yvonne F Heijdra, André J A M van der Ven
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is well known for its cardiovascular co-morbidities. Increased platelet-monocyte interaction is found in COPD and may reflect altered platelet function and a potential role for anti-platelet therapy. OBJECTIVES: The objectives were to investigate platelet-monocyte interaction, platelet activation and reactivity and plasmatic coagulation in stable COPD. METHODS: Platelet-monocyte interaction and platelet activation were determined by flow cytometry in 30 stable COPD patients and 25 controls...
October 12, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29018081/platelet-interaction-with-activated-endothelium-mechanistic-insights-from-microfluidics
#6
Daniëlle M Coenen, Tom G Mastenbroek, Judith M E M Cosemans
Traditionally, in vitro flow chamber experiments and in vivo arterial thrombosis studies have been proven to be of vital importance to elucidate the mechanisms of platelet thrombus formation after vessel wall injury. In recent years, it has become clear that platelets also act as modulators of inflammatory processes, such as atherosclerosis. A key element herein is the complex crosstalk between platelets, the coagulation system, leukocytes and the activated endothelium. This review provides insight into the platelet-endothelial interface, based on in vitro flow chamber studies and cross referenced with in vivo thrombosis studies...
October 10, 2017: Blood
https://www.readbyqxmd.com/read/29016136/specific-unbinding-forces-between-mutated-human-p-selectin-glycoprotein-ligand-1-and-viral-protein-1-measured-using-force-spectroscopy
#7
Chen-Chu Wang, Kundan Sivashanmugan, Chung-Ku Chen, Jian-Ren Hong, Wei-I Sung, Jiunn-Der Liao, Yuh-Shyong Yang
Protein tyrosine sulfation (PTS) is a key modulator of extracellular protein-protein interaction (PPI), which regulates principal biological processes. For example, the capsid protein VP1 of enterovirus 71 (EV71) specifically interacts with sulfated P-selectin glycoprotein ligand-1 (PSGL-1) to facilitate virus invasion. Currently available methods cannot be used to directly observe PTS-induced PPI. In this study, atomic force microscopy was used to measure the interaction between sulfated or mutated PSGL-1 and VP1...
October 13, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28992257/glomerular-function-in-relation-to-circulating-adhesion-molecules-and-inflammation-markers-in-a-general-population
#8
Ying-Mei Feng, Lutgarde Thijs, Zhen-Yu Zhang, Wen-Yi Yang, Qi-Fang Huang, Fang-Fei Wei, Tatiana Kuznetsova, Ann-Marie Jennings, Christian Delles, Rachael Lennox, Peter Verhamme, Anna Dominiczak, Jan A Staessen
Background: Inflammation is a hallmark of chronic kidney disease (CKD) and stimulates glomerular expression of vascular adhesion molecules (VCAMs). We investigated in a general population whether estimated glomerular filtration rate (eGFR) is associated with circulating adhesion molecules, inflammation markers or both. Methods: We measured serum levels of five adhesion molecules [VCAM-1, intracellular adhesion molecule-1 (ICAM-1), P-selectin, E-selectin and monocyte chemoattractant protein-1 (MCP-1)] and seven inflammation markers [C-reactive protein (CRP), neutrophil gelatinase-associated lipocalin (NGAL), tumour necrosis factor receptor 1 (TNF-R1), TNF-α, interleukin 6 (IL-6), IL-8 and vascular endothelial growth factor] in 1338 randomly recruited people (50...
August 23, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28991552/a-platelet-factor-4-dependent-platelet-activation-assay-facilitates-early-detection-of-pathogenic-heparin-induced-thrombocytopenia-antibodies
#9
Curtis G Jones, Shannon M Pechauer, Brian R Curtis, Daniel W Bougie, Mehraboon S Irani, Binod Dhakal, Brenda Pierce, Richard H Aster, Anand Padmanabhan
Heparin-induced thrombocytopenia (HIT) is a dangerous complication of heparin therapy. HIT diagnosis is established by recognizing thrombocytopenia and/or thrombosis in an affected patient and from the results of serological tests such as the platelet factor 4 (PF4)/heparin immunoassay (PF4 ELISA) and serotonin release assay (SRA). Recent studies suggest that HIT antibodies activate platelets by recognizing PF4 in a complex with platelet glycosaminoglycans (and/or polyphosphates) and that an assay based on this principle, the PF4-dependent P-selectin expression assay (PEA), may be even more accurate than the SRA for HIT diagnosis...
October 2017: Chest
https://www.readbyqxmd.com/read/28988898/elevated-aqueous-cytokine-levels-in-eyes-with-ocular-surface-diseases
#10
Naohiko Aketa, Takefumi Yamaguchi, Teru Asato, Yukari Yagi-Yaguchi, Terumasa Suzuki, Kazunari Higa, Toshihide Kurihara, Yoshiyuki Satake, Kazuo Tsubota, Jun Shimazaki
PURPOSE: To evaluate cytokine and protein levels in the aqueous humor (AqH) of eyes with ocular surface diseases. DESIGN: Prospective consecutive case series. METHODS: This study includes 14 patients (62.4±13.7 years old) with chronic-phase ocular surface diseases (4 with ocular cicatricial pemphigoid, 5 with chemical burns, 2 with a thermal burn, 2 with Stevens-Johnson syndrome, and 1 with exposure keratitis), 14 matched patients without ocular surface disease (controls with corneal scar) and 30 patients who underwent cataract surgery (healthy controls)...
October 5, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28986926/adam8-expression-in-breast-cancer-derived-metastases-functional-implications-on-mmp-9-expression-and-transendothelial-migration-in-breast-cancer-cells
#11
Catharina Conrad, Malena Götte, Uwe Schlomann, Marion Roessler, Axel Pagenstecher, Peter Anderson, Jane Preston, Jessica Pruessmeyer, Andreas Ludwig, Ran Li, Roger D Kamm, Rainer Ritz, Barbara Carl, Christopher Nimsky, Jörg W Bartsch
Metastatic breast cancer affects long-term survival and is a major cause of cancer death for women worldwide. The Metalloprotease-Disintegrin ADAM8 promotes breast cancer development and brain metastasis in a mouse breast cancer model. Here, abundant ADAM8 expression was detected in primary human breast tumors and associated brain metastases. To investigate the function of ADAM8 in metastasis, MB-231 breast cancer cells with ADAM8 knockdown (MB-231_shA8) and scramble control cells (MB-231_shCtrl) were analyzed for their capability to develop metastases...
October 7, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28986057/myeloid-related-protein-8-14-in-acute-coronary-syndrome
#12
Masashi Sakuma, Atsushi Tanaka, Norihiko Kotooka, Yutaka Hikichi, Shigeru Toyoda, Shichiro Abe, Isao Taguchi, Koichi Node, Daniel I Simon, Teruo Inoue
BACKGROUND: The alarmin family member myeloid-related protein (MRP)-14 (S100A9), which has been identified by platelet transcriptional profiling as an acute myocardial infarction gene, regulates vascular inflammation and thrombosis. Elevated plasma levels of MRP-8/14 (S100A8/A9) heterodimer predict first and recurrent cardiovascular events. The aim of this study was to elucidate pathophysiological roles of MRP-8/14 in acute coronary syndrome (ACS). METHODS AND RESULTS: In 38 consecutive ACS patients, the MRP-8/14 level in coronary artery blood obtained at thrombus aspiration was higher in 23 patients, in whom aspirated thrombus was confirmed, compared to the 15 patients, in whom it was absent [4...
September 20, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28981555/platelets-contribute-to-the-accumulation-of-matrix-metalloproteinase-type-2-in-synovial-fluid-in-osteoarthritis
#13
Alessia Alunno, Emanuela Falcinelli, Filippo Luccioli, Eleonora Petito, Elena Bartoloni, Stefania Momi, Giulia Mirabelli, Giovanni B Mancini, Roberto Gerli, Paolo Gresele
Inflammation plays a role in the initiation and progression of osteoarthritis (OA), a chronic degenerative joint disorder. Platelets are inflammatory cells, contain and release matrix metalloproteinases (MMPs) and favour the release of these enzymes, key effectors of cartilage and subchondral bone degradation, by other cells; however, their role in OA has not been investigated yet. Our aims were (1) to assess the presence of platelets and of MMP-2 in synovial fluid (SF) of OA patients; (2) to evaluate the contribution of platelets to MMP-2 release by fibroblast-like synoviocytes (FLS); and (3) to investigate if hyaluronic acid (HA) interferes with these processes...
October 4, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28979814/breast-cancer-pulmonary-metastasis-is-increased-in-mice-undertaking-spontaneous-physical-training-in-the-running-wheel-a-call-for-revising-beneficial-effects-of-exercise-on-cancer-progression
#14
Marta Smeda, Kamil Przyborowski, Bartosz Proniewski, Agnieszka Zakrzewska, Dawid Kaczor, Marta Stojak, Elzbieta Buczek, Zenon Nieckarz, Jerzy A Zoladz, Joanna Wietrzyk, Stefan Chlopicki
It has been repeatedly shown that regular aerobic exercise exerts beneficial effects on incidence and progression of cancer. However, the data regarding effects of exercise on metastatic dissemination remain conflicting. Therefore, in the present study the possible preventive effects of voluntary wheel running on primary tumor growth and metastases formation in the model of spontaneous pulmonary metastasis were analyzed after orthotopic injection of 4T1 breast cancer cells into mammary fat pads of female Balb/C mice...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28978870/anthocyanin-cyanidin-3-glucoside-attenuates-platelet-granule-release-in-mice-fed-high-fat-diets
#15
Fang-Hang Zhou, Xiu-Juan Deng, Yan-Qiu Chen, Fu-Li Ya, Xian-Dan Zhang, Fenglin Song, Dan Li, Yan Yang
Platelet granule release is considered an important target for preventing and treating cardiovascular diseases (CVDs). Cyanidin-3-glucoside (Cy-3-g) is a predominant bioactive anthocyanin compound in many edible plants and has been reported to be protective against CVDs by attenuating platelet dysfunction. However, direct evidence of the action of Cy-3-g on platelet granule secretion in purified platelets from in vivo assays is still poor. In the present study, we demonstrated that dietary supplementation of purified Cy-3-g reduces serum lipid levels and facilitates down-regulation of the platelet granule release of substances such as P-selectin, CD40L, 5-HT, RANTES and TGF-β1 in gel-filtered platelets, in addition to attenuating serum PF4 and β-TG levels in mice fed high-fat diets...
2017: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/28976305/co-targeting-the-tumor-endothelium-and-p-selectin-expressing-glioblastoma-cells-leads-to-a-remarkable-therapeutic-outcome
#16
Shiran Ferber, Galia Tiram, Ana Sousa-Herves, Anat Eldar-Boock, Adva Krivitsky, Anna Scomparin, Eilam Yeini, Paula Ofek, Dikla Ben-Shushan, Laura Isabel Vossen, Kai Licha, Rachel Grossman, Zvi Ram, Jack Henkin, Eytan Ruppin, Noam Auslander, Rainer Haag, Marcelo Calderón, Ronit Satchi-Fainaro
Glioblastoma is a highly aggressive brain tumor. Current standard-of-care results in a marginal therapeutic outcome, partly due to acquirement of resistance and insufficient blood-brain barrier (BBB) penetration of chemotherapeutics. To circumvent these limitations, we conjugated the chemotherapy paclitaxel (PTX) to a dendritic polyglycerol sulfate (dPGS) nanocarrier. dPGS is able to cross the BBB, bind to P/L-selectins and accumulate selectively in intracranial tumors. We show that dPGS has dual targeting properties, as we found that P-selectin is not only expressed on tumor endothelium but also on glioblastoma cells...
October 4, 2017: ELife
https://www.readbyqxmd.com/read/28972956/does-polycystic-ovary-syndrome-increase-the-risk-of-subclinical-vascular-disease-in-normal-weight-type-1-diabetic-women
#17
Agnieszka Łebkowska, Agnieszka Adamska, Małgorzata Jacewicz, Joanna Tołwińska, Anna Krentowska, Justyna Hryniewicka, Monika Leśniewska, Artur Bossowski, Maria Górska, Irina Kowalska
INTRODUCTION The prevalence of polycystic ovary syndrome (PCOS) among type 1 diabetic women (T1DM) is higher than in general population. Both diseases are associated with higher risk of premature atherosclerosis. OBJECTIVES The aim of our study was to evaluate whether the cardiovascular risks conferred by T1DM and PCOS are additive. PATIENTS AND METHODS The study group included seventy-eight women divided into 4 groups: 19 women with PCOS and T1DM (T1DM+PCOS), 16 women with T1DM only (T1DM/no-PCOS), 27 women with PCOS only (PCOS), and 16 healthy women (control group)...
September 30, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28964327/performance-of-first-trimester-biochemical-markers-and-mean-arterial-pressure-in-prediction-of-early-onset-pre-eclampsia
#18
Jaana Nevalainen, Teemu Korpimaki, Heikki Kouru, Mikko Sairanen, Markku Ryynanen
OBJECTIVE: To develop a predictive risk model for early-onset pre-eclampsia (EO-PE) using maternal characteristics, combined screening markers, previously reported biomarkers for PE and mean arterial pressure (MAP). METHODS: This retrospective study was conducted at Oulu University hospital between 2006 and 2010. Maternal serum from first trimester combined screening was further analyzed for alpha fetoprotein (AFP), placental growth factor (PlGF), soluble tumor necrosis factor receptor-1 (sTNFR1), retinol binding protein-4 (RBP4), a disintegrin and metalloprotease-12 (ADAM12), soluble P-selectin (sP-selectin), follistatin like-3 (FSTL3), adiponectin, angiopoietin-2 (Ang-2) and sex hormone binding globulin (SHBG)...
October 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28960464/pde3-inhibitor-attenuates-rat-sinusoidal-obstruction-syndrome-through-inhibition-of-platelet-aggregation-in-disse-s-space
#19
Takashi Miyata, Hidehiro Tajima, Miki Hirata, Shin-Ichi Nakanuma, Isamu Makino, Hironori Hayashi, Katsunobu Oyama, Tomoharu Miyashita, Hiroyuki Takamura, Itasu Ninomiya, Sachio Fushida, Shoichi Iseki, Shin-Ichi Harada, Tomohiko Wakayama, Tetsuo Ohta
BACKGROUND AND AIM: Sinusoidal obstruction syndrome (SOS) is a serious drug-induced liver injury. However, the pathophysiology of the disease remains unclear. This study investigated the effects of cilostazol (CZ), a phosphodiesterase III inhibitor, in a monocrotaline (MCT)-induced rat model of SOS. METHODS: Male Wistar rats were administrated MCT to induce SOS. Rats were divided into control, MCT, and MCT+CZ groups. In the MCT+CZ group, CZ was administered at 48 h, 24 h, and 30 min prior to and 8 h and 24 h after MCT administration...
September 28, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28960147/platelet-function-investigation-by-flow-cytometry-sample-volume-needle-size-and-reference-intervals
#20
Oliver Heidmann Pedersen, Peter H Nissen, Anne-Mette Hvas
Flow cytometry is an increasingly used method for platelet function analysis because it has some important advantages compared with other platelet function tests. Flow cytometric platelet function analyses only require a small sample volume (3.5 mL); however, to expand the field of applications, e.g., for platelet function analysis in children, even smaller volumes are needed. Platelets are easily activated, and the size of the needle for blood sampling might be of importance for the pre-activation of the platelets...
September 29, 2017: Platelets
keyword
keyword
28641
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"