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https://www.readbyqxmd.com/read/29449706/pre-pregnancy-endothelial-dysfunction-and-birth-outcomes-the-coronary-artery-risk-development-in-young-adults-cardia-study
#1
Abbi D Lane-Cordova, Erica P Gunderson, Mercedes R Carnethon, Janet M Catov, Alex P Reiner, Cora E Lewis, Annie M Dude, Philip Greenland, David R Jacobs
Endothelial dysfunction is a form of subclinical cardiovascular disease that may be involved in preterm birth and small-for-gestational-age deliveries. However, concentrations of biomarkers of endothelial dysfunction before pregnancy have rarely been measured. We hypothesized that higher levels of biomarkers of endothelial dysfunction (cellular adhesion molecules and selectins) would be associated with odds of preterm birth and/or small-for-gestational-age deliveries. We included 235 women from the Coronary Artery Risk Development in Young Adults (CARDIA) study who were nulliparous at Y7, reported ≥1 live birth through Y25, and had ≥1 biomarker measured at Y7...
February 15, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29442046/microrna-146-regulates-the-inflammatory-cytokines-expression-in-vascular-endothelial-cells-during-sepsis
#2
Ning Gao, Lei Dong
AIMS: The purpose of this study was to investigate the functional role of microRNA (miR)-146 in sepsis, as well as the underlying mechanism. METHODS: Human vascular endothelial cell line EA. hy926 cells were treated with lipopolysaccharide (LPS) and/or transfected with miR-146 mimics, inhibitor, and their corresponding controls. Expression of miR-146 was then analyzed after treatment and/or transfection, as well as the expression of inflammatory cytokines, including tumor necrosis factor (TNF)-α, interleukin (IL)-6, intercellular adhesion molecule (ICAM)-1, and E-selectin, and nuclear factor kappa B (NF-κB) binding activity...
November 1, 2017: Die Pharmazie
https://www.readbyqxmd.com/read/29441333/the-effect-of-mesenchymal-stem-cell-use-on-intra-abdominal-adhesions-in-a-rat-model
#3
Gökhan Karaca, Faruk Pehlivanli, Oktay Aydin, Canan Altunkaya, Hafize Uzun, Mehmet Niyaz, Hüseyin Özden, Huri Bulut
Purpose: Intra-abdominal adhesions (IAA) are among the most frequently seen pathologies in general surgery practice with an increased morbidity and mortality. In the present study, we investigated the effect of locally applied mesenchymal stem cells (MSCs) on IAA. Methods: Twenty-four Wistar Albino rats were used in the study. The rats were divided into three groups including: Sham, control, and MSCs group. On day 0, cecum was reached under anesthesia in all groups, except the Sham group...
February 2018: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29438200/switching-from-abacavir-to-tenofovir-disoproxil-fumarate-is-associated-with-rises-in-soluble-glycoprotein-vi-suggesting-changes-in-platelet-collagen-interactions
#4
Jane A O'Halloran, Eimear Dunne, Willard Tinago, Stephanie Denieffe, Dermot Kenny, Patrick W G Mallon
OBJECTIVES: Altered platelet function has been proposed as an underlying mechanism to explain increased risk of myocardial infarction in people living with HIV associated with use of the nucleoside reverse transcriptase inhibitor abacavir (ABC). We aimed to examine changes in platelet biomarkers in people living with HIV switching from ABC. METHODS: In a prospective, 48-week substudy of virally suppressed HIV-1-positive subjects randomized to remain on ABC/lamivudine (ABC/3TC) or switch to tenofovir disoproxil fumarate/emtricitabine, we measured soluble glycoprotein VI (sGPVI), soluble P-selectin, soluble CD40 ligand and von Willebrand factor in plasma collected over time and assessed differences using mixed effect models...
February 12, 2018: AIDS
https://www.readbyqxmd.com/read/29437579/mouse-platelet-ral-gtpases-control-p-selectin-surface-expression-regulating-platelet-leukocyte-interaction
#5
Andreas Wersäll, Chris M Williams, Edward Brown, Tommaso Iannitti, Neil Williams, Alastair W Poole
OBJECTIVE: RalA and RalB GTPases are important regulators of cell growth, cancer metastasis, and granule secretion. The purpose of this study was to determine the role of Ral GTPases in platelets with the use of platelet-specific gene-knockout mouse models. APPROACH AND RESULTS: This study shows that platelets from double knockout mice, in which both GTPases have been deleted, show markedly diminished (≈85% reduction) P-selectin translocation to the surface membrane, suggesting a critical role in α-granule secretion...
February 8, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29436605/novel-iridium-iii-%C3%A2-derived-organometallic-compound-for-the-inhibition-of-human-platelet-activation
#6
Kou-Gi Shyu, Marappan Velusamy, Chih-Wei Hsia, Chih-Hao Yang, Chih-Hsuan Hsia, Duen-Suey Chou, Thanasekaran Jayakumar, Joen-Rong Sheu, Jiun-Yi Li
Since cisplatin achieved clinical success, transition metal platinum (Pt) drugs have been effectively used for the treatment of cancer. Iridium (Ir) compounds are considered to be potential alternatives to Pt compounds, as they possess promising anticancer effects with minor side effects. Platelet activation is associated with the metastasis and progression of cancer, and also with arterial thrombosis. Therefore, it is necessary to develop novel, effective antithrombotic agents. An Ir (III)‑derived complex, [Ir (Cp*) 1‑(2‑pyridyl)‑3‑(3‑methoxyphenyl)imidazo[1,5‑a]pyridine Cl]BF4 (Ir‑3), was developed as a novel antiplatelet drug...
February 7, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29433672/protective-role-of-%C3%AE-patchoulene-from-pogostemon-cablin-against-indomethacin-induced-gastric-ulcer-in-rats-involvement-of-anti-inflammation-and-angiogenesis
#7
Jia-Zhen Wu, Yu-Hong Liu, Jia-Li Liang, Qiong-Hui Huang, Yao-Xing Dou, Juan Nie, Jian-Yi Zhuo, Xue Wu, Jian-Nan Chen, Zi-Ren Su, Qi-Duan Wu
BACKGROUND: Non-steroidal anti-inflammatory drugs (NSAIDs) are most widely used as effective anti-inflammatory agents. However, their clinical application brings about inevasible gastrointestinal side effects. Pogostemon cablin is a traditional herbal medicine used for the treatment of gastrointestinal diseases in China. One of its representative components, the tricyclic triterpenoid β-patchoulone (β-PAE) has demonstrated great anti-inflammatory activity and gastroprotective effect against ethanol-induced gastric injury, but its protective effect against gastric ulcer induced by indomethacin is still unknown...
January 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29433150/cx3cr1-cx3cl1-axis-mediates-platelet-leukocyte-adhesion-to-arterial-endothelium-in-younger-patients-with-a-history-of-idiopathic-deep-vein-thrombosis
#8
Elena Furio, Maria Jose García-Fuster, Josep Redon, Patrice Marques, Rebeca Ortega, Maria Jesus Sanz, Laura Piqueras
Mechanisms linking deep vein thrombosis (DVT) and subclinical atherosclerosis and risk of cardiovascular events are poorly understood. The aim of this study was to investigate the potential impact of CX3CR1/CX3CL1 axis in DVT-associated endothelial dysfunction. The study included 22 patients (age: 37.5 ± 8.2 years) with a history of idiopathic DVT and without known cardiovascular risk factors and 23 aged-matched control subjects (age: 34 ± 7.8 years). Flow cytometry was used to evaluate peripheral markers of platelet activation, leukocyte immunophenotypes and CX3CR1/CX3CL1 expression in both groups...
February 12, 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29433015/effect-of-strenuous-exercise-on-mediators-of-inflammation-in-patients-with-coronary-artery-disease
#9
Joanna Cwikiel, Ingebjørg Seljeflot, Eivind Berge, Ida Unhammer Njerve, Hilde Ulsaker, Harald Arnesen, Arnljot Flaa
BACKGROUND: Coronary artery disease (CAD) is considered a low-grade inflammatory disease. We aimed to identify effects of short-term strenuous exercise on mediators of systemic inflammation, endothelial and platelet activation in patients with angiographically verified CAD. We hypothesized that a more pronounced inflammatory response would be present in patients with CAD than in those without CAD. METHODS: In subjects with symptoms indicative of stable CAD, an exercise stress test on a bicycle ergometer was performed...
February 9, 2018: Cytokine
https://www.readbyqxmd.com/read/29429213/-effect-of-acidic-oligosaccharides-on-p-selectin-of-pulmonary-hypertensive-rats-induced-by-monocrotaline
#10
Z Feng, Y Hu, N N An, W J Feng, T Hu, Y J Mao
Objective: To observe the effects of acidic oligosaccharides (AOS) on P-selectin levels in the serum and the pulmonary arteries of pulmonary hypertensive rats induced by monocrotaline. Methods: Sixty healthy adult male Sprague-Dawley rats were randomly divided into control group (n=10), model group (n=10), Alprostadil group (n=10), low-dose AOS group (AOS-L, n=10), medium-dose AOS group (AOS-M, n=10) and high-dose AOS group (AOS-H, n=10). The rat model of pulmonary arterial hypertension was made by a single intraperitoneal injection of monocrotaline(60 mg/kg)...
February 12, 2018: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/29425463/genome-wide-association-study-in-african-americans-with-acute-respiratory-distress-syndrome-identifies-the-selectin-p-ligand-gene-as-a-risk-factor
#11
Christian Bime, Nima Pouladi, Saad Sammani, Ken Batai, Nancy Casanova, Tong Zhou, Carrie L Kempf, Xiaoguang Sun, Sara M Camp, Ting Wang, Rick A Kittles, Yves A Lussier, Tiffanie K Jones, John P Reilly, Nuala J Meyer, Jason D Christie, Jason Karnes, Manuel Gonzalez-Garay, David C Christiani, Charles R Yates, Mark M Wurfel, Gianfranco U Meduri, Joe G N Garcia
RATIONALE: Genetic factors are involved in acute respiratory distress syndrome (ARDS) susceptibility. Identification of novel candidate genes associated with increased risk and severity will improve our understanding of ARDS pathophysiology and enhance efforts to develop novel preventive and therapeutic approaches. METHODS: A genome-wide association study was performed on 232 African-American patients with ARDS and 162 at-risk controls. The Identify Candidate Causal single nucleotide polymorphisms (SNPs) and Pathways platform was used to infer the association of known gene sets with the top prioritized intragenic SNPs...
February 9, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29421656/inhibition-of-5-lipoxygenase-represses-neutrophils-activation-and-activates-apoptosis-in-pancreatic-tissues-during-acute-necrotizing-pancreatitis
#12
Dan Liao, Bo Qian, Yefei Zhang, Kai Wu, Min Xu
Pancreatic glandular necrosis is rapid inflammation of the pancreas and contributes to severe acute pancreatitis in humans. The pathogenesis of pancreatic tissue inflammation during acute pancreatitis is still largely unknown. Recent studies suggest that 5-lipoxygenase (5-LOX) is an essential mediator in modulating cell death pathways in human diseases. In this study, we aimed to evaluate the effects of a 5-LOX inhibitor, zileuton, on tissue apoptosis and neutrophils activation in pancreatic tissues during acute necrotizing pancreatitis (ANP) in a rat model...
February 5, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29416693/serum-levels-of-adipokines-and-cytokines-in-psoriasis-patients-a-systematic-review-and-meta-analysis
#13
Fan Bai, Wen Zheng, Yan Dong, Juan Wang, Malgorzata A Garstka, Ruilian Li, Jingang An, Huiqun Ma
Purpose: To evaluate the association of serum levels of adipokines and cytokines with psoriasis. Materials and Methods: A comprehensive literature search was performed in PubMed, ScienceDirect and Web of Science for the available relevant studies published before December 1, 2016. Differences in serum marker levels between patients and controls were pooled as standardized mean differences (SMDs) with 95% confidence interval to combine the effect estimations. We also conducted stratified analysis, meta-regression analysis and sensitivity analysis...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29416612/docking-of-thpdtpi-to-explore-p-selectin-as-a-common-target-of-anti-tumor-anti-thrombotic-and-anti-inflammatory-agent
#14
Haimei Zhu, Yuji Wang, Ce Song, Qiqi Feng, Jianhui Wu, Shurui Zhao, Lin Gui, Xiaoyi Zhang, Ming Zhao, Shiqi Peng
The impact of soluble P-selectin on tumor growth, thrombosis and inflammation has been individually documented. Whether the down-regulation of P-selectin expression can simultaneously slow the tumor growth, inhibit the thrombosis and attenuate the inflammatory response remains unknown. In this context, (2'S,5'S)- tetrahydropyrazino[1',2':1,6]-di{2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole}-1',4'-dione (THPDTPI) was designed as an inhibitor of P-selectin. The suitable docking of THPDTPI towards the active site of P-selectin, the significant down-regulation of THPDTPI to P-selectin expression, and the direct action of THPDTPI on P-selectin suggest that P-selectin could be a target of THPDTPI...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29407626/laboratory-biomarkers-for-venous-thromboembolism-risk-in-patients-with-hematologic-malignancies-a-review
#15
REVIEW
B T Samuelson Bannow, B A Konkle
INTRODUCTION: Despite high rates of venous thromboembolism (VTE) among patients with hematologic malignancies, few tools exist to assist providers in identifying those patients at highest risk for this potentially fatal complication. Laboratory biomarkers, such as d-dimer, have demonstrated utility in some clinical settings to distinguish patients at increased risk. MATERIALS AND METHODS: We performed a systematic review of the literature utilizing search terms including "biomarker", "venous thromboembolism", "hematologic malignancy", "lymphoma", "myeloma" and "leukemia" in the Medline database...
January 31, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29407321/protective-effect-of-a-novel-technique-for-liver-transplantation-in-the-rat
#16
B Qu, F Yu, G-N Sheng, W Zhang, Y-M Zhang, Y-L Deng, Y Shi, Z-Y Shen
The rat orthotopic liver transplantation model with extremely short anhepatic phase was established to study its protective effect on the recipients and graft. One hundred fifty adult male Wistar rats were randomly divided into three groups: group A (n = 30), using magnetic rings for the suprahepatic vena cava reconstruction; group B (n = 30), using 7/0 Prolene sutures for suprahepatic vena cava running anastomosis as control; and a sham-operated group (n = 30) as a blank control group. The changes in liver enzyme, serum creatinine, endotoxin, and cytokine levels and histopathology were recorded...
January 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29401699/the-effect-of-a-leisure-time-physical-activity-intervention-delivered-via-a-workplace-15-month-follow-up-study
#17
Marit Skogstad, Lars-Kristian Lunde, Bente Ulvestad, Hans Christian D Aass, Thomas Clemm, Asgeir Mamen, Øivind Skare
In line with recommendations from both the World Health Organization and the European Union some employers encourage workplace health promotion through physical activity (PA) facilities and leisure time PA-initiatives. The current study describes a 15-month follow-up after an 8-week workplace delivered PA-initiative, investigates if improvements in cardiovascular risk status are sustainable, and elucidates differences according to educational level. One hundred and twenty one employees (43 women) were examined before and after the 8-week PA-initiative and 94 at the 15-month follow-up...
February 4, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29400123/increased-adhesion-molecule-levels-in-systemic-lupus-erythematosus-relationships-with-severity-of-illness-autoimmunity-metabolic-syndrome-and-cortisol-levels
#18
L F da Rosa Franchi Santos, N P Stadtlober, L G Costa Dall'Aqua, B M Scavuzzi, P M Guimarães, T Flauzino, M A Batisti Lozovoy, T V Mayumi Iriyoda, E M Vissoci Reiche, I Dichi, M Maes, A Colado Simão
Background This study was performed to assess adhesion molecules in systemic lupus erythematosus (SLE). Methods This case-control study examined 126 SLE patients and 48 healthy individuals. Blood levels of six adhesion molecules, cortisol, nuclear autoantibody (ANA) and anti-double stranded DNA (anti-dsDNA) titers were measured, while disease activity was assessed using the SLE Disease Activity Index (SLEDAI) score. Results Platelet endothelial cell adhesion molecule 1 (PECAM-1), vascular cell adhesion molecule 1 (VCAM-1), E-selectin, P-selectin, and plasminogen activator inhibitor type-1 (PAI-1) were significantly higher in SLE patients than in controls...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29399204/thrombi-produced-in-stagnation-point-flows-have-a-core-shell-structure
#19
Bradley A Herbig, Scott L Diamond
Introduction: In regions of flow separation/reattachment within diseased arteries, the local hemodynamics can result in stagnation point flow that provides an atypical environment in atherosclerosis. Impinging flows occur with recirculation eddies distal of coronary stenosis or diseased carotid bifurcations. Methods: By perfusing whole blood directly perpendicular to a fibrillar collagen thrombotic surface, a microfluidic device produced a stagnation point flow...
December 2017: Cellular and Molecular Bioengineering
https://www.readbyqxmd.com/read/29393453/synthetic-e-selectin-prevents-postoperative-vascular-restenosis-by-inhibiting-nuclear-factor-%C3%AE%C2%BAb-in-rats
#20
Jiangang Liu, Zhongjie Liu, Xiaohui Hu, Yuan Zhang, Shiming Zhang
During the development of postoperative vascular restenosis, the aberrant proliferation of vascular smooth muscle cells (VSMCs) is a critical event resulting in intimal hyperplasia. Inflammatory responses involving the activation of nuclear factor (NF)‑κB are among the major molecular processes underlying restenosis. The present study aimed to investigate the roles of NF‑κB in VSMC proliferation and restenosis following vascular anastomosis, as well as to evaluate the potential of synthetic E‑selectin to downregulate NF‑κB and thus inhibit vascular hyperplasia...
February 1, 2018: Molecular Medicine Reports
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