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https://www.readbyqxmd.com/read/27764208/is-endotoxemia-in-stable-hemodialysis-patients-an-artefact-limitations-of-the-limulus-amebocyte-lysate-assay-and-role-of-1%C3%A2-3-%C3%AE-d-glucan
#1
Jonathan Wong, Yonglong Zhang, Ashish Patidar, Enric Vilar, Malcolm Finkelman, Ken Farrington
BACKGROUND: Elevated blood endotoxin levels are frequently reported in the dialysis population and are strongly linked with inflammation, a major predictor of mortality. Virtually all studies have employed the Limulus Amoebocyte Lysate (LAL) assay to detect endotoxin. However this assay is not endotoxin-specific and can be activated by (1→3)-β-glucan (BG), a component of fungal cell walls leading to false positive signals. Very few studies have taken account of this. We examined the influence of BG-based activation of the LAL assay on the detection of endotoxemia in this setting...
2016: PloS One
https://www.readbyqxmd.com/read/27753964/os-10-03-the-distinctive-effect-of-polysaccharide-peptides-ganoderma-lucidum-as-anti-atherogenesis-in-stable-angina-patients
#2
Nizamuddin Ubaidillah, Djanggan Sargowo, Adriawan Widya, Vitryaturrida Jakfar, Kartika Siwi Proboretno, Mirza Failasufi, Yoga Warahugraha, Fadli Ramadhan, Hesti Wulandari, Dinarsari Hayuning Putri
OBJECTIVE: This study was aimed to evaluate the effects of polysaccharide peptides (PsP) of Ganoderma lucidum as anti inflammation, anti oxidant, anti diabetic and anti lipid in stable angina pectoris patients. DESIGN AND METHOD: This is a quasi clinical trial experimental study on 34 Stable Angina patients in Saiful Anwar General Hospital was determined based on ESC Stable CAD guidelines, with pre-test and post-test design without control. Parameter measured were TNF alfa, IL-6, MDA, SOD, HbA1c, Fasting glucose and Total cholesterol...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27643361/os-10-03-the-distinctive-effect-of-polysaccharide-peptides-ganoderma-lucidum-as-anti-atherogenesis-in-stable-angina-patients
#3
Nizamuddin Ubaidillah, Djanggan Sargowo, Adriawan Widya, Vitryaturrida Jakfar, Kartika Siwi Proboretno, Mirza Failasufi, Yoga Warahugraha, Fadli Ramadhan, Hesti Wulandari, Dinarsari Hayuning Putri
OBJECTIVE: This study was aimed to evaluate the effects of polysaccharide peptides (PsP) of Ganoderma lucidum as anti inflammation, anti oxidant, anti diabetic and anti lipid in stable angina pectoris patients. DESIGN AND METHOD: This is a quasi clinical trial experimental study on 34 Stable Angina patients in Saiful Anwar General Hospital was determined based on ESC Stable CAD guidelines, with pre-test and post-test design without control. Parameter measured were TNF alfa, IL-6, MDA, SOD, HbA1c, Fasting glucose and Total cholesterol...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27551771/microrna-expression-profiles-in-patients-with-acute-crimean-congo-hemorrhagic-fever-reveal-possible-adjustments-to-cellular-pathways
#4
Zekiye Cemre Demir, Aliye Bastug, Hurrem Bodur, Koray Ergunay, Aykut Ozkul
Several viral diseases are associated with altered microRNA (miRNA) expression, which can provide vital information about how cellular pathways respond to infection. However, the miRNA profile of Crimean Congo Hemorrhagic Fever (CCHFV) infections are not known. To address this gap, we performed real-time PCR-based miRNA analysis in individuals with acute Crimean Congo Hemorrhagic Fever (CCHFV) infections, with the goal of identifying pathways that might be associated with this disease. Peripheral blood mononuclear cells were analysed in eight individuals with detectable viral RNA and compared to five healthy subjects...
August 23, 2016: Journal of Medical Virology
https://www.readbyqxmd.com/read/27527810/expression-of-several-cytokines-in-prostate-cancer-correlation-with-clinical-variables-of-patients-relationship-with-biochemical-progression-of-the-malignance
#5
Norelia Torrealba, Gonzalo Rodríguez-Berriguete, Benito Fraile, Gabriel Olmedilla, Pilar Martínez-Onsurbe, Manuel Guil-Cid, Ricardo Paniagua, Mar Royuela
BACKGROUND: This work is focused on finding new markers that complement or diagnoses currently used towards improving knowledge histological and statistical aspects that allow us to predict the local stage carcinomas and to identify and understand all the factors related to the progression of this disease. MATERIALS AND METHODS: Prostates were obtained from: normal prostates from 20 men, diagnosis of BPH (Benign Prostatic Hyperplasia) from 35 men and prostate cancer from 86 men...
August 12, 2016: Cytokine
https://www.readbyqxmd.com/read/27494077/subcutaneous-anti-tnf-alfa-induced-sustained-minimal-disease-activity-and-remission-in-psoriatic-arthritis-patients-a-retrospective-study
#6
Fabio Massimo Perrotta, Ennio Lubrano
OBJECTIVE: The aim of the present study was to assess the rate of sustained Minimal Disease Activity (MDA) and remission in a group of psoriatic arthritis (PsA) patients treated with TNFα blockers. METHODS: We perform a retrospective study on our database of PsA patients treated with adalimumab, etanercept and golimumab, with a minimum of 12 months of follow up. Patients were considered in sustained MDA when they met at least 5/7 of the criteria previously defined for at least 12 months of follow up...
September 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/27487282/the-acute-effects-of-preoperative-ozone-theraphy-on-surgical-wound-healing
#7
Hasan Sahin, Tuncer Simsek, Hakan Turkon, Yıldıray Kalkan, Faruk Ozkul, M Turgut Alper Ozkan, Mesut Erbas, Ugur Altinisik, Yavuz Demiraran
PURPOSE: To investigate the effects of preoperative rectal ozone insufflation on surgical wound healing over the proinflammatory cytokines and histopathological changes. METHODS: Twenty one rabbits were divided into 3 groups. Sham, surgical wound, and ozone applied (6 sessions, every other day 70 µg/mL in 12 mL O2-O3 mixture rectally) surgical wound groups were created. TNF-alpha and IL-6 levels from all rabbits were studied at the basal, 24th hour, and 72nd hour...
July 2016: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/27275852/effects-of-platelet-rich-plasma-on-fascial-healing-in-rats-with-fecal-peritonitisassociate-professor-department-of-general-surgery-faculty-of-medicine-firat-university-elazig-turkey-design-of-the-study-surgical-procedures-statistical-analysis-firat-university
#8
Mustafa Girgin, Kenan Binnetoglu, Kazim Duman, Burhan Hakan Kanat, Ziya Cetinkaya, Refik Ayten, Yavuz Selim Ilhan, Necip Ilhan, Ibrahim Seker, Necati Timurkaan
PURPOSE: To evaluate the effects of platelet rich plasma (PRP) on the healing of fascia wherein peritonitis has been created. METHODS: Twenty eight Wistar Albino rats were divided into four groups. Only a primary fascial repair following laparotomy was performed on Group 1, a primary fascial repair performed and PRP treatment applied following laparotomy on Group 2, and a fecal peritonitis created following laparotomy and a primary fascial repair carried out on Group 3...
May 2016: Acta Cirúrgica Brasileira
https://www.readbyqxmd.com/read/27271552/update-on-the-role-of-molecular-factors-and-fibroblasts-in-the-pathogenesis-of-dupuytren-s-disease
#9
Massimiliano Tripoli, Adriana Cordova, Francesco Moschella
The mechanism by which the fibroblast is able to trigger palmar fibromatosis is still not yet fully understood. It would appear certain that the "abnormal" fibroblasts continuously synthesise profibrotic cytokines which are able to determine the activation to myofibroblasts, to stimulate them to the further proliferation and synthesis of other cytokines, to modify the cells' differentiation and ultrastructural characteristics, as well as the production of matrix and other proteins. Several fibroblast growth factors have been suggested to be responsible of an abnormal cell activation with an aberrantly elevated collagen synthesis and extracellular deposition in Dupuytren's disease, as TGF-Beta, TNF-Alfa, PDGF, GM-CSF, free radicals, metalloproteinases, sex hormones, gene modified expression, mechanical stimulation...
June 7, 2016: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/27224907/protective-effect-of-guggulipid-in-high-fat-diet-and-middle-cerebral-artery-occlusion-mcao-induced-ischemic-cerebral-injury-in-rats
#10
M A Ahmad, A K Najmi, M Mujeeb, M Akhtar
AIM: The role of guggulipid was evaluated in high fat diet and middle cerebral artery occlusion (MCAO) induced ischemic cerebral dysfunctions in rats of either sex. MATERIALS AND METHODS: Ethyl acetate extract of guggul known as guggulipid was prepared and administered to rats. Animals were divided into 9 groups, consisting 6 rats, each receiving different treatments per orally for 8 weeks. Control group rats received normal control diet while rest of the other groups animals were fed high fat diet (HFD) for 8 weeks...
August 2016: Drug Research
https://www.readbyqxmd.com/read/27216712/b7h6-derived-peptides-trigger-tnf-%C3%AE-dependent-immunostimulatory-activity-of-lymphocytic-nk92-mi-cells
#11
Mariana Phillips, Francesca Romeo, Constantine Bitsaktsis, David Sabatino
The rise of biologics that can stimulate immune responses towards the eradication of tumors has led to the evolution of cancer-based immunotherapy. Representatively, B7H6 has been recently identified as a protein ligand on tumor cells that binds specifically to the NKp30 receptor and triggers NK cell-derived cytokine production, which ultimately leads to tumor cell lysis and death. In an effort to develop effective immunotherapy approaches, the rational design of a novel class of immunostimulatory peptides (IPs) derived from the binding interface of B7H6:NKp30 is described in this study...
September 2016: Biopolymers
https://www.readbyqxmd.com/read/27163486/surgical-trauma-caused-by-different-abdominal-access-routes-comparison-of-open-surgical-laparoscopic-and-notes-transgastric-techniques-in-a-porcine-model
#12
Jorge Arroyo Vázquez, Maria Bergström, Joan Dot, Monder Abu-Suboh-Abadia, Carla Fonseca, Marielle Esteves, Asghar Azadani, Jordi Armengol, Miquel Masachs, José Ramon Armengol-Miró, Per-Ola Park
BACKGROUND: Investigations indicate that natural orifice translumenal endoscopic surgery (NOTES) procedures induce a less pronounced postoperative inflammatory response than open or laparoscopic surgery, inflicting less trauma. In NOTES procedures, no skin incision is performed. We compare the inflammatory response added by the type of incision by measuring C-reactive protein (CRP) and tumors necrosis factor-alfa (TNF-α). METHODS: Twenty-seven pigs were randomized to open surgical, laparoscopic, or transgastric NOTES abdominal access...
July 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/27134662/clinical-experience-with-infliximab-biosimilar-remsima-ct-p13-in-inflammatory-bowel-disease-patients
#13
REVIEW
Jørgen Jahnsen
Many reference biological therapies have now reached or are near to patent expiry, and therefore a number of biosimilars have been or will be developed. The term biosimilar can be defined as a biotherapeutic product that is similar in efficacy, safety and quality to the licensed reference product. Biosimilars may lead to a reduced price and significant cost savings for the health community and hopefully more patients globally will have easier access to biological therapy when indicated. CT-P13, which is a TNF-alfa inhibitor, is the first monoclonal antibody biosimilar being used in clinical practice...
May 2016: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/27104819/substitution-with-alternative-anti-tnf%C3%AE-therapy-savant-outcomes-of-a-crohn-s-disease-cohort-undergoing-substitution-therapy-with-certolizumab
#14
Moheb Boktor, Andrew Motlis, Avinash Aravantagi, Ankur Sheth, Paul Jordan, James Morris, Kenneth Manas, Nazneen Hussain, Urska Cvek, Marjan Trutschl, Felix Becker, J Steven Alexander
BACKGROUND: Biological therapy targeting tumor necrosis factor-alfa has revolutionized the treatment of Crohn's disease (CD). Our study retrospectively reviewed clinical outcomes of 60 patients administratively substituted from Infliximab or Adalimumab to Certolizumab. Maintenance of disease and failure rates after substitution of anti-tumor necrosis factor-alfa agents in CD patients were monitored over 1 year, and this is the first outcomes study of patients maintained on Infliximab or Adalimumab substituted to Certolizumab...
June 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27075461/assessment-of-vascular-function-in-systemic-onset-juvenile-idiopathic-arthritis
#15
Betul Sozeri, Basak Yildiz Atikan, Kadriye Ozdemir, Sevgi Mir
An increased incidence of cardiovascular disease has been found in rheumatic disorders. Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in children. Prolonged immunological inflammatory process leads these patients to an early onset of atherosclerosis. We aimed to assess the presence of early vascular dysfunction in patients with systemic onset juvenile idiopathic arthritis (sJIA) and investigate the role of therapy sJIA in vascular health. Thirty-three patients (22 males, 11 females) diagnosed with sJIA according to the International League of Associations for Rheumatology criteria were compared to 72 age- and sex-matched controls...
July 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27015185/correlations-between-leptin-gene-polymorphisms-223-a-g-1019-g-a-492-g-c-976-c-a-and-anthropometrical-and-biochemical-parameters-in-children-with-obesity-a-prospective-case-control-study-in-a-romanian-population-the-nutrichild-study
#16
Cristina Oana Mărginean, Claudiu Mărginean, Septimiu Voidăzan, Lorena Meliţ, Andrei Crauciuc, Carmen Duicu, Claudia Bănescu
The aim of this study was to establish the manner in which the LEPR 223, 1019, 492, and 976 gene polymorphisms influence child obesity.We performed a prospective case-control study on 264 hospitalized children from Romania (Nutrichild study) whom we divided into 2 groups: Group I -143 controls and Group II-121 obese children.The 2 groups were evaluated regarding the anthropometry (MUAC, TST, H/L, hip, and abdominal circumference), paraclinical results (protein, leptin, adiponectin, TNF alfa, IL 6, IL 8, VEGF, protein, albumin) and LEPR 223, 1019, 492, and 976 gene polymorphisms...
March 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26790130/effects-of-the-new-generation-synthetic-reconstituted-surfactant-chf5633-on-pro-and-anti-inflammatory-cytokine-expression-in-native-and-lps-stimulated-adult-cd14-monocytes
#17
Kirsten Glaser, Markus Fehrholz, Tore Curstedt, Steffen Kunzmann, Christian P Speer
BACKGROUND: Surfactant replacement therapy is the standard of care for the prevention and treatment of neonatal respiratory distress syndrome. New generation synthetic surfactants represent a promising alternative to animal-derived surfactants. CHF5633, a new generation reconstituted synthetic surfactant containing SP-B and SP-C analogs and two synthetic phospholipids has demonstrated biophysical effectiveness in vitro and in vivo. While several surfactant preparations have previously been ascribed immunomodulatory capacities, in vitro data on immunomodulation by CHF5633 are limited, so far...
2016: PloS One
https://www.readbyqxmd.com/read/26597191/subclinical-inflammation-and-endothelial-dysfunction-in-patients-with-chronic-pancreatitis-and-newly-diagnosed-pancreatic-cancer
#18
A Gasiorowska, R Talar-Wojnarowska, A Kaczka, A Borkowska, L Czupryniak, E Małecka-Panas
BACKGROUND: Recent studies have suggested that various cytokines may be important players in the development and progression of chronic pancreatitis (CP) and pancreatic adenocarcinoma (PC). AIMS: We studied endothelial dysfunction and subclinical inflammation in patients with newly diagnosed pancreatic adenocarcinoma and CP. METHODS: A total of 45 patients were included in the present investigation, 27 with CP and 18 with PC. In addition, the study included 13 age- and body weight-matched healthy subjects served as controls...
April 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/26318460/l-carnitine-reduces-acute-lung-injury-in-experimental-biliary-obstruction
#19
Ozgur Kaya, Yavuz S Koca, İbrahim Barut, Sirin Baspinar, Mehmet Z Sabuncuoglu
OBJECTIVES: To investigate the protective effects of L-carnitine (LC) on lungs in an experimental obstructive jaundice (OJ) model. METHODS: This was conducted for 2 months between May 2011 and July 2011 at Suleyman Demirel University School of Medicine Experimental and Clinical Research Center, Isparta, Turkey. Thirty-eight Wistar-Albino rats with an average weight of 250-300 g were divided into 3 groups of control, OJ, and OJ + L-carnitine treatment (LCT). L-carnitine was injected intravenously into the tail vein at a dose of 50 mg/kg/day for 10 days to the LCT group...
September 2015: Saudi Medical Journal
https://www.readbyqxmd.com/read/26253295/protective-effect-of-infliximab-a-tumor-necrosis-factor-alfa-inhibitor-on-bleomycin-induced-lung-fibrosis-in-rats
#20
Nejat Altintas, Mustafa Erboga, Cevat Aktas, Bulent Bilir, Murat Aydin, Aysun Sengul, Zehra Ates, Birol Topcu, Ahmet Gurel
We aimed to investigate the preventive effect of Infliximab (IFX), a tumor necrosis factor (TNF)-α inhibitor, on bleomycin (BLC)-induced lung fibrosis in rats. Rats were assigned into four groups as follows: I-BLC group, a single intra-tracheal BLC (2.5 mg/kg) was installed; II-control group, a single intra-tracheal saline was installed; III-IFX + BLC group, a single-dose IFX (7 mg/kg) was administered intraperitoneally (i.p.), 72 h before the intra-tracheal BLC installation; IV-IFX group, IFX (7 mg/kg) was administered alone i...
February 2016: Inflammation
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