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https://www.readbyqxmd.com/read/29907185/density-measurement-of-demodex-canis-by-qpcr-and-analysis-of-serum-cytokine-levels-in-dogs-with-different-clinical-forms-of-demodicosis
#1
Naiani Domingos Gasparetto, Arleana do Bom Parto Ferreira Almeida, Luciano Nakazato, Eduardo Luzía França, Adenilda Cristina Honorio França, Danny Laura Gomes Fagundes, Juliano Bortolini, Valéria Régia Franco Sousa
OBJECTIVES: To quantify (by qPCR) the density of Demodex canis mites in the skin of dogs with demodicosis and in healthy dogs, as well as measuring the serum concentrations of interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-12, and tumour necrosis factor-alfa (TNF-α). METHODS: Fifty-four dogs were divided into three groups: localized demodicosis (LD, n = 16), generalized demodicosis (GD, n = 22), and control group (CG, n = 16). All dogs were subjected to skin scraping, blood collection, and skin biopsy...
June 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29888839/cd56-bright-natural-killer-cells-induce-hbsag-reduction-via-cytolysis-and-cccdna-decay-in-long-term-entecavir-treated-patients-switching-to-peginterferon-alfa-2a
#2
Aichao Shi, Xiaoping Zhang, Fang Xiao, Lin Zhu, Weiming Yan, Meifang Han, Xiaoping Luo, Tao Chen, Qin Ning
HBV surface antigen (HBsAg) reduction is well observed in chronic hepatitis B (CHB) patients treated with pegylated interferon-alpha-2a (Peg-IFNα). However, the mechanism of HBsAg suppression has not been fully elucidated. Twenty-seven of 55 Entecavir-treated CHB e antigen positive patients were switched to Peg-IFNα treatment (Group A) whereas 28 patients continued entecavir treatment (Group B). The percentage or absolute number of CD56bright /CD56dim NK cells, expression of receptors and cytokines were evaluated by flow cytometry for 48 weeks and correlated with treatment efficacy...
June 11, 2018: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29802679/soluble-cd163-correlates-with-lipid-metabolic-adaptations-in-human-type-1-diabetes-patients-during-ketoacidosis
#3
Mads Svart, Nikolaj Rittig, Niels Møller, Holger J Møller, Henning Gronbaek
BACKGROUND: Diabetic ketoacidosis (DKA) is associated with inflammation and increased lipolysis. The macrophage activation marker soluble CD163 (sCD163) is associated with obesity, non-alcoholic fatty liver disease, and type-2 diabetes. We aimed to investigate whether sCD163 correlates with, key elements of lipolysis in type-1 diabetes (DM1) patients during mild diabetic ketoacidosis. METHODS: We investigated nine patients with DM1 twice during: (i) euglycaemic control conditions (CTR) and a bolus of saline and (ii) hyperglycaemic ketotic conditions (KET) induced by lipopolysaccharide (LPS) administration combined with insulin deprivation...
May 26, 2018: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/29802649/effect-of-endurance-versus-resistance-training-on-local-muscle-and-systemic-inflammation-and-oxidative-stress-in-copd
#4
C K Ryrsø, P Thaning, C Siebenmann, C Lundby, P Lange, B K Pedersen, Y Hellsten, U W Iepsen
Limb muscle dysfunction in patients with COPD may be associated with local muscle and/or systemic inflammation, and therefore, we investigated whether exercise training altered markers of inflammation and oxidative stress. We obtained vastus lateralis muscle biopsies and venous blood samples from patients with COPD (n=30) before and after 8 weeks of resistance training (RT) (n=15) or endurance training (ET) (n=15). Healthy age-matched subjects were included as baseline controls (n=8). Inflammatory markers in muscle and systemically were determined by interleukins (IL), tumour necrosis factor alfa (TNF-α), leukocyte concentration together with immunohistochemical staining for macrophages...
May 26, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29705991/the-therapeutic-potential-of-tnf-%C3%AE-antagonists-in-toxic-epidermal-necrosis-insights-from-two-cases-and-adverse-event-reports
#5
LETTER
S Vural, A Arakawa, Y Arakawa, J C Prinz
No abstract text is available yet for this article.
April 28, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29619433/increased-apoptosis-skull-of-pups-born-to-toxoplasma-gondii-infected-mice-associated-with-increased-expression-of-interferon-gamma-but-not-tumor-necrosis-factor-alfa
#6
Lucia Tri Suwanti, Mufasirin
Bacground: Toxoplasma gondii is an intracellular obligate protozoan parasite that infects most warm-blooded animals including humans. It can cause congenital infection with clinical symptoms ranging from mild to severe including microcephaly. At the cellular level, infection T. gondii causes apoptosis in some tissues and it is induced by proinflammatory cytokines, such as IFN-γ and TNF-α. The purpose of this study is to determine the role of proinflammatory cytokines (TNF-α and IFN-γ) to apoptosis skull of newborn from T...
2018: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29521269/the-effect-of-darbepoetin-alfa-on-renal-fibrosis-in-rats-with-acute-unilateral-ureteral-obstruction
#7
Ozgur Haki Yuksel, Caglar Yildirim, Ahmet Urkmez, Nurver Ozbay, Fatih Uruc, Aytac Sahin, Serkan Akan, Ayhan Verit
OBJECTIVES: The most important treatment strategy for obstructive nephropathy is to protect renal tissue from the deleterious effects of fibrosis. Therefore, we sought to investigate the renoprotective effects of darbepoetin alfa on unilateral ureteral obstructions. METHODS: We used 12 female and 12 male 3-monthold Wistar rats weighing between 250 and 350 g. The rats were divided equally into sham, darbepoetin and control groups. With the exception of the sham group, left unilateral obstructions were applied to all of the rats...
March 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29406811/vedolizumab-for-the-treatment-of-crohn-s-disease
#8
Marjorie Argollo, Gionata Fiorino, Laurent Peyrin-Biroulet, Silvio Danese
Crohn's disease (CD) is an immune-mediated condition characterized by inflammation of the gut tissue, associated with progressive damage of the affected intestinal tract and possible complications. A treat-to-target approach is strongly advocated, consisting of early and aggressive inflammatory control. However, a great proportion of affected subjects lack response or are intolerant to conventional therapy. Even though the first-line biologic therapy targeting tumor necrosis factor-alfa (TNF-α) is associated with improvement of inflammation in some patients, others do not respond at first or lose response over time...
March 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29334162/prevalence-of-metabolic-syndrome-in-children-with-moderate-to-severe-psoriasis-treated-with-tnf-inhibitors-in-comparison-to-conventional-agents
#9
Nawaf Al Mutairi, Dhuha Alrqobah, Nasser Haji Hussain
Association of childhood psoriasis with metabolic syndrome has not been studied well. TNF-alfa contributes to the inflammation seen in metabolic syndrome, and recently etanercept has shown to reduce the levels of inflammatory markers. Assessment of prevalence of metabolic syndrome in juvenile psoriasis patients in Kuwait. We included 236 patients with moderate to severe psoriasis below 18 years treated for at least 24 weeks with TNF inhibitors (Group A), and equal number of age and sex matched cases treated with conventional medications (Group B)...
January 2018: Dermatologic Therapy
https://www.readbyqxmd.com/read/29180213/cross-talk-between-tgf-beta-and-tnf-alfa-in-regression-of-myointimal-hyperplasia
#10
Antonio V Sterpetti, Valeria Borrelli, Alessandra Cucina, Marco Ventura
BACKGROUND: The phenomena involved in regression of arterial myointimal hyperplasia have not been analyzed in detail. MATERIALS AND METHODS: In 24 Lewis rats, a 1-cm-long venous graft, obtained from syngenic Lewis rats, was implanted in the infrarenal aorta. After 4 wk, the grafts were removed and analyzed using scanning electron microscopy and histochemistry. The grafts showed evidence of myointimal hyperplasia; 16 of these explanted grafts were reimplanted in the vein circulation of syngenic Lewis rats...
December 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29042071/influence-of-ginkgo-biloba-extract-egb-761-on-expression-of-il-1-beta-il-6-tnf-alfa-hsp-70-hsf-1-and-cox-2-after-noise-exposure-in-the-rat-cochlea
#11
Remzi Dogan, Alev Pektas Sjostrand, Alper Yenıgun, Ersin Karatas, Abdurrahim Kocyigit, Orhan Ozturan
OBJECTIVE: The objective of this study was to investigate the influence of Ginkgo Biloba in early treatment of noise induced hearing loss on expression of IL-6, IL-1 Beta, TNF-alfa, HSP-70, HSF-1 and COX-2 in the rat cochlea. METHODS: Thirty two female rats were randomly divided into four groups (Acoustic Trauma, Ginkgo Biloba, Acoustic Trauma+Ginkgo Biloba, Non Treatment). Auditory brainstem response (ABR) was applied in all the groups. At the end of the study, IL-1Beta, IL-6, TNF-alpha, HSP-70, HSF-1 and COX-2 were studied in cochlear tissue with ELISA and Western blot analysis...
October 14, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28922437/molecular-biomarkers-as-predictors-for-biliary-complications-following-liver-transplantation-a-prospective-study
#12
Bogdan Dorobantu, Irinel Popescu, Simona Dima, Anca Nastase, Speranta Iacob
BACKGROUND: The biliary complications (BC) have been always considered the "Achilles' heel" of liver transplantation (LT), being one of the leading causes of postoperative morbidity. AIM: To analyse predictors of BC, by monitoring in the peripheral blood the biomarkers involved in the inflammation and hepatic fibrosis, such as the matrix metalloproteinases (MMP 2, 9) and their tissue inhibitors (TIMP1), the interleukins (IL 2, 8), alfa-TNF, the endothelins and their receptors...
September 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/28895041/unmet-needs-in-the-pathogenesis-and-treatment-of-vasculitides
#13
REVIEW
Francesco Muratore, Giulia Pazzola, Alessandra Soriano, Nicolò Pipitone, Stefania Croci, Martina Bonacini, Luigi Boiardi, Carlo Salvarani
Despite the progress in the last years on the field of vasculitides, there are several unmet needs regarding classification, disease activity assessment, predictors of flares and complications, and type of treatment for the different forms. The 1990 American College of Rheumatology (ACR) classification criteria currently used to define giant cell arteritis and Takayasu arteritis were designed to discriminate between different types of vasculitides but not to differentiate vasculitis from other disorders. Recently, efforts have been made to overcome the shortcomings of the ACR criteria...
April 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28872345/intra-cerebral-cannabidiol-infusion-induced-neuroprotection-is-partly-associated-with-the-tnf-%C3%AE-tnfr1-nf-%C3%B0%C2%BAb-pathway-in-transient-focal-cerebral-ischaemia
#14
Sepideh Khaksar, Mohammad Reza Bigdeli
BACKGROUND: Stroke is a neurological disease, which, in addition to high mortality, imposes many financial and mental burdens on families and the society. The main objective of this study was to investigate the effect of cannabidiol (CBD) on one of the major inflammatory pathways in cerebral ischaemia. METHOD: Using stereotaxic surgery, the cannula was implanted into the right lateral ventricle of rats. CBD (50, 100, and 200 ng/rat; i.c.v.) was administrated for five consecutive days...
2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28711286/novel-therapeutic-targets-for-inflammatory-bowel-disease
#15
REVIEW
Marjorie Argollo, Gionata Fiorino, Pieter Hindryckx, Laurent Peyrin-Biroulet, Silvio Danese
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and Ulcerative Colitis (UC), are immune mediated conditions associated with progressive damage of the inflamed gut tissue, and have a considerable impact on the patient's quality of life. The pathogenesis remains uncertain, but it is clear that complex mechanisms associated with host and luminal factors are involved, generating an unbalance between pro- and anti-inflammatory signaling. It is well established that the purpose of an adequate and complete control of the intestinal inflammation measured not only by clinical symptoms, but also with more objective data such as fecal biomarkers (calprotectin) and endoscopy...
December 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28687339/inflammation-and-myointimal-hyperplasia-correlation-with-hemodynamic-forces
#16
Antonio V Sterpetti, Alessandra Cucina, Valeria Borrelli, Marco Ventura
OBJECTIVES: The aim of our study was to correlate flow dynamics and the release of inflammatory cytokines Interleukin 1, 2, 6, TNF (Tumour Necrosis Factor) alfa, both in vitro and in vivo. MATERIALS AND METHODS: Endothelial cells were exposed to laminar flow (6dyne/cm(2)) in an in vitro circulatory system and the release of Interleukin 1, 2, 6 and TNF alfa was quantified by ELISA. Interleukin 1, 2, 6 and TNF alfa release was also assessed in vein grafts implanted in the arterial circulation of Lewis rats...
July 5, 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/28501584/thiamine-potentiates-chemoprotective-effects-of-ibuprofen-in-den-induced-hepatic-cancer-via-alteration-of-oxidative-stress-and-inflammatory-mechanism
#17
Muhammad Afzal, Imran Kazmi, Ruqaiyah Khan, Poonam Rana, Vikas Kumar, Fahad A Al-Abbasi, Mazin A Zamzami, Firoz Anwar
Present study, was an effort to scrutinize the molecular and biochemical role of ibuprofen and thiamine combination in diethylnitrosamine (DEN)-induced HCC in Wistar rats. Single intraperitoneal injection of DEN (200 mg/kg) was used for induction of HCC in rats. The rats were divided into eight various groups. DEN induced rats were treated with pure ibuprofen (40 mg/kg) and thiamine in combination for the period of 12th weeks. The protocol was terminated after the 16th week. Exposure of DEN up-regulated the levels of different serum biochemical parameters, antioxidant enzyme level, Alfa-fetoprotein (AFP) and reduced the level of High density lipoprotein (HDL) in Wistar rats along with the alteration in pro-inflammatory cytokines viz...
June 1, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28480686/variation-in-plasma-cytokine-concentration-during-a-training-season-in-elite-kayakers
#18
Grasiely Faccin Borges, Luis Rama, Humberto Moreira Carvalho, Joana Gaspar, Amandio Santos, Alain Massart, Beatriz Gomes, Luciele Guerra Minuzzi, Artur Paiva, Ana M Teixeira
BACKGROUND: The purpose of this study was to investigate the differences in cytokines levels in the peripheral blood of kayakers at different moments of training. MATERIALS AND METHODS: The sample comprised 12 elite kayakers preparing for the Beijing Olympic Games. Blood samples were collected at different time points of the training season: baseline (t0 - November) after six week of off-training and before the start of the training season; t1 (January) at week 11 after a period of high-volume training; t2 (April) at week 26 at the end of a period of high intensity training sessions; t3 (June) at week 31 after a competitive period...
May 5, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28471237/anti-dsdna-antibodies-and-their-association-with-paradoxical-psoriasis-induced-by-tnf-alfa-inhibitors
#19
K Vorcakova, T Pecova, L Turonova
No abstract text is available yet for this article.
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28162854/malignancy-rates-in-a-large-cohort-of-patients-with-systemically-treated-psoriasis-in-a-managed-care-population
#20
Maryam M Asgari, G Thomas Ray, Jamie L Geier, Charles P Quesenberry
BACKGROUND: Moderate to severe psoriasis often requires treatment with systemic agents, many of which have immunosuppressive properties and could increase cancer risk, including nonmelanoma skin cancer (NMSC). OBJECTIVE: We sought to estimate the overall malignancy rate (excluding NMSC) and NMSC rate among 5889 patients with systemically treated psoriasis. METHODS: We identified a cohort of adult Kaiser Permanente Northern California health plan members with psoriasis diagnosed from 1998 to 2011 and treated with at least 1 systemic antipsoriatic agent and categorized them into ever-biologic or nonbiologic users...
April 2017: Journal of the American Academy of Dermatology
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