Rodolfo Furlan Damiano, Cristiana Castanho de Almeida Rocca, Antonio de Pádua Serafim, Jennifer M Loftis, Leda Leme Talib, Pedro Mário Pan, Edecio Cunha-Neto, Jorge Kalil, Gabriela Salim de Castro, Marilia Seelaender, Bruno F Guedes, Suely K Nagahashi Marie, Heraldo Possolo de Souza, Ricardo Nitrini, Euripedes Constantino Miguel, Geraldo Busatto, Orestes V Forlenza
OBJECTIVE: To analyze the potential impact of sociodemographic, clinical and biological factors on the long-term cognitive outcome of patients who survived moderate and severe forms of COVID-19. METHODS: We assessed 710 adult participants (Mean age = 55 ± 14; 48.3% were female) 6 to 11 months after hospital discharge with a complete cognitive battery, as well as a psychiatric, clinical and laboratory evaluation. A large set of inferential statistical methods was used to predict potential variables associated with any long-term cognitive impairment, with a focus on a panel of 28 cytokines and other blood inflammatory and disease severity markers...
2023: Frontiers in Immunology