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https://www.readbyqxmd.com/read/28811304/selectin-catch-bonds-mechanotransduce-integrin-activation-and-neutrophil-arrest-on-inflamed-endothelium-under-shear-flow
#1
Vasilios A Morikis, Shannon Chase, Ted Wun, Elliot L Chaikof, John L Magnani, Scott I Simon
E-selectin extends from the plasma membrane of inflamed endothelium and serves to capture leukocytes from flowing blood via long-lived catch-bonds that support slow leukocyte rolling under shear stress. Its ligands are glycosylated with the tetrasaccharide sialyl Lewis(x) (sLe(x)), which contributes to bond affinity and specificity. E-selectin mediated rolling transmits signals into neutrophils that triggers activation of high-affinity β2-integrins necessary for transition to shear resistant adhesion and transendothelial migration...
August 15, 2017: Blood
https://www.readbyqxmd.com/read/28801093/current-developments-and-applications-of-microfluidic-technology-toward-clinical-translation-of-nanomedicines
#2
Dongfei Liu, Hongbo Zhang, Flavia Fontana, Jouni T Hirvonen, Hélder A Santos
Nanoparticulate drug delivery systems hold great potential for the therapy of many diseases, especially cancer. However, the translation of nanoparticulate drug delivery systems from academic research to the industrial and clinical practice has been slow. This slow translation can be ascribed to the high batch-to-batch variations and insufficient production rate of the conventional methods, and the lack of technologies for rapid screening of nanoparticulate drug delivery systems with high correlation to the in vivo tests...
August 8, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28799763/iminothioethers-as-hydrogen-sulfide-donors-from-the-gasotransmitter-release-to-the-vascular-effects
#3
Elisabetta Barresi, Giulia Nesi, Valentina Citi, Eugenia Piragine, Ilaria Piano, Sabrina Taliani, Federico Da Settimo, Simona Rapposelli, Lara Testai, Maria Cristina Breschi, Claudia Gargini, Vincenzo Calderone, Alma Martelli
The gasotransmitter hydrogen sulfide (H2S) is an important tuner of the cardiovascular homeostasis and its deficiency is etiologically associated with a number of cardiovascular diseases. Therefore, the research of original moieties able to release H2S represents a timely issue for drug discovery. In this work, we developed a collection of iminothioethers (ITEs), exhibiting H2S-releasing properties and producing vasorelaxing effects on rat aortic rings. Derivatives 4 and 11, selected as representative of slow and fast rate H2S-donors respectively, produced a complete recovery of the basal coronary flow, reverting the AngII-induced effects in isolated rat hearts...
August 11, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28798856/fast-responsive-hydrogel-as-an-injectable-pump-for-rapid-on-demand-fluidic-flow-control
#4
Rongcong Luo, Ngoc-Duy Dinh, Chia-Hung Chen
Chemically synthesized functional hydrogels have been recognized as optimized soft pumps for on-demand fluidic regulation in micro-systems. However, the challenges regarding the slow responses of hydrogels have very much limited their application in effective fluidic flow control. In this study, a heterobifunctional crosslinker (4-hydroxybutyl acrylate)-enabled two-step hydrothermal phase separation process for preparing a highly porous hydrogel with fast response dynamics was investigated for the fabrication of novel microfluidic functional units, such as injectable valves and pumps...
May 2017: Biomicrofluidics
https://www.readbyqxmd.com/read/28797412/optical-coherence-tomography-characterization-of-coronary-lithoplasty-for-treatment-of-calcified-lesions-first-description
#5
Ziad A Ali, Todd J Brinton, Jonathan M Hill, Akiko Maehara, Mitsuaki Matsumura, Keyvan Karimi Galougahi, Uday Illindala, Matthias Götberg, Robert Whitbourn, Nicolas Van Mieghem, Ian T Meredith, Carlo Di Mario, Jean Fajadet
OBJECTIVES: This study sought to determine the mechanistic effects of a novel balloon-based lithoplasty system on heavily calcified coronary lesions and subsequent stent placement using optical coherence tomography (OCT). BACKGROUND: The Shockwave Coronary Rx Lithoplasty System (Shockwave Medical, Fremont, California) delivers localized, lithotripsy-enhanced disruption of calcium within the target lesion (i.e., lithoplasty) for vessel preparation before stent implantation...
August 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28793765/electrokinetic-lattice-boltzmann-solver-coupled-to-molecular-dynamics-application-to-polymer-translocation
#6
Adwait V Datar, Maria Fyta, Umberto Marini Bettolo Marconi, Simone Melchionna
We develop a theoretical and computational approach to deal with systems that involve a disparate range of spatio-temporal scales, such as those comprised of colloidal particles or polymers moving in a fluidic molecular environment. Our approach is based on a multiscale modeling that combines the slow dynamics of the large particles with the fast dynamics of the solvent into a unique framework. The former is numerically solved via Molecular Dynamics and the latter via a multi-component Lattice Boltzmann. The two techniques are coupled together to allow for a seamless exchange of information between the descriptions...
August 9, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28792278/astrocytic-endfoot-ca-2-correlates-with-parenchymal-vessel-responses-during-4-ap-induced-epilepsy-an-in%C3%A2-vivo-two-photon-lifetime-microscopy-study
#7
Cong Zhang, Maryam Tabatabaei, Samuel Bélanger, Hélène Girouard, Mohammad Moeini, Xuecong Lu, Frédéric Lesage
Neurovascular coupling (NVC) underlying the local increase in blood flow during neural activity forms the basis of functional brain imaging and is altered in epilepsy. Because astrocytic calcium (Ca(2+)) signaling is involved in NVC, this study investigates the role of this pathway in epilepsy. Here, we exploit 4-AP induced epileptic events to show that absolute Ca(2+) concentration in cortical astrocyte endfeet in vivo correlates with the diameter of precapillary arterioles during neural activity. We simultaneously monitored free Ca(2+) concentration in astrocytic endfeet with the Ca(2+)-sensitive indicator OGB-1 and diameter of adjacent arterioles in the somatosensory cortex of adult mice by two-photon fluorescence lifetime measurements following 4-AP injection...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28791238/the-underactive-bladder-diagnosis-and-surgical-treatment-options
#8
REVIEW
Johan Gani, Derek Hennessey
The underactive bladder (UAB)/detrusor underactivity (DU) is a relatively common condition. It is difficult to diagnose and can be difficult to manage. The aim of this review is to provide a review of the diagnosis and different surgical treatment options for UAB/DU. A comprehensive literature review using medical search engines was performed. The search included a combination of the following terms, UAB, DU, TURP, reduction cystoplasty, bladder diverticulectomy and sacral neuromodulation (SNM). Search results were assessed for their overall relevance to this review...
July 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28790132/trb3-is-elevated-in-psoriasis-vulgaris-lesions-and-mediates-hacat-cells-proliferation-in-vitro
#9
Xiao-Jing Yu, Tie-Jun Song, Lu-Wei Zhang, Ying Su, Ke-Yu Wang, Qing Sun
Psoriasis is a chronic skin disease characterized by abnormal keratinocyte proliferation and differentiation, inflammation, and angiogenesis. Overexpression of tribbles homolog3 (TRB3), which belongs to the tribbles family of pseudokinases, has been found in several human tumors and metabolic diseases, but its role in psoriasis has not been fully clarified. The aim of this study is to investigate the expression of TRB3 in psoriasis and explore its roles in the proliferation of keratinocytes. Twenty-four patients with psoriasis vulgaris were recruited for the study...
August 7, 2017: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/28782059/measuring-global-disease-with-wikipedia-success-failure-and-a-research-agenda
#10
Reid Priedhorsky, Dave Osthus, Ashlynn R Daughton, Kelly R Moran, Nicholas Generous, Geoffrey Fairchild, Alina Deshpande, Sara Y Del Valle
Effective disease monitoring provides a foundation for effective public health systems. This has historically been accomplished with patient contact and bureaucratic aggregation, which tends to be slow and expensive. Recent internet-based approaches promise to be real-time and cheap, with few parameters. However, the question of when and how these approaches work remains open. We addressed this question using Wikipedia access logs and category links. Our experiments, replicable and extensible using our open source code and data, test the effect of semantic article filtering, amount of training data, forecast horizon, and model staleness by comparing across 6 diseases and 4 countries using thousands of individual models...
February 2017: CSCW: Proceedings of the Conference on Computer-Supported Cooperative Work
https://www.readbyqxmd.com/read/28780853/inhibition-of-biodegradation-of-hydraulic-fracturing-compounds-by-glutaraldehyde-groundwater-column-and-microcosm-experiments
#11
Jessica D Rogers, Imma Ferrer, Shantal S Tummings, Angela Bielefeldt, Joseph N Ryan
The rapid expansion of unconventional oil and gas development has raised concerns about the potential contamination of aquifers; however, the groundwater fate and transport of hydraulic fracturing fluid compounds and mixtures remains a significant data gap. Degradation kinetics of five hydraulic fracturing compounds (2-propanol, ethylene glycol, propargyl alcohol, 2-butoxyethanol, and 2-ethylhexanol) in the absence and presence of the biocide glutaraldehyde were investigated under a range of redox conditions using sediment-groundwater microcosms and flow-through columns...
August 7, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28770549/therapy-related-longitudinal-brain-perfusion-changes-in-patients-with-chronic-pelvic-pain-syndrome
#12
Christian Weisstanner, Livio Mordasini, George N Thalmann, Rajeev K Verma, Christian Rummel, Andrea Federspiel, Thomas M Kessler, Roland Wiest
BACKGROUND: The imaging method most frequently employed to identify brain areas involved in neuronal processing of nociception and brain pain perception is blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI). Arterial spin labelling (ASL), in contrast, offers advantages when slow varying changes in brain function are investigated. Chronic pelvic pain syndrome (CPPS) is a disorder of, mostly, young males that leads to altered pain perceptions in structures related to the pelvis...
August 3, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28769102/relaxation-oscillations-and-ultrafast-emission-pulses-in-a-disordered-expanding-polariton-condensate
#13
Maciej Pieczarka, Marcin Syperek, Łukasz Dusanowski, Andrzej Opala, Fabian Langer, Christian Schneider, Sven Höfling, Grzegorz Sęk
Semiconductor microcavities are often influenced by structural imperfections, which can disturb the flow and dynamics of exciton-polariton condensates. Additionally, in exciton-polariton condensates there is a variety of dynamical scenarios and instabilities, owing to the properties of the incoherent excitonic reservoir. We investigate the dynamics of an exciton-polariton condensate which emerges in semiconductor microcavity subject to disorder, which determines its spatial and temporal behaviour. Our experimental data revealed complex burst-like time evolution under non-resonant optical pulsed excitation...
August 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28767637/osmotic-pressure-alters-time-dependent-recovery-behavior-of-the-intervertebral-disc
#14
Semih E Bezci, Grace D O'Connell
STUDY DESIGN: Disc recovery behavior under hypo- and hyper-osmotic pressure OBJECTIVE.: To evaluate the effect of osmotic pressure on the unloaded recovery response of healthy discs SUMMARY OF BACKGROUND DATA.: The intervertebral disc is a poroviscoelastic material that experiences large fluctuations in water composition throughout a diurnal loading cycle. Fluid flow out of the disc occurs through mechanical loading, while fluid flow into the disc occurs through passive diffusion due to an imbalance of ions between the disc and its surrounding environment...
August 1, 2017: Spine
https://www.readbyqxmd.com/read/28766752/unlocking-opportunities-in-food-design-for-infants-children-and-the-elderly-understanding-milestones-in-chewing-and-swallowing-across-the-lifespan-for-new-innovations
#15
REVIEW
Julie A Y Cichero
Intake of a variety of foods increases the likelihood of good general health. From as early as life in utero, humans are exposed to flavor. Further flavor imprinting occurs via breast milk, increasing the likelihood of acceptance of a variety flavors when solids are introduced. While first foods need to be smooth and runny, experience managing soft lumps is required for rudimentary development of chewing skills. Texture experiences are critical to providing building blocks for food acceptance and gradual increase in the range of food textures eaten...
August 2017: Journal of Texture Studies
https://www.readbyqxmd.com/read/28765175/e-selectin-mediated-rolling-facilitates-pancreatic-cancer-cell-adhesion-to-hyaluronic-acid
#16
Daniel J Shea, Yi W Li, Kathleen J Stebe, Konstantinos Konstantopoulos
Tumor cell extravasation is a multistep process preceded by cell rolling and arrest on the vessel wall via the formation of specific receptor-ligand bonds. The strength, availability, and number of receptor-ligand bonds regulate the rate by which tumor cells tether, roll, and adhere to vascular walls. Although the mechanics of selectin-mediated rolling have been extensively studied, little is known regarding how tumor cell rolling on selectins facilitates adhesion to a distinct substrate-bound protein with different kinetic properties...
August 1, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28756335/computational-approaches-to-understand-the-adverse-drug-effect-on-potassium-sodium-and-calcium-channels-for-predicting-tdp-cardiac-arrhythmias
#17
Mohsen Sharifi
Ion channels play a crucial role in the cardiovascular system. Our understanding of cardiac ion channel function has improved since their first discoveries. The flow of potassium, sodium and calcium ions across cardiomyocytes is vital for regular cardiac rhythm. Blockage of these channels, delays cardiac repolarization or tend to shorten repolarization and may induce arrhythmia. Detection of drug risk by channel blockade is considered essential for drug regulators. Advanced computational models can be used as an early screen for torsadogenic potential in drug candidates...
July 8, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28754857/enhanced-radiosensitizing-by-sodium-glycididazole-in-a-recurrent-esophageal-carcinoma-tumor-model
#18
Peipei Wu, Jing Liu, Xiaorong Sun, Xiaolin Li, Ligang Xing, Jinming Yu
Re-irradiation is challenging for esophageal cancer patients with local-regional recurrence after initial radiotherapy. The purpose of this study is to establish a recurrent esophageal tumor model and investigate radiosensitizing effects of sodium glycididazole (CMNa). Tumor models were established by pre-irradiation (0 Gy, 10 Gy or 20 Gy) to the right hind leg of the nude mice 24 hours before tumor transplantation (ECA109 human esophageal carcinoma cells). Tumor growth curves were analyzed. Hypoxic microenvironment was exhibited in tumor frozen slides stained for pimonidazole, Hoechst 33342, hematoxylin-eosin and CD34...
July 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28751436/a-striking-image-of-spontaneous-echo-contrast-in-severe-mitral-stenosis-in-a-patient-with-good-inr-control
#19
Daniel A Jeffery, Guy Lloyd, Arjun K Ghosh
A 38 year old man was referred to our valve clinic for assessment. He had been diagnosed with untreated rheumatic mitral stenosis (MS) in 2009. He was diagnosed with atrial fibrillation in 2016 [on warfarin with good INR control]. Transthoracic echocardiography demonstrated severe MS. A large amount of spontaneous echo contrast (SEC) was noted in the severely dilated left atrium and a transoesophageal echocardiogram (TOE) was requested for further assessment of the MS (Image 1 and Videos 1-3). He was symptomatic with shortness of breath and reduced exercise tolerance consistent with NYHA class III-IV...
July 27, 2017: Echo Research and Practice
https://www.readbyqxmd.com/read/28740398/focusing-on-a-complete-blood-cell-parameter-mean-platelet-volume-levels-may-be-a-predictor-of-coronary-slow-flow
#20
Mücahid Yılmaz, Mustafa Necati Dağlı, Ökkeş Uku, Mehmet Nail Bilen, Hasan Korkmaz, Kenan Erdem, Ertuğrul Kurtoğlu
BACKGROUND: The relationship between increased mean platelet volume (MPV) and atherosclerosis is well known. In the present study, MPV in patients with coronary slow flow (CSF) and in cases with normal coronary anatomy (NCA) was investigated and compared with the aim of identifying the relationship between CSF and MPV. PATIENTS AND METHODS: We studied 40 patients previously determined via coronary angiography as having NCA and 40 patients with CSF in the coronary blood stream, as identified by thrombolysis in myocardial infarction square...
2017: Vascular Health and Risk Management
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