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https://www.readbyqxmd.com/read/28345735/-supratentorial-cavernous-malformations-in-an-argentinian-institution-experience-with-surgical-treatment
#1
G E Vergara, A Cervio, M Farez, R Mormandi, S Condomi-Alcorta, J Salvat
INTRODUCTION: Cavernous malformations are vascular malformations of the central nervous system formed by a group of capillaries not covered by pia mater and communicated to the vascular system at very low pressure with very slow flow. Surgery or radiosurgery are the treatment modalities. AIMS: To analyze our results after surgical treatment of supratentorial cavernous malformations, reviewing clinical presentation, surgical indications and postoperative complications...
April 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28337269/the-role-of-prrx1-in-the-apoptosis-of-a549-cells-induced-by-cisplatin
#2
Hongbin Zhu, Gengyun Sun, Jiahui Dong, Liming Fei
Paired related homeobox1 (PRRX1) was a newly identified Epithelial mesenchymal transition (EMT) inducer. It was found that the decreased expression of PRRX1 in breast cancer and liver cancer could enable tumor cells to obtain tumor stem cell characteristics in vitro studies. However, the role of PRRX1 in lung cancer was still unknown. The down-regulated PRRX1 gene in A549 cells was established by slow virus infection in this study. The apoptosis of A549 cells was observed after the treatment of different concentrations of cisplatin and the role of PRRX1 in the apoptosis of A549 cells was explored...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28328073/surfactant-assisted-stabilization-of-au-colloids-on-solids-for-heterogeneous-catalysis
#3
Wangcheng Zhan, Yuan Shu, Yujie Sheng, Huiyuan Zhu, Yanglong Guo, Li Wang, Yun Guo, Jinshui Zhang, Guanzhong Lu, Sheng Dai
The stabilization of surfactant-assisted synthesized colloidal noble metal nanoparticles (NPs, such as Au NPs) on solids is a promising strategy for preparing supported nanocatalysts for heterogeneous catalysis because of their uniform particle sizes, controllable shapes, and tunable compositions. However, surfactant removal to obtain clean surfaces for catalysis through traditional approaches (such as solvent extraction and thermal decomposition) can easily induce the sintering of NPs, greatly hampering their use in synthesis of novel catalysts...
March 22, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28324943/overcoming-spatio-temporal-limitations-using-dynamically-scaled-in-vitro-pc-mri-a-flow-field-comparison-to-true-scale-computer-simulations-of-idealized-stented-and-patient-specific-left-main-bifurcations
#4
Susann Beier, John Ormiston, Mark Webster, John Cater, Stuart Norris, Pau Medrano-Gracia, Alistair Young, Kathleen Gilbert, Brett Cowan
The majority of patients with angina or heart failure have coronary artery disease. Left main bifurcations are particularly susceptible to pathological narrowing. Flow is a major factor of atheroma development, but limitations in imaging technology such as spatio-temporal resolution, signal-to-noise ratio (SNRv), and imaging artefacts prevent in vivo investigations. Computational fluid dynamics (CFD) modelling is a common numerical approach to study flow, but it requires a cautious and rigorous application for meaningful results...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28322436/modelling-hydraulic-transport-and-anaerobic-uptake-by-paos-and-gaos-during-wastewater-feeding-in-ebpr-granular-sludge-reactors
#5
David G Weissbrodt, Christof Holliger, Eberhard Morgenroth
New-generation bioprocesses using granular sludge aim for a high-rate removal of nutrients from wastewater with low footprint. Achieving enhanced biological phosphorus removal (EBPR) relies on the design of sludge beds and wastewater feeding conditions to optimally load the biomass and to select for polyphosphate- (PAOs) over glycogen-accumulating organisms (GAOs) and other heterotrophs. A hydraulic-metabolic mathematical model was developed to elucidate the impact of hydraulic transport patterns and environmental conditions on the PAO/GAO competition during up-flow feeding through an EBPR granular sludge bed...
March 21, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28322100/could-neutrophil-lymphocyte-ratio-be-an-indicator-of-coronary-artery-disease-coronary-artery-ectasia-and-coronary-slow-flow
#6
Mücahid Yılmaz, Hasan Korkmaz, Mehmet Nail Bilen, Ökkeş Uku, Ertuğrul Kurtoğlu
Objective To determine whether neutrophil/lymphocyte ratio (NLR) differed between patients with isolated coronary artery disease (CAD), isolated coronary artery ectasia (CAE), coronary slow flow and normal coronary anatomy. Methods Patients who underwent coronary angiography were consecutively enrolled into one of four groups: CAD, coronary slow flow, CAE and normal coronary anatomy. Results The CAD ( n = 40), coronary slow flow ( n = 40), and CAE ( n = 40) groups had similar NLRs (2.51 ± 0...
December 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/28318488/computational-models-of-o-lm-cells-are-recruited-by-low-or-high-theta-frequency-inputs-depending-on-h-channel-distributions
#7
Vladislav Sekulić, Frances K Skinner
Although biophysical details of inhibitory neurons are becoming known, it is challenging to map these details onto function. Oriens-lacunosum/moleculare (O-LM) cells are inhibitory cells in the hippocampus that gate information flow, firing while phase-locked to theta rhythms. We build on our existing computational model database of O-LM cells to link model with function. We place our models in high-conductance states and modulate inhibitory inputs at a wide range of frequencies. We find preferred spiking recruitment of models at high (4-9 Hz) or low (2-5 Hz) theta depending on, respectively, the presence or absence of h-channels on their dendrites...
March 20, 2017: ELife
https://www.readbyqxmd.com/read/28315816/longest-gallbladder-a-case-report
#8
Rahul Yadav, Jeevan Kankaria
INTRODUCTION: A gallbladder mucocele is the distention of the gallbladder by an inappropriate accumulation of mucus. Decreased bile flow, decreased gallbladder motility, and altered absorption of water from the gallbladder lumen are predisposing factors to biliary sludge. However, it is more likely to be a small part of a complex disease process involving inflammation of the gallbladder wall and changes to the lining of the gallbladder changing the consistency of its secretions. We would like to present a case of mucocele gallbladder operated successfully by laparoscopic cholecystectomy...
February 28, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28315484/probing-fast-ribozyme-reactions-under-biological-conditions-with-rapid-quench-flow-kinetics
#9
Jamie L Bingaman, Kyle J Messina, Philip C Bevilacqua
Reaction kinetics on the millisecond timescale pervade the protein and RNA fields. To study such reactions, investigators often perturb the system with abiological solution conditions or substrates in order to slow the rate to timescales accessible by hand mixing; however, such perturbations can change the rate-limiting step and obscure key folding and chemical steps that are found under biological conditions. Mechanical methods for collecting data on the millisecond timescale, which allow these perturbations to be avoided, have been developed over the last few decades...
March 14, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28314817/fef-controlled-alpha-delay-activity-precedes-stimulus-induced-gamma-band-activity-in-visual-cortex
#10
Tzvetan Popov, Sabine Kastner, Ole Jensen
Recent findings in the visual system of non-human primates have demonstrated an important role of gamma band activity (40 - 100 Hz) in the feed-forward flow of sensory information, whereas feedback control appears to be dynamically established by oscillations in the alpha (8 - 13 Hz) and beta bands (13 - 18 Hz) (van Kerkoerle et al., 2014; Bastos et al., 2015). It is not clear, however, how alpha oscillations are controlled and how they interact with the flow of visual information mediated by gamma band activity...
March 17, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28314673/can-we-perform-rotational-atherectomy-in-patients-with-severe-aortic-stenosis-substudy-from-the-ocean-tavi-registry
#11
Toru Naganuma, Hiroyoshi Kawamoto, Kensuke Takagi, Hiroto Yabushita, Satoru Mitomo, Yusuke Watanabe, Shinichi Shirai, Motoharu Araki, Norio Tada, Futoshi Yamanaka, Masanori Yamamoto, Hirokazu Onishi, Sunao Nakamura, Akihiro Higashimori, Minoru Tabata, Kazuki Mizutani, Hiroshi Ueno, Kentaro Hayashida
PURPOSE: The aim of this study was to report the safety of coronary rotational atherectomy (RA) in patients with severe aortic stenosis (AS). RA in the clinical setting seems challenging because coronary slow flow leads to hemodynamic instability. METHODS: Between October 2013 and May 2016, 1401 patients in the Optimized transCathEter vAlvular iNtervention (OCEAN) registry in Japan underwent transcatheter aortic valve implantation (TAVI). The primary study endpoint was procedural success, defined as residual stenosis <20% with final Thrombolysis in Myocardial Infarction flow 3...
February 28, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28300407/dynamic-succession-of-groundwater-sulfate-reducing-communities-during-prolonged-reduction-of-uranium-in-a-contaminated-aquifer
#12
Ping Zhang, Zhili He, Joy D Van Nostrand, Yujia Qin, Ye Deng, Liyou Wu, Qichao Tu, Jianjun Wang, Christopher W Schadt, Matthew W Fields, Terry C Hazen, Adam P Arkin, David A Stahl, Jizhong Zhou
To further understand the diversity and dynamics of SRB in response to substrate amendment, we sequenced genes coding for the dissimilatory sulfite reductase (dsrA) in groundwater samples collected after an emulsified vegetable oil (EVO) amendment, which sustained U(VI)-reducing conditions for one year in a fast-flowing aquifer. EVO amendment significantly altered the composition of groundwater SRB communities. Sequences having no closely related-described species dominated (80%) the indigenous SRB communities in nonamended wells...
March 16, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28298467/swimming-and-diving-energetics-in-dolphins-a-stroke-by-stroke-analysis-for-predicting-the-cost-of-flight-responses-in-wild-odontocetes
#13
Terrie M Williams, Traci L Kendall, Beau P Richter, Courtney R Ribeiro-French, Jason S John, Kim L Odell, Barbara A Losch, David A Feuerbach, M Andrew Stamper
Exponential increases in hydrodynamic drag and physical exertion occur when swimmers move quickly through water, and underlie the preference for relatively slow routine speeds by marine mammals regardless of body size. Because of this and the need to balance limited oxygen stores when submerged, flight (escape) responses may be especially challenging for this group. To examine this, we used open-flow respirometry to measure the energetic cost of producing a swimming stroke during different levels of exercise in bottlenose dolphins (Tursiops truncatus)...
March 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28289373/reentrant-information-flow-in-electrophysiological-rat-default-mode-network
#14
Wei Jing, Daqing Guo, Yunxiang Zhang, Fengru Guo, Pedro A Valdés-Sosa, Yang Xia, Dezhong Yao
Functional MRI (fMRI) studies have demonstrated that the rodent brain shows a default mode network (DMN) activity similar to that in humans, offering a potential preclinical model both for physiological and pathophysiological studies. However, the neuronal mechanism underlying rodent DMN remains poorly understood. Here, we used electrophysiological data to analyze the power spectrum and estimate the directed phase transfer entropy (dPTE) within rat DMN across three vigilance states: wakeful rest (WR), slow-wave sleep (SWS), and rapid-eye-movement sleep (REMS)...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28283549/mild-hypothermia-preserves-myocardial-conduction-during-ischemia-by-maintaining-gap-junction-intracellular-communication-and-sodium-channel-function
#15
Michelle Mj Nassal, Xiaoping Wan, Zack Dale, Isabelle Deschenes, Lance D Wilson, Joseph Stephen Piktel
BACKGROUND: Acute cardiac ischemia induces conduction velocity (CV) slowing and conduction block, promoting reentrant arrhythmias leading to sudden cardiac arrest (SCA). Previously, we found that mild hypothermia (MH, 32°C) attenuates ischemia-induced conduction block and CV slowing in a canine model of early global ischemia. Acute ischemia impairs cellular excitability and the GJ protein connexin 43 (Cx43). We hypothesized that MH prevented ischemia-induced conduction block and CV slowing by preserving GJ expression and localization...
March 10, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28280106/dynamics-of-middle-cerebral-artery-blood-flow-velocity-during-moderate-intensity-exercise
#16
Sandra A Billinger, Jesse C Craig, Sarah J Kwapiszeski, Jason-Flor Villarosa Sisante, Eric Dennis Vidoni, Rebecca Maletsky, David C Poole
The dynamic response to a stimulus such as exercise can reveal valuable insights into systems control in health and disease that is not evident from the steady-state perturbation. However, the dynamic response profile and kinetics of cerebrovascular function have not been determined to date. We tested the hypotheses that bilateral middle cerebral artery blood flow velocity (MCAV) increases exponentially following the onset of moderate intensity exercise in ten healthy young subjects. The MCAV response profiles were well fit to a delay (TD) + exponential (time constant, τ) model with substantial agreement for baseline (L: 69, R: 64 cm·s(-1), coefficient of variation, c...
March 9, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28277381/working-toward-quality-in-obstetric-anesthesia-a-business-approach
#17
Grant C Lynde
PURPOSE OF REVIEW: Physicians are increasingly required to demonstrate that they provide quality care. How does one define quality? A significant body of literature in industries outside of health care provides guidance on how to define appropriate metrics, create teams to troubleshoot problem areas, and sustain those improvements. RECENT FINDINGS: The modern quality movement in the United States began in response to revolutionary gains in both quality and productivity in Japanese manufacturing in the 1980's...
March 8, 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28270291/feasibility-study-of-low-dose-prostate-ct-perfusion-on-third-generation-dual-source-ct
#18
Gumuyang Zhang, Hao Sun, Huadan Xue, Yun Wang, Jixiang Liang, Kai Xu, Ming Wang, Man Wang, Zhengyu Jin
Objective To investigate the feasibility of using low-dose prostate CT perfusion (pCTP)on a third-generation dual-source CT. Methods Nine patients with elevated prostate-specific antigen underwent pCTP before having prostate biopsy. We measured the blood flow (BF),blood volume (BV),mean transit time (MTT),permeability surface (PS),and time to peak(TTP)of both lesions and normal prostate tissue. The effective dose (ED)was calculated. Results Of the 9 cases,6 were prostate cancers and 3 were prostate hyperplasia with chronic inflammation...
February 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28269228/leg-fluid-accumulation-during-prolonged-sitting
#19
Daniel Vena, Jonathan Rubianto, Milos Popovic, Azadeh Yadollahi
The accumulation of fluid in the legs due to sedentariness can be a health risk in extreme cases. Negative health impacts associated with leg fluid accumulation include leg edema and risk of blood clots. Furthermore, fluid accumulating in the legs is accompanied by fluid shift into the upper body which is also associated with health risks such as: increased blood pressure when lying down, respiratory problems in people with heart failure, and increased sleep apnea. Understanding the pattern by which fluid accumulates in the legs can aid in the development of devices for reducing leg fluid accumulation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268423/dynamic-cerebral-autoregulation-in-young-athletes-following-concussion
#20
Kyriaki Kostoglou, Alexander D Wright, Jonathan D Smirl, Kelsey Bryk, Paul van Donkelaar, Georgios D Mitsis
The purpose of this study was to examine cerebral autoregulation (CA) in young athletes experiencing concussion. The subjects were monitored and repeatedly tested 72 hours, 2 weeks and 1 month post-injury. Mean arterial blood pressure (MABP), end-tidal partial pressure of carbon dioxide (PETCO2) and cerebral blood flow velocity (CBFV) in the middle and posterior cerebral arteries were monitored during mental activation paradigms. In order to characterize CA we employed autoregressive models with exogenous inputs (ARX) and impulse response models based on the Laguerre expansion technique (LET)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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