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https://www.readbyqxmd.com/read/28651248/evaluation-of-plasma-thrombomodulin-in-patients-with-coronary-slow-flow
#1
Yong Wang, Peng-Yu Jia, Bao-Jun Chen, Yan Chen, Hang Yu, Yao Yu, Hui-Min Yang, Da-Lin Jia, Chun-Yan Ma
BACKGROUND: It has been reported that coronary slow flow (CSF) is associated with acute myocardial infarction, ventricular tachycardia, ventricular fibrillation, and even sudden cardiac death. Although studies concerning the etiopathogenesis of CSF are scarce, diffuse atherosclerosis and endothelial dysfunction are thought to play important roles. It has been suggested that a high plasma thrombomodulin (TM) level seems to play an important role in the pathogenesis of atherosclerosis and endothelial dysfunction...
June 27, 2017: Cardiology
https://www.readbyqxmd.com/read/28647250/constructed-wetlands-for-wastewater-treatment-in-cold-climate-a-review
#2
REVIEW
Mo Wang, Dong Qing Zhang, Jian Wen Dong, Soon Keat Tan
Constructed wetlands (CWs) have been successfully used for treating various wastewaters for decades and have been identified as a sustainable wastewater management option worldwide. However, the application of CW for wastewater treatment in frigid climate presents special challenges. Wetland treatment of wastewater relies largely on biological processes, and reliable treatment is often a function of climate conditions. To date, the rate of adoption of wetland technology for wastewater treatment in cold regions has been slow and there are relatively few published reports on CW applications in cold climate...
July 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28646097/highly-suggestive-preliminary-evidence-that-the-renal-interstitium-contracts-in%C3%A2-vivo
#3
Omar Flores-Sandoval, María Eugenia Sánchez-Briones, Juan F López-Rodríguez, Miriam Z Calvo-Turrubiartes, Lilia Llamazares-Azuara, Manuel Rodríguez-Martínez
To learn more about controlling renal interstitial hydrostatic pressure (RIHP), we assessed its response to renal medullary direct interstitial volume expansion (rmDIVE = 100 μL bolus infusion/30 sec). Three experimental series (S) were performed in hydropenic, anesthetized, right-nephrectomized, acute left renal-denervated and renal perfusion pressure-controlled rats randomly assigned to groups in each S. S1: Rats without hormonal clamp were contrasted before and after rmDIVE induced via 0.9% saline solution bolus (SS group) or 2% albumin in SS bolus (2% ALB + SS group)...
June 2017: Physiological Reports
https://www.readbyqxmd.com/read/28641977/a-novel-fluorescent-probe-reveals-starvation-controls-the-commitment-of-amyloid-precursor-protein-to-the-lysosome
#4
Leanne K Hein, Pirjo M Apaja, Kathryn Hattersley, Randall H Grose, Jianling Xie, Christopher G Proud, Timothy J Sargeant
Alzheimer's disease is the most important cause of dementia but there is no therapy that has been demonstrated to stop or slow disease progression. Amyloid precursor protein (APP) is the source of amyloid-β (Aβ), which aggregates in Alzheimer's disease to form toxic oligomeric species. The endo-lysosomal system can clear APP and Aβ from the cell if these molecular species are trafficked through to the lysosome. Currently, there are no easy methods available for the analysis of lysosomal APP trafficking. We therefore generated a fusion protein (tandem-fluorescent, or tf-APP) that allows detection of changes in APP trafficking using accessible techniques such as flow cytometry...
June 19, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28641143/spectroscopic-and-thermodynamic-studies-of-light-harvesting-perylenediimide-derivative-zinc-porphyrin-complex-in-aqueous-media
#5
Ahmed El-Refaey, Shaban Y Shaban, Maged El-Kemary, Mohamed E El-Khouly
Self-assembly of perylene derivative such as N,N'-bis(2(trimethylammonium iodide) ethylene)perylene-3,4,9,10-tetracarboxyldiimide (TAIPDI) can produce one-dimensional form (1D) in an aqueous media. The ability of one-dimensional TAIPDI to form light harvesting complex with water-soluble zinc porphyrin (ZnTPPS4) via the π-π and electrostatic interactions has been described. Owing to electronic interactions between the π-systems, the complex formation is accompanied by pronounced absorption spectral changes in the UV/Vis absorption bands...
June 15, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28632908/prediction-of-groundwater-quality-trends-resulting-from-anthropogenic-changes-in-southeast-florida
#6
Quanghee Yi, Mark Stewart
The effects of surface water flow system changes caused by constructing water-conservation areas and canals in southeast Florida on groundwater quality under the Atlantic Coastal Ridge was investigated with numerical modeling. Water quality data were used to delineate a zone of groundwater with low total dissolved solids (TDS) within the Biscayne aquifer under the ridge. The delineated zone has the following characteristics. Its location generally coincides with an area where the Biscayne aquifer has high transmissivities, corresponds to a high recharge area of the ridge, and underlies a part of the groundwater mound formed under the ridge prior to completion of the canals...
June 20, 2017: Ground Water
https://www.readbyqxmd.com/read/28631042/dispersal-towards-food-the-singular-limit-of-an-allen-cahn-equation
#7
Danielle Hilhorst, Yong-Jung Kim, Dohyun Kwon, Thanh Nam Nguyen
The effect of dispersal under heterogeneous environment is studied in terms of the singular limit of an Allen-Cahn equation. Since biological organisms often slow down their dispersal if food is abundant, a food metric diffusion is taken to include such a phenomenon. The migration effect of the problem is approximated by a mean curvature flow after taking the singular limit which now includes an advection term produced by the spatial heterogeneity of food distribution. It is shown that the interface moves towards a local maximum of the food distribution...
June 19, 2017: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/28624852/vasoconstrictor-responsiveness-in-contracting-human-muscle-influence-of-contraction-frequency-contractile-work-and-metabolic-rate
#8
Nicholas T Kruse, William E Hughes, Kenichi Ueda, Darren P Casey
PURPOSE: The aim of this study was to examine whether independent effects exist between contractile work and metabolic demand (VO2m) on vasoconstrictor responsiveness (i.e., functional sympatholysis) under different contraction durations matched for total contractile work in exercising human skeletal muscle. METHODS: Ten young men performed rhythmic forearm contractions at 10 and 15% of maximum voluntary contraction (MVC) which consisted of muscle contractions using the same duty cycle but altering the duration of the contraction-relaxation cycles of exercise and included: 1) fast frequency contractions at 10% MVC (FFC10%) using a contraction relaxation cycle at 1:2 s; 2) slow frequency contractions at 10% MVC (SFC10%) at 2:4 s; and 3) SFC at 15% MVC (SFC15%) at 2:4 s...
June 17, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28624444/distribution-lipid-bilayer-affinity-and-kinetics-of-the-metabolic-effects-of-dinoseb-in-the-liver
#9
Gabriela Bueno Franco Salla, Lívia Bracht, Anacharis Babeto de Sá-Nakanishi, Angela Valderrama Parizotto, Fabrício Bracht, Rosane Marina Peralta, Adelar Bracht
Dinoseb is a highly toxic pesticide of the dinitrophenol group. Its use has been restricted, but it can still be found in soils and waters in addition to being a component of related pesticides that, after ingestion by humans or animals, can originate the compound by enzymatic hydrolysis. As most dinitrophenols, dinoseb uncouples oxidative phosphorylation. In this study, distribution, lipid bilayer affinity and kinetics of the metabolic effects of dinoseb were investigated, using mainly the isolated perfused rat liver, but also isolated mitochondria and molecular dynamics simulations...
June 15, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28623795/transport-of-road-salt-contamination-in-karst-aquifers-and-soils-over-multiple-timescales
#10
Heather K Robinson, Elizabeth A Hasenmueller
Road deicing has caused widespread environmental Na(+) and Cl(-) release for decades, yet the transport and retention of these contaminants in karst aquifers and soils are poorly understood. We examined the transport dynamics of Na(+) and Cl(-) from road salt in shallow groundwater during flooding and over seasonal timescales by intensively monitoring an urban and a rural karst spring over approximately 2 years. Furthermore, we used a 20-year dataset for the rural spring to determine how salt retention affected long-term geochemical trends in the shallow groundwater...
June 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28622670/adaptive-clutter-demodulation-for-non-contrast-ultrasound-perfusion-imaging
#11
Jaime Tierney, Crystal Coolbaugh, Theodore Towse, Brett Byram
Conventional Doppler ultrasound is useful for visualizing fast blood flow in large resolvable vessels. However, frame rate and tissue clutter caused by movement of the patient or sonographer make visualizing slow flow with ultrasound difficult. Patient and sonographer motion causes spectral broadening of the clutter signal, which limits ultrasound's sensitivity to velocities greater than 5-10mm/s for typical clinical imaging frequencies. To address this, we propose a clutter filtering technique that may increase the sensitivity of Doppler measurements to at least as low as 0...
June 13, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28619000/astrocytes-pathology-in-als-a-potential-therapeutic-target
#12
Sonja Johann
The mechanisms underlying neurodegeneration in amyotrophic lateral sclerosis (ALS) are multifactorial and include genetic and environmental factors. Nowadays, it is well accepted that neuronal loss is driven by non-cell autonomous toxicity. Non-neuronal cells, such as astrocytes, have been described to significantly contribute to motoneuron cell death and disease progression in cell culture experiments and animal models of ALS. Astrocytes are essential for neuronal survival and function by regulating neurotransmitter and ion homeostasis, immune response, blood flow and glucose uptake, antioxidant defence and growth factor release...
June 15, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28618493/simple-wealth-distribution-model-causing-inequality-induced-crisis-without-external-shocks
#13
Henri Benisty
We address the issue of the dynamics of wealth accumulation and economic crisis triggered by extreme inequality, attempting to stick to most possibly intrinsic assumptions. Our general framework is that of pure or modified multiplicative processes, basically geometric Brownian motions. In contrast with the usual approach of injecting into such stochastic agent models either specific, idiosyncratic internal nonlinear interaction patterns or macroscopic disruptive features, we propose a dynamic inequality model where the attainment of a sizable fraction of the total wealth by very few agents induces a crisis regime with strong intermittency, the explicit coupling between the richest and the rest being a mere normalization mechanism, hence with minimal extrinsic assumptions...
May 2017: Physical Review. E
https://www.readbyqxmd.com/read/28614353/as-time-passes-by-observed-motion-speed-and-psychological-time-during-video-playback
#14
Thomas Jonathan Nyman, Eric Per Anders Karlsson, Jan Antfolk
Research shows that psychological time (i.e., the subjective experience and assessment of the passage of time) is malleable and that the central nervous system re-calibrates temporal information in accordance with situational factors so that psychological time flows slower or faster. Observed motion-speed (e.g., the visual perception of a rolling ball) is an important situational factor which influences the production of time estimates. The present study examines previous findings showing that observed slow and fast motion-speed during video playback respectively results in over- and underproductions of intervals of time...
2017: PloS One
https://www.readbyqxmd.com/read/28613315/bulk-advection-and-interfacial-flows-in-the-binary-coalescence-of-surfactant-laden-and-surfactant-free-drops
#15
Emilia Nowak, Zhihua Xie, Nina M Kovalchuk, Omar K Matar, Mark J H Simmons
This work focuses on the study of bulk flows accompanying the coalescence of two aqueous drops, one containing surfactant and the other surfactant-free, in silicone oils of various viscosities. It is observed that the surfactant-free drop intrudes into the surfactant-laden drop in the form of a penetrating jet whose speed increases and average radius decreases with increasing outer phase viscosity. Mixing patterns within the coalescing drops are due to the force imbalance caused by capillary pressure difference and surfactant-induced Marangoni stresses...
June 14, 2017: Soft Matter
https://www.readbyqxmd.com/read/28612181/low-density-lipoprotein-receptor-related-protein-1-lrp1-c4408r-mutant-promotes-amyloid-precursor-protein-app-%C3%AE-cleavage-in-vitro
#16
Huayan Hou, Ahsan Habib, Dan Zi, Kathy Tian, Jun Tian, Brian Giunta, Darrell Sawmiller, Jun Tan
Previous studies have demonstrated that the low-density lipoprotein receptor-related protein-1 (LRP1) plays conflicting roles in Alzheimer's disease (AD) pathogenesis, clearing β-amyloid (Aβ) from the brain while also enhancing APP endocytosis and resultant amyloidogenic processing. We have recently discovered that co-expression of mutant LRP1 C-terminal domain (LRP1-CT C4408R) with Swedish mutant amyloid precursor protein (APPswe) in Chinese hamster ovary (CHO) cells decreases Aβ production, while also increasing sAPPα and APP α-C-terminal fragment (α-CTF), compared with CHO cells expressing APPswe alone...
June 13, 2017: Neuromolecular Medicine
https://www.readbyqxmd.com/read/28609542/effect-of-single-use-laser-cut-slow-flow-nipples-on-respiration-and-milk-ingestion-in-preterm-infants
#17
Katlyn E McGrattan, David H McFarland, Jesse C Dean, Elizabeth Hill, David R White, Bonnie Martin-Harris
Purpose: Single-use, laser-cut, slow-flow nipples were evaluated for their effect on respiration and milk ingestion in 13 healthy preterm infants (32.7-37.1 weeks postmenstrual age) under nonlaboratory, clinical conditions. Method: The primary outcomes of minute ventilation and overall milk transfer were measured by using integrated nasal airflow and volume-calibrated bottles during suck bursts and suck burst breaks during slow-flow and standard-flow nipple bottle feedings...
June 13, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28607174/aqueous-humour-dynamics-and-biometrics-in-the-ageing-chinese-eye
#18
Tao Guo, Sruthi Sampathkumar, Shan Fan, Nathan Morris, Fang Wang, Carol B Toris
AIMS: This study evaluates ocular biometrics and aqueous humour dynamics (AHD) in healthy Chinese volunteers to determine how the various ocular parameters interact to maintain physiological intraocular pressure (IOP) at all ages. METHODS: Sixty-nine volunteers enrolled in this cross-sectional study and were categorised into young (20-30 years) and old (≥50 years) groups. Measurements included IOP, ocular biometrics and AHD. Data were analysed using mixed model with random sampling to account for both eyes from the same individual...
June 12, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28599199/the-haemodynamic-effects-of-bolus-versus-slower-infusion-of-intravenous-crystalloid-in-healthy-volunteers
#19
Ida F Ukor, Andrew K Hilton, Michael J Bailey, Rinaldo Bellomo
PURPOSE: This pilot study aimed to characterise the haemodynamic effect of 1L of IV normal saline (NS) administered as a rapid versus slow infusion on cardiac output (CO), heart rate (HR), systemic blood pressures, and carotid blood flow in six healthy volunteers. MATERIALS AND METHODS: Six healthy male volunteers aged 18-65years were randomized to receive 1L NS given over 30min or 120min. On a subsequent study session the alternate fluid regimen was administered...
May 30, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28595700/angiotensin-converting-enzyme-inhibition-early-after-heart-transplantation
#20
William F Fearon, Kozo Okada, Jon A Kobashigawa, Yuhei Kobayashi, Helen Luikart, Sean Sana, Tiffany Daun, Steven A Chmura, Seema Sinha, Garett Cohen, Yasuhiro Honda, Michael Pham, David B Lewis, Daniel Bernstein, Alan C Yeung, Hannah A Valantine, Kiran Khush
BACKGROUND: Cardiac allograft vasculopathy (CAV) remains a leading cause of mortality after heart transplantation (HT). Angiotensin-converting enzyme inhibitors (ACEIs) may retard the development of CAV but have not been well studied after HT. OBJECTIVES: This study tested the safety and efficacy of the ACEI ramipril on the development of CAV early after HT. METHODS: In this prospective, multicenter, randomized, double-blind, placebo-controlled trial, 96 HT recipients were randomized to undergo ramipril or placebo therapy...
June 13, 2017: Journal of the American College of Cardiology
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