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ST-segment elevation myocardial infarction

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https://www.readbyqxmd.com/read/29028739/association-of-the-syntax-score-ii-with-cardiac-rupture-in-patients-with-st-segment-elevation-myocardial-infarction-undergoing-a-primary-percutaneous-coronary-intervention
#1
Ibrahim Rencuzogullari, Metin Çağdaş, Yavuz Karabağ, Süleyman Karakoyun, Mahmut Yesin, Mustafa O Gürsoy, Sabri Seyis, İnanç Artaç, Doğan İliş, Süleyman Ç Efe, İbrahim H Tanboğa
BACKGROUND: Despite advances in reperfusion strategies, medical therapy, and emergent surgery, cardiac rupture (CR) is still a major lethal complication. Numerous parameters have been found to be associated with CR development after a primary percutaneous coronary intervention (pPCI). SYNTAX Score (SS) and SYNTAX Score II (SSII) have been studied in ST-segment elevation myocardial infarction (STEMI) patients, and higher scores have been associated with higher mortality. However, the relationship between CR and SSII is unclear...
October 12, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29026414/acute-myocardial-infarction-in-very-young-adults-a-clinical-presentation-risk-factors-hospital-outcome-index-and-their-angiographic-characteristics-in-north-india-amiya-study
#2
Santosh Kumar Sinha, Vinay Krishna, Ramesh Thakur, Ashutosh Kumar, Vikas Mishra, Mukesh Jitendra Jha, Karandeep Singh, Mohit Sachan, Rupesh Sinha, Mohammad Asif, Nasar Afdaali, Chandra Mohan Varma
BACKGROUND: India is currently in the fourth stage of epidemiological transitions where cardiovascular disease is the leading cause of mortality and morbidity. Purpose of the present study was to assess the risk factors, clinical presentation, angiographic profile including severity, and in-hospital outcome of very young adults (aged ≤ 30 years) with first acute myocardial infarction (AMI). METHODS: Total of 1,116 consecutive patients with ST-segment elevation acute myocardial infarction (STEMI) were studied between March 2013 and February 2015 at LPS Institute of Cardiology, Kanpur, Uttar Pradesh, India...
March 2017: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/29026412/the-role-of-manual-thrombectomy-in-cardiovascular-outcome-among-patients-with-total-cutoff-vessel-myocardial-infarction-undergoing-primary-percutaneous-coronary-intervention
#3
Alireza Khosravi, Davoud Rajabi, Masoud Pourmoghaddas, Afzal Roohi, Masoumeh Esmaeili
BACKGROUND: The applicability of manual aspiration thrombectomy in patients with ST-segment elevation myocardial infarction (STEMI) has been a challenging issue. This study aimed to compare the impact of additive manual thrombectomy on patients with myocardial infarction (MI) and total cutoff vessel with standard primary percutaneous coronary intervention (PPCI) with bailout thrombectomy. METHODS: In this case-control study, 181 patients with acute STEMI were enrolled who referred to Chamran Hospital (Isfahan, Iran) between August to December 2014...
March 2017: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/29022423/combination-antiplatelet-treatment-in-coronary-artery-disease-patients-a-necessary-evil-or-an-overzealous-practice
#4
Dimitrios Alexopoulos, Konstantinos Katogiannis, Danai Sfantou, John Lekakis
In seeking to improve care in coronary artery disease patients, further platelet inhibition has been occasionally applied beyond that provided by aspirin and a P2Y12 receptor antagonist. This review aims to offer insights about the rationale, the efficacy and safety of combination antiplatelet therapy, involving three or more agents. Overall, the use of glycoprotein (GP) IIb/IIIa inhibitors did not significantly modify the treatment effect of different antiplatelet strategies, including double vs standard clopidogrel, prasugrel vs clopidogrel, ticagrelor vs clopidogrel, cangrelor vs clopidogrel, and vorapaxar vs placebo...
October 12, 2017: Platelets
https://www.readbyqxmd.com/read/29020374/asian-dust-exposure-triggers-acute-myocardial-infarction
#5
Sunao Kojima, Takehiro Michikawa, Kayo Ueda, Tetsuo Sakamoto, Kunihiko Matsui, Tomoko Kojima, Kenichi Tsujita, Hisao Ogawa, Hiroshi Nitta, Akinori Takami
Aims: To elucidate whether Asian dust is associated with the incidence of acute myocardial infarction (AMI) and to clarify whether patients who are highly sensitive to Asian dust will develop AMI. Methods and results: Twenty-one participating institutions located throughout Kumamoto Prefecture and capable of performing coronary intervention were included in the study. Data for ground-level observations of Asian dust events were measured at the Kumamoto Local Meteorological Observatory...
August 29, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29020248/relationship-between-microvascular-obstruction-and-adverse-events-following-primary-primary-percutaneous-coronary-intervention-for-st-segment-elevation-myocardial-infarction-an-individual-patient-data-pooled-analysis-from-seven-randomized-trials
#6
Suzanne de Waha, Manesh R Patel, Christopher B Granger, E Magnus Ohman, Akiko Maehara, Ingo Eitel, Ori Ben-Yehuda, Paul Jenkins, Holger Thiele, Gregg W Stone
Aims: Microvascular obstruction (MVO) is the underlying cause for the no-reflow phenomenon in ST-segment elevation myocardial infarction (STEMI). The association between MVO assessed by cardiac magnetic resonance imaging (CMR) and prognosis has not been convincingly demonstrated. We sought to determine the relationship between MVO assessed early after primary percutaneous coronary intervention (PCI) in STEMI and all-cause mortality, hospitalization for heart failure (HF), and reinfarction...
July 28, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29020244/impact-of-total-occlusion-of-culprit-artery-in-acute-non-st-elevation-myocardial-infarction-a-systematic-review-and-meta-analysis
#7
Abdur R Khan, Harsh Golwala, Avnish Tripathi, Aref A Bin Abdulhak, Chirag Bavishi, Haris Riaz, Vishnu Mallipedi, Ambarish Pandey, Deepak L Bhatt
Aims: Total occlusion (TO) of the culprit artery usually presents with ST-elevation myocardial infarction. A subset of patients with TO present as non-ST segment elevation myocardial infarction (NSTEMI) without classic ST-elevation on the electrocardiogram. This may lead to delay in identification of these patients and further management. We performed a meta-analysis to estimate the difference in outcomes between totally occluded and non-occluded culprit arteries in patients with NSTEMI...
August 7, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29018137/incidence-and-outcomes-of-myocardial-infarction-in-patients-admitted-with-acute-ischemic-stroke
#8
Fahad Alqahtani, Sami Aljohani, Abdul Tarabishy, Tatiana Busu, Amelia Adcock, Mohamad Alkhouli
BACKGROUND AND PURPOSE: Data on the incidence and outcomes of acute myocardial infarction (AMI) complicating acute ischemic stroke (AIS) are limited. We aim to evaluate the incidence, treatment patterns, and outcomes of AMI in patients with AIS using a nationwide database. METHODS: The National Inpatient Sample was used to identify patient with AIS between 2003 and 2014. Trends of incidence of AMI and its associated in-hospital mortality were evaluated. Univariate and multivariate logistic regressions were used to evaluate predictors of AMI...
October 10, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29017645/-effect-of-regional-synergistic-treatment-system-on-the-treatment-time-and-short-term-prognosis-of-st-segment-elevation-myocardial-infarction
#9
Guoxin Zhang, Changshun Li, Hengtao Li, Lijuan Gao, Geng Li, Xianhui Zhang, Jie Guo, Binquan You, Feng Liu
OBJECTIVE: To explore the effect of regional synergistic treatment system on the treatment time and short-term prognosis of patients with ST-segment elevation myocardial infarction (STEMI). METHODS: A retrospective analysis of the clinical data of STEMI patients who admitted to emergency center of Suzhou Kowloon Hospital Affiliated to Shanghai Jiaotong University School of Medicine and underwent primary percutaneous coronary intervention (PPCI) from January 2013 to January 2017 were conducted...
October 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28993843/in-hospital-mortality-after-acute-stemi-in-patients-undergoing-primary-pci
#10
M Ali, S A Lange, T Wittlinger, G Lehnert, A G Rigopoulos, M Noutsias
BACKGROUND: Acute myocardial infarction (AMI) is the main cause of global and in-hospital mortality in patients with cardiovascular diseases. We aimed to examine the association between the coronary artery involved and the in-hospital mortality in patients who underwent primary percutaneous coronary intervention (pPCI) after ST segment elevation myocardial infarction (STEMI). METHODS: The in-hospital mortality of STEMI patients who underwent pPCI was assessed at the Department of Cardiology, Harzklinik Goslar, Germany, which has no access to immediate mechanical circulatory support (MCS), between 2013 and 2017...
October 9, 2017: Herz
https://www.readbyqxmd.com/read/28992151/a-comparison-of-in-hospital-acute-myocardial-infarction-management-between-portugal-and-the-united-states-2000-2010
#11
Mariana F Lobo, Vanessa Azzone, Luís Filipe Azevedo, Bruno Melica, Alberto Freitas, Leonor Bacelar-Nicolau, Francisco N Rocha-Gonçalves, Cláudia Nisa, Armando Teixeira-Pinto, José Pereira-Miguel, Frederic S Resnic, Altamiro Costa-Pereira, Sharon-Lise Normand
Objective: To compare healthcare in acute myocardial infarction (AMI) treatment between contrasting health systems using comparable representative data from Europe and USA. Design: Repeated cross-sectional retrospective cohort study. Setting: Acute care hospitals in Portugal and USA during 2000-2010. Participants: Adults discharged with AMI. Interventions: Coronary revascularizations procedures (percutaneous coronary intervention (PCI), coronary artery bypass graft (CABG) surgery)...
October 1, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28990972/managing-chest-pain-in-patients-with-concomitant-left-bundle-branch-block
#12
Andrew Wyant, Somu Chatterjee, Tamara Bennett
Diagnosis and timely management of acute myocardial infarction (MI) relies heavily on the ST-segment elevation sum. Presence of concomitant left bundle-branch block (LBBB) in patients presenting with possible acute MI presents a diagnostic dilemma. The LBBB pattern distorts ST-segment changes, delaying or preventing accurate diagnosis. This article reviews the Sgarbossa criteria and ST/S ratio and presents a treatment algorithm that may help improve patient care and reduce morbidity and mortality.
October 5, 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/28988425/the-safety-and-effectiveness-of-adenosine-diphosphate-receptor-inhibitor-pretreatment-among-acute-myocardial-infarction-patients-treated-with-percutaneous-coronary-intervention-in-community-practice-insights-from-the-translate-acs-study
#13
Mark B Effron, Tracy Y Wang, Gregg C Fonarow, Timothy D Henry, Marjorie E Zettler, Brian A Baker, Lisa A McCoy, Eric D Peterson
OBJECTIVES: To understand the optimal timing of adenosine diphosphate (ADP) receptor inhibitor pretreatment prior to percutaneous coronary intervention (PCI) among acute myocardial infarction (MI) patients. BACKGROUND: The role of ADP receptor inhibitor pretreatment in this population is unclear. METHODS: A total of 9,251 ADP receptor inhibitor-naïve MI patients undergoing PCI at 229 TRANSLATE-ACS sites were evaluated. Adjusted risks of in-hospital major adverse cardiovascular events (MACE) and major bleeding were compared among patients with and without pretreatment using inverse probability-weighted propensity adjustment...
October 8, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28984758/expression-of-matrix-metalloproteinases-12-in-st-segment-elevation-myocardial-infarction-a-case-control-study
#14
Jing Wang, Guoqing Wei, Wei Hu, Linhua Li, Yujia Ye, Huawei Wang, Wen Wan, Rui Li, Longjun Li, Linling Ma, Zhaohui Meng
Matrix metalloproteinases-12 (MMP12) can lead to degradation of elastin resulting in plaque destabilization and rupture. MMP12 also facilitates platelet aggregation, adhesion, and granule secretion. However, evidence in the literature related to the function of MMP12 in ST-segment elevation myocardial infarction (STEMI) is little. This study investigated the expression of MMP12 in human coronary thrombus and examined the relationship between plasma MMP12 and STEMI.Arterial plasma was obtained from 46 STEMI patients and 52 stable angina pectoris (SAP) patients and 30 controls with angiographically normal coronary arteries...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28984671/early-coronary-angiography-for-survivors-of-out-of-hospital-cardiac-arrests-without-st-elevation
#15
Michael Goldfarb, Bojan Cercek
There are over 300,000 out-of-hospital cardiac arrests (OOHCA) in the United States each year, and the long-term survival rate is less than 10%. Despite improvements in postarrest management, the greatest drop-off in survival occurs during hospitalization, mostly due to myocardial dysfunction and neurological injury. Coronary artery disease is common in postcardiac arrest patients, with an incidence of approximately 60-80%. In patients with a chest pain syndrome and an ST-segment-elevation myocardial infarction pattern evident on the presenting electrocardiogram, immediate revascularization is recommended by cardiovascular societies due to established mortality benefits...
November 2017: Cardiology in Review
https://www.readbyqxmd.com/read/28984467/the-9p21-rs-1333040-polymorphism-is-associated-with-coronary-microvascular-obstruction-in-st-segment-elevation-myocardial-infarction-treated-by-primary-angioplasty
#16
Francesco Fracassi, Giampaolo Niccoli, Vincenzo Vetrugno, Michele Cauteruccio, Antonino Buffon, Ilaria Gatto, Igor Giarretta, Paolo Tondi, Roberto Pola, Filippo Crea
BACKGROUND: Microvascular obstruction (MVO) after primary percutaneous coronary intervention (pPCI) leads to higher incidence of both early and late complications. A number of single nucleotide polymorphisms in 9p21 chromosome have been shown to affect angiogenesis in response to ischaemia. In particular, Rs1333040 with its three genotypic vriants C/C, T/C and T/T might influence the occurrence of MVO after pPCI. METHODS: We enrolled ST-elevation myocardial infarction (STEMI) patients undergoing pPCI...
October 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28982673/multivessel-versus-culprit-vessel-only-percutaneous-coronary-intervention-among-patients-with-acute-myocardial-infarction-insights-from-the-translate-acs-observational-study
#17
Homam Ibrahim, Praneet K Sharma, David J Cohen, Gregg C Fonarow, Lisa A Kaltenbach, Mark B Effron, Marjorie E Zettler, Eric D Peterson, Tracy Y Wang
BACKGROUND: Among patients with acute myocardial infarction (MI) who have multivessel disease, it is unclear if multivessel percutaneous coronary intervention (PCI) improves clinical and quality-of-life outcomes compared with culprit-only intervention. We sought to compare clinical and quality-of-life outcomes between multivessel and culprit-only PCI. METHODS AND RESULTS: Among 6061 patients with acute MI who have multivessel disease in the TRANSLATE-ACS (Treatment With Adenosine Diphosphate Receptor Inhibitors: Longitudinal Assessment of Treatment Patterns and Events After Acute Coronary Syndrome) study, we used inverse probability-weighted propensity adjustment to study the associations between multivessel and culprit-only intervention during the index PCI and major adverse cardiovascular events, unplanned all-cause readmission, and angina frequency at 6 weeks and 1 year...
October 5, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28982666/platelet-specific-p38%C3%AE-deficiency-improved-cardiac-function-after-myocardial-infarction-in-mice
#18
Panlai Shi, Lin Zhang, Mingliang Zhang, Wenlong Yang, Kemin Wang, Junfeng Zhang, Kinya Otsu, Gonghua Huang, Xuemei Fan, Junling Liu
OBJECTIVE: MAPKs (mitogen-activated protein kinases), especially p38, play detrimental roles in cardiac diseases and cardiac remodeling post-myocardial infarction. However, the activation and function of MAPKs in coronary thrombosis in vivo and its relationship with clinical outcomes remain poorly understood. APPROACH AND RESULTS: Here, we showed that p38α was the major isoform expressed in human and mouse platelets. Platelet-specific p38α-deficient mice presented impaired thrombosis and hemostasis but had improved cardiac function, reduced infarct size, decreased inflammatory response, and microthrombus in a left anterior descending artery ligation model...
October 5, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28982497/characterization-of-the-average-daily-ischemic-and-bleeding-risk-after-primary-pci-for-stemi
#19
Gennaro Giustino, Roxana Mehran, George D Dangas, Ajay J Kirtane, Björn Redfors, Philippe Généreux, Sorin J Brener, Jayne Prats, Stuart J Pocock, Efthymios N Deliargyris, Gregg W Stone
BACKGROUND: The risk of recurrent ischemic and bleeding events after primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) may not be uniform over time, which may affect the benefit-to-risk ratio of guideline-recommended antithrombotic therapies in different intervals. OBJECTIVES: This study sought to characterize the average daily ischemic rates (ADIRs) and average daily bleeding rates (ADBRs) within the first year after primary PCI for STEMI...
October 10, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28980483/clinical-outcomes-following-primary-percutaneous-coronary-intervention-for-st-elevation-myocardial-infarction-according-to-sex-and-race
#20
Arvindra Krishnamurthy, Claire Keeble, Natalie Burton-Wood, Kathryn Somers, Michelle Anderson, Charlotte Harland, Paul D Baxter, James M McLenachan, Jonathan M Blaxill, Daniel J Blackman, Christopher J Malkin, Stephen B Wheatcroft, John P Greenwood
BACKGROUND: Female sex and South Asian race have been associated with poor clinical outcomes following primary percutaneous coronary intervention (PPCI) for ST-segment elevation myocardial infarction (STEMI) but remain understudied in large real-world series. We therefore investigated the association of sex and race with clinical outcomes following PPCI. METHODS: We conducted a prospective study of all patients undergoing PPCI for STEMI between January 2009 and December 2011 at a large UK cardiac centre...
October 1, 2017: European Heart Journal. Acute Cardiovascular Care
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