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ST-segment elevation myocardial infarction

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https://www.readbyqxmd.com/read/29665154/development-and-validation-of-a-risk-stratification-score-for-new-onset-atrial-fibrillation-in-stemi-patients-undergoing-primary-percutaneous-coronary-intervention
#1
Annamaria Mazzone, Marco Scalese, Umberto Paradossi, Serena Del Turco, Nicoletta Botto, Alberto De Caterina, Giuseppe Trianni, Marcello Ravani, Antonio Rizza, Sabrina Molinaro, Cataldo Palmieri, Sergio Berti, Giuseppina Basta
AIM: New-onset atrial fibrillation (NOAF) is a complication not infrequent in patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (pPCI) and has been associated with worse in-hospital and long-term prognosis. We aimed to develop and validate a risk score based on common clinical risk factors and routine blood biomarkers to assess the early incidence of NOAF post-pPCI, before discharge. METHODS: The risk score for NOAF occurrence during hospitalisation (about 5 days) was developed in a cohort of 1135 consecutive STEMI patients undergoing pPCI while was externally validated in a temporal cohort of 771 STEMI patients...
April 17, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29664423/long-term-follow-up-of-antithrombotic-management-patterns-in-acute-coronary-syndrome-patients
#2
Fatih Sinan Ertaş, Lale Tokgozoglu
OBJECTIVE: The aim of this study was to evaluate the longterm, post-discharge follow-up of antithrombotic management patterns (AMPs), clinical outcomes, and real-life health status of patients hospitalized acute coronary syndrome (ACS). METHODS: A total of 1034 patients hospitalized for ACS within 24 hours of symptom onset who survived to discharge were included. Of those, 514 had ST-segment elevation myocardial infarction (STEMI) and 520 had unstable angina (UA)/non-STEMI (NSTEMI)...
April 2018: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/29659354/-electrocardiographic-differences-between-apical-hypertrophic-cardiomyopathy-and-apical-non-st-segment-myocardial-infarction
#3
Iván Chillik, Andreina Gil Ramírez, Santiago Ordóñez, Leandro Tomás, Josefina Parodi, Juan Pablo Costabel
Apocal hypertrophic cardiomyopathy (AHCM) is a phenotypic variant within hypertrophic cardiomyopathies, in which ventricular repolarization alterations are present. These electrocardiographic disturbances can mimic an anterior infarction which triggers a series of studies and treatments that may be unnecessary. The aim of this study was to describe and compare electrocardiographic differences in a series of patients with AHCM and apical non-ST segment elevation myocardial infarction in patients (NSTEMI) with T-wave changes...
2018: Medicina
https://www.readbyqxmd.com/read/29658326/cardioprotective-role-of-colchicine-against-inflammatory-injury-in-a-rat-model-of-acute-myocardial-infarction
#4
Oussama Bakhta, Simon Blanchard, Anne-Laure Guihot, Sophie Tamareille, Delphine Mirebeau-Prunier, Pascale Jeannin, Fabrice Prunier
BACKGROUND: Inflammation plays a crucial role in the pathophysiology of myocardial ischemia/reperfusion (I/R) injury. A clinical trial has recently reported a smaller infarct size in a cohort of patients with ST-segment elevation myocardial infarction (MI) treated with a short colchicine course. The mechanism underlying colchicine-induced cardioprotection in the early MI phase remains unclear. We hypothesized that a short pretreatment with colchicine could induce acute beneficial effects by protecting the heart against inflammation in myocardial I/R injury...
January 1, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29656656/effect-of-coronary-collaterals-on-prognosis-in-patients-undergoing-primary-percutaneous-coronary-intervention-for-acute-st-segment-elevation-myocardial-infarction-a-meta-analysis
#5
Kongyong Cui, Shuzheng Lyu, Xiantao Song, Fei Yuan, Feng Xu, Min Zhang, Mingduo Zhang, Wei Wang, Dongfeng Zhang, Jinfan Tian
The impact of coronary collaterals on the prognosis in patients with acute ST-segment elevation myocardial infarction (STEMI) in the era of coronary revascularization remains controversial. The purpose of this meta-analysis was to investigate the effect of coronary collateral on clinical outcomes, especially mortality (≥6 months), in patients undergoing primary percutaneous coronary intervention (PCI) for STEMI. Eligible observational studies were selected by searching PubMed, EMBASE, and Cochrane Library up to August 9, 2017...
January 1, 2018: Angiology
https://www.readbyqxmd.com/read/29656279/drug-eluting-resorbable-magnesium-scaffold-implantation-in-st-segment-elevation-myocardial-infarction-a-pilot-study
#6
Quentin de Hemptinne, Fabien Picard, Rachid Briki, Ahmad Awada, Paul-Gaël Silance, Dariouch Dolatabadi, Nadia Debbas, Philippe Unger
OBJECTIVES: To assess feasibility and short-term clinical outcomes associated with resorbable magnesium scaffold (RMS) implantation in the setting of primary percutaneous coronary intervention for ST-segment elevation myocardial infarction (STEMI). BACKGROUND: RMS implantation has demonstrated favorable clinical outcomes in stable coronary artery disease patients. However, to date, data are lacking in the setting of STEMI. METHODS: This is a single-center prospective non-randomized pilot study...
April 15, 2018: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29655768/cell-free-dna-and-microvascular-damage-in-st-segment-elevation-myocardial-infarction-treated-with-primary-percutaneous-coronary-intervention
#7
Juan Sanchis, Sergio García-Blas, Luis Ortega-Paz, Ana Paula Dantas, Enrique Rodríguez, Lidia Abellán, Salvatore Brugaletta, Ernesto Valero, Gema Miñana, Manuel Garabito, África Corchón, Julio Núñez, Arturo Carratalá, Manel Sabaté
INTRODUCTION AND OBJECTIVES: Cell-free DNA (cfDNA) in ST-segment elevation myocardial infarction might originate from hyperactivated leukocytes at the coronary lesion. Our aim was to investigate the relationship between cfDNA and coronary reperfusion. METHODS: We studied 116 patients treated with primary angioplasty using thrombus aspiration. Coronary (during aspiration) and peripheral (at the end of the procedure) blood samples were drawn for cfDNA, as well as high-sensitivity troponin T and myeloperoxidase quantification...
April 11, 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29652672/early-discontinuation-of-prasugrel-or-clopidogrel-in-acute-coronary-syndromes-insights-from-the-trilogy-acs-trial
#8
Andrew T Yan, Matthew T Roe, Megan Neely, Derek D Cyr, Harvey White, Keith A A Fox, Dorairaj Prabhakaran, Paul W Armstrong, Erik M Ohman, Shaun G Goodman
BACKGROUND: In the Targeted Platelet Inhibition to Clarify the Optimal Strategy to Medically Manage Acute Coronary Syndromes (TRILOGY ACS) trial of patients with non-ST-segment elevation acute coronary syndrome managed medically without revascularization, treated with prasugrel versus clopidogrel for less than or equal to 30 months after index acute coronary syndrome, post-hoc analyses showed a divergence of treatment effect in favor of prasugrel after 12 months. Potential influential factors, including a potential late treatment effect after early study drug discontinuation in the intention-to-treat analysis, have not been explored...
April 12, 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29652430/immediate-surgical-repair-of-left-ventricular-wall-rupture-complicating-st-segment-elevation-myocardial-infarction
#9
Barbara Zając, Ewa Szymczyk, Grzegorz Religa, Tomasz Kaszczyński, Piotr Lipiec, Jarosław D Kasprzak
No abstract text is available yet for this article.
2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29651617/delayed-vs-immediate-stenting-in-stemi-with-a-high-thrombus-burden-a-systematic-review-and-meta-analysis
#10
B Sun, J Liu, H Yin, S Yang, Z Liu, T Chen, J Li, C Guo, Z Jiang
BACKGROUND: The results of several large-scale randomized controlled trials are controversial regarding the advantages of delayed stenting (DS) compared with immediate stenting (IS). We sought to determine whether DS has benefits for patients with ST-segment elevation myocardial infarction (STEMI) with a high thrombus burden compared with IS. METHODS: We systematically searched four electronic databases. Thrombolysis in Myocardial Infarction (TIMI) grade 3 flow, TIMI myocardial blush grade (TMBG), complete ST-segment resolution (>70%), major adverse cardiac events (MACE), and major bleeding complications were studied as outcomes...
April 12, 2018: Herz
https://www.readbyqxmd.com/read/29643279/comparison-of-clinical-outcomes-between-ticagrelor-and-prasugrel-in-patients-with-st-segment-elevation-myocardial-infarction-results-from-the-korea-acute-myocardial-infarction-registry-national-institutes-of-health
#11
Min Chul Kim, Myung Ho Jeong, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Youngkeun Ahn, Tae Hoon Ahn, Ki Bae Seung, Dong-Ju Choi, Hyo-Soo Kim, Hyeon Cheol Gwon, In Whan Seong, Kyoung-Kook Hwang, Shung Chull Chae, Seung Ho Hur, Kwang Soo Cha, Seok Kyu Oh, Jei Keon Chae
BACKGROUND: There is little information regarding comparison of ticagrelor and prasugrel in patients with ST-segment elevation myocardial infarction (STEMI). We sought to compare clinical outcomes between ticagrelor and prasugrel in STEMI.Methods and Results:A total of 1,440 patients with STEMI who underwent successful primary percutaneous coronary intervention were analyzed; the data were obtained from the Korea Acute Myocardial Infarction Registry-National Institutes of Health. Of the patients, 963 received ticagrelor, and 477 received prasugrel...
April 12, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29629961/reduction-of-thrombus-burden-a-still-unmet-need-in-patients-with-st-segment-elevation-myocardial-infarction
#12
Erion Xhepa, Adnan Kastrati
No abstract text is available yet for this article.
May 2018: Coronary Artery Disease
https://www.readbyqxmd.com/read/29628473/acute-inferior-wall-st-segment-elevation-myocardial-infarction-caused-atrial-lead-dysfunction-reversed-by-primary-percutaneous-coronary-intervention
#13
Hui-Ting Wang, Yung-Lung Chen, Chiung-Jen Wu
The mechanism of atrial lead dysfunction varies in patients receiving pacemaker implantation and this needs to be investigated, especially when the causes are reversible. We report and discuss a 76-year-old female who had atrial lead dysfunction caused by acute myocardial infarction and who was recovered after primary percutaneous coronary intervention. The sequential electrocardiographic changes were demonstrated and the possible mechanisms were discussed.
April 6, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29628023/effects-of-erythropoietin-on-the-clinical-outcomes-of-patients-with-acute-st-segment-elevation-myocardial-infarction-after-percutaneous-coronary-intervention-a-meta-analysis
#14
Hai-Tao Yang, Wen-Juan Xiu, Ying-Ying Zheng, Yi-Tong Ma, Xiang Xie
AIMS: To investigate the effects of erythropoietin (EPO) on the clinical outcomes of patients with acute ST segment elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI). MATERIAL AND METHODS: We collected randomized controlled studies conducted before April 15, 2017, and performed a meta-analysis using RevMan5.3 software. RESULTS: Compared with the conventional revascularization group, mortality (RR = 0...
April 9, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29627944/complete-versus-culprit-only-revascularization-in-stemi-a-contemporary-review
#15
REVIEW
Daniel Y Lu, Ming Zhong, Dmitriy N Feldman
PURPOSE OF REVIEW: In ST-segment elevation myocardial infarction, urgent revascularization of the culprit coronary vessel and restoration of coronary flow is the goal of the initial management. However, obstructive non-culprit disease is frequently concomitantly found during initial angiography and portends a poor prognosis. Management of non-culprit lesions in ST-segment elevation myocardial infarction (STEMI) has been the subject of extensive debate. This review will examine the currently available evidence, with a specific focus on randomized clinical trials performed to date...
April 7, 2018: Current Treatment Options in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29627109/myocardial-infarction-subtypes-in-patients-with-type-2-diabetes-mellitus-and-the-effect-of-liraglutide-therapy-from-the-leader-trial
#16
Steven P Marso, Michael A Nauck, Tea Monk Fries, Søren Rasmussen, Marianne Bach Treppendahl, John B Buse
Diabetes mellitus (DM) is a known risk factor for myocardial infarction (MI); however, data regarding MI subtypes in people with diabetes are limited. In the Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER) trial (n = 9,340), liraglutide significantly reduced the risk of major adverse cardiovascular (CV) events (composite of CV death, nonfatal MI, or nonfatal stroke) versus placebo in patients with type 2 DM and high CV risk. Liraglutide also reduced risk of first MI (292 events with liraglutide vs 339 with placebo)...
March 15, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29626151/metabolomic-profiling-in-acute-st-segment-elevation-myocardial-infarction-identifies-succinate-as-an-early-marker-of-human-ischemia-reperfusion-injury
#17
Matthias Kohlhauer, Sam Dawkins, Ana S H Costa, Regent Lee, Timothy Young, Victoria R Pell, Robin P Choudhury, Adrian P Banning, Rajesh K Kharbanda, Kourosh Saeb-Parsy, Michael P Murphy, Christian Frezza, Thomas Krieg, Keith M Channon
BACKGROUND: Ischemia-reperfusion injury following ST-segment-elevation myocardial infarction (STEMI) is a leading determinant of clinical outcome. In experimental models of myocardial ischemia, succinate accumulation leading to mitochondrial dysfunction is a major cause of ischemia-reperfusion injury; however, the potential importance and specificity of myocardial succinate accumulation in human STEMI is unknown. We sought to identify the metabolites released from the heart in patients undergoing primary percutaneous coronary intervention for emergency treatment of STEMI...
April 6, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29625885/prognostic-value-of-transthoracic-doppler-echocardiography-coronary-flow-velocity-reserve-in-patients-with-nonculprit-stenosis-of-intermediate-severity-early-after-primary-percutaneous-coronary-intervention
#18
Milorad Tesic, Ana Djordjevic-Dikic, Vojislav Giga, Jelena Stepanovic, Milan Dobric, Ivana Jovanovic, Marija Petrovic, Zlatko Mehmedbegovic, Dejan Milasinovic, Vladimir Dedovic, Milorad Zivkovic, Stefan Juricic, Dejan Orlic, Sinisa Stojkovic, Vladan Vukcevic, Goran Stankovic, Milan Nedeljkovic, Miodrag Ostojic, Branko Beleslin
BACKGROUND: Treatment of nonculprit coronary stenosis during primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction may be beneficial, but the mode and timing of the intervention are still controversial. The aim of this study was to examine the significance and prognostic value of preserved coronary flow velocity reserve (CFVR) in patients with nonculprit intermediate stenosis early after primary percutaneous coronary intervention. METHODS: Two hundred thirty patients with remaining intermediate (50%-70%) stenosis of non-infarct-related arteries, in whom CFVR was performed within 7 days after primary percutaneous coronary intervention, were prospectively enrolled...
April 3, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29623168/stenting-in-primary-percutaneous-coronary-intervention-for-acute-st-segment-elevation-myocardial-infarction
#19
REVIEW
Sanjog Kalra, Hemal Bhatt, Ajay J Kirtane
The treatment of ST-segment elevation myocardial infarction (STEMI) has advanced dramatically over the past 30 years since the introduction of reperfusion therapies, such that mechanical reperfusion with primary percutaneous coronary intervention is now the standard of care. With STEMI, as with other forms of acute coronary syndrome, stent deployment in culprit lesions is the dominant form of reperfusion in the developed world and is supported by contemporary guidelines. However, the precise timing of stenting and the extent to which both culprit and non-culprit lesions should be treated continue to be active areas of study...
January 2018: Methodist DeBakey Cardiovascular Journal
https://www.readbyqxmd.com/read/29622963/role-of-2d-speckle-tracking-echocardiography-in-predicting-acute-coronary-occlusion-in-patients-with-non-st-segment-elevation-myocardial-infarction
#20
Viola William Keddeas, Salwa Mohammed Swelim, Ghada Kamel Selim
Background: A substantial fraction of patients with non ST-elevation acute coronary syndrome have an occluded culprit vessel on coronary angiography. Acute coronary occlusion often results in myocardial infarction and loss of systolic function. Identification of these patients may have considerable impact on treatment and prognosis. Aim: The study aims at investigating role of 2D speckle tracking echocardiography as a non-invasive predictor of acute coronary artery occlusion in patients with non ST-segment elevation myocardial infarction...
June 2017: The Egyptian heart journal: (EHJ): official bulletin of the Egyptian Society of Cardiology
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