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https://www.readbyqxmd.com/read/29053867/molecular-cloning-and-functional-analysis-of-peafowl-pavo-cristatus-toll-like-receptor-7
#1
H Song, M Zhang, W Gao, L Wu, G Li
In order to clone the peafowl (Pavo cristatus) Toll-like receptor 7 (TLR7) gene and study its biological function, the peafowl TLR7 coding sequences (CDS) were amplified by PCR of cDNA from the whole spleen of peafowl. The full-length sequence of the peafowl TLR7 gene CDS is 3,141 bp and encodes a 1,046-amino acid protein with a classic TLR composition of 16 leucine-rich repeats (LRR). Insertions of amino acids were found at position 15 of LRR2, LRR5, LRR7, LRR9, LRR11, LRR12, LRR14, and LRR15; and position 10 of LRR11...
October 5, 2017: Poultry Science
https://www.readbyqxmd.com/read/29052937/targeting-of-c-type-lectin-like-receptor-2-or-p2y12-for-the-prevention-of-platelet-activation-by-immunotherapeutic-cpg-oligodeoxynucleotides-comment
#2
U Flierl, T L Nero, B Lim, R K Andrews, M W Parker, E E Gardiner, K Peter
We read with great interest the article by Delierneux et al. [1] in the Journal of Thrombosis and Haemostasis. The authors elegantly describe a mechanism of platelet activation by CpG oligodeoxynucleotides (ODNs) through CLEC-2 mediated binding and uptake. This is the second platelet activation mechanism to be attributed to CpG ODNs, the first being the one described by our group involving platelet-specific collagen receptor glycoprotein VI (GPVI) [2]. CpG ODNs are short single-stranded DNA molecules resembling bacterial DNA and they were developed as potential drug candidates, largely due to their immunostimulatory properties via activation of toll-like receptor 9 (TLR9) [3]...
October 20, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29052054/suppression-of-the-toll-like-receptor-7-dependent-type-i-interferon-production-pathway-by-autophagy-resulting-from-enterovirus-71-and-coxsackievirus-a16-infections-facilitates-their-replication
#3
Jie Song, Yajie Hu, Jiaqi Li, Huiwen Zheng, Jingjing Wang, Lei Guo, Haijng Shi, Longding Liu
Toll-like receptors (TLRs) act as molecular sentinels, detecting invading viral pathogens and triggering host innate immune responses, including autophagy. However, many viruses have evolved a series of strategies to manipulate autophagy for their own benefit. Enterovirus 71 (EV71) and coxsackievirus A16 (CA16), as the primary agents causing hand, foot and mouth disease (HFMD), can induce autophagy leading to their replication. Therefore, the objective of this study was to investigate whether enhanced viral replication caused by autophagy in EV71 and CA16 infections was associated with a TLR-related signaling pathway...
October 19, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29050341/geraniol-alleviates-lps-induced-acute-lung-injury-in-mice-via-inhibiting-inflammation-and-apoptosis
#4
Kangfeng Jiang, Tao Zhang, Nannan Yin, Xiaofei Ma, Gan Zhao, Haichong Wu, Changwei Qiu, Ganzhen Deng
Geraniol (GOH), a special type of acyclic monoterpene alcohol, has been widely used to treat many diseases associated with inflammation and apoptosis. Acute lung injury (ALI) is a common clinical disease in humans characterized by pulmonary inflammation and apoptosis. In the present study, we investigated the protective effects of GOH in a mouse model of ALI induced by the intranasal administration of lipopolysaccharide (LPS) and elucidated the underlying molecular mechanisms in RAW 264.7 cells. In vivo, GOH treatment markedly ameliorated pathological injury and pulmonary cell apoptosis and reduced the wet/dry (W/D) weight ratio of lungs, myeloperoxidase (MPO) activity and the production of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α)...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050325/toll-like-receptor-3-pathway-restricts-marek-s-disease-virus-infection
#5
Haitao Zou, Ruixue Su, Jing Ruan, Hongxia Shao, Kun Qian, Jianqiang Ye, Aijian Qin
Marek's disease virus (MDV) is an α-herpesvirus that causes immune suppression and T lymphoma in chickens. Toll-like receptor 3 (TLR3) is critical for the host immune response against MDV infection. Previously, our team demonstrated that pre-treatment of TLR3 agonist poly (I:C) inhibited Marek's disease virus infection in chicken embryo fibroblasts (CEFs). However, whether TLR3 inhibits the aggravation of MDV infection is unknown. In the current study, we found that TLR3 activation in MDV-infected CEFs effectively inhibited virus spread...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29045935/emodinol-ameliorates-urate-nephropathy-by-regulating-renal-organic-ion-transporters-and-inhibiting-immune-inflammatory-responses-in-rats
#6
Hui Wu, Mengze Zhou, Guo Lu, Zhonglin Yang, Hui Ji, Qinghua Hu
Emodinol, 1β, 3β, 23-trihydroxyolean-12-en-28-acid, as the main active ingredient firstly extracted from the rhizomes of Elaeagus pungens by our Research Group, was identified with apparent uricosuric and nephroprotective effects in hyperuricemia mice in our previous study. This study aimed to investigate the renal protective effect of emodinol in urate nephropathy rats. Rats were orally administrated by combined adenine and ethambutol to induce urate nephropathy. Emodinol at various doses were administered intragastrically to urate nephropathy rats daily...
October 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29040945/quercetin-protects-mouse-liver-against-triptolide-induced-hepatic-injury-by-restoring-th17-treg-balance-through-tim-3-and-tlr4-myd88-nf-%C3%AE%C2%BAb-pathway
#7
Cai-Bing Wei, Kun Tao, Rong Jiang, Lian-Di Zhou, Qi-Hui Zhang, Chun-Su Yuan
Triptolide (TP) is a diterpene triepoxide with various biological activities, but its clinical applications have been limited by potential hepatotoxicity, which can be attributed to T helper 17 (Th17)/T regulatory (Treg) cell imbalance. Quercetin (QE), a natural flavonoid, has been reported to have many benefits and medicinal properties, including hepatoprotective activity against TP-induced liver injury. However, the hepatoprotection mechanisms have not been clarified. The present study was designed to explore the protective effect and the mechanism of QE against TP-induced liver injury...
October 14, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29039447/paralemmin-3-contributes-to-lipopolysaccharide-induced-inflammatory-response-and-is-involved-in-lipopolysaccharide-toll-like-receptor-4-signaling-in-alveolar-macrophages
#8
Xu-Xin Chen, Lu Tang, Yu-Mei Fu, Yi Wang, Zhi-Hai Han, Ji-Guang Meng
Alveolar macrophages (AMs) are the first line of defense against foreign stimulation in alveoli, and they participate in inflammatory responses during acute lung injury (ALI). Previous studies indicated that paralemmin-3 (PALM3) expression is induced by lipopolysaccharides (LPS) and may be involved in LPS-Toll-like receptor 4 (TLR4) signaling in alveolar epithelial cells. The aim of the present study was to investigate the effect of PALM3 on LPS-induced inflammation and its underlying mechanisms in rat AMs...
September 28, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29037921/tlr-expression-profile-of-human-alveolar-bone-proper-derived-stem-progenitor-cells-and-osteoblasts
#9
Karim M Fawzy El-Sayed, Josephine Boeckler, Christof E Dörfer
Alveolar bone proper-derived mesenchymal stem/progenitor cells (AB-MSCs) and alveolar osteoblasts (OBs) are pivotal cells with positive attributes in regenerative medicine. During regenerative approaches, AB-MSCs may interact with their surrounding environment via their expressed toll-like-receptors (TLRs). This study aimed to depict for the first time the TLRs expression profile of AB-MSCs and OBs. Cells were isolated from human alveolar bone proper, and STRO-1-immunomagnetically sorted to segregate AB-MSCs and OBs...
September 18, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29037381/dietary-supplementation-of-enzymatically-treated-artemisia-annua-could-alleviate-the-intestinal-inflammatory-response-in-heat-stressed-broilers
#10
Zhihua Song, Kang Cheng, Lili Zhang, Tian Wang
The study was undertaken to evaluate the effects of enzymatically treated Artemisia annua (EA) on the intestinal inflammatory response of heat-stressed broilers. A total of 144 male Arbor Acres broilers aged 21 days were randomly divided into 3 groups with 6 replicates per group and 8 broilers in each replicate. The 3 treatment groups were as follows: the control group, in which broiler chickens were raised at 22 ± 1°C and fed basal diets, the heat stress (HS) and HS-EA groups, in which broiler chickens were raised at 34 ± 1°C for 8h (0900-1700h) and 22 ± 1°C for 16h, and fed basal diets supplemented with 0 or 1g/kg EA, respectively...
October 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29036979/-role-of-ash2-absent-small-or-homeotic-like-and-jumonji-domain-containing-protein-3-on-histone-methylation-of-interferon-gamma-gene-and-their-associations-with-vascular-damage-of-kawasaki-disease
#11
J H Mei, G Tang, Q Wang, P Q Wen, M G Xu, D Cui, D L Ma, C Liu, G B Wang
Objective: To investigate the impacts of ash2 (absent, small, or homeotic)-like (Ash2L) and Jumonji domain-containing protein 3 (Jmjd3) on histone methylation of interferon-gamma(IFN-γ) gene and association with vascular damage of Kawasaki disease (KD) in acute phase. Methods: This study was performed among 36 children with KD in acute phase (KD group) and 28 age-matched health children (control group), who were treated or underwent physical examination in our hospital between February 2015 and June 2016. Patients were further divided into KD groups with or without coronary artery lesions (KD-CAL(+) , 16 cases; KD-CAL(-), 20 cases)...
September 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/29034530/gene-expression-and-morphological-changes-in-the-intestinal-mucosa-associated-with-increased-permeability-induced-by-short-term-fasting-in-chickens
#12
S Gilani, G S Howarth, G Nattrass, S M Kitessa, R Barekatain, R E A Forder, C D Tran, R J Hughes
Short-term fasting for 4.5 and 9 hr has been demonstrated to increase intestinal permeability (IP) in chickens. This study aimed to investigate the effects of 0, 4.5, 9 and 19.5 hr fasting on intestinal gene expression and villus-crypt architecture of enterocytes in jejunal and ileal samples. On day 38, Ross-308 male birds were fasted according to their group and then euthanised. Two separate intestinal sections (each 2 cm long, jejunum and ileum) were collected. One section was utilised for villus height and crypt depth measurements...
October 16, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29032115/toll-like-receptor-4-tlr4-impairs-nitric-oxide-contributing-to-angiotensin-ii-induced-cavernosal-dysfunction
#13
Kenia P Nunes, Gisele F Bomfim, Haroldo A Toque, Theodora Szasz, R Clinton Webb
AIM: Angiotensin II (AngII), a corpus cavernosum (CC) constrictor peptide, modulates Toll like receptor (TLR) expression, a key element of the innate immune system, contributing to impaired vascular function in pathological conditions. However, it is unknown whether TLR4 is involved in AngII-induced erectile dysfunction. In this study, we investigated whether TLR4 plays a role in cavernosal dysfunction caused by AngII upregulation. MATERIAL AND METHODS: Cavernosal smooth muscle cells (CSMC) from C57/BL6 mice were treated with AngII (0...
October 11, 2017: Life Sciences
https://www.readbyqxmd.com/read/29031816/designing-immunostimulatory-double-stranded-messenger-rna-with-maintained-translational-activity-through-hybridization-with-poly-a-sequences-for-effective-vaccination
#14
Satoshi Uchida, Naoto Yoshinaga, Kayoko Yanagihara, Eiji Yuba, Kazunori Kataoka, Keiji Itaka
Messenger (m)RNA vaccines require a safe and potent immunostimulatory adjuvant. In this study, we introduced immunostimulatory properties directly into mRNA molecules by hybridizing them with complementary RNA to create highly immunogenic double stranded (ds)RNAs. These dsRNA formulations, comprised entirely of RNA, are expected to be safe and highly efficient due to antigen expression and immunostimulation occurring simultaneously in the same antigen presenting cells. In this strategy, design of dsRNA is important...
September 27, 2017: Biomaterials
https://www.readbyqxmd.com/read/29023393/flavanol-rich-cocoa-powder-interacts-with-lactobacillus-rhamnossus-lgg-to-alter-the-antibody-response-to-infection-with-the-parasitic-nematode-ascaris-suum
#15
Saebyeol Jang, Sukla Lakshman, Ethiopia Beshah, Yue Xie, Aleksey Molokin, Bryan T Vinyard, Joseph F Urban, Cindy D Davis, Gloria I Solano-Aguilar
Consumption of the probiotic bacteria LactobacillusrhamnosusLGG and flavanol-rich cocoa have purported immune modulating effects. This study compared the host response to infection with Ascaris suum in three-month-old pigs fed a standard growth diet supplemented with a vehicle control: LGG, cocoa powder (CP) or LGG + CP. Pigs were inoculated with infective A. suum eggs during Week 5 of dietary treatment and euthanized 17 days later. Lactobacillus abundance was increased in pigs fed LGG or LGG + CP. Specific anti-A...
October 12, 2017: Nutrients
https://www.readbyqxmd.com/read/29017971/induction-of-suppressor-of-cytokine-signaling-3-via-hsf-1-hsp70-tlr4-axis-attenuates-neuroinflammation-and-ameliorates-postoperative-pain
#16
Yi-Xin Fan, Cheng Qian, Bingqian Liu, Chaoyu Wang, Haijiao Liu, Xiuxiu Pan, Peng Teng, Liang Hu, Guangqin Zhang, Yuan Han, Mi Yang, Xue-Feng Wu, Wen-Tao Liu
Postoperative pain is a common form of acute pain that, if not managed effectively, can become chronic pain. Evidence has shown that glia, especially microglia, mediate neuroinflammation, which plays a vital role in pain sensitization. Moreover, toll-like receptor 4 (TLR4), the tumor necrosis factor receptor (TNF-R), the interleukin-1 receptor (IL-1R), and the interleukin-6 receptor (IL-6R) have been considered key components in central pain sensitization and neuroinflammation. Therefore, we hypothesized that activation of the body's endogenous "immune brakes" will inhibit these receptors and achieve inflammation tolerance as well as relieve postoperative pain...
October 7, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29017949/tumor-necrosis-factor-receptor-associated-factor-3-from-anodonta-woodiana-is-an-important-factor-in-bivalve-immune-response-to-pathogen-infection
#17
Fufa Qu, Zhiming Xiang, Yingli Zhou, Yanping Qin, Ziniu Yu
Tumor necrosis factor receptor-associated factor 3 (TRAF3) is a multifunctional adaptor protein in innate and acquired immune system that plays a key role in the regulation of the RIG-I-like receptor (RLR) and Toll-like receptor (TLR) signaling pathway in mammals. However, the immune function of TRAF3 homologs in freshwater mollusks is not well understood. In this study, we identified a bivalve TRAF3 gene (AwTRAF3) from Anodonta woodiana and investigated its potential roles during immune challenges. The present AwTRAF3 encoded a polypeptide of 562 amino acids with predicted molecular mass of 64...
October 7, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29017654/-therapeutic-effect-of-hesperidin-on-severe-acute-pancreatitis-in-rats-and-its-mechanism
#18
Min Li, Zhisong Guo, Huanzhang Shao, Bingyu Qin
OBJECTIVE: To investigate the protective effect of hesperidin on severe acute pancreatitis (SAP) in rats and its related mechanism. METHODS: Sixty male Sprague-Dawley (SD) rats were randomly divided into five groups (n = 12 in each group): sham group, SAP model group, dexamethasone group (5 mg/kg), low and high dose of hesperidin groups (10 mg/kg and 20 mg/kg). SAP rats were administered a retrograde infusion of 3.5% sodium taurocholate solution into the biliopancreatic duct after laparotomy...
October 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29017604/il-17-differentiated-macrophages-secrete-pro-inflammatory-cytokines-in-response-to-oxidized-low-density-lipoprotein
#19
María de la Paz Sánchez-Martínez, Francisco Blanco-Favela, Mónica Daniela Mora-Ruiz, Adriana Karina Chávez-Rueda, Mariela Bernabe-García, Luis Chávez-Sánchez
BACKGROUND: Cytokines and macrophages play a central role in the development of atherosclerosis. Interleukin (IL)-17 is a pro-inflammatory cytokine with differential effects on innate immune cells. We investigated the effects of IL-17 on macrophage differentiation and foam cell formation and activation in response to oxidized low-density lipoprotein (oxLDL). METHODS: Human monocytes were treated with IL-17 to induce macrophage differentiation. As controls, human monocytes were differentiated into M1 macrophages (M1) or M2 macrophages (M2)...
October 10, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29016111/crystallinity-of-double-stranded-rna-antimicrobial-peptide-complexes-modulates-toll-like-receptor-3-mediated-inflammation
#20
Ernest Y Lee, Toshiya Takahashi, Tine Curk, Jure Dobnikar, Richard L Gallo, Gerard C L Wong
Double-stranded RNA (dsRNA) induces production of pro-inflammatory cytokines in normal human epidermal keratinocytes (NHEK) by specific binding to endosomal Toll-like receptor-3 (TLR3). Recently, it has been shown that hyperactivation of TLR3 in psoriatic keratinocytes by dsRNA can occur in the presence of human antimicrobial peptide (AMP) LL37. Here, we combine synchrotron X-ray scattering, microscopy, computer simulations, and measurements of NHEK cytokine production to elucidate a previously unanticipated form of specific molecular pattern recognition...
October 19, 2017: ACS Nano
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