Ji Hyun Kim, Seung-Joo Nam, Sung Chul Park, Sang Hoon Lee, Tae Suk Kim, Minjong Lee, Jin Myung Park, Dae Hee Choi, Chang Don Kang, Sung Joon Lee, Young Joon Ryu, Kyungyul Lee, So Young Park
Interstitial cells of Cajal (ICC) are known as the pacemaker cells of gastrointestinal tract, and it has been reported that acute gastroenteritis induces intestinal dysmotility through antibody to vinculin, a cytoskeletal protein in gut, resulting in small intestinal bacterial overgrowth, so that anti-vinculin antibody can be used as a biomarker for irritable bowel syndrome. This study aimed to determine correlation between serum anti-vinculin antibody and ICC density in human stomach. Gastric specimens from 45 patients with gastric cancer who received gastric surgery at Kangwon National University Hospital from 2013 to 2017 were used...
March 2020: Korean Journal of Physiology & Pharmacology