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https://www.readbyqxmd.com/read/29650939/-a-case-of-successful-treatment-with-gemcitabine-plus-nab-paclitaxel-therapy-for-nonresected-pancreatic-body-cancer-stage-ivb
#1
Jun Kaneko, Ayako Kamiya, Kenta Kobayashi, Yasushi Takatsuno, Ito Kondoh, Kentaro Maejima, Jun Isogai, Kumi Hasegawa, Takeshi Endo, Shizuaki Maejima
A 61-year-old woman was introduced for consultation with a chief complaint of frequent vomiting. CT revealed a pancreatic body cancer approximately 40mm in size; an invading stenosis from the horizontal part of the duodenum to the jejunum, superior mesenteric artery, and portal vein, splenic vein obstruction, lymphadenopathy, and some ascitic fluid. We diagnosed a passage disorder due to the invasive stenosis from the horizontal part of the duodenum of the pancreatic body cancer to the jejunum, and subsequently performed a duodenum and jejunum bypass operation...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650932/-a-case-of-sigmoid-colon-cancer-with-locally-advanced-infiltration-curatively-resected-after-capeox-therapy
#2
Yuki Suematsu, Mao Nakayama, Shunsuke Yamagishi, Hiroyuki Saito, Miyuki Takahashi, Kyohei Kanematsu, Michiko Fukabori, Kazuhiko Wakabayashi, Yutaka Itoh
A 68-year-old man presented with malaise and abdominal swelling.Lower gastrointestinal endoscopy revealed a type 2 circumferential sigmoid colon cancer.Computed tomography suggested the cancer infiltrating bladder and abdominal wall with abscess.Because of locally advanced infiltration, the patient was treated with capecitabine plus oxaliplatin(CapeOX) plus bevacizumab therapy after loop-colostomy.After 2 courses of chemotherapy, a CT revealed tumor reduction and increased abscess, which was punctured drainage...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29650052/weighting-of-orthostatic-intolerance-time-measurements-with-standing-difficulty-score-stratifies-me-cfs-symptom-severity-and-analyte-detection
#3
Alice M Richardson, Don P Lewis, Badia Kita, Helen Ludlow, Nigel P Groome, Mark P Hedger, David M de Kretser, Brett A Lidbury
BACKGROUND: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is clinically defined and characterised by persistent disabling tiredness and exertional malaise, leading to functional impairment. METHODS: This study introduces the weighted standing time (WST) as a proxy for ME/CFS severity, and investigates its behaviour in an Australian cohort. WST was calculated from standing time and subjective standing difficulty data, collected via orthostatic intolerance assessments...
April 12, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29650038/a-lifelong-study-of-a-pack-rhodesian-ridgeback-dogs-reveals-subclinical-and-clinical-tick-borne-anaplasma-phagocytophilum-infections-with-possible-reinfection-or-persistence
#4
Emil Hovius, Arnout de Bruin, Leo Schouls, Joppe Hovius, Niels Dekker, Hein Sprong
BACKGROUND: Various tick-borne infections often occur without specific clinical signs and are therefore notoriously hard to diagnose separately in veterinary practice. Longitudinal studies over multiple tick seasons performing clinical, serological and molecular investigations in parallel, may elucidate the relationship between infection and disease. In this regard, six related Rhodesian Ridgeback dogs living as a pack became subject of lifetime studies due to ongoing tick infestations and recurring clinical problems...
April 12, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29648682/elderly-onset-varicella-pneumonia-in-a-patient-with-rheumatoid-arthritis-taking-tofacitinib
#5
Nobuya Abe, Takashi Kudo, Satoshi Jodo
A 68-year-old woman with rheumatoid arthritis, who was treated with tofacitinib, a type of Janus kinase (JAK) inhibitor, was admitted for dyspnea and generalized purpuric vesicular rash, following 3 days of fever and malaise. She developed hypoxia from respiratory insufficiency. On physical examination, the systemic eruptions had an erythematous base and were present in various stages, from maculopapular to vesicular and pustular, with crusting (left). Chest radiograph demonstrated diffuse infiltrates with reticular and nodular lesions in the bilateral lung fields (right)...
April 12, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29643124/myocardial-ischemia-as-a-result-of-external-coronary-compression-from-infective-aortic-root-aneurysm-atypical-presentation-of-prosthetic-valve-endocarditis
#6
Baskar Sekar, Richard Wheeler, Navroz Masani, Sean Gallagher
This case describes an unusual presentation of prosthetic valve endocarditis: an acute coronary syndrome. A 67-year-old gentleman presented with cardiac sounding chest pain on a background of a short history of night sweats, weight loss and general malaise. Four months previously he had undergone bio-prosthetic aortic valve replacement for severe aortic stenosis and single vessel bypass grafting of the obtuse marginal. Whilst having chest pain his ECG showed infero-lateral ST depression. Early coronary angiography revealed a new right coronary artery lesion that was not present prior to his cardiac surgery...
April 11, 2018: Echo Research and Practice
https://www.readbyqxmd.com/read/29625183/extracellular-matrix-the-driving-force-of-mammalian-diseases
#7
REVIEW
Renato V Iozzo, Maria A Gubbiotti
Like the major theme of a Mozart concerto, the immense and pervasive extracellular matrix drives each movement and ultimately closes the symphony, embracing a unique role as the fundamental mediator for most, if not all, ensuing intracellular events. As such, it comes as no surprise that the mechanism of just about every known disease can be traced back to some part of the matrix, typically in the form of an abnormal amount or activity level of a particular matrix component. These defects considerably affect downstream signaling axes leading to overt cellular dysfunction, organ failure, and death...
April 3, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29624767/systemic-exertion-intolerance-disease-chronic-fatigue-syndrome-is-common-in-sleep-centre-patients-with-hypersomnolence-a-retrospective-pilot-study
#8
Caroline Maness, Prabhjyot Saini, Donald L Bliwise, Victoria Olvera, David B Rye, Lynn M Trotti
Symptoms of the central disorders of hypersomnolence extend beyond excessive daytime sleepiness to include non-restorative sleep, fatigue and cognitive dysfunction. They share much in common with myalgic encephalomyelitis/chronic fatigue syndrome, recently renamed systemic exertion intolerance disease, whose additional features include post-exertional malaise and orthostatic intolerance. We sought to determine the frequency and correlates of systemic exertion intolerance disease in a hypersomnolent population...
April 6, 2018: Journal of Sleep Research
https://www.readbyqxmd.com/read/29623227/fulminant-diabetes-in-a-patient-with-advanced-melanoma-on-nivolumab
#9
Nora Chokr, Hafsa Farooq, Elizabeth Guadalupe
Background: Anti-PD-1 agents were approved for advanced melanoma after the landmark trial Checkmate-037. Anti-PD-1 agents can breach immunologic tolerance. Fulminant diabetes is an immune endocrinopathy that results from a violent immune attack leading to complete destruction of pancreatic beta cells in genetically predisposed people. We present a rare case of fulminant diabetes precipitated by anti-PD-1 immunotherapy. Case: A 61-year-old male with advanced melanoma presented with a three-day history of nausea, vomiting, and malaise...
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29618693/-long-term-remission-with-mogamulizumab-monotherapy-in-a-patient-with-refractory-adult-t-cell-leukemia-lymphoma
#10
Yosuke Nakaya, Minako Tsutsumi, Hoyuri Fuseya, Mirei Horiuchi, Takuro Yoshimura, Yoshiki Hayashi, Hiroshi Kanashima, Takafumi Nakao, Takahisa Yamane
A 73-year-old female with malaise, anorexia, and hydrodipsia was referred to our department. Peripheral blood tests revealed leukocytosis with 51% blast cells exhibiting flower-shaped nuclei. Flow-cytometry to detect tumor cells in peripheral blood indicated CD3+, CD4+, CD8-, and CD25- expression, but those in the lymph nodes expressed CD25+. Southern blots revealed clonal HTLV-1 provirus in the tumor cells, consistent with adult T-cell leukemia-lymphoma. Cytotoxic chemotherapy was ineffective, but eight cycles of mogamulizumab induced complete remission (CR)...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/29604992/first-description-of-the-pathogenicity-of-babesia-vogeli-in-experimentally-infected-dogs
#11
Jiawei Wang, Jilei Zhang, Patrick Kelly, Xiaofeng Zheng, Min Li, Jinfeng You, Ke Huang, Haixiang Qiu, Yaoyao Wang, Rong Zhang, Jianji Li, Junsheng Dong, Yi Feng, Jinlin Zhou, Chengming Wang
Babesiosis is a tick-borne disease that occurs worldwide with the most recognized Babesia species that infect dogs being Babesia canis, B. vogeli, B. rossi and B. gibsoni. While B. vogeli is reported in dogs worldwide, clinical and laboratory data on infections is based on reports of naturally infected dogs. To provide reliable data on the clinical and laboratory abnormalities associated with acute and more chronic infections in healthy dogs free of other tick-borne diseases, we experimentally infected dogs with a Chinese strain of B...
April 15, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29602480/-tunnelled-central-venous-catheter-infection-during-treatment-with-epoprostenol
#12
M Koszutski, M Faure, A Guillaumot, E Gomez, M Mercy, F Chabot, A Chaouat
INTRODUCTION: Pulmonary arterial hypertension is a pulmonary vascular disease with a poor prognosis. Continuous intravenous treatment with prostacyclin analogues requires the placement of a tunnelled catheter. The occurrence of catheter-related infections in this context is unusual due to the alkaline pH of the prostacyclin analogue solutions. OBSERVATION: A 50-year-old patient with inherited pulmonary artery hypertension, treated with bosentan, sildenafil and epoprostenol, experienced generalized malaise associated with a weight loss of 9kg over a 12-month period without evidence of a source of infection or malignancy...
March 28, 2018: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29593615/who-cares-for-those-who-take-care-risks-and-resources-of-work-in-care-homes
#13
Caterina Gozzoli, Diletta Gazzaroli, Chiara D'Angelo
Over the years - due to the aging population, the process of corporatisation and a demand for a higher quality of services - professionals who work in Care Homes have been exposed to an increasing risk of physical and emotional malaise because of the number of challenges they've been asked to manage. Given these factors, there is a growing interest in the study and understanding of professions in geriatric care settings. In the literature there is a prevalence of quantitative studies offering an overview in terms of indicators - at the individual or group or organizational level - concerning the potential development of situations of professional malaise...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29588890/endoscopic-transsphenoidal-salvage-surgery-for-symptomatic-residual-cystic-craniopharyngioma-after-radiotherapy
#14
Enzo Emanuelli, Giuliana Frasson, Diego Cazzador, Daniele Borsetto, Luca Denaro
Objectives  Ideal treatment of craniopharyngiomas is still controversial. Radiotherapy (RT) is considered effective for recurrences or after subtotal tumor removal (STR). About 40 to 50% of patients may experience tumor cyst expansion soon after RT; in these cases, the role of salvage surgery is debated. Design  Operative video. Setting  Tertiary care center. Participants  An 11-year-old boy diagnosed with persistent craniopharyngioma. In 2015, the patient underwent right frontotemporal craniotomy for STR at another center, complicated by panhypopituitarism...
April 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29581813/atypical-presentation-of-acute-myeloid-leukemia
#15
Kavita Agrawal, Levin Miles, Nirav Agrawal, Asim Khan
We present a case of a 48-year-old male who presented with worsening pleuritic chest pain for 2 h. He also complained of fever, malaise, headache and severe neck pain. Electrocardiogram (ECG) showed ST segment elevation in leads I, II, aVL and V5 with PR elevation and ST depression in aVR. On admission, troponin-I was 14.8 ng/mL. Based on ECG changes, elevated troponin and family history of early coronary artery disease, the patient was emergently taken to cardiac catheterization lab. Angiography showed non-obstructive coronaries, mild hypokinesis of mid inferior and anterolateral wall with ejection fraction (EF) of 40-45%...
February 2018: World Journal of Oncology
https://www.readbyqxmd.com/read/29564278/thrombocytopenia-in-hiv-patients-coinfected-with-tuberculosis
#16
A S Sandhya, Brijesh Prajapat
Thrombocytopenia is one of the most common hematological manifestations seen in HIV patients with approximately 40% of the patients developing thrombocytopenia during their course of illness. Opportunistic infection like tuberculosis is a rare but curative cause of thrombocytopenia in these patients. Clinically, it is a challenge to determine the exact cause and decide the treatment of thrombocytopenia in these patients as both infections can lead to significant thrombocytopenia by varied mechanisms. The treatment options are limited by drug antitubercular treatment highly active antiretroviral therapy (ATT and HAART)-induced thrombocytopenia...
October 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29558355/-cutaneous-polyarteritis-nodosa
#17
Monika Turska, Jolanta Parada-Turska
Cutaneous polyarteritis nodosa is a rare disease that affects vessels of the deep skin and the subcutaneous tissue. Its etiopathology remains unknown. It predominantly affects skin, and the main cutaneous symptoms are subcutaneous nodules, livedo reticularis, and ulcerations that are mainly located on legs. Cutaneous polyarteritis nodosa can also cause extracutaneous symptoms (fever, malaise, myalgias, arthralgias, neuropathy). It is a chronic benign disease with a relapsing course. Diagnostic criteria for this disease were recently proposed and both clinical and typical histological features must be present to confirm the diagnosis...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29557353/intraperitoneal-cerebrospinal-fluid-pseudocyst-with-ventriculoperitoneal-shunt
#18
Mohammad Sadegh Masoudi, Marziye Rasafian, Zahra Naghmehsanj, Fariborz Ghaffarpasand
Ventriculoperitoneal (VP) shunting is mostly used in the treatment of hydrocephalus and many complications have been reported with this method. Abdominal Pseudocyst (APC) are relatively uncommon but important complications in patients with VP shunts. We herein report the case of a 9-year-old boy with VP shunt who presented with abdominal distension, abdominal pain, malaise, and decrease of appetite. Abdominal pelvic computed tomography confirmed a diagnosis of APC. Laparotomy was done and VP shunt was placed into the other side of peritoneal cavity again...
July 2017: African Journal of Paediatric Surgery: AJPS
https://www.readbyqxmd.com/read/29555183/toxic-epidermal-necrolysis-a-dermatologic-emergency-and-the-role-of-the-oral-and-maxillofacial-surgeon
#19
Brian Wolf, Rory Sadoff, Victor Nannini
Toxic epidermal necrolysis (TEN) is a rare and severe mucocutaneous disorder characterized by mucosal and epidermal necrosis and sloughing. This potentially life-threatening condition, together with the less severe Stevens-Johnson syndrome, is commonly caused by an immunologic reaction to medications and can lead to many long-term complications. The disorder initially presents with fever, malaise, and painful mucosal ulcerations (most commonly oral) but progresses to widespread cutaneous lesions. A 14-year-old male patient was prescribed minocycline for treatment of his acne by his primary care doctor...
February 23, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29554857/aortic-graft-infection-secondary-to-iatrogenic-transcolonic-graft-malposition
#20
Jacqueline J Blank, Abby E Rothstein, Cheong Jun Lee, Michael J Malinowski, Brian D Lewis, Timothy J Ridolfi, Mary F Otterson
Aortic graft infections are a rare but devastating complication of aortic revascularization. Often infections occur due to contamination at the time of surgery. Iatrogenic misplacement of the limbs of an aortobifemoral graft is exceedingly rare, and principles of evaluation and treatment are not well defined. We report 2 cases of aortobifemoral bypass graft malposition through the colon. CASE REPORT: Case 1 is a 54-year-old male who underwent aortobifemoral bypass grafting for acute limb ischemia...
January 1, 2018: Vascular and Endovascular Surgery
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