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Camila V Ventura, Maria Paula Fernandez, Ivan A Gonzalez, Delia M Rivera-Hernandez, Roberto Lopez-Alberola, Maria Peinado, Angelica A Floren, Patricia A Rodriguez, Basil K Williams, Gabriela de la Vega Muns, Ana J Rodriguez, Catherin Negron, Brenda Fallas, Audina M Berrocal
A 6-day-old female baby with known diagnosis of congenital Zika infection was referred for ophthalmologic examination. The mother (37 years old) was referred for a pruritic rash, conjunctival hyperemia, and malaise at 12 weeks of gestation while still living in Venezuela. Upon arrival to Miami, Zika virus (ZIKV) exposure was confirmed during prenatal screening. At birth, due to the known exposure, a complete congenital ZIKV workup was performed, including brain ultrasound and MRI, which disclosed calcifications in the frontal lobe...
October 1, 2016: Ophthalmic Surgery, Lasers & Imaging Retina
Sergio Pina-Oviedo, Carlos A Torres-Cabala, Roberto N Miranda, Michael T Tetzlaff, Selina Singh, Ronald P Rapini, Victor G Prieto, Phyu P Aung
Leukemia cutis develops in <4% of all acute leukemias. Concurrent acute myeloid leukemia (AML) and Langerhans cell histiocytosis (LCH) is rare, with most cases involving lymph nodes or spleen, and no cutaneous involvement. We report the case of a 59-year-old man who presented with fever, malaise, and fatigue. The CBC showed leukocytosis (30.4 × 10/L, 9% blasts), anemia, and thrombocytopenia. Bone marrow biopsy was diagnosed with AML, not otherwise specified, with mutations of FLT3 and IDH2 (R140Q). The patient developed skin rash on the right flank with the clinical differential diagnosis of herpes simplex virus or varicella-zoster virus infection/reactivation versus leukemia cutis...
October 18, 2016: American Journal of Dermatopathology
Mandy Day-Calder
After your first few shifts and catching up with colleagues, you will usually quickly get back into the swing of working life. But sometimes, especially if you have been nursing for a while and weathered many healthcare storms, you may feel a deeper sense of malaise for your work.
September 14, 2016: Nursing Standard
Wais Afzal, Talal Arab, Tofura Ullah, Katerina Teller, Kaushik J Doshi
Lymphadenopathy could represent a vast spectrum of etiologies including infectious and non-infectious diseases. Besides proper history taking, physical examination, and laboratory investigations, a tissue diagnosis is often necessary to unmask the cause of generalized lymphadenopathy. Here we present a 23-year-old woman who was admitted for diffuse generalized lymphadenopathy, fatigue, malaise, weight loss, nausea, and bilateral lower extremity edema. She reported a history of seizures as well as stroke 2 years prior with no other medical conditions present...
November 2016: Journal of Clinical Medicine Research
Ludovic Giloteaux, Maureen R Hanson, Betsy A Keller
BACKGROUND Patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) present with profound fatigue, flu-like symptoms, pain, cognitive impairment, orthostatic intolerance, and post-exertional malaise (PEM), and exacerbation of some or all of the baseline symptoms. CASE REPORT We report on a pair of 34-year-old monozygotic twins discordant for ME/CFS, with WELL, the non-affected twin, and ILL, the affected twin. Both twins performed a two-day cardiopulmonary exercise test (CPET), pre- and post-exercise blood samples were drawn, and both provided stool samples for biochemical and molecular analysis...
October 10, 2016: American Journal of Case Reports
Olivier Malaise, Biserka Relic, Edith Charlier, Mustapha Zeddou, Sophie Neuville, Céline Deroyer, Philippe Gillet, Edouard Louis, Michel G Malaise, Dominique de Seny
BACKGROUND: Glucocorticoid-induced leucine zipper (GILZ) is a mediator of the anti-inflammatory activities of glucocorticoids. However, GILZ deletion does not impair the anti-inflammatory activities of exogenous glucocorticoids in mice arthritis models and GILZ could also mediate some glucocorticoid-related adverse events. Osteoarthritis (OA) is a metabolic disorder that is partly attributed to adipokines such as leptin, and we previously observed that glucocorticoids induced leptin secretion in OA synovial fibroblasts...
October 4, 2016: Arthritis Research & Therapy
Sara Wallström, Kerstin Ulin, Elmir Omerovic, Inger Ekman
OBJECTIVE: The aim of the study was to investigate the meaning of narrated symptoms in connection to takotsubo syndrome. DESIGN, METHOD, PARTICIPANTS AND SETTING: Qualitative study consisting of 25 interviews, 23 women and 2 men aged 39-84 and living in Region Västra Götaland, Sweden. The transcribed text was analysed with phenomenological hermeneutics. RESULTS: The interviewees reported a large number of symptoms before, during and after the acute onset of takotsubo syndrome, including pain, affected breathing, lassitude, malaise and nausea...
October 5, 2016: BMJ Open
Kohei Fujita, Masaki Fujita, Yutaka Ito, Toyohiro Hirai, Tadashi Mio, Kentaro Watanabe, Michiaki Mishima
Although sitafloxacin (STFX) is known to have a favorable minimum inhibitory concentration for Mycobacterium avium, few studies have evaluated the clinical efficacy of an STFX-containing regimen for pulmonary M avium complex (MAC) disease. To evaluate the clinical efficacy of STFX-containing regimens for relapsed or refractory pulmonary MAC disease, we retrospectively reviewed 18 patients with pulmonary MAC disease who received STFX for at least 4 weeks for pulmonary MAC disease between January 2008 and February 2016...
September 2016: Open Forum Infectious Diseases
Liyuan Yang, Christopher H Dietrich, Yalin Zhang
The fauna of Thailand was previously known to include only a single species of Macropsini. Study of an extensive collection of recent Malaise trap samples from Thailand revealed the presence of five additional species of this leafhopper tribe, including two new species, Pediopsis thailandensis and Varicopsella odontoida spp. nov., described and illustrated herein; and three additional species, Macropsis hainanensis, P. rufoscutellata and V. elegans, previously recorded from neighboring countries. A key to genera and species of the Macropsini of Thailand is provided...
September 14, 2016: Zootaxa
Wilawan Thipmontree, Kittipong Suwattanabunpot, Yupin Supputtamonkol
Spontaneous rupture of the spleen is rarely described as a complication of scrub typhus infection. We report a previously healthy 74-year-old Thai female farmer who presented in Nakhon Ratchasima, Thailand, with a history of fever and malaise for 5 days, followed by abdominal pain for 1 day. An exploratory laparotomy was performed due to peritonitis. Operative findings revealed a ruptured spleen and hemoperitoneum. A splenectomy was performed afterward. Scrub typhus was confirmed by a 4-fold increase of IgM titer using an indirect immunofluorescence antibody assay and a positive result from the polymerase chain reaction targeting the 47- and 56-kDa genes in Orientia tsutsugamushi She responded well to intravenous chloramphenicol and defervesced within 24 hours without any complication...
October 3, 2016: American Journal of Tropical Medicine and Hygiene
Malik Asif Humayun, Tristan Richardson, Augustin Brooks
A 17-year-old male presented with diarrhoea and malaise following his return from Kenya and Tunisia. He was managed as a case of traveller's diarrhoea. Stool cultures were negative for pathogenic bacterial growth. Two weeks later he presented with worsening lower back pain. MRI of lumbosacral spine suggested L1 osteomyelitis. CT-guided spinal aspirate grew no organisms and repeat viral serology and blood cultures (including tuberculosis screening) were negative. He was treated with a 6-week course of ceftriaxone...
September 30, 2016: BMJ Case Reports
Samit Kumar Nandi, Samiran Bandyopadhyay, Piyali Das, Indranil Samanta, Prasenjit Mukherjee, Subhasis Roy, Biswanath Kundu
Chronic osteomyelitis is a major challenge in bone surgery. Conventional use of antibiotics is not an effective way to control the malaise due to so many reasons. Determination of optimal treatment strategy becomes difficult for the orthopaedic surgeons and as a consequence, the patients suffer not only from therapeutic failure but also due to adverse side effects of antibiotics and financial loss due to additional stay at hospitals. A wide application of carrier systems, as a medium for local delivery of antibiotics, is being used experimentally and clinically for the treatment of osteomyelitis...
September 28, 2016: Biotechnology Advances
J R A Lemes, A Köhler
It is recorded for the first time in the state of Rio Grande do Sul the occurrence of Scobina melanocephala (Lepeletier, 1823), Scobina thoracica (Jorgensen, 1913) and Scobina poeciloides (Ashmead, 1895), being this last the first record for Brazil. Scobina melanopyga (Klug, 1834) and Scobina torquata (Konow, 1903) were also found in the study. The analyzed material was collected utilizing Malaise traps in tobacco (Nicotiana tabacum L.) fields and is deposited at the Entomological Collection of Santa Cruz do Sul...
September 26, 2016: Brazilian Journal of Biology, Revista Brasleira de Biologia
Mette Christiansen, Sandra Ammann, Carsten Speckmann, Trine Hyrup Mogensen
A 16-year-old boy of Caucasian ethnicity was evaluated for recurrent febrile episodes occurring during most of his life without establishment of any microbial aetiology. During febrile episodes he developed extensive splenomegaly, lymphadenopathy, anaemia, severe abdominal pain and general malaise. Lymph node biopsies demonstrated inflammation and sinus histiocytosis but no malignancy or granuloma. The patient underwent seroconversion for Epstein-Barr virus (EBV) infection during the hospitalisation. Genetic testing identified a hemizygous frameshift mutation in the X linked inhibitor of apoptosis (XIAP)-gene as well as variants in the MEFV gene indicating Familial Mediterranean Fever (FMF)...
2016: BMJ Case Reports
J R Curtis, F Xie, D Mackey, N Gerber, A Bharat, T Beukelman, K G Saag, L Chen, B Nowell, S Ginsberg
BACKGROUND: Despite the prominent position of methotrexate (MTX) in Rheumatoid Arthiris (RA) therapeutics, its real-world effectiveness may be influenced by a relative lack of tolerability or other side effects that physicians may not be aware of but that are bothersome to patients. The aim of this study is to identify suboptimal patient experience with MTX and to raise awareness for clinicians to identify opportunities to mitigate bothersome symptoms and side effects and optimize response to MTX...
September 26, 2016: BMC Musculoskeletal Disorders
Öznur Küçük, Suat Biçer, Meltem Ugraş, Defne Çöl, Tuba Giray, Gülay Çiler Erdag, Yeşim Gürol, Gülden Yilmaz, Zerrin Yalvaç, Ayça Vitrinel, Çigdem Kaspar
The purpose of this study was to evaluate the clinical and laboratory data of children with acute gastroenteritis caused by non-typhoid Salmonella spp. infections. Clinical (demographic data, symptoms and findings) and laboratory data (stool microscopy, rapid antigen tests, culture, multiplex polymerase chain reaction and blood test results) of children with acute gastroenteritis caused by non-typhoid Salmonella spp. between January 2010 and October 2012 were evaluated. Differences between the groups for categorical variables were estimated with a chi-square or Fisher exact test; for continuous variables with two independent samples a t test was used...
September 1, 2016: Le Infezioni in Medicina
Yuichi Sagara, Satoshi Shinozaki, Tomonori Yano, Hirotsugu Sakamoto, Yoshikazu Hayashi, Alan Kawarai Lefor, Hironori Yamamoto
The over-the-scope clip (OTSC) system is a new technology that enables closure of fistulae which cannot be closed with a conventional clip. A 57-year-old woman had long-term hypoalbuminemia, edema and general malaise. Peroral double-balloon endoscopy (DBE) showed a jejuno-sigmoid fistula and blind loop syndrome of the jejunum and ileum, because ingested food bypassed the ileum through the fistula. She was advised to undergo surgical closure of the fistula, but she refused the procedure. For 7 years following DBE, repeat courses of antibiotics were required to treat bacterial overgrowth due to blind loop syndrome...
September 23, 2016: Clinical Journal of Gastroenterology
Maria Licursi, Christian O Alberto, Alex Dias, Kensuke Hirasawa, Michiru Hirasawa
OBJECTIVE: High-fat diet (HFD) is known to induce low-grade hypothalamic inflammation. Whether inflammation occurs in other brain areas remains unknown. This study tested the effect of short-term HFD on cytokine gene expression and identified leukemia inhibitory factor (LIF) as a responsive cytokine in the brain stem. Thus, functional and cellular effects of LIF in the brain stem were investigated. METHODS: Male rats were fed chow or HFD for 3 days, and then gene expression was analyzed in different brain regions for IL-1β, IL-6, TNF-α, and LIF...
September 24, 2016: Obesity
Michael Joseph Skvarla, Jeffrey K Barnes, Danielle M Fisher, Ashley P G Dowling
BACKGROUND: This is the fourth in a series of papers detailing the terrestrial arthropods collected during an intensive survey of a site near Steel Creek campground along the Buffalo National River in Arkansas. The survey was conducted over a period of eight and a half months in 2013 using twelve trap types, including Malaise and canopy traps, Lindgren multifunnel traps, and pan traps. NEW INFORMATION: We provide collection records for 38 species of Asilidae and other Diptera, 7 of which are new state records for Arkansas: (Asilidae) Lasiopogon opaculus Loew, 1874; (Lygistorrhinidae) Lygistorrhina sancthecatharinae Thompson, 1975; (Stratiomyidae) Cephalochrysa nigricornis (Loew, 1866), Gowdeyana punctifera (Malloch, 1915), Sargus decorus Say, 1824; (Ulidiidae) Callopistromyia annulipes Macquart, 1855; and (Xylophagidae) Rachicerus obscuripennis Loew, 1863...
2016: Biodiversity Data Journal
Jenny Stuart-Smith, Anita Thapar, Barbara Maughan, Ajay Thapar, Stephan Collishaw
PURPOSE: Childhood hyperactivity leads to mental health problems, but it is not known whether there are long-term risks for adult mood problems in unselected population cohorts that extend to mid-life. Aims were to examine links between childhood hyperactivity and mood problems up to age 50 years and to consider confounding factors and gender differences in associations. METHODS: The National Child Development Study (NCDS) is a UK cohort of children born in 1958...
September 22, 2016: Social Psychiatry and Psychiatric Epidemiology
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