Md Hridoy Ahmed, Nure Sharaf Nower Samia, Gagandeep Singh, Vandana Gupta, Mohammed Faizan Mohammed Mishal, Alomgir Hossain, Kamrul Hassan Suman, Adnan Raza, Amit Kumar Dutta, Moriom Akhter Labony, Jakia Sultana, Emdadul Haque Faysal, Sulaiman Mohammed Alnasser, Prawez Alam, Faizul Azam
A worrying new outbreak of Monkeypox (Mpox) in humans is caused by the Mpox virus (MpoxV). The pathogen has roughly 28 hypothetical proteins of unknown structure, function, and pathogenicity. Using reliable bioinformatics tools, we attempted to analyze the MpoxV genome, identify the role of hypothetical proteins (HPs), and design a potential candidate vaccine. Out of 28, we identified seven hypothetical proteins using multi-server validation with high confidence for the occurrence of conserved domains. Their physical, chemical, and functional characterizations, including molecular weight, theoretical isoelectric point, 3D structures, GRAVY value, subcellular localization, functional motifs, antigenicity, and virulence factors, were performed...
July 31, 2023: Journal of Biomolecular Structure & Dynamics