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TLR-3

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https://www.readbyqxmd.com/read/29237464/tlr3-promotes-mmp-9-production-in-primary-human-airway-epithelial-cells-through-wnt-%C3%AE-catenin-signaling
#1
P-J Royer, K Henrio, M Pain, J Loy, A Roux, A Tissot, P Lacoste, C Pison, S Brouard, A Magnan
BACKGROUND: Airway epithelial cells (AEC) act as the first line of defence in case of lung infections. They constitute a physical barrier against pathogens and they participate in the initiation of the immune response. Yet, the modalities of pathogen recognition by AEC and the consequences on the epithelial barrier remain poorly documented. METHOD: We investigated the response of primary human AEC to viral (polyinosinic-polycytidylic acid, poly(I:C)) and bacterial (lipopolysaccharide, LPS) stimulations in combination with the lung remodeling factor Transforming Growth Factor-β (TGF-β)...
December 13, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29221139/epstein-barr-virus-in-tumor-infiltrating-b-cells-of-myasthenia-gravis-thymoma-an-innocent-bystander-or-an-autoimmunity-mediator
#2
Paola Cavalcante, Stefania Marcuzzo, Sara Franzi, Barbara Galbardi, Lorenzo Maggi, Teresio Motta, Raffaella Ghislandi, Antonella Buzzi, Luisella Spinelli, Lorenzo Novellino, Fulvio Baggi, Carlo Antozzi, Fabio Conforti, Tommaso Martino De Pas, Massimo Barberis, Pia Bernasconi, Renato Mantegazza
The thymus plays a key role in myasthenia gravis (MG), a B cell-mediated autoimmune disorder affecting neuromuscular junction. Most MG patients have thymic abnormalities, including hyperplasia and thymoma, a neoplasm of thymic epithelial cells. Epstein-Barr virus (EBV) is associated with autoimmune diseases and tumors. Recently, we showed EBV persistence and reactivation in hyperplastic MG thymuses, suggesting that EBV might contribute to intra-thymic B cell dysregulation in MG patients. Here, we investigated EBV involvement in thymoma-associated MG, by searching for EBV markers in MG (n=26) and non-MG (n=14) thymomas...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29196206/divergence-of-protein-sensing-tlr-4-5-and-nucleic-acid-sensing-tlr-3-7-within-the-reptilian-lineage
#3
Manisha Priyam, Mamta Tripathy, Umesh Rai, Soma Mondal Ghorai
No abstract text is available yet for this article.
November 28, 2017: Molecular Phylogenetics and Evolution
https://www.readbyqxmd.com/read/29136027/expression-of-toll-like-receptors-tlrs-in-the-lungs-of-an-experimental-sepsis-mouse-model
#4
Anargyros Bakopoulos, Alkistis Kapelouzou, Diamantis I Tsilimigras, Michalis Katsimpoulas, Dimitrios Schizas, Chrysostomos Aravanis, Evaggelos Balafas, Manolis Mavroidis, Kitty Pavlakis, Anastasios Machairas, Theodore Liakakos
BACKGROUND: Sepsis is a condition characterized by high mortality rates and often accompanied by multiple-organ dysfunction. During sepsis, respiratory system may be affected and possibly result in acute respiratory distress syndrome (ARDS). Toll-like receptors (TLRs), as a first line defense against invading pathogens, seem to be highly expressed in septic states. Therefore, expression of TLRs in the lungs of a sepsis animal model could indicate the involvement of the respiratory system and appear as a severity index of the clinical course...
2017: PloS One
https://www.readbyqxmd.com/read/29123946/tumor-cell-death-by-pattern-sensing-of-exogenous-rna-tumor-cell-tlr3-directly-induces-necroptosis-by-poly-i-c-in-vivo-independent-of-immune-effector-mediated-tumor-shrinkage
#5
Hiromi Takaki, Hiroaki Shime, Misako Matsumoto, Tsukasa Seya
Poly(I:C) acts on dendritic cells to induce potent antitumor effects through the production of cytokines/interferons, activation of natural killer cells and proliferation of cytotoxic T lymphocytes. In some tumor or myeloid lineages, poly(I:C) seemed to induce necroptosis in concert with a pan-caspase inhibitor by directly acting on toll-like receptor (TLR) 3 in both in vivo and in vitro models.
2017: Oncoimmunology
https://www.readbyqxmd.com/read/29107742/polyvalent-protective-immunogens-identified-from-outer-membrane-proteins-of-vibrio-parahaemolyticus-and-their-induced-innate-immune-response
#6
Bo Peng, Xiao-Peng Lin, Sheng-Nan Wang, Man-Jun Yang, Xuan-Xian Peng, Hui Li
Vaccines are the most economic, efficient and environment-friendly agents in protecting host against bacterial infection. In aquaculture, polyvalent vaccines targeting more than one bacterial specie are highly demanded due to the presence of various types of bacterial pathogens in farming environment. Here eighteen genes encoding outer membrane proteins of Vibrio parahaemolyticus were cloned and expressed. The expressed recombinant proteins were used for antiserum preparation. Passive and active immune protection of the antiserum and recombinant proteins was investigated in the zebrafish model...
October 28, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29070776/ccl5-is-induced-by-tlr-3-signaling-in-hucct1-human-biliary-epithelial-cells-possible-involvement-in-the-pathogenesis-of-biliary-atresia
#7
Taku Shimada, Tadaatsu Imaizumi, Kyogo Shirai, Tetsuya Tatsuta, Toshiro Kimura, Ryo Hayakari, Hidemi Yoshida, Tomoh Matsumiya, Hiroshi Kijima, Hiroki Mizukami, Kenichi Hakamada
Biliary atresia (BA) is a disease of the newborn that is characterized by progressive, inflammatory and sclerosing cholangiopathy. Innate immune responses to viral components are thought to be involved in the pathogenesis of BA. It is also reported that some chemokines, such as CCL5, are possibly involved in the pathogenesis of experimental animal model of BA. We treated human biliary epithelial HuCCT1 cells with polyinosinic-polycytidylic acid (poly IC), an authentic double-stranded RNA (dsRNA) which mimics viral RNA, and analyzed the CCL5 expression by quantitative reverse transcription-PCR (qRT-PCR) and enzyme-linked immunosorbent assay (ELISA)...
2017: Biomedical Research
https://www.readbyqxmd.com/read/29061187/elevated-microrna-129-5p-level-ameliorates-neuroinflammation-and-blood-spinal-cord-barrier-damage-after-ischemia-reperfusion-by-inhibiting-hmgb1-and-the-tlr3-cytokine-pathway
#8
Xiao-Qian Li, Feng-Shou Chen, Wen-Fei Tan, Bo Fang, Zai-Li Zhang, Hong Ma
BACKGROUND: Ischemia-reperfusion (IR) affects microRNA (miR) expression and causes substantial inflammation. Multiple roles of the tumor suppressor miR-129-5p in cerebral IR have recently been reported, but its functions in the spinal cord are unclear. Here, we investigated the role of miR-129-5p after spinal cord IR, particularly in regulating high-mobility group box-1 (HMGB1) and the Toll-like receptor (TLR)-3 pathway. METHODS: Ischemia was induced via 5-min occlusion of the aortic arch...
October 23, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29054829/poly-i-c-and-imiquimod-induced-immune-responses-and-their-effects-on-the-survival-of-olive-flounder-paralichthys-olivaceus-from-viral-haemorrhagic-septicaemia
#9
Satheesha Avunje, Sung-Ju Jung
The stimulation of immune genes by polyinosinic:polycytidylic acid (poly (I:C)) and imiquimod in olive flounder (Paralichthys olivaceus) and their role in control of viral haemorrhagic septicaemia virus (VHSV) infection were examined. Poly (I:C) (100 μg/fish) treated olive flounder had very low mortality (5%) post VHSV infection, while the imiquimod treated group had 65% and 85% mortality at a dose of 100 μg/fish and 50 μg/fish, respectively. Though the imiquimod treated group had high mortality, it was lower than the untreated group, which had 90% mortality...
October 18, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29031816/designing-immunostimulatory-double-stranded-messenger-rna-with-maintained-translational-activity-through-hybridization-with-poly-a-sequences-for-effective-vaccination
#10
Satoshi Uchida, Naoto Yoshinaga, Kayoko Yanagihara, Eiji Yuba, Kazunori Kataoka, Keiji Itaka
Messenger (m)RNA vaccines require a safe and potent immunostimulatory adjuvant. In this study, we introduced immunostimulatory properties directly into mRNA molecules by hybridizing them with complementary RNA to create highly immunogenic double stranded (ds)RNAs. These dsRNA formulations, comprised entirely of RNA, are expected to be safe and highly efficient due to antigen expression and immunostimulation occurring simultaneously in the same antigen presenting cells. In this strategy, design of dsRNA is important...
September 27, 2017: Biomaterials
https://www.readbyqxmd.com/read/28971586/dietary-n-glycans-from-bovine-lactoferrin-and-tlr-modulation
#11
Susana Figueroa-Lozano, Rivca L Valk-Weeber, Sander S van Leeuwen, Lubbert Dijkhuizen, Paul de Vos
SCOPE: Bovine lactoferrin (bLF) is an ingredient of food supplements and infant formulas given its antimicrobial and antiviral properties. We modified bLF enzymatically to alter its N-glycosylation and to isolate the glycan chains. The aims of this study were 1) to evaluate whether such derivates induce responses via Pattern Recognition Receptors (PRRs) namely Toll-like receptors (TLRs) and 2) to relate those responses to their different glycosylation profiles. METHODS AND RESULTS: The unmodified and modified bLF fractions were incubated with reporter cell lines expressing PRRs...
October 3, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28963751/tiomax-a-spanish-multicenter-registry-of-the-real-world-use-of-the-titanium-optimax-%C3%A2-biostent-tiomax-registro-espa%C3%A3-ol-multic%C3%A3-ntrico-del-biostent-de-titanio-optimax-%C3%A2-en-la-vida-real
#12
José R López-Mínguez, Juan M Nogales-Asensio, Sebastián Romani, Fernando Rivero-Crespo, Victor M Aragón-Extremera, Jesús M Jiménez-Mazuecos, Fernando Carrasco, Juan Francisco Oteo-Domínguez, Francisco Bosa-Ojeda, Joan A Gómez-Hospital
OBJECTIVES: To compare the safety and efficacy of the new cobalt-chromium bioactive stent Titan Optimax(®) (Hexacath, France) with its predecessor, Titan-2(®) . BACKGROUND: The TIOMAX registry includes 784 patients who underwent percutaneous coronary intervention with these stents in 21 Spanish hospitals. METHODS: Analysis of all patients in the registry without exclusion criteria, candidates for revascularization (March-2013/July-2014)...
September 30, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28963016/delivery-of-the-tlr-ligand-poly-i-c-to-liver-cells-in-vitro-and-in-vivo-by-calcium-phosphate-nanoparticles-leads-to-a-pronounced-immunostimulation
#13
Viktoriya Sokolova, Zou Shi, Shunmei Huang, Yanqin Du, Mathis Kopp, Annika Frede, Torben Knuschke, Jan Buer, Dongliang Yang, Jun Wu, Astrid Maria Westendorf, Matthias Epple
The selective activation of the immune system is a concurrent problem in the treatment of persistent diseases like viral infections (e.g. hepatitis). For the delivery of the toll-like receptor ligand poly(I:C), an immunostimulatory action was discovered earlier by hydrodynamic injection. However, this technique is not clinically transferable to human patients. A modular system where the immunoactive toll-like-receptor ligand 3 (TLR-3) poly(I:C) was incorporated into calcium phosphate nanoparticles was developed...
December 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28924346/co-delivery-of-polyinosinic-polycytidylic-acid-and-flagellin-by-poly-lactic-co-glycolic-acid-mps-synergistically-enhances-immune-response-elicited-by-intranasally-delivered-hepatitis-b-surface-antigen
#14
Xiaojing Dai, Jintian He, Ruxia Zhang, Guanghao Wu, Fangfang Xiong, Baohua Zhao
The aim of the present work was to investigate the synergistic effect between toll-like receptor (TLR) 3 ligand polyinosinic:polycytidylic acid (pI:C) and TLR5 ligand flagellin (FLN) on immune responses induced by nasally delivered hepatitis B virus surface antigen (HBsAg). Mannan and chitosan oligosaccharide-modified, pH-responsive poly(lactic-co-glycolic acid) (MC-PLGA) microparticles (MPs) containing HBsAg, FLN, pI:C or both ligands were prepared with a double-emulsion method. In vitro uptake experiments show that cellular uptake of MC-PLGA MPs by macrophages was through energy-dependent, receptor-mediated endocytosis mechanism...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28921745/transcription-factor-ccaat-enhancer-binding-protein-%C3%AE-upregulates-microrna-let-7f-1-in-human-endocervical-cells
#15
Kanchana Ayyar, Kudumula Venkata Rami Reddy
PROBLEM: In endocervical epithelial cells (End1/E6E7), miRNA let-7f plays an important role in the control of innate immunity. The underlying molecular mechanism for let-7f regulation in these cells remains largely unclear. METHODS OF STUDY: let-7f was knocked down in End1/E6E7 cells using siRNA, and differential gene expression was analyzed by microarray. Differentially expressed genes were validated by qPCR and Western blot. Expression of let-7f was studied by qPCR after inhibition of C/EBPβ with betulinic acid (BA) and pCMVβ plasmid and after overexpression of C/EBPβ with pCMVβ+ plasmid...
September 16, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28900156/dual-roles-of-two-isoforms-of-autophagy-related-gene-atg10-in-hcv-subgenomic-replicon-mediated-autophagy-flux-and-innate-immunity
#16
Qiong Zhao, Zhan-Ying Hu, Jing-Pu Zhang, Jian-Dong Jiang, Yuan-Yuan Ma, Jian-Rui Li, Zong-Gen Peng, Jin-Hua Chen
Autophagy and immune response are two defense systems that human-body uses against viral infection. Previous studies documented that some viral mechanisms circumvented host immunity mechanisms and hijacked autophagy for its replication and survival. Here, we focus on interactions between autophagy mechanism and innate-immune-response in HCV-subgenomic replicon cells to find a mechanism linking the two pathways. We report distinct effects of two autophagy-related protein ATG10s on HCV-subgenomic replication...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28891416/role-of-innate-immunity-in-preeclampsia-a-systematic-review
#17
Ana P Bouças, Bianca M de Souza, Andrea C Bauer, Daisy Crispim
Innate immune system dysfunction has been known to be a key player in preeclampsia (PE). Activation of the maternal innate immunity may be triggered by invading microorganisms or endogenous ligands, which are detected by different pattern recognition receptors (PRRs). Although some studies have linked PRR activation to PE, it is still unclear if dysregulated PRR expression is associated with the development of this complication. Therefore, we conducted a systematic review of the literature, searching articles that evaluated associations of PRRs with PE...
October 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28878771/coordinated-role-of-toll-like-receptor-3-and-retinoic-acid-inducible-gene-i-in-the-innate-response-of-bovine-endometrial-cells-to-virus
#18
Luisa C Carneiro, Carmen Bedford, Sarah Jacca, Alfonso Rosamilia, Vera F de Lima, Gaetano Donofrio, I Martin Sheldon, James G Cronin
Bovine herpesvirus-4 (BoHV-4) and bovine viral diarrhea virus (BVDV) infect the uterus of cattle, often resulting in reduced fertility, or abortion of the fetus, respectively. Here, exposure of primary bovine endometrial cells to BoHV-4 or BVDV modulated the production of inflammatory mediators. Viral pathogen-associated molecular patterns (PAMPs) are detected via pattern-recognition receptors (PRRs). However, the relative contribution of specific PRRs to innate immunity, during viral infection of the uterus, is unclear...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28878760/respiratory-commensal-bacteria-corynebacterium-pseudodiphtheriticum-improves-resistance-of-infant-mice-to-respiratory-syncytial-virus-and-streptococcus-pneumoniae-superinfection
#19
Paulraj Kanmani, Patricia Clua, Maria G Vizoso-Pinto, Cecilia Rodriguez, Susana Alvarez, Vyacheslav Melnikov, Hideki Takahashi, Haruki Kitazawa, Julio Villena
Corynebacterium pseudodiphtheriticum is a Gram-positive bacterium found as a member of the normal microbiota of the upper respiratory tract. It was suggested that C. pseudodiphtheriticum may be potentially used as a next-generation probiotic for nasal application, although no deep studies were performed in this regard. We hypothesized that human isolate C. pseudodiphtheriticum strain 090104 is able to modulate the respiratory innate immune response and beneficially influence the resistance to viral and bacterial infections...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28872665/expression-of-human-cathelicidin-peptide-ll-37-in-inflammatory-bowel-disease
#20
S Kusaka, A Nishida, K Takahashi, S Bamba, H Yasui, M Kawahara, O Inatomi, M Sugimoto, A Andoh
Cathelicidin peptide LL-37 plays an important role in the early host response against invading pathogens via its broad-spectrum anti-microbial activity. In this study, we investigated LL-37 expression in the inflamed mucosa of inflammatory bowel disease (IBD) patients. Furthermore, the regulatory mechanism of LL-37 induction was investigated in human colonic subepithelial myofibroblasts (SEMFs). LL-37 mRNA expression and protein secretion were analysed using real-time polymerase chain reaction and enzyme-linked immunosorbent assay, respectively...
September 5, 2017: Clinical and Experimental Immunology
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