Nicolas Grillot, Gilles Lebuffe, Olivier Huet, Sigismond Lasocki, Xavier Pichon, Mathieu Oudot, Nathalie Bruneau, Jean-Stéphane David, Pierre Bouzat, Alexandra Jobert, Martine Tching-Sin, Fanny Feuillet, Raphael Cinotti, Karim Asehnoune, Antoine Roquilly
IMPORTANCE: It is uncertain whether a rapid-onset opioid is noninferior to a rapid-onset neuromuscular blocker during rapid sequence intubation when used in conjunction with a hypnotic agent. OBJECTIVE: To determine whether remifentanil is noninferior to rapid-onset neuromuscular blockers for rapid sequence intubation. DESIGN, SETTING, AND PARTICIPANTS: Multicenter, randomized, open-label, noninferiority trial among 1150 adults at risk of aspiration (fasting for <6 hours, bowel occlusion, recent trauma, or severe gastroesophageal reflux) who underwent tracheal intubation in the operating room at 15 hospitals in France from October 2019 to April 2021...
January 3, 2023: JAMA