Teruya Tamaru, Mitsuru Hattori, Yasuharu Ninomiya, Genki Kawamura, Guillaume Varès, Kousuke Honda, Durga Prasad Mishra, Bing Wang, Ivor Benjamin, Paolo Sassone-Corsi, Takeaki Ozawa, Ken Takamatsu
Dysfunction of circadian clocks exacerbates various diseases, in part likely due to impaired stress resistance. It is unclear how circadian clock system responds toward critical stresses, to evoke life-protective adaptation. We identified a reactive oxygen species (ROS), H2O2 -responsive circadian pathway in mammals. Near-lethal doses of ROS-induced critical oxidative stress (cOS) at the branch point of life and death resets circadian clocks, synergistically evoking protective responses for cell survival. The cOS-triggered clock resetting and pro-survival responses are mediated by transcription factor, central clock-regulatory BMAL1 and heat shock stress-responsive (HSR) HSF1...
2013: PloS One