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Acid stress yeast

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https://www.readbyqxmd.com/read/29329458/three-fatty-acyl-coenzyme-a-reductases-bdfar1-bdfar2-and-bdfar3-are-involved-in-primary-alcohols-biosynthesis-of-cuticular-wax-in-brachypodium-distachyon
#1
Yong Wang, Yulin Sun, Qiuye You, Wenqiao Luo, Cong Wang, Shuai Zhao, Guaiqiang Chai, Tingting Li, Xue Shi, Chunlian Li, Reinhard Jetter, Zhonghua Wang
Plant cuticular wax is a heterogeneous mixture of very-long-chain fatty acids (VLCFAs) and their derivatives. Primary alcohols are the dominant wax components throughout leaf development of Brachypodium distachyon (Brachypodium). However, the genes involved in primary alcohols biosynthesis have not been investigated and their exact biological function remains currently unclear in Brachypodium to date. Here, we monitored the leaf wax profile and crystal morphology during Brachypodium leaf morphogenesis, and isolated three Brachypodium fatty acyl-CoA reductase (FAR) genes, named BdFAR1, BdFAR2 and BdFAR3, then analyzed their biochemical activities, substrate specificities, expression patterns, subcellular localization, and stress induction...
January 9, 2018: Plant & Cell Physiology
https://www.readbyqxmd.com/read/29299181/antioxidant-agents-against-trichothecenes-new-hints-for-oxidative-stress-treatment
#2
REVIEW
Qinghua Wu, Xu Wang, Eugenie Nepovimova, Yun Wang, Hualin Yang, Li Li, Xiujuan Zhang, Kamil Kuca
Trichothecenes are a group of mycotoxins mainly produced by fungi of genus Fusarium. Due to high toxicity and widespread dissemination, T-2 toxin and deoxynivalenol (DON) are considered to be the most important compounds of this class. Trichothecenes generate free radicals, including reactive oxygen species (ROS), which induce lipid peroxidation, decrease levels of antioxidant enzymes, and ultimately lead to apoptosis. Consequently, oxidative stress is an active area of research on the toxic mechanisms of trichothecenes, and identification of antioxidant agents that could be used against trichothecenes is crucial for human health...
December 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/29285618/oryza-sativa-salt-induced-ring-e3-ligase-2-ossirp2-acts-as-a-positive-regulator-of-transketolase-in-plant-response-to-salinity-and-osmotic-stress
#3
Sandeep Chapagain, Yong Chan Park, Ju Hee Kim, Cheol Seong Jang
A rice gene (OsSIRP2) encoding the RING Ub E3 ligase was highly induced under salinity stress and physically interacted with a transketolase (OsTKL1). Overexpression of OsSIRP2 conferred salinity and osmotic stress tolerance in plants. The RING E3 ligases play a vital role in post transitional modification through ubiquitination-mediated protein degradation that mediate plants responses during abiotic stresses and signal transduction. In this study, we report an Oryza sativa salt induced Really Interesting New Gene (RING) finger protein 2 gene (OsSIRP2) and elucidate its role under salinity and osmotic stress...
December 28, 2017: Planta
https://www.readbyqxmd.com/read/29247800/de-novo-rna-seq-based-transcriptome-analysis-of-papiliotrema-laurentii-strain-ry1-under-nitrogen-starvation
#4
Soumyadev Sarkar, Somnath Chakravorty, Avishek Mukherjee, Debanjana Bhattacharya, Semantee Bhattacharya, Ratan Gachhui
Nitrogen is a key nutrient for all cell forms. Most organisms respond to nitrogen scarcity by slowing down their growth rate. On the contrary, our previous studies have shown that Papiliotrema laurentii strain RY1 has a robust growth under nitrogen starvation. To understand the global regulation that leads to such an extraordinary response, we undertook a de novo approach for transcriptome analysis of the yeast. Close to 33 million sequence reads of high quality for nitrogen limited and enriched condition were generated using Illumina NextSeq500...
December 13, 2017: Gene
https://www.readbyqxmd.com/read/29242620/protective-role-of-trehalose-during-radiation-and-heavy-metal-stress-in-aureobasidium-subglaciale-f134
#5
Tingting Liu, Liying Zhu, Zhiping Zhang, He Huang, Zhidong Zhang, Ling Jiang
An isolated black yeast-like strain was obtained from radiation-polluted soil collected from Xinjiang province in northwest China. On the basis of ITS and LSU rDNA sequence analysis, in combination with the colony morphology and phenotypic properties, the isolated strain was revealed to represent a novel variety of Aureobasidium subglaciale, designated as A. subglaciale F134. Compared to other yeasts and bacteria, this isolate displayed superior resistance to gamma irradiation, UV light, and heavy metal ions...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29234347/ectopic-expression-of-pumpkin-nac-transcription-factor-cmnac1-improves-multiple-abiotic-stress-tolerance-in-arabidopsis
#6
Haishun Cao, Li Wang, Muhammad A Nawaz, Mengliang Niu, Jingyu Sun, Junjun Xie, Qiusheng Kong, Yuan Huang, Fei Cheng, Zhilong Bie
Drought, cold and salinity are the major environmental stresses that limit agricultural productivity. NAC transcription factors regulate the stress response in plants. Pumpkin (Cucurbita moschata) is an important cucurbit vegetable crop and it has strong resistance to abiotic stress; however, the biological functions of stress-related NAC genes in this crop are largely unknown. This study reports the function of CmNAC1, a stress-responsive pumpkin NAC domain protein. The CmNAC1-GFP fusion protein was transiently expressed in tobacco leaves for subcellular localization analysis, and we found that CmNAC1 is localized in the nucleus...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29230363/genome-wide-identification-of-aba-receptor-pyl-family-and-expression-analysis-of-pyls-in-response-to-aba-and-osmotic-stress-in-gossypium
#7
Gaofeng Zhang, Tingting Lu, Wenwen Miao, Lirong Sun, Mi Tian, Ji Wang, Fushun Hao
Abscisic acid (ABA) receptor pyrabactin resistance1/PYR1-like/regulatory components of ABA receptor (PYR1/PYL/RCAR) (named PYLs for simplicity) are core regulators of ABA signaling, and have been well studied in Arabidopsis and rice. However, knowledge is limited about the PYL family regarding genome organization, gene structure, phylogenesis, gene expression and protein interaction with downstream targets in Gossypium. A comprehensive analysis of the Gossypium PYL family was carried out, and 21, 20, 40 and 39 PYL genes were identified in the genomes from the diploid progenitor G...
2017: PeerJ
https://www.readbyqxmd.com/read/29230001/diacylglycerol-triggers-rim101-pathway-dependent-necrosis-in-yeast-a-model-for-lipotoxicity
#8
Patrick Rockenfeller, Martin Smolnig, Jutta Diessl, Mina Bashir, Vera Schmiedhofer, Oskar Knittelfelder, Julia Ring, Joakim Franz, Ines Foessl, Muhammad J Khan, René Rost, Wolfgang F Graier, Guido Kroemer, Andreas Zimmermann, Didac Carmona-Gutierrez, Tobias Eisenberg, Sabrina Büttner, Stephan J Sigrist, Ronald P Kühnlein, Sepp D Kohlwein, Campbell W Gourlay, Frank Madeo
The loss of lipid homeostasis can lead to lipid overload and is associated with a variety of disease states. However, little is known as to how the disruption of lipid regulation or lipid overload affects cell survival. In this study we investigated how excess diacylglycerol (DG), a cardinal metabolite suspected to mediate lipotoxicity, compromises the survival of yeast cells. We reveal that increased DG achieved by either genetic manipulation or pharmacological administration of 1,2-dioctanoyl-sn-glycerol (DOG) triggers necrotic cell death...
December 11, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29228272/an-investigation-into-the-possible-regulation-of-the-expression-of-genes-by-yapa-in-talaromyces-marneffei-using-the-qrt-pcr-method
#9
Wiyada Dankai, Monsicha Pongpom, Nongnuch Vanittanakom
The pathogenic dimorphic fungus Talaromyces marneffei is known to cause a fatal systemic mycosis in immunocompromised patients, especially in HIV patients in Southeast Asia. The basic leucine-zipper (bZip) transcription factor gene, yapA, has been identified in T. marneffei. A prior study described that yapA was involved in the oxidative and nitrosative stress response in T. marneffei. Interestingly, an essential role of Saccharomyces cerevisiae Yap1p in the oxidative stress response is the activation of the transcription of its target genes...
December 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29227949/a-cbl-interacting-protein-kinase-tacipk27-confers-drought-tolerance-and-exogenous-aba-sensitivity-in-transgenic-arabidopsis
#10
Yan Wang, Tingting Li, Shanita Judith John, Mingjie Chen, Junli Chang, Guangxiao Yang, Guangyuan He
Drought is one of the major environmental stresses to plants. The calcium sensor, calcineurin B-like (CBL) proteins, and their interacting protein kinases (CIPK) play important roles in responding to abiotic stresses. In this study, we functionally characterized a CIPK gene from Triticum aestivum designated TaCIPK27. The transcriptional levels of TaCIPK27 were increased both in roots and leaves after treatment with polyethylene glycol 8000, abscisic acid and H2O2. Besides, TaCIPK27 interacted with AtCBL1, AtCBL3, AtCBL4, AtCBL5 and AtCBL9 in yeast two-hybrid assays...
December 1, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29224051/quercetin-protects-yeast-saccharomyces-cerevisiae-pep4-mutant-from-oxidative-and-apoptotic-stress-and-extends-chronological-lifespan
#11
Phaniendra Alugoju, Sudharshan Setra Janardhanshetty, Subasri Subaramanian, Latha Periyasamy, Madhu Dyavaiah
The yeast Saccharomyces cerevisiae PEP4 gene encodes vacuolar endopeptidase proteinase A (Pep4p), which is a homolog of the human CTSD gene that encodes cathepsin D. Mutation of CTSD gene in human resulted in a number of neurodegenerative diseases. In this study, we have shown that yeast pep4 mutant cells are highly sensitive to oxidative and apoptotic stress induced by hydrogen peroxide and acetic acid, respectively. pep4∆ cells also showed accumulation of reactive oxygen species (ROS), apoptotic markers, and reduced chronological lifespan...
December 9, 2017: Current Microbiology
https://www.readbyqxmd.com/read/29209456/novel-glutathione-containing-dry-yeast-extracts-inhibit-eosinophilia-and-mucus-overproduction-in-a-murine-model-of-asthma
#12
Yun-Ho Kim, Yean-Jung Choi, Eun-Jung Lee, Min-Kyung Kang, Sin-Hye Park, Dong Yeon Kim, Hyeongjoo Oh, Sang-Jae Park, Young-Hee Kang
BACKGROUND/OBSECTIVE: Airway inflammation by eosinophils, neutrophils and alveolar macrophages is a characteristic feature of asthma that leads to pathological subepithelial thickening and remodeling. Our previous study showed that oxidative stress in airways resulted in eosinophilia and epithelial apoptosis. The current study investigated whether glutathione-containing dry yeast extract (dry-YE) ameliorated eosinophilia, goblet cell hyperplasia and mucus overproduction. MATERIALS/METHOD: This study employed 2 µg/mL lipopolysaccharide (LPS)- or 20 ng/mL eotaxin-1-exposed human bronchial epithelial cells and ovalbumin (OVA)-challenged mice...
December 2017: Nutrition Research and Practice
https://www.readbyqxmd.com/read/29196872/seleno-compounds-and-carnosic-acid-added-to-diets-with-rapeseed-and-fish-oils-affect-concentrations-of-selected-elements-and-chemical-composition-in-the-liver-heart-and-muscles-of-lambs
#13
Marian Czauderna, Anna Ruszczyńska, Ewa Bulska, Katarzyna Agnieszka Krajewska
The objective of our studies was to investigate effects of carnosic acid (CA), selenized yeast (SeY) and selenate (SeVI) added to the diet including rapeseed oil (RO) and fish oil (FO) on concentrations of elements, fatty acids (FAs), tocopherols, cholesterol, and malondialdehyde in the liver, heart, musculus longissimus dorsi (MLD), and musculus biceps femoris (MBF) of lambs. Lambs were fed diets: group I-the basal diet (BD) with RO; group II-BD with RO and FO; group III-BD with RO, FO, and CA; group IV-BD with RO, FO, CA, and SeY; group V-BD with RO, FO, CA, and SeVI...
December 2, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/29187516/amyloid-like-%C3%AE-aggregates-as-force-sensitive-switches-in-fungal-biofilms-and-infections
#14
REVIEW
Peter N Lipke, Stephen A Klotz, Yves F Dufrene, Desmond N Jackson, Melissa C Garcia-Sherman
Cellular aggregation is an essential step in the formation of biofilms, which promote fungal survival and persistence in hosts. In many of the known yeast cell adhesion proteins, there are amino acid sequences predicted to form amyloid-like β-aggregates. These sequences mediate amyloid formation in vitro. In vivo, these sequences mediate a phase transition from a disordered state to a partially ordered state to create patches of adhesins on the cell surface. These β-aggregated protein patches are called adhesin nanodomains, and their presence greatly increases and strengthens cell-cell interactions in fungal cell aggregation...
March 2018: Microbiology and Molecular Biology Reviews: MMBR
https://www.readbyqxmd.com/read/29176648/evidence-for-pii-with-nagk-interaction-that-regulates-arg-synthesis-in-the-microalga-myrmecia-incisa-in-response-to-nitrogen-starvation
#15
Yan Li, Wei Liu, Li-Ping Sun, Zhi-Gang Zhou
To understand why most eukaryotic microalgae accumulate lipids during nitrogen starvation stress, a gene, MiglnB, encoding PII, a signal transduction protein, was cloned from the arachidonic acid-rich microalga Myrmecia incisa Reisigl. Similarly to its homologues, MiPII contains three conserved T-, B-, and C-loops. In the presence of abundant Mg2+, ATP, and Gln, MiPII upregulates Arg biosynthesis by interacting with the rate-limiting enzyme, MiNAGK, as evidenced by yeast two-hybrid, co-immunoprecipitation assays, and kinetics analysis of enzyme-catalyzed reactions...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29175998/structural-determinants-for-protein-unfolding-and-translocation-by-the-hsp104-protein-disaggregase
#16
Jungsoon Lee, Nuri Sung, Lythou Yeo, Changsoo Chang, Sukyeong Lee, Francis T F Tsai
The ring-forming Hsp104 ATPase cooperates with Hsp70 and Hsp40 molecular chaperones to rescue stress-damaged proteins from both amorphous and amyloid-forming aggregates. The ability to do so relies upon pore loops present in the ATP-binding domains of Hsp104 (loop-1 and loop-2 in AAA-1, and loop-3 in AAA-2), which face the protein translocating channel and couple ATP-driven changes in pore loop conformation to substrate translocation. A hallmark of loop-1 and loop-3 is an invariable and mutational sensitive aromatic amino acid (Tyr257 and Tyr662) involved in substrate binding...
November 24, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/29162040/cloning-and-expression-of-bpmyc4-and-bpbhlh9-genes-and-the-role-of-bpbhlh9-in-triterpenoid-synthesis-in-birch
#17
Jing Yin, Xin Li, Yaguang Zhan, Ying Li, Ziyue Qu, Lu Sun, Siyao Wang, Jie Yang, Jialei Xiao
BACKGROUND: Birch (Betula platyphylla Suk.) contains triterpenoids with anti-HIV and anti-tumor pharmacological activities. However, the natural abundance of these triterpenoids is low, and their chemical synthesis is costly. Transcription factors have the ability to regulate the metabolite pathways of triterpenoids via multi-gene control, thereby improving metabolite yield. Thus, transcription factors have the potential to facilitate the production of birch triterpenoids. Plant bHLH (basic helix-loop-helix) transcription factors play important roles in stress response and secondary metabolism...
November 21, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/29158977/the-sensitivity-of-the-yeast-saccharomyces-cerevisiae-to-acetic-acid-is-influenced-by-dom34-and-rpl36a
#18
Bahram Samanfar, Kristina Shostak, Houman Moteshareie, Maryam Hajikarimlou, Sarah Shaikho, Katayoun Omidi, Mohsen Hooshyar, Daniel Burnside, Imelda Galván Márquez, Tom Kazmirchuk, Thet Naing, Paula Ludovico, Anna York-Lyon, Kama Szereszewski, Cindy Leung, Jennifer Yixin Jin, Rami Megarbane, Myron L Smith, Mohan Babu, Martin Holcik, Ashkan Golshani
The presence of acetic acid during industrial alcohol fermentation reduces the yield of fermentation by imposing additional stress on the yeast cells. The biology of cellular responses to stress has been a subject of vigorous investigations. Although much has been learned, details of some of these responses remain poorly understood. Members of heat shock chaperone HSP proteins have been linked to acetic acid and heat shock stress responses in yeast. Both acetic acid and heat shock have been identified to trigger different cellular responses including reduction of global protein synthesis and induction of programmed cell death...
2017: PeerJ
https://www.readbyqxmd.com/read/29158332/ethylene-receptors-signal-via-a-non-canonical-pathway-to-regulate-abscisic-acid-responses
#19
Arkadipta Bakshi, Sarbottam Piya, Jessica C Fernandez, Christian Chervin, Tarek Hewezi, Brad Binder
Ethylene is a gaseous plant hormone perceived by a family of receptors in Arabidopsis thaliana including ETHYLENE RESPONSE1 (ETR1) and ETR2. Previously we showed that etr1-6 loss-of-function plants germinate better and etr2-3 loss-of-function plants germinate worse than wild-type under NaCl stress and in response to abscisic acid (ABA). In this study, we expanded these results by showing that ETR1 and ETR2 have contrasting roles in the control of germination under a variety of inhibitory conditions for seed germination such as treatment with KCl, CuSO4, ZnSO4, and ethanol...
November 20, 2017: Plant Physiology
https://www.readbyqxmd.com/read/29157199/characterization-of-wheat-myb-genes-responsive-to-high-temperatures
#20
Yue Zhao, Xuejun Tian, Fei Wang, Liyuan Zhang, Mingming Xin, Zhaorong Hu, Yingyin Yao, Zhongfu Ni, Qixin Sun, Huiru Peng
BACKGROUND: Heat stress is one of the most crucial environmental factors, which reduces crop yield worldwide. In plants, the MYB family is one of the largest families of transcription factors (TFs). Although some wheat stress-related MYB TFs have been characterized, their involvement in response to high-temperature stress has not been properly studied. RESULTS: Six novel heat-induced MYB genes were identified by comparison with previously established de novo transcriptome sequencing data obtained from wheat plants subjected to heat treatment; genomic and complete coding sequences of these genes were isolated...
November 21, 2017: BMC Plant Biology
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