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Gastric bypass diabetes mellitus type 2

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https://www.readbyqxmd.com/read/27921048/surgical-treatment-of-metabolic-syndrome
#1
REVIEW
Norbert Runkel, Rainer Brydniak
BACKGROUND: Bariatric surgery is gastrointestinal surgery for weight control, and metabolic surgery refers to the use of surgery to primarily and purposely treat type 2 diabetes mellitus (T2DM)/metabolic syndrome mellitus. METHODS: The most recent literature was reviewed for surgery and T2DM in a non-systematic fashion. RESULTS: Roux-Y gastric bypass, biliopancreatic diversion with duodenal switch, and sleeve gastrectomy (SG) are the dominant procedures today...
October 2016: Visceral Medicine
https://www.readbyqxmd.com/read/27899816/bariatric-surgery-for-obesity-and-metabolic-disorders-state-of-the-art
#2
REVIEW
Ninh T Nguyen, J Esteban Varela
Obesity is one of the most important public health conditions worldwide. Bariatric surgery for severe obesity is an effective treatment that results in the improvement and remission of many obesity-related comorbidities, as well as providing sustained weight loss and improvement in quality of life. Contemporary bariatric operations include Roux-en-Y gastric bypass, sleeve gastrectomy, adjustable gastric band and the duodenal switch. The vast majority of these procedures are now performed using laparoscopic technique, the main advantages of which include rapid recovery, the reduction of postoperative pain and the reduction of wound-related complications, compared with open surgery...
November 30, 2016: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27867860/laparoscopic-sleeve-gastrectomy-for-the-treatment-of-diabetes-mellitus-type-2-patients-single-center-early-experience
#3
Piotr Major, Michal Wysocki, Michał Pędziwiatr, Piotr Małczak, Magdalena Pisarska, Andrzej Budzyński
BACKGROUND: In recent years, laparoscopic sleeve gastrectomy (LSG) has become one of the most commonly used primary bariatric procedures for morbid obesity. While laparoscopic Roux-en-Y gastric bypass (LRYGB) has well documented positive clinical influence on type 2 diabetes, the role of LSG in diabetes treatment is debatable. The main aim of this study is to present our early experience in LSG as a method of bariatric treatment in patients with type 2 diabetes or abnormalities in glucose homeostasis...
October 2016: Gland Surgery
https://www.readbyqxmd.com/read/27867859/new-endoscopic-procedures-for-diabetes-mellitus-type-2-and-obesity-treatment
#4
Francesco Frattini, Giacomo Borroni, Matteo Lavazza, Xiaoli Liu, Hoon Yub Kim, Renbin Liu, Angkoon Anuwong, Stefano Rausei, Gianlorenzo Dionigi
BACKGROUND: Obesity continues to be a growing epidemic worldwide. Obese patients have severe comorbidities that make risky and technically demanding the execution of bariatric surgery from both surgical and anesthetic point of view; therefore, the focus of bariatric surgeons is increasingly moving towards minimally invasive, endoscopic techniques. METHODS: The present review presents and discusses recent endoscopic techniques employed in obesity treatment, their features and results...
October 2016: Gland Surgery
https://www.readbyqxmd.com/read/27864670/relationship-between-vitamin-d-deficiency-and-the-components-of-metabolic-syndrome-in-patients-with-morbid-obesity-before-and-1%C3%A2-year-after-laparoscopic-roux-en-y-gastric-bypass-or-sleeve-gastrectomy
#5
Ana Obispo Entrenas, David Legupin Tubio, Fabiola Lucena Navarro, Francisco Martin Carvajal, Norberto Gandara Adan, Maximino Redondo Bautista, Jimena Abiles Osinaga
BACKGROUND: Vitamin D deficiency (VDD) is associated with obesity and metabolic syndrome (MS). After bariatric surgery (BS), high rates of VDD often persist and some patients are refractory to the resolution of comorbidities. The aim of the present study is to analyse the relationship between the levels of vitamin D and the persistence of MS components at 12 months after BS, according to the surgical technique used. METHODS: We performed a retrospective study of 46 patients undergoing BS: 23 underwent laparoscopic Roux-en-Y gastric bypass (LRYGBP) and 23 laparoscopic sleeve gastrectomy (LSG)...
November 18, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27842762/-evolution-of-type-2-diabetes-and-carbohydrate-intolerance-following-bariatric-surgery-in-a-mexican-mestizo-population
#6
Eva Ramírez-Avilés, Omar Espinosa-González, Mónica Amado-Galván, Hernán Maydón-González, Elisa Sepúlveda-Guerrero, Carlos Zerrweck-López
BACKGROUND: Bariatric surgery continues to be the best treatment for weight loss and control of obesity related comorbidities. Gastric bypass and sleeve gastrectomy have demonstrated to be the most effective surgeries, but this has not been established in a Mexican (non-American) population. OBJECTIVE: To analyse the improvement in type 2 diabetes mellitus and carbohydrate intolerance in obese patients after bariatric surgery. MATERIAL AND METHODS: A retrospective analysis was performed on the data collected prospectively between 2013 and 2015 on every obese patient with diabetes and carbohydrate intolerance submitted for bariatric surgery...
November 11, 2016: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/27834300/the-surmetagit-study-design-and-rationale-for-a-prospective-pan-omics-examination-of-the-gastrointestinal-response-to-roux-en-y-gastric-bypass-surgery
#7
Priscila Sala, Giliane Belarmino, Natasha Mendonça Machado, Camila Siqueira Cardinelli, Karina Al Assal, Mariane Marques Silva, Danielle Cristina Fonseca, Robson Kiyoshi Ishida, Marco Aurélio Santo, Eduardo Guimarães Hourneaux de Moura, Paulo Sakai, Ismael Francisco Mota Siqueira Guarda, Ismael Dale Cotrim Guerreiro da Silva, Agatha Sacramento Rodrigues, Carlos Alberto de Bragança Pereira, Steven Heymsfield, Joel Doré, Raquel Susana Matos de Miranda Torrinhas, Daniel Giannella-Neto, Dan Linetzky Waitzberg
OBJECTIVE: To describe the protocol of the SURgically induced Metabolic effects on the Human GastroIntestinal Tract (SURMetaGIT) study, a clinical pan-omics study exploring the gastrointestinal tract as a central organ driving remission of type 2 diabetes mellitus (T2DM) after Roux-en-Y gastric bypass (RYGB). The main points considered in the study's design and challenges faced in its application are detailed. METHODS: This observational, longitudinal, prospective study involved collection of gastrointestinal biopsy specimens, faeces, urine, and blood from 25 obese women with T2DM who were candidates for RYGB (20 patients for omics assessment and 5 for omics validation)...
November 10, 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/27829412/gastric-bypass-surgery-reveals-independency-of-obesity-and-diabetes-melitus-type-2
#8
Mogens Fenger, Dorte Lindqvist Hansen, Dorte Worm, Lisbeth Hvolris, Viggo B Kristiansen, Elin Rebecka Carlsson, Sten Madsbad
BACKGROUND: Roux-en-Y gastric bypass surgery is widely applied to ameliorate morbid obesity, including diabetes in people with type 2 diabetes. The latter vanish a few days after surgery for many, but not in all patients before any weight reduction has occurred. The explanation for this change in metabolic status is poorly understood, but the observation may suggest that the fate obesity and diabetes is only partly linked after surgery. METHODS: The trajectories of weight reduction measured as reduced body mass index (BMI) in 741obese subjects with and without diabetes were evaluated...
November 9, 2016: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/27783367/national-differences-in-remission-of-type-2-diabetes-mellitus-after-roux-en-y-gastric-bypass-surgery-subgroup-analysis-of-2-year-results-of-the-diabetes-surgery-study-comparing-taiwanese-with-americans-with-mild-obesity-bmi-30-35%C3%A2-kg-m-2
#9
Keong Chong, Sayeed Ikramuddin, Wei-Jei Lee, Charles J Billington, John P Bantle, Qi Wang, Avis J Thomas, John E Connett, Daniel B Leslie, William B Inabnet, Robert W Jeffery, Michael G Sarr, Michael D Jensen, Adrian Vella, Leaque Ahmed, Kumar Belani, Joyce L Schone, Amy E Olofson, Heather A Bainbridge, Patricia S Laqua, Judith Korner, Lee-Ming Chuang
BACKGROUND: The purpose of this study is to compare effects of different nations on Roux-en-Y gastric bypass (RYGB) vs. intensive medical management (IMM) in achieving remission of type 2 diabetes mellitus (T2DM). MATERIALS AND METHODS: Between April 2008 and December 2011, this randomized, controlled clinical trial was conducted at four teaching hospitals in the United States and Taiwan involving 71 participants with mild obesity (BMI 30-35 kg/m(2)). Thirty-six of 71 participants were randomly assigned to the RYGB group, and the others were in IMM group...
October 25, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27778252/successful-treatment-of-an-unusual-case-of-fpld2-the-role-of-roux-en-y-gastric-bypass-case-report-and-literature-review
#10
Sharon Grundfest-Broniatowski, JingLiang Yan, Matthew Kroh, Holly Kilim, Andrew Stephenson
Familial partial lipodystrophy type 2 (FPLD2) is a rare disorder associated with LMNA gene mutations. It is usually marked by loss of subcutaneous fat on the limbs and trunk and severe insulin resistance. Scattered reports have indicated that Roux-en-Y bypass helps to control the diabetes mellitus in these patients. We present here a very unusual patient with FPLD2 who had life-threatening retroperitoneal and renal fat accumulation accompanied by bilateral renal cancers. Following cryotherapy of one renal cancer and a contralateral nephrectomy with debulking of the retroperitoneal fat, Roux-en-Y gastric bypass (RYGB) has successfully controlled the disease for 3 years...
October 24, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27720197/long-term-and-midterm-outcomes-of-laparoscopic-sleeve-gastrectomy-versus-roux-en-y-gastric-bypass-a-systematic-review-and-meta-analysis-of-comparative-studies
#11
Saeed Shoar, Alan A Saber
OBJECTIVE: This study aimed to compare midterm and long-term weight loss and resolution of co-morbidity with laparoscopic Roux-en-Y gastric bypass (LRYGB) and laparoscopic sleeve gastrectomy (LSG). SUMMARY: LRYGB and LSG are the most common procedures performed in bariatric surgery. However, their weight loss efficacy in the midterm and long-term has not been well compared. METHODS: A meta-analysis was performed by systematically identifying comparative studies conducted until the end of June 2016 that investigated weight loss outcome and resolution of co-morbidities (type 2 diabetes mellitus, hypertension, hyperlipidemia, hypertriglyceridemia, and obstructive sleep apnea) with LRYGB and LSG in the midterm (3-5 years) and long term (≥5 years)...
August 18, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/27720195/can-low-bmi-chinese-patients-with-type-2-diabetes-benefit-from-laparoscopic-roux-en-y-gastric-bypass-surgery
#12
Guohui Wang, Liyong Zhu, Weizheng Li, Xiangwu Yang, Pengzhou Li, Shaihong Zhu
BACKGROUND: The efficacy of laparoscopic Roux-en-Y gastric bypass (LRYGB) in type 2 diabetes mellitus (T2D) is closely associated with the preoperative body mass index (BMI) of the patient. There is a lack of long-term and large sampling evidence on the efficacy of LRYGB in T2D patients with low BMI in China. OBJECTIVES: This retrospective study aimed to evaluate the efficacy of surgical treatment in a Chinese population with T2D (especially patients with BMI<27...
July 12, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/27683788/the-role-of-metabolic-surgery-for-patients-with-obesity-grade-i-and-type-2-diabetes-not-controlled-clinically
#13
Josemberg Campos, Almino Ramos, Thomaz Szego, Bruno Zilberstein, Heládio Feitosa, Ricardo Cohen
Introduction: Even considering the advance of the medical treatment in the last 20 years with new and more effective drugs, the outcomes are still disappointing as the control of obesity and type 2 Diabetes Mellitus (T2DM) with a large number of patients under the medical treatment still not reaching the desired outcomes. Objective: To present a Metabolic Risk Score to better guide the surgical indication for T2DM patients with body mass index (BMI) where surgery for obesity is still controversial...
2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/27683769/effects-of-long-term-roux-en-y-gastric-bypass-on-body-weight-and-clinical-metabolic-comorbidities-in-bariatric-surgery-service-of-a-university-hospital
#14
Cátia Ferreira da Silva, Larissa Cohen, Luciana d'Abreu Sarmento, Felipe Monnerat Marino Rosa, Eliane Lopes Rosado, João Régis Ivar Carneiro, Antônio Augusto Peixoto de Souza, Fernanda Cristina Carvalho Mattos Magno
Background: Due to the high failure rate observed in the clinical treatment of morbid obesity an increase in bariatric surgery indications, as an alternative for the control of obesity and comorbidities, is noticeable. Aim: To evaluate the performance of type 2 diabetes mellitus, high blood pressure and dyslipidemia in patients submitted to Roux-en-Y gastric bypass in late follow-up. Methods: Retrospective analysis of 59 patients included in the bariatric surgery program...
2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/27671525/physiological-and-molecular-responses-to-bariatric-surgery-markers-or-mechanisms-underlying-t2dm-resolution
#15
Chelsea R Hutch, Darleen A Sandoval
Bariatric surgery is currently the most effective treatment for obesity and associated comorbidities, including rapid resolution of type 2 diabetes mellitus (T2DM). Although the weight loss itself has substantial impact, bariatric surgery also has weight loss-independent effects on T2DM. Several variations of bariatric surgery exist, including the widely studied Roux-en-Y gastric bypass and vertical sleeve gastrectomy. The success of both of these bariatric surgeries was originally attributed to restrictive and malabsorptive modes of action; however, mounting evidence from both human and animal studies implicates mechanisms beyond surgery-induced mechanical changes to the gastrointestinal (GI) system...
September 26, 2016: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/27644433/five-year-results-of-laparoscopic-sleeve-gastrectomy-with-duodenojejunal-bypass-for-weight-loss-and-type-2-diabetes-mellitus
#16
Yosuke Seki, Kazunori Kasama, Hidenori Haruta, Atsushi Watanabe, Renzo Yokoyama, Jose Paolo Cabreira Porciuncula, Akiko Umezawa, Yoshimochi Kurokawa
BACKGROUND: Laparoscopic sleeve gastrectomy with duodenojejunal bypass (LSG-DJB) has been designated as a novel bariatric surgery procedure. This combination of sleeve gastrectomy and proximal intestinal bypass theoretically offers an effective and prolonged anti-diabetes effect. This is a follow-up of our institution's previous report on the short-term effects of LSG-DJB on type 2 diabetes mellitus (T2DM), which a 68.7 % remission (HbA1c <6 % without diabetes medication) rate 1 year after surgery...
September 19, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27642058/home-parenteral-nutrition-hpn-in-patients-with-post-bariatric-surgery-complications
#17
A Van Gossum, L Pironi, C Chambrier, M Dreesen, C F Brandt, L Santarpia, F Joly
BACKGROUND & AIMS: Obesity is a worldwide health problem. Bariatric surgery (BS) is becoming one of the most commonly used methods for fighting obesity and its associated comorbidities. However, current BS techniques can be associated with early or late complications that may require nutritional support. The aim of this retrospective observational study was to determine the indications and outcomes for patients on Home parenteral nutrition (HPN) due to post-bariatric surgery complications...
September 8, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27631329/long-term-outcomes-of-bariatric-and-metabolic-surgery-in-japan-results-of-a-multi-institutional-survey
#18
Hidenori Haruta, Kazunori Kasama, Masayuki Ohta, Akira Sasaki, Hiroshi Yamamoto, Yasuhiro Miyazaki, Takashi Oshiro, Takeshi Naitoh, Yoshinori Hosoya, Takeshi Togawa, Yosuke Seki, Alan Kawarai Lefor, Toru Tani
BACKGROUND: The number of bariatric procedures performed in Japan is increasing. There are isolated reports of bariatric surgery, but there have been no nationwide surveys including long-term data. METHODS: We retrospectively reviewed data for patients who underwent bariatric and metabolic surgery throughout Japan and reviewed outcomes. Surveys were sent to ten institutions for number of procedures, preoperative patient weight and preoperative obesity-related comorbidities, and data at 1, 3, and 5 years postoperatively...
September 8, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27613192/limitations-of-the-diarem-score-in-predicting-remission-of-diabetes-following-roux-en-y-gastric-bypass-rygb-in-an-ethnically-diverse-population-from-a-single-institution-in-the-uk
#19
George Tharakan, Rebecca Scott, Olivia Szepietowski, Alexander D Miras, Alexandra I Blakemore, Sanjay Purkayastha, Ahmed Ahmed, Harvinder Chahal, Tricia Tan
PURPOSE: This study aimed to determine the predictive power of the DiaRem score following Roux-en-Y gastric bypass to identify patients who would have diabetes remission at 1 year in an ethnically diverse population. METHODS: We performed a retrospective review of 262 patients with type 2 diabetes mellitus who underwent RYGB at the Imperial Weight Centre, UK, from 2007 to 2014. Data was collected on the parameters required to calculate the DiaRem score as well as pre- and post-surgical weight and the ethnicity of the subjects...
September 10, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27589345/beneficial-metabolic-effects-of-duodenal-jejunal-bypass-liner-for-the-treatment-of-adipose-patients-with-type-2-diabetes-mellitus-analysis-of-responders-and-non-responders
#20
B Stratmann, Y Krepak, E Schiffer, I Jarick, M Hauber, Y H Lee-Barkey, M Fischer, D Tschoepe
Implantation of a duodenal-jejunal endoluminal bypass liner (DJBL) has shown to induce weight loss and to improve metabolic parameters. DJBL is a reversible endoduodenal sleeve mimicking duodenal bypass while lacking risks and limitations of bariatric surgery.Effects on metabolic control, body mass parameters, appetite regulation, glucose tolerance, organ health, and lipid profile were determined in 16 morbidly overweight patients with type 2 diabetes mellitus. In addition, relevant hormones (leptin, ghrelin, gastric inhibitory peptide, glucagon-like peptide, and insulin) were measured by enzyme-linked immunosorbent assay (ELISA) and chemiluminescent microparticle immunoassay (CMIA) at 0, 1, 32, and 52 weeks post-implant following a mixed meal tolerance test...
September 2016: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
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