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https://www.readbyqxmd.com/read/29786840/spray-drying-of-milk-blackberry-pulp-mixture-effect-of-carrier-agent-on-the-physical-properties-of-powder-water-sorption-and-glass-transition-temperature
#1
Matheus Boeira Braga, Sandra Cristina Dos Santos Rocha, Miriam Dupas Hubinger
Spray dryer was used to produce particles from a milk-blackberry pulp mixture (25%:75% (w/w)). Maltodextrin 10DE and 20DE and gum Arabic were used as adjuvants in order to improve powder quality. The particles were analyzed with emphasis on physical and physicochemical characteristics: moisture content, bulk density, particle size, morphology, water activity, anthocyanins retention, anthocyanins content, hygroscopicity, solubility, water sorption, and glass transition temperature. The best results were obtained for the paste composition of 25% concentrated milk-70% blackberry pulp-5% gum Arabic, yielding high anthocyanins retention (>87...
May 22, 2018: Journal of Food Science
https://www.readbyqxmd.com/read/29786828/oral-contraceptives-for-pain-associated-with-endometriosis
#2
REVIEW
Julie Brown, Tineke J Crawford, Shree Datta, Andrew Prentice
BACKGROUND: Endometriosis is a common gynaecological condition which affects many women of reproductive age worldwide and is a major cause of pain and infertility. The combined oral contraceptive pill (COCP) is widely used to treat pain occurring as a result of endometriosis, although the evidence for its efficacy is limited. OBJECTIVES: To determine the effectiveness, safety and cost-effectiveness of oral contraceptive preparations in the treatment of painful symptoms ascribed to the diagnosis of laparoscopically proven endometriosis...
May 22, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29786682/-the-implementation-of-the-method-of-enhanced-external-counter-pulsation-for-the-treatment-of-cardiovascular-diseases
#3
V A Badtieva, D N Voroshilova
The cardiovascular diseases occupy a leading place in the structure of overall morbidity affecting the population not only of Russia but also of the majority of the developed countries throughout the world; they thus impose the heavy social and economic burden on both the public healthcare services and the modern society in general. At the same time, systemic atherosclerosis is considered to be one of the most common, severe, and life-threatening condition. Despite the presence of a large number of pharmaceutical and surgical methods for the treatment of this pathology, they are not infrequently lacking the desired effectiveness...
May 21, 2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29786562/application-of-hepatocyte-like-cells-to-enhance-hepatic-safety-risk-assessment-in-drug-discovery
#4
REVIEW
Dominic P Williams
Hepatic stress and injury from drugs continues to be a major concern within the pharmaceutical industry, leading to preclinical and clinical attrition precautionary warnings and post-market withdrawal of drugs. There is a requirement for more predictive and mechanistically accurate models to aid risk assessment. Primary human hepatocytes, subject to isolation stress, cryopreservation, donor-to-donor variation and a relatively short period of functional capability in two-dimensional cultures, are not suitable for high-throughput screening procedures...
July 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29785806/chemiluminescence-of-copper-nanoclusters-and-its-application-for-trihexyphenidyl-hydrochloride-detection
#5
Xiaoxia Chen, Junmei Zhang, Yue Li, Suqin Han
Chemiluminescence (CL) of copper nanoclusters (CuNCs) induced by cerium (IV) (Ce(IV)) or potassium permanganate (KMnO4 ) in acidic medium was observed. The potential application of CuNCs CL in analytical chemistry was also demonstrated using trihexyphenidyl hydrochloride (THP) as an example based on its enhancing CL intensity for the CuNCs-Ce(IV)/KMnO4 systems. The excited state of the CuNCs acted as a luminophore in the CuNCs-Ce(IV) system, while CuNCs played the role of reductant in the CuNCs-KMnO4 system...
May 21, 2018: Luminescence: the Journal of Biological and Chemical Luminescence
https://www.readbyqxmd.com/read/29785774/thymol-thyme-and-other-plant-sources-health-and-potential-uses
#6
REVIEW
Bahare Salehi, Abhay Prakash Mishra, Ila Shukla, Mehdi Sharifi-Rad, María Del Mar Contreras, Antonio Segura-Carretero, Hannane Fathi, Nafiseh Nasri Nasrabadi, Farzad Kobarfard, Javad Sharifi-Rad
Thymol is a naturally occurring phenol monoterpene derivative of cymene and isomer of carvacrol. Thymol (10-64%) is one of the major constituent of essential oils of thyme (Thymus vulgaris L., Lamiaceae), a medicinal plant with several therapeutic properties. This plant, native to Mediterranean regions, is commonly used as a culinary herb and also with a long history of use for different medicinal purposes. Nowadays, thymol and thyme present a wide range of functional possibilities in pharmacy, food, and cosmetic industry...
May 22, 2018: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29785728/ultrafast-capillary-electrophoresis-method-for-the-simultaneous-determination-of-ammonium-and-diphenhydramine-in-pharmaceutical-samples
#7
Brenda M C Costa, Mariana C Marra, Thiago C Oliveira, Rodrigo A A Munoz, Alex D Batista, Claudimir L do Lago, Eduardo M Richter
Ammonium and diphenhydramine are active ingredients commonly found in the same pharmaceutical preparations. We report for the first time a sub-minute method for the simultaneous determination of ammonium and diphenhydramine. The method is based on capillary electrophoresis with capacitively coupled contactless conductivity detection. Both analytes can be quantified in a single run (∼80 injections h-1 ) using 30 mmol L-1 2-(N-morpholino)ethanesulfonic acid and 15 mmol L-1 lithium hydroxide (pH = 6.0) as a background electrolyte...
May 22, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29785613/neuroinfections-caused-by-fungi
#8
REVIEW
Katarzyna Góralska, Joanna Blaszkowska, Magdalena Dzikowiec
BACKGROUND: Fungal infections of the central nervous system (FIs-CNS) have become significantly more common over the past 2 decades. Invasion of the CNS largely depends on the immune status of the host and the virulence of the fungal strain. Infections with fungi cause a significant morbidity in immunocompromised hosts, and the involvement of the CNS may lead to fatal consequences. METHODS: One hundred and thirty-five articles on fungal neuroinfection in PubMed, Google Scholar, and Cochrane databases were selected for review using the following search words: "fungi and CNS mycoses", CNS fungal infections", "fungal brain infections", " fungal cerebritis", fungal meningitis", "diagnostics of fungal infections", and "treatment of CNS fungal infections"...
May 21, 2018: Infection
https://www.readbyqxmd.com/read/29785231/advantages-of-evaluating-%C3%AE-h2ax-induction-in-non-clinical-drug-development
#9
REVIEW
Shigeki Motoyama, Akira Takeiri, Kenji Tanaka, Asako Harada, Kaori Matsuzaki, Junko Taketo, Saori Matsuo, Etsuko Fujii, Masayuki Mishima
γH2AX, the phosphorylated form of a histone variant H2AX at Ser 139, is already widely used as a biomarker to research the fundamental biology of DNA damage and repair and to assess the risk of environmental chemicals, pollutants, radiation, and so on. It is also beginning to be used in the early non-clinical stage of pharmaceutical drug development as an in vitro tool for screening and for mechanistic studies on genotoxicity. Here, we review the available information on γH2AX-based test systems that can be used to develop drugs and present our own experience of practically applying these systems during the non-clinical phase of drug development...
2018: Genes and Environment: the Official Journal of the Japanese Environmental Mutagen Society
https://www.readbyqxmd.com/read/29785057/computational-redesign-of-enzymes-for-regio-and-enantioselective-hydroamination
#10
Ruifeng Li, Hein J Wijma, Lu Song, Yinglu Cui, Marleen Otzen, Yu'e Tian, Jiawei Du, Tao Li, Dingding Niu, Yanchun Chen, Jing Feng, Jian Han, Hao Chen, Yong Tao, Dick B Janssen, Bian Wu
Introduction of innovative biocatalytic processes offers great promise for applications in green chemistry. However, owing to limited catalytic performance, the enzymes harvested from nature's biodiversity often need to be improved for their desired functions by time-consuming iterative rounds of laboratory evolution. Here we describe the use of structure-based computational enzyme design to convert Bacillus sp. YM55-1 aspartase, an enzyme with a very narrow substrate scope, to a set of complementary hydroamination biocatalysts...
May 21, 2018: Nature Chemical Biology
https://www.readbyqxmd.com/read/29784465/-proper-use-of-fluoroquinolones-in-hospitalized-elderly-patients-realisation-of-a-clinical-audit-in-geriatric-hospitals-of-lyon-university-hospital
#11
C Papailhau, S Gaujard, R Girard, L Bourguignon, C Mouchoux
INTRODUCTION: Fluoroquinolones (FQ) are widely used because of their broad spectrum and their ease of use, especially in the elderly. Nevertheless, their misuse is behind the development and the emergence of bacterial resistances. The objective of this study was to evaluate the compliance of FQ prescriptions in the elderly hospitalized, before and after pharmaceutical interventions (PI). METHODS: A prospective clinical audit was conducted for three months in three geriatric hospitals...
May 18, 2018: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/29784415/statistical-analysis-of-the-chemical-attribution-signatures-of-3-methylfentanyl-and-its-methods-of-production
#12
Brian P Mayer, Carlos A Valdez, Alan J DeHope, Paul E Spackman, Audrey M Williams
Chemical attribution of the origin of an illegal drug is a key component of forensic efforts aimed at combating illicit and clandestine manufacture of drugs and pharmaceuticals. The results of these studies yield detailed information on synthesis byproducts, reagents, and precursors that can be used to identify the method of manufacture. In the present work, chemical attribution signatures (CAS) associated with the synthesis of the analgesic 3-methylfentanyl, N-(3-methyl-1-phenethylpiperidin-4-yl)-N-phenylpropanamide, were investigated...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29784394/multiresidue-analytical-method-for-pharmaceuticals-and-personal-care-products-in-sewage-and-sewage-sludge-by-online-direct-immersion-spme-on-fiber-derivatization-gcms
#13
Rebeca López-Serna, David Marín-de-Jesús, Rubén Irusta-Mata, Pedro Antonio García-Encina, Raquel Lebrero, María Fdez-Polanco, Raúl Muñoz
The work here presented aimed at developing an analytical method for the simultaneous determination of 22 pharmaceuticals and personal care products, including 3 transformation products, in sewage and sludge. A meticulous method optimization, involving an experimental design, was carried out. The developed method was fully automated and consisted of the online extraction of 17 mL of water sample by Direct Immersion Solid Phase MicroExtraction followed by On-fiber Derivatization coupled to Gas Chromatography - Mass Spectrometry (DI-SPME - On-fiber Derivatization - GC - MS)...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29784354/a-comparative-study-of-sterically-and-electro-statically-stabilized-silver-nanoparticles-for-the-determination-of-muscle-relaxant-tizanidine-insights-of-localized-surface-plasmon-resonance-surface-enhanced-raman-spectroscopy-and-electrocatalytic-activity
#14
Marwa R El-Zahry
A comparative study of two types of silver nanoparticles was investigated. The effect of the surface chemistry of the studied silver nanoparticles (AgNPs) on their localized surface plasmon resonance was utilized for the quantitative determination of muscle relaxant tizanidine drug. The studied AgNPs are classified according to the type of stabilizing agent used in their synthesis into electrostatically and sterically stabilized AgNPs. The electrostatically-stabilized AgNPs (AA AgNPs) were prepared using ascorbic acid as both reducing and protective agents in alkaline medium...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29784352/application-of-gradient-ratio-flow-injection-technique-to-implementation-of-the-chemical-h-point-standard-addition-method
#15
Marcin Wieczorek, Marek Dębosz, Paweł Świt, Aneta Woźniakiewicz, Paweł Kościelniak
A new gradient ratio approach to Chemical H-point Standard Addition Method (C-HPSAM) was developed in flow injection analysis with spectrophotometric detection. C-HPSAM is based on an idea to use SAM for calibration in several different chemical conditions in order to correct unspecific (additive) interferences in samples with unknown matrix. The approach proposed in this paper employs the gradient ratio flow-injection technique to generate a continuous change of chemical conditions. By doing so a set of two-point SAM calibration curves with different slopes are possible of registering that are intersected in a common point indicating the values of both unspecific interferences and analyte concentration in a sample...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29784348/flow-manifold-for-chemical-h-point-standard-addition-method-implemented-to-electrochemical-analysis-based-on-the-capacitance-measurements
#16
Marcin Wieczorek, Maria Madej, Karolina Starzec, Paweł Knihnicki, Anna Telk, Jolanta Kochana, Paweł Kościelniak
The paper presents a novel analytical method for electrochemical potassium determination using gold electrodes with self-assembled thiol monolayers (SATMs) deposited on its surface. The whole analytical procedure was carried out in a dedicated flow manifold using capacitance detection mode. The terminal functional groups on the surface of the dielectric monolayer interacts selectively with the analyte, changing the thickness of the layer depending on the amount of the analyte and the applied voltage, resulting in a change in the registered dielectric capacitance...
August 15, 2018: Talanta
https://www.readbyqxmd.com/read/29783967/characterization-of-a-novel-thermostable-and-xylose-tolerant-gh-39-%C3%AE-xylosidase-from-dictyoglomus-thermophilum
#17
Qi Li, Tao Wu, Zhipeng Qi, Linguo Zhao, Jianjun Pei, Feng Tang
BACKGROUND: β-D-xylosidase is a vital exoglycosidase with the ability to hydrolyze xylooligosaccharides to xylose and to biotransform some saponins by cleaving outer β-xylose. β-D-xylosidase is widely used as one of the xylanolytic enzymes in a diverse range of applications, such as fuel, food and the pharmaceutical industry; therefore, more and more studies have focused on the thermostable and xylose-tolerant β-D-xylosidases. RESULTS: A thermostable β-xylosidase gene (xln-DT) of 1509 bp was cloned from Dictyoglomus thermophilum and expressed in E...
May 21, 2018: BMC Biotechnology
https://www.readbyqxmd.com/read/29783864/a-logic-model-for-pharmaceutical-care
#18
Carolina Moltó-Puigmartí, Robert Aa Vonk, Gerlise L van Ommeren, Ingrid Hegger
Objectives To develop a logic model for pharmaceutical care that can be used by stakeholders as a tool to support innovation and to monitor the performance of the pharmaceutical care system in the Netherlands and abroad. The ultimate aim of such a system is the responsible provision of drug therapy to improve patients' quality of life. Methods The logic model for pharmaceutical care was created following a process consisting of four steps: (1) a literature review to identify what pharmaceutical care is and what elements it consists of; (2) separate interviews with 10 stakeholder organizations to discuss the results of the literature review; (3) construction of the logic model based on the findings from steps 1 and 2; and (4) separate interviews with three stakeholder organizations to discuss and fine-tune the model...
January 1, 2018: Journal of Health Services Research & Policy
https://www.readbyqxmd.com/read/29783752/pro-apoptotic-and-anti-cancer-properties-of-diosgenin-a-comprehensive-and-critical-review
#19
REVIEW
Gautam Sethi, Muthu K Shanmugam, Sudha Warrier, Myriam Merarchi, Frank Arfuso, Alan Prem Kumar, Anupam Bishayee
Novel and alternative options are being adopted to combat the initiation and progression of human cancers. One of the approaches is the use of molecules isolated from traditional medicinal herbs, edible dietary plants and seeds that play a pivotal role in the prevention/treatment of cancer, either alone or in combination with existing chemotherapeutic agents. Compounds that modulate these oncogenic processes are potential candidates for cancer therapy and may eventually make it to clinical applications. Diosgenin is a naturally occurring steroidal sapogenin and is one of the major bioactive compounds found in dietary fenugreek ( Trigonella foenum-graecum ) seeds...
May 19, 2018: Nutrients
https://www.readbyqxmd.com/read/29783687/impact-of-particle-size-and-polydispersity-index-on-the-clinical-applications-of-lipidic-nanocarrier-systems
#20
REVIEW
M Danaei, M Dehghankhold, S Ataei, F Hasanzadeh Davarani, R Javanmard, A Dokhani, S Khorasani, M R Mozafari
Lipid-based drug delivery systems, or lipidic carriers, are being extensively employed to enhance the bioavailability of poorly-soluble drugs. They have the ability to incorporate both lipophilic and hydrophilic molecules and protecting them against degradation in vitro and in vivo. There is a number of physical attributes of lipid-based nanocarriers that determine their safety, stability, efficacy, as well as their in vitro and in vivo behaviour. These include average particle size/diameter and the polydispersity index (PDI), which is an indication of their quality with respect to the size distribution...
May 18, 2018: Pharmaceutics
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