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https://www.readbyqxmd.com/read/28934664/targeted-h-triggered-bubble-generating-nanosystems-for-effective-therapy-in-cancer-cells
#1
Zhili Deng, Menghuan Tang, Li Zhao, Yijuan Long, Zuhuang Wen, Yuan Cheng, Huzhi Zheng
A novel targeting drug delivery system for cancer therapy based on H(+)-triggered bubble-generating nanosystems (BGNSs) was engineered. First, hollow mesoporous silica nanoparticles (HMSNs) were used to load doxorubicin (DOX). Then, the obtained drug-loaded HMSNs were treated with NaHCO3 to prepare the BGNSs. The BGNSs were coated with polydopamine (pDA), and finally, folic acids (FA) were anchored on the nanosystems to obtain the desired nanoscale drug delivery system (BGNSs@pDA-FA). BGNSs@pDA-FA was effectively internalized by cancer cells through folate receptor-mediated endocytosis and generated CO2 bubbles under the acidic environment of the lysosomes, thus enhancing lysosomal membrane permeability (LMP) to release caspase-3 into the cytoplasm, resulting in cancer cell death via an apoptosis-like pathway...
September 14, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28934403/improving-inpatient-medication-adherence-using-attendant-education-in-a-tertiary-care-hospital-in-uganda
#2
Patricia Alupo, Richard Ssekitoleko, Tracy Rabin, Robert Kalyesubula, Ivan Kimuli, Benjamin E Bodnar
Quality problem: Although widely utilized in resource-rich health care systems, the use of quality improvement (QI) techniques is less common in resource-limited environments. Uganda is a resource-limited country in Sub-Saharan Africa that faces many challenges with health care delivery. These challenges include understaffing, inconsistent drug availability and inefficient systems that limit the provision of clinical care. Initial assessment: Poor adherence to prescribed inpatient medications was identified as a key shortcoming of clinical care on the internal medicine wards of Mulago National Referral Hospital, Kampala, Uganda...
August 1, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28934281/smart-thermosensitive-liposomes-for-effective-solid-tumor-therapy-and-in-vivo-imaging
#3
Kevin Affram, Ofonime Udofot, Mandip Singh, Sunil Krishnan, Renee Reams, Jens Rosenberg, Edward Agyare
In numerous studies, liposomes have been used to deliver anticancer drugs such as doxorubicin to local heat-triggered tumor. Here, we investigate: (i) the ability of thermosensitive liposomal nanoparticle (TSLnp) as a delivery system to deliver poorly membrane-permeable anticancer drug, gemcitabine (Gem) to solid pancreatic tumor with the aid of local mild hyperthermia and, (ii) the possibility of using gadolinium (Magnevist®) loaded-TSLnps (Gd-TSLnps) to increase magnetic resonance imaging (MRI) contrast in solid tumor...
2017: PloS One
https://www.readbyqxmd.com/read/28934172/topical-nano-and-microemulsions-for-skin-delivery
#4
REVIEW
Christofori M R R Nastiti, Thellie Ponto, Eman Abd, Jeffrey E Grice, Heather A E Benson, Michael S Roberts
Nanosystems such as microemulsions (ME) and nanoemulsions (NE) offer considerable opportunities for targeted drug delivery to and via the skin. ME and NE are stable colloidal systems composed of oil and water, stabilised by a mixture of surfactants and cosurfactants, that have received particular interest as topical skin delivery systems. There is considerable scope to manipulate the formulation components and characteristics to achieve optimal bioavailability and minimal skin irritancy. This includes the incorporation of established chemical penetration enhancers to fluidize the stratum corneum lipid bilayers, thus reducing the primary skin barrier and increasing permeation...
September 21, 2017: Pharmaceutics
https://www.readbyqxmd.com/read/28933815/magnetotactic-bacteria-powered-biohybrids-target-e-coli-biofilms
#5
Morgan M Stanton, Byung-Wook Park, Diana Vilela, Klaas Bente, Damien Faivre, Metin Sitti, Samuel Sanchez
Biofilm colonies are typically resistant to general antibiotic treatment and require targeted methods for their removal. One of these methods include the use of nanoparticles as carriers for antibiotic delivery, where they randomly circulate in fluid until they make contact with the infected areas. However, the required proximity of the particles to the biofilm results in only moderate efficacy. We demonstrate here that the non-pathogenic magnetotactic bacteria, Magnetosopirrillum gryphiswalense (MSR-1), can be integrated with drug-loaded mesoporous silica microtubes (MSMs) to build controllable microswimmers (biohybrids) capable of antibiotic delivery to target an infectious biofilm...
September 21, 2017: ACS Nano
https://www.readbyqxmd.com/read/28933696/a-novel-topical-wound-therapy-delivery-system
#6
Ingrid Herskovitz, Flor E MacQuhae, Luis J Borda, Stephanie Bhagwandin, Juan A Paredes, Thais Polanco, John C Lantis, Paul J Kim, Tania J Phillips, Robert S Kirsner
INTRODUCTION: Wound care dressings have evolved over time, from bandaging to the development of occlusive dressings to negative pressure wound therapy. A novel therapeutic delivery system dressing has been cleared by the United States Food and Drug Administration. This semi occlusive wound dressing has been developed to provide local, continuous delivery of aqueous topical agents, such as therapeutics (anesthetics, antiseptics, antibiotics, steroids, topical beta-blockers, immune modulatory agents, growth factors, and fibrinolytic agents, among others), at a rate of about ¾ mL per day, thus maintaining a hydrated environment and providing topical treatment...
September 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28933296/inflammation-and-cancer-in-medio-stat-nano
#7
Roberto Molinaro, Claudia Corbo, Megan Livingston, Michael Evangelopoulos, Alessandro Parodi, Christian Boada, Marco Agostini, Ennio Tasciotti
Cancer treatment still remains a challenge due to the several limitations of currently used chemotherapeutics, such as their poor pharmacokinetics, unfavorable chemical properties, as well as inability to discriminate between healthy and diseased tissue. Nanotechnology offered potent tools to overcome these limitations. Drug encapsulation within a delivery system permitted i) to protect the payload from enzymatic degradation/inactivation in the blood stream, ii) to improve the physicochemical properties of poorly water-soluble drugs, like paclitaxel, and iii) to selectively deliver chemotherapeutics to the cancer lesions, thus reducing the off-target toxicity, and promoting the intracellular internalization...
September 20, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28933273/microsponge-embedded-tablet-for-sustained-delivery-of-nifedipine
#8
Indu Pal Kaur, Rakesh Tekade
BACKGROUND: Nifedipine is a potential therapeutic agent for the treatment of cardiovascular disturbances, although it suffers from short half-life (t1/2, 2 hr). OBJECTIVE: To address the problem, we first prepared nifedipine loaded sustained releases microsponges and then formulated tablets for effective clinical application and patient compliance. METHOD: Preparations of microsponges were carried out using different composition of nifedipine and polymer (1:1, 1:2 and 1:3 % molar ratio) using emulsion solvent diffusion technique...
September 21, 2017: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/28933269/drug-delivery-and-cosmeceutical-applications-of-polylactic-acid-based-novel-constructs-a-review
#9
Hafiz M N Iqbal, Federico Ruiz-Ruiz, Elena Ivonne Mancera-Andrade, Roberto Parra-Saldivar, Tajalli Keshavarz
In recent years, there has been a great research interest in bio-based biopolymers due to their potential as alternative polymers to the traditional petroleum-based synthetic counterparts. Research is underway around the globe on the development of 'greener' technologies. Recently, bio-based bio-constructs are being engineered for target applications in different bio- and non-bio sectors of the modern world to address growing concerns of a global dependence on non-renewable petroleum-based resources. The utilization of properly designed and structured materials thus allows for the creation of well-defined environment that induces a series of directed measures, and so on...
September 19, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28933201/glioma-and-microenvironment-dual-targeted-nanocarrier-for-improved-antiglioblastoma-efficacy
#10
Xiuzhen Wang, Qing Zhang, Lingyan Lv, Junjie Fu, Yan Jiang, Hongliang Xin, Qizheng Yao
Drug delivery systems based on nanoparticles (nano-DDS) have aroused attentions for the treatment of glioblastoma (GBM), the most malignant brain cancer with a dismal prognosis. However, there are still numerous unmet challenges for traditional nano-DDS, such as the poor nanoparticle penetration, short retention in the GBM parenchyma and low glioma targeting ability. Herein, we used Pep-1 and CREKA peptides to construct a novel multifunctional GBM targeting nano-DDS (PC-NP). Pep-1 was used to overcome the blood-brain tumor barrier (BBTB) and home to glioma cells via interleukin-13 receptor-α2-mediated endocytosis, and CREKA was used to bind to fibrin-fibronectin complexes abundantly expressed in tumor microenvironment for enhanced retention in the GBM...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28933057/healthcare-finance-in-the-kingdom-of-saudi-arabia-a-qualitative-study-of-householders-attitudes
#11
Mohammed Khaled Al-Hanawi, Omar Alsharqi, Saja Almazrou, Kirit Vaidya
BACKGROUND: The public sector healthcare system in Saudi Arabia, essentially financed by oil revenues and 'free at the point of delivery', is coming under increasing strain due to escalating expenditure and an increasingly volatile oil market and is likely to be unsustainable in the medium to long term. OBJECTIVES: This study examines how satisfied the Saudi people are with their public sector healthcare services and assesses their willingness to contribute to financing the system through a national health insurance scheme...
September 20, 2017: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/28932851/modulation-in-the-acidity-constant-of-acridine-dye-with-cucurbiturils-stimuli-responsive-pka-tuning-and-dye-relocation-into-live-cells
#12
R Khurana, N Barooah, A C Bhasikuttan, J Mohanty
The noncovalent host-guest interactions of the cationic (AcH(+)) and neutral (Ac) forms of an acridine dye with macrocyclic hosts such as cucurbit[7]uril (CB7) and cucurbit[8]uril (CB8) have been investigated to evaluate the effect of cavity size on the photophysical properties and the protolytic equilibrium of the acridine dye. The cationic form undergoes significant complexation with CB7 (Keq = 10(6) M(-1)), causing a sharp decrease in the fluorescence intensity, whereas the neutral Ac form of the dye undergoes weak complexation with CB7 (Keq = 10(3) M(-1)) and the binding constant is lowered by three orders of magnitude compared to that of the CB7-AcH(+) system...
September 21, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28932838/engineered-biomimetic-nanovesicles-show-intrinsic-anti-inflammatory-properties-for-the-treatment-of-inflammatory-bowel-diseases
#13
Claudia Corbo, Walter E Cromer, Roberto Molinaro, Naama E Toledano Furman, Kelly A Hartman, Enrica De Rosa, Christian Boada, Xin Wang, David C Zawieja, Marco Agostini, Francesco Salvatore, Bincy P Abraham, Ennio Tasciotti
Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is a chronic inflammatory condition of the gastrointestinal (GI) tract. Currently, it is treated with immunosuppressant or biologics that often induce severe adverse effects. Thus, there is an urgent clinical need for more specific treatments. To provide a valid therapeutic tool for IBD therapy, in this work we developed biomimetic nanovesicles by manipulating leukocyte membranes to exploit mechanisms of T-cell recruitment during inflammation...
September 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28932674/propulsion-and-chemotaxis-in-bacteria-driven-microswimmers
#14
Jiang Zhuang, Byung-Wook Park, Metin Sitti
Despite the large body of experimental work recently on biohybrid microsystems, few studies have focused on theoretical modeling of such systems, which is essential to understand their underlying functioning mechanisms and hence design them optimally for a given application task. Therefore, this study focuses on developing a mathematical model to describe the 3D motion and chemotaxis of a type of widely studied biohybrid microswimmer, where spherical microbeads are driven by multiple attached bacteria. The model is developed based on the biophysical observations of the experimental system and is validated by comparing the model simulation with experimental 3D swimming trajectories and other motility characteristics, including mean squared displacement, speed, diffusivity, and turn angle...
September 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28932494/nanotechnology-advancing-the-translational-respiratory-research
#15
Kamal Dua, Shakti Dhar Shukla, Terezinha de Jesus Andreoli Pinto, Philip Michael Hansbro
Considering the various limitations associated with the conventional dosage forms, nanotechnology is gaining increased attention in drug delivery particularly in respiratory medicine and research because of its advantages like targeting effects, improved pharmacotherapy, and patient compliance. This paper provides a quick snapshot about the recent trends and applications of nanotechnology to various translational and formulation scientists working on various respiratory diseases, which can help paving a new path in developing effective drug delivery system...
March 2017: Interventional Medicine & Applied Science
https://www.readbyqxmd.com/read/28932227/targeted-delivery-of-neutralizing-anti-c5-antibody-to-renal-endothelium-prevents-complement-dependent-tissue-damage
#16
Paolo Durigutto, Daniele Sblattero, Stefania Biffi, Luca De Maso, Chiara Garrovo, Gabriele Baj, Federico Colombo, Fabio Fischetti, Antonio F Di Naro, Francesco Tedesco, Paolo Macor
Complement activation is largely implicated in the pathogenesis of several clinical conditions and its therapeutic neutralization has proven effective in preventing tissue and organ damage. A problem that still needs to be solved in the therapeutic control of complement-mediated diseases is how to avoid side effects associated with chronic neutralization of the complement system, in particular, the increased risk of infections. We addressed this issue developing a strategy based on the preferential delivery of a C5 complement inhibitor to the organ involved in the pathologic process...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28932197/antiplasmodial-activity-and-toxicological-assessment-of-curcumin-plga-encapsulated-nanoparticles
#17
Zulaikha A Busari, Kabiru A Dauda, Olajumoke A Morenikeji, Funmilayo Afolayan, Oyetunde T Oyeyemi, Jairam Meena, Debasis Sahu, Amulya K Panda
Curcumin is a polyphenolic pigment isolated from the rhizomes of Curcuma longa (turmeric), a medicinal plant widely used in the ancient Indian and Chinese medicine. The antiplasmodial activity of curcumin is often hampered by its fast metabolism and poor water solubility, thus its incorporation into a delivery system could circumvent this problem. This study aimed to evaluate the in vivo antiplasmodial activity and the toxicity assessment of curcumin incorporated into poly (lactic-co-glycolic) acid (PLGA) nanoparticles...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28932119/delivery-of-a-chemotherapeutic-drug-using-novel-hollow-carbon-spheres-for-esophageal-cancer-treatment
#18
Li Zhang, Mengchu Yao, Wei Yan, Xiaoning Liu, Baofei Jiang, Zhaoye Qian, Yong Gao, Xiao-Jie Lu, Xiaofei Chen, Qi-Long Wang
Low toxicity and high efficacy are the key factors influencing the real-world clinical applications of nanomaterial-assisted drug delivery. In this study, novel hollow carbon spheres (HCSs) with narrow size distribution were developed. In addition to demonstrating their ease of synthesis for large-scale production, we also demonstrated in vitro that the HCSs possessed high drug-loading capacity, lower cell toxicity, and optimal drug release profile at low pH, similar to the pH in the tumor microenvironment...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28932118/fabrication-optimization-and-characterization-of-umbelliferone-%C3%AE-d-galactopyranoside-loaded-plga-nanoparticles-in-treatment-of-hepatocellular-carcinoma-in-vitro-and-in-vivo-studies
#19
Vikas Kumar, Prakash Chandra Bhatt, Mahfoozur Rahman, Gaurav Kaithwas, Hani Choudhry, Fahad A Al-Abbasi, Firoz Anwar, Amita Verma
Umbelliferone β-D-galactopyranoside (UFG), isolated from plants, exhibits promising inhibitory action on numerous diseases. The present research was initiated to develop a suitable delivery system for UFG with an intention to enhance its therapeutic efficacy against diethyl nitrosamine (DEN)-induced hepatocellular carcinoma (HCC) in Wistar rats. UFG-loaded polymeric nanoparticles prepared by sonication were scrutinized for average size, drug loading capacity, zeta potential, and drug release potency in animals...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28932114/spermidine-mediated-poly-lactic-co-glycolic-acid-nanoparticles-containing-fluorofenidone-for-the-treatment-of-idiopathic-pulmonary-fibrosis
#20
Jing Tang, Jianming Li, Guo Li, Haitao Zhang, Ling Wang, Dai Li, Jinsong Ding
Idiopathic pulmonary fibrosis is a progressive, fatal lung disease with poor survival. The advances made in deciphering this disease have led to the approval of different antifibrotic molecules, such as pirfenidone and nintedanib. An increasing number of studies with particles (liposomes, nanoparticles [NPs], microspheres, nanopolymersomes, and nanoliposomes) modified with different functional groups have demonstrated improvement in lung-targeted drug delivery. In the present study, we prepared, characterized, and evaluated spermidine (Spd)-modified poly(lactic-co-glycolic acid) (PLGA) NPs as carriers for fluorofenidone (AKF) to improve the antifibrotic efficacy of this drug in the lung...
2017: International Journal of Nanomedicine
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