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https://www.readbyqxmd.com/read/28806683/asymmetric-polyplex-nanocapsules-loaded-with-photosentisizer-for-light-assisted-gene-transfer
#1
Xuemin Lu, Li Liu
Inefficient intracellular gene delivery is still a limitation for the clinical translation of gene therapy. Recently, photochemical internalization (PCI) has emerged with the opportunity to overcome endo-lysosomal sequestration in gene delivery, which utilizes photosensitizer (PS) plus light generating reactive oxygen species (ROS) at sub-lethal level to facilitate intracellularly targeted drug delivery. In this work, asymmetric polyplex-nanocapsules were prepared based on the triblock copolymers of PEG-PCL-PEI by using the simple solvent-injection method...
August 7, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28806666/doxorubicin-loaded-environmentally-friendly-carbon-dots-as-a-novel-drug-delivery-system-for-nucleus-targeted-cancer-therapy
#2
Yifang Yuan, Bin Guo, Liying Hao, Na Liu, Yunfeng Lin, Wushuang Guo, Xiaoguang Li, Bin Gu
Chemotherapy is widely applied against various kinds of carcinoma. Generally, chemotherapeutic agents, such as Doxorubicin (DOX), Paclitaxel (PTX), 5-Fluorouracil (5-FU), Methotrexate (MTX), and Vinblastine (VLB) are combined with a view to maximizing their efficacy. Unfortunately, chemotherapeutics are indiscriminate and also kill normal healthy cells, resulting in serious side effects. This non-productive and destructive distribution of chemotherapeutics is regarded as one of the largest problems associated with chemotherapy...
July 10, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28806653/novel-microemulsion-based-gels-for-topical-delivery-of-indomethacin-formulation-physicochemical-properties-and-in-vitro-drug-release-studies
#3
Anna Froelich, Tomasz Osmałek, Agnieszka Snela, Paweł Kunstman, Barbara Jadach, Marta Olejniczak, Grzegorz Roszak, Wojciech Białas
HYPOTHESIS: Microemulsion-based semisolid systems may be considered as an interesting alternative to the traditional dosage forms applied in topical drug delivery. Mechanical properties of topical products are important both in terms of application and dosage form effectiveness. In this study we designed and evaluated novel microemulsion-based gels with indomethacin and analyzed the factors affecting their mechanical characteristics and drug release. EXPERIMENTS: The impact of the microemulsion composition on the extent of isotropic region was investigated with the use of pseudoternary phase diagrams...
August 4, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28806519/pluronic-p85-f68-micelles-of-baicalein-could-interfere-with-mitochondria-to-overcome-mrp2-mediated-efflux-and-offer-improved-anti-parkinsonian-activity
#4
Tongkai Chen, Ye Li, Chuwen Li, Xiang Yi, Ruibing Wang, Simon Ming Yuen Lee, Ying Zheng
Overexpression of the drug efflux transporter multidrug resistance-associated protein 2 (MRP2) in the gastrointestinal tract and blood-brain barrier compromises the oral delivery of drugs to the circulation system and brain in the treatment of Parkinson's disease (PD). In this study, we aim to develop small-sized Pluronic P85/F68 micelles loaded with baicalein (B-MCs) to overcome MRP2-mediated efflux and to investigate related mechanism, as well as the anti-Parkinsonian efficacy. Spherical and sustained-release B-MCs have a mean particle size of 40...
August 14, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28806513/intraperitoneal-delivery-of-cisplatin-via-a-hyaluronan-based-nanogel-in-situ-crosslinkable-hydrogel-hybrid-system-for-peritoneal-dissemination-of-gastric-cancer
#5
Seiichi Ohta, Shota Hiramoto, Yuki Amano, Shigenobu Emoto, Hironori Yamaguchi, Hironori Ishigami, Joji Kitayama, Taichi Ito
Intraperitoneal administration of chemotherapeutics is expected for the treatment of peritoneally disseminated gastric cancer, because of poor migration of the drugs from the systemic circulation to the peritoneal cavity. In this study, for intraperitoneal delivery of cisplatin (CDDP), we developed a hyaluronan (HA)-based hybrid system in which CDDP-loaded HA nanogels were either physically encapsulated in or chemically conjugated to injectable HA hydrogels. Physical encapsulation enabled sustained release of HA nanogels from the HA hydrogel matrix for over a week...
August 14, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28806476/dna-trojan-horses-the-self-assembled-floxuridine-containing-dna-polyhedra-for-cancer-therapy
#6
Quanbing Mou, Yuan Ma, Gaifang Pan, Bai Xue, Deyue Yan, Chuan Zhang, Xinyuan Zhu
Based on the structural similarity, herein, nucleoside analogue therapeutics were integrated into DNA strands through conventional solid-phase synthesis. By elaborately designing their sequences, floxuridine-integrated DNA strands were synthesized and self-assembled into well-defined DNA polyhedra with definite drug loading ratio as well as tunable size and morphology. As a novel drug delivery system, these drug-containing DNA polyhedra could ideally mimic the Trojan Horse to deliver chemotherapeutics into tumor cells and fight against cancer...
August 14, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28806055/selective-release-system-for-antioxidative-and-anti-inflammatory-activities-using-h2o2-responsive-therapeutic-nanoparticles
#7
A Young Kim, Ji Hoon Ha, Soo Nam Park
We developed nanoparticles that were degraded by H2O2, a reactive oxygen species (ROS), to study a drug delivery system that targets damaged skin cells with oxidative stress and inflammation. In this study, tyrosol-incorporated copolyoxalate (TPOX) was synthesized by using 1,4-cyclohexanedimethanol, 4-(2-hydroxyethyl)phenol (tyrosol) and oxalyl chloride (Mw ~8835 Da). In vitro drug release behavior was assessed by loading nile red, a lipophilic fluorescent material such as quercetin, into the TPOX nanoparticles...
August 14, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28805867/coumarin-containing-thermoresponsive-hyaluronic-acid-based-nanogels-as-delivery-systems-for-anticancer-chemotherapy
#8
Talitha F Stefanello, Benoit Couturaud, Anna Szarpak-Jankowska, David Fournier, Benoit Louage, Francielle P Garcia, Celso V Nakamura, Bruno G De Geest, Patrice Woisel, Boudewijn van der Sanden, Rachel Auzély-Velty
Multi-stimuli responsive nanogels based on biocompatible hydrophilic polymers have emerged as promising drug delivery systems to improve anticancer therapy with hydrophobic drugs, through increase of circulating-time in the bloodstream, tumor-targeting and reduction of systemic toxicity. This paper reports on the synthesis, characterization and biological perspectives of light- and thermoresponsive hyaluronic acid (HA)-based nanogels containing coumarin as the photocleavable group. Newly synthesized nanogels exhibited interesting features: formation by a temperature-triggered self-assembly process, successful incorporation of poorly water-soluble molecules, light-responsiveness as demonstrated by a significant shift in the critical aggregation temperature after light irradiation, efficient internalization by cancer cells overexpressing the CD44 receptor of HA, ability to circulate for a prolonged period of time in the bloodstream after intravenous injection in mice and considerable detection in tumor tissues...
August 14, 2017: Nanoscale
https://www.readbyqxmd.com/read/28805551/bone-targeted-cabazitaxel-nanoparticles-for-metastatic-prostate-cancer-skeletal-lesions-and-pain
#9
Andrew S Gdowski, Amalendu Ranjan, Marjana R Sarker, Jamboor K Vishwanatha
AIM: The aim of this study was to develop a novel cabazitaxel bone targeted nanoparticle (NP) system for improved drug delivery to the bone microenvironment. MATERIALS & METHODS: Nanoparticles were developed using poly(D,L-lactic-co-glycolic acid) and cabazitaxel as the core with amino-bisphosphonate surface conjugation. Optimization of nanoparticle physiochemical properties, in vitro evaluation in prostate cancer cell lines and in vivo testing in an intraosseous model of metastatic prostate cancer was performed...
August 14, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28805542/plasma-protein-adsorption-and-biological-identity-of-systemically-administered-nanoparticles
#10
Dongyu Chen, Shanthi Ganesh, Weimin Wang, Mansoor Amiji
Although a variety of nanoparticles (NPs) have been used for drug delivery applications, their surfaces are immediately covered by plasma protein corona upon systemic administration. As a result, the adsorbed proteins create a unique biological identity of the NPs that lead to unpredictable performance. The protein corona on NPs could also impede active targeting, induce off-target effects, trigger particle clearance and even provoke toxicity. This article reviews the fundamentals of NP-plasma protein interaction, the consequences of the interactions, and provides insights into the correlations of protein corona with biodistribution and cellular delivery...
August 14, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28805085/strategies-to-release-doxorubicin-from-doxorubicin-delivery-vehicles
#11
Juan Li, Bin Zhang, Chunwen Yue, Jing Wu, Lanxia Zhao, Deqing Sun, Rongmei Wang
Doxorubicin (DOX) is one of the most effective cytotoxic anticancer drugs and has been successfully applied in clinics to treat haematological malignancies and a broad range of solid tumours. However, the clinical applications of DOX have long been limited due to severe dose-dependent toxicities. Recent advances in the development of DOX delivery vehicles have addressed some of the non-specific toxicity challenges associated with DOX. These DOX-loaded vehicles are designed to release DOX in cancer cells effectively by cutting off linkers between DOX and carriers response to stimuli...
August 13, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28804515/mmx-%C3%A2-technology-and-its-applications-in-gastrointestinal-diseases
#12
REVIEW
Silvia Nardelli, Laura Francesca Pisani, Gian Eugenio Tontini, Maurizio Vecchi, Luca Pastorelli
The Multimatrix(®) (MMX(®)) preparation MMX(®) is a recently obtained drug formulation developed to facilitate release of high concentrations of active drugs into the colon, with a homogeneous distribution along all colonic segments, particularly the most distal ones; the distal colonic tracts, indeed, are the most difficult to reach in significant amounts when a drug is given orally. The MMX(®) formulation is characterized by a lipophilic matrix dispersed in a hydrophilic structure. Indeed, in the last few years, MMX(®) technology has been widely used in the development of various drugs for the treatment of inflammatory and infectious gastrointestinal diseases localized in the colon...
July 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/28803939/bubble-generating-nano-lipid-carriers-for-ultrasound-ct-imaging-guided-efficient-tumor-therapy
#13
Nan Zhang, Jia Li, Ruirui Hou, Jiangnan Zhang, Pei Wang, Xinyang Liu, Zhenzhong Zhang
Ideal therapeutic effectiveness of chemotherapy is obtained only when tumor cells are exposed to a maximal drug concentration, which is often hindered by dose-limiting toxicity. We designed a bubble-generating liposomal delivery system by introducing ammonium bicarbonate and gold nanorods into folic acid-conjugated liposomes to allow both multimodal imaging and the local release of drug (doxorubicin) with hyperthermia. The key component, ammonium bicarbonate, allows a controlled, rapid release of doxorubicin to provide an effective drug concentration in the tumor microenvironment...
August 10, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28803883/the-provision-of-emergency-contraception-in-kinshasa-s-private-sector-pharmacies-experiences-of-mystery-clients
#14
Julie H Hernandez, Mbadu Muanda Fidèle, Mélissa Garcia, Annie Glover
OBJECTIVES: Recent programmatic and research efforts on addressing gaps in health systems of low-income countries increasingly see task shifting, i.e. the provision of healthcare by non-medically trained personnel, as a possible solution to increase the availability of specific services and commodities. In Kinshasa, private-sector pharmacies are the primary and preferred provider of family planning (FP) methods, and thus constitute a potential resource for expanding access to specific contraceptives...
August 10, 2017: Contraception
https://www.readbyqxmd.com/read/28803753/recent-progresses-in-biomedical-applications-of-aptamer-functionalized-systems
#15
REVIEW
Fei Ding, Yangguang Gao, Xianran He
Aptamers, known as "chemical antibodies" are screened via a combinational technology of systematic evolution of ligands by exponential enrichment (SELEX). Due to their specific targeting ability, high binding affinity, low immunogenicity and easy modification, aptamer-functionalized systems have been extensively applied in various fields and exhibit favorable results. However, there is still a long way for them to be commercialized, and few aptamer-functionalized systems have yet successfully entered clinical and industrial use...
March 18, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28802736/synthesis-of-pegylated-polyglutamic-acid-peptide-dendrimer-and-its-application-in-dissolving-thrombus
#16
Shao-Fei Zhang, Chunmei Gao, Shaoyu Lü, Jiujun He, Mingzhu Liu, Can Wu, Yijing Liu, Xinyu Zhang, Zhen Liu
Nattokinase (NK) has been used as a new generation thrombolytic drug, due to its high safety, low cost and low side effects. However, it is sensitive to external environment and may lose the enzyme activity easily. Peptide dendrimer possesses functional groups on its surface, adjustable sizes, biodegradability, biocompatibility, and low toxicity, which could be used as ideal carrier for drug protection and delivery. Demonstrated for the first time in this paper, a PEGylated dendrimer (Gn-PEG-Gn) composed of polyglutamic acid is designed and synthesized as delivery platform of NK for thrombus treatment...
August 4, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28802690/nanoparticle-releasing-nanofiber-composites-for-enhanced-in%C3%A2-vivo-vaginal-retention
#17
Emily A Krogstad, Renuka Ramanathan, Christina Nhan, John C Kraft, Anna K Blakney, Shijie Cao, Rodney J Y Ho, Kim A Woodrow
Current approaches for topical vaginal administration of nanoparticles result in poor retention and extensive leakage. To overcome these challenges, we developed a nanoparticle-releasing nanofiber delivery platform and evaluated its ability to improve nanoparticle retention in a murine model. We individually tailored two components of this drug delivery system for optimal interaction with mucus, designing (1) mucoadhesive fibers for better retention in the vaginal tract, and (2) PEGylated nanoparticles that diffuse quickly through mucus...
August 1, 2017: Biomaterials
https://www.readbyqxmd.com/read/28802567/nano-sized-and-other-improved-reporters-for-magnetic-resonance-imaging-of-angiogenesis
#18
Simonetta Geninatti Crich, Enzo Terreno, Silvio Aime
Magnetic Resonance Imaging (MRI) enables to provide anatomical, functional and molecular information of pathological angiogenesis when used with properly tailored imaging probes. Functional studies have been the domain of Dynamic Contrast Enhancement (DCE) -MRI protocols from which it is possible to extract quantitative estimations on key parameters such as the volumes of vascular and extracellular compartments and the rates of the bidirectional exchange of the imaging reporters across the endothelial barrier...
August 9, 2017: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/28802202/a-thermosensitive-drug-delivery-system-prepared-by-blend-electrospinning
#19
Heyu Li, Kailin Liu, Qingqing Sang, Gareth R Williams, Junzi Wu, Haijun Wang, Jianrong Wu, Li-Min Zhu
In this study, the thermosensitive polymer poly(di(ethylene glycol) methyl ether methacrylate) (PDEGMA) was synthesized and electrospun into fibers by blending with ethyl cellulose (EC). Fibers were additionally prepared loaded with ketoprofen (KET) as a model drug. Smooth cylindrical fibers could generally be observed by electron microscopy, although there were some beads and fused fibers visible in the KET-loaded materials. KET was found to be amorphously distributed in the fibers on the basis of X-ray diffraction data...
July 25, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28801266/lipogels-responsive-to-near-infrared-light-for-the-triggered-release-of-therapeutic-agents
#20
Francisco Martín-Saavedra, Eduardo Ruiz-Hernández, Clara Escudero-Duch, Martin Prieto, Manuel Arruebo, Negar Sadeghi, Roel Deckers, Gert Storm, Wim E Hennink, Jesús Santamaría, Nuria Vilaboa
Here we report a composite system based on fibrin hydrogels that incorporate in their structure near-infrared (NIR) responsive nanomaterials and thermosensitive liposomes (TSL). Polymerized fibrin networks entrap simultaneously gold-based nanoparticles (NPs) capable of transducing NIR photon energy into heat, and lysolipid-incorporated TSL (LTSL) loaded with doxorubicin hydrochloride (DOX). NIR irradiation of the resulting hydrogels (referred to as "lipogels") with 808 nm laser light increased the temperature of the illuminated areas, leading to the release of the liposomal cargo...
August 8, 2017: Acta Biomaterialia
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