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https://www.readbyqxmd.com/read/28107705/incorporation-of-antimicrobial-peptides-in-nanostructured-lipid-membrane-mimetic-bilayer-cubosomes
#1
Thomas G Meikle, Alexandru Zabara, Lynne J Waddington, Frances Separovic, Calum J Drummond, Charlotte E Conn
The inverse bicontinuous lipidic cubic phase offers a simple and robust membrane mimetic with the ability to encapsulate peptides, potentially increasing bioavailability, while also offering a platform from which functionalized, targeted nanoparticles can be developed. Herein we have investigated the use of a number of cubic phase nanoparticle systems with encapsulated antimicrobial peptides gramicidin A', melittin, and alamethicin. The optimal peptide loading ranges, over which cubic symmetry was retained, were determined using small angle X-ray scattering...
January 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28106955/cypate-mediated-thermosensitive-nanoliposome-for-tumor-imaging-and-photothermal-triggered-drug-release
#2
Zhihao Han, Liwei Lv, Yi Ma, Zhaohui Wang, Yuxi Liu, Min Zhang, Siwen Li, Yueqing Gu
It is an emerging focus to explore controlled release drug delivery systems for simultaneous cancer imaging and therapy. Herein, we synthesized a photothermal sensitive multifunctional nano-liposome drug delivery system, with doxorubicin wrapped in the hydropholic layer as the therapeutical agent and cypate doped in the hydrophobic layer as the diagnostic agent. A series of in vitro and in vivo characterization demonstrated the stability of synthesized liposome, as the DL% was 9 ± 1.5 and the EE% was 82.7 ± 2...
January 20, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28106379/sustainable-release-of-vancomycin-from-silk-fibroin-nanoparticles-for-treating-severe-bone-infections-in-a-rat-tibia-osteomyelitis-model
#3
Negar Hassani Besheli, Fatemeh Mottaghitalab, Masoud Eslami, Mahdi Gholami, Subhas C Kundu, David L Kaplan, Mehdi Farokhi
The successful treatment of bone infections is a major challenge in the field of orthopedics. There are some common methods for treating bone infections, including systemic antibiotic administration, local non-degradable drug vehicles, and surgical debridement and each of these approaches has advantages and disadvantages. In the present study, the antibiotic vancomycin (VANCO) was loaded in silk fibroin nanoparticles (SFNPs) and the complexes were then entrapped in silk scaffolds to form sustained drug delivery systems...
January 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28106372/folate-engineered-microvesicles-for-enhanced-target-and-synergistic-therapy-towards-breast-cancer
#4
Lian Zhu, Di Dong, Zi-Li Yu, Yi-Fang Zhao, Dai-Wen Pang, Zhi-Ling Zhang
As an ideal nanovector candidate, microvesicles (MVs) have been gradually utilized for packaging kinds of functional molecules for effective tumor diagnosis and therapy; however, the deficiency of their tumor targeting influenced their therapy efficacy. Through a facile phospholipid substitution strategy, MVs based drug delivery system (DDS) was apparently endowed with high tumor targeting towards breast cancer thanks to the modified folate onto the membrane of MVs, simultaneously possessed of synergistic anti-tumor effect, and in vivo tumor imaging attributed to the SA-QDs labeling...
January 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28106163/synergistically-enhanced-selective-intracellular-uptake-of-anticancer-drug-carrier-comprising-folic-acid-conjugated-hydrogels-containing-magnetite-nanoparticles
#5
Haneul Kim, Ara Jo, Seulgi Baek, Daeun Lim, Soon-Yong Park, Soo Kyung Cho, Jin Woong Chung, Jinhwan Yoon
Targeted drug delivery has long been extensively researched since drug delivery and release at the diseased site with minimum dosage realizes the effective therapy without adverse side effects. In this work, to achieve enhanced intracellular uptake of anticancer drug carriers for efficient chemo-therapy, we have designed targeted multifunctional anticancer drug carrier hydrogels. Temperature-responsive poly(N-isopropylacrylamide) (PNIPAm) hydrogel core containing superparamagnetic magnetite nanoparticles (MNP) were prepared using precipitation polymerization, and further polymerized with amine-functionalized copolymer shell to facilitate the conjugation of targeting ligand...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28105892/molecularly-imprinted-cryogel-membranes-for-mitomycin-c-delivery
#6
Pınar Öncel, Kemal Çetin, Aykut Arif Topçu, Handan Yavuz, Adil Denizli
In this study, cryogel-based implantable molecularly imprinted drug delivery systems were designed for the delivery of antineoplastic agent. Mitomycin C imprinted poly(2-hydroxyethyl methacrylate-N-methacryloyl-l-glutamic acid) cryogel membranes were produced by free-radical bulk polymerization under partially frozen conditions. The membranes were characterized by swelling tests, Fourier transform infrared spectroscopy, scanning electron microscopy, surface area measurements and in vitro hemocompatibility tests...
January 20, 2017: Journal of Biomaterials Science. Polymer Edition
https://www.readbyqxmd.com/read/28105857/feasibility-of-obtaining-in-situ-nanocapsules-through-modified-self-microemulsifying-drug-delivery-systems-a-new-manufacturing-approach-for-oral-route-administration
#7
Viridiana Gisela Llera-Rojas, L Alicia Del Real, Néstor Mendoza-Muñoz, Luz María Melgoza-Contreras, David Quintanar-Guerrero
Nanocapsules (NCs) are submicron-sized core shell systems which present important advantages such as improvement of drug efficacy and bioavailability, prevention of drug degradation, and provision of controlled-release delivery. The available methods for NC production require expensive recovery and purification steps which compromised the morphology of nanocapsules. Industrial applications of NCs have been avoided due to the aforementioned issues. In this study, we developed a new method based on a modified self automicroemulsifying drug delivery system (SMEDDS) for in situ NCs production within the gastrointestinal tract...
January 20, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28105850/next-generation-tau-models-in-alzheimer-s%C3%A2-disease-research-virus-based-gene-delivery-systems
#8
V Cubinková, B Valachová, V Brezovaková, R Szabó, I Zimová, Z Kostecká, S Jadhav
Alzheimer's disease (AD) the most common form of dementia is characterized by cognitive decline and progressive loss of neurons in the central nervous system. Despite huge scientific progress, there are only few animal models that recapitulate at least majority of the AD pathology and related symptomatology. Therefore, alternative methods to develop animal models for neurodegenerative diseases are constantly explored. Recently, recombinant adeno-associated viruses (AAVs) are widely used viral vectors in development of novel models for neurodegenerative diseases...
January 19, 2017: Acta Virologica
https://www.readbyqxmd.com/read/28105390/reactive-oxygen-species-responsive-drug-delivery-systems-promises-and-challenges
#9
REVIEW
Gurusamy Saravanakumar, Jihoon Kim, Won Jong Kim
Given the increasing evidence indicates that many pathological conditions are associated with elevated reactive oxygen species (ROS) levels, there have been growing research efforts focused on the development of ROS-responsive carrier systems because of their promising potential to realize more specific diagnosis and effective therapy. By judicious utilization of ROS-responsive functional moieties, a wide range of carrier systems has been designed for ROS-mediated drug delivery. In this review article, insights into design principle and recent advances on the development of ROS-responsive carrier systems for drug delivery applications are provided alongside discussion of their in vitro and in vivo evaluation...
January 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28105279/nanoconjugated-nap-as-a-potent-and-periphery-selective-mu-opioid-receptor-modulator-to-treat-opioid-induced-constipation
#10
Guoyan G Xu, Olga Yu Zolotarskaya, Dwight A Williams, Yunyun Yuan, Dana E Selley, William L Dewey, Hamid I Akbarali, Hu Yang, Yan Zhang
Opioids are the mainstay for cancer and noncancer pain management. However, their use is often associated with multiple adverse effects. Among them, the most common and persistent one is probably opioid-induced constipation (OIC). Periphery selective opioid antagonists may alleviate the symptoms of OIC without compromising the analgesic effects of opioids. Recently our laboratories have identified one novel lead compound, 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6β-[(4'-pyridyl)acetamido]morphinan (NAP), as a peripherally selective mu opioid receptor ligand carrying subnanomolar affinity to the mu opioid receptor and over 100-folds of selectivity over both the delta and kappa opioid receptors, with reasonable oral availability and half-life, and potential to treat OIC...
January 12, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28105196/nanotechnology-for-multimodality-treatment-of-cancer
#11
Xiao-Ying Zhang, Pei-Ying Zhang
Nanotechnology is the latest evolving field and its applications in medicine in recent decades has shown great potential. It has also given a new face to the therapeutics against cancer in recent years. The electronic databases of MEDLINE, EMBASE and PubMed were searched for recent studies, reporting the importance of nanomedicine. The concluding remarks of the above papers mostly confirmed the growing potential of nanomedicine, particularly in the field of cancer. Furthermore, nanomedicine has been observed to promote the therapeutic effect of agents by formulating them into nanocarriers...
December 2016: Oncology Letters
https://www.readbyqxmd.com/read/28103774/formulation-development-and-evaluation-of-lyophilized-nasal-inserts-for-migraine-treatment
#12
Atishkumar Mundada, Harshada Sarode
BACKGROUND: Nasal inserts are novel, solid, bioadhesive dosage forms administered via nasal route for prolonged systemic drug delivery. The principle of the dosage form is that, after administration nasal inserts imbibe nasal fluid from the mucosa and form a gel in the nasal cavity in order to avoid foreign body sensation. The objective of this investigation was the development of chitosan/xanthan gum based bioadhesive nasal inserts of antimigraine drug. METHODS: Lyophilization is more usual technique for the preparation of nasal inserts and it is one of the applied methods for drying of solids either in the form of aqueous solution or rarely in the form of aqueous suspension by using freeze dryers...
January 18, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/28103740/novel-functionalization-strategies-to-improve-drug-delivery-from-polymers
#13
Emanuele Mauri, Simonetta Papa, Maurizio Masi, Pietro Veglianese, Filippo Rossi
The utility of controlled and sustained release of drugs from polymeric systems, both bulk (hydrogels) and colloids (nanoparticles), is a key point that should be addressed. Unfortunately, classic delivery systems are essentially driven by diffusion, which is very quick due to the high concentration gradient present in the body. Area covered: This review provides an overview of functionalization strategies which have been used to reduce release rates by taking advantage of post-polymerization functionalization of polymers...
January 20, 2017: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/28103530/an-anti-oxidant-%C3%AE-lipoic-acid-conjugated-oleoyl-sn-phosphatidylcholineas-a-helper-lipid-in-cationic-liposomal-formulations
#14
Priya Dharmalingam, Balakrishna Marrapu, Chandrashekhar Voshavar, Rasagna Nadella, Vignesh Kumar Rangasami, R V Shaji, Salar Abbas, R B N Prasad, Shiva Shanker Kaki, Srujan Marepally
Development of safe non-viral carrier systems for efficient intra-cellular delivery of drugs and genes hold promise in the area of translational research. Liposome based delivery systems have emerged as one of the attractive strategies for efficient delivery of drugs and nucleic acids. To this end, number of investigations was carried on liposomal formulations using lipids for achieving higher efficiency in transfection with lower cytotoxicities. In our efforts to develop safer and efficient liposomal delivery systems, we synthesized a novel anti-oxidant lipid, α-lipoyl, oleyl-sn-phosphatidylcholine (LOPC) and used as a helper lipid in combination with a cationic amphiphile, Di-Stearyl Dihydroxy Ethyl Ammonium Chloride (DSDEAC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) at varying concentrations of LOPC...
January 10, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28103046/food-protein-based-core-shell-nanocarriers-for-oral-drug-delivery-effect-of-shell-composition-on-in-vitro-and-in-vivo-functional-performance-of-zein-nanocarriers
#15
Mohammed S Alqahtani, Md Saiful Islam, Satheesh Podaralla, Radhey S Kaushik, Joshua J Reineke, Tofuko Woyengo, Omathanu Perumal
The study was aimed at systematically investigating the influence of shell composition on the particle size, stability, release, cell uptake, permeability and in-vivo gastrointestinal distribution of food protein-based nanocarriers for oral delivery applications. Three different core-shell nanocarriers were prepared using food-grade biopolymers including zein-casein (ZC) nanoparticles, zein-lactoferrin (ZLF) nanoparticles and zein-PEG (ZPEG) micelles. Nile red was used as a model hydrophobic dye for in-vitro studies...
January 19, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28103014/reactive-oxygen-species-and-glutathione-dual-redox-responsive-supramolecular-assemblies-with-controllable-release-capability
#16
Yang Kang, Xin Ju, Li-Sheng Ding, Sheng Zhang, Bang-Jing Li
A dual redox and bio-relevant triggered supramolecular system is developed through the non-covalent host-guest interactions between the ferrocene (Fc) on camptothecin (CPT) and β-cyclodextrin (β-CD) at the end of methoxy polyethylene glycol (mPEG). The two segments can form a stable non-covalent supramolecular block copolymer mPEG-β-CD/Fc-CPT, which could further self-assemble into stable micelles in aqueous solution. Interestingly, these supramolecular micelles showed uniform sphere structure, high and constant drug loading content, hyper-fast redox-responsive drug release, and exhibited equal cellular proliferation inhibition toward A549 cancer cells, while the cytotoxicity evaluation of mPEG-β-CD indicated good biocompatibility...
January 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28102776/targeted-delivery-of-cisplatin-to-tumor-xenografts-via-the-nanoparticle-component-of-nano-diamino-tetrac
#17
Thangirala Sudha, Dhruba J Bharali, Murat Yalcin, Noureldien He Darwish, Melis Debreli Coskun, Kelly A Keating, Hung-Yun Lin, Paul J Davis, Shaker A Mousa
AIM: Nano-diamino-tetrac (NDAT) targets a receptor on integrin αvβ3; αvβ3 is generously expressed by cancer cells and dividing endothelial cells and to a small extent by nonmalignant cells. The tetrac (tetraiodothyroacetic acid) of NDAT is covalently bound to a poly(lactic-co-glycolic acid) nanoparticle that encapsulates anticancer drugs. We report NDAT delivery efficiency of cisplatin to agent-susceptible urinary bladder cancer xenografts. MATERIALS & METHODS: Cisplatin-loaded NDAT (NDAT-cisplatin) was administered to xenograft-bearing nude mice...
January 19, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28101857/fibrous-protein-structures-hierarchy-history-and-heroes
#18
John M Squire, David A D Parry
During the 1930s and 1940s the technique of X-ray diffraction was applied widely by William Astbury and his colleagues to a number of naturally-occurring fibrous materials. On the basis of the diffraction patterns obtained, he observed that the structure of each of the fibres was dominated by one of a small number of different types of molecular conformation. One group of fibres, known as the k-m-e-f group of proteins (keratin - myosin - epidermin - fibrinogen), gave rise to diffraction characteristics that became known as the α-pattern...
2017: Sub-cellular Biochemistry
https://www.readbyqxmd.com/read/28101766/crossing-the-blood-brain-barrier-recent-advances-in-drug-delivery-to-the-brain
#19
Mayur M Patel, Bhoomika M Patel
CNS disorders are on the rise despite advancements in our understanding of their pathophysiological mechanisms. A major hurdle to the treatment of these disorders is the blood-brain barrier (BBB), which serves as an arduous janitor to protect the brain. Many drugs are being discovered for CNS disorders, which, however fail to enter the market because of their inability to cross the BBB. This is a pronounced challenge for the pharmaceutical fraternity. Hence, in addition to the discovery of novel entities and drug candidates, scientists are also developing new formulations of existing drugs for brain targeting...
January 18, 2017: CNS Drugs
https://www.readbyqxmd.com/read/28101726/development-of-timolol-loaded-galactosylated-chitosan-nanoparticles-and-evaluation-of-their-potential-for-ocular-drug-delivery
#20
Ruobing Zhao, Jing Li, Jingyi Wang, Zhenya Yin, Yongtao Zhu, Wei Liu
This study was conducted to develop timolol maleate (TM)-loaded galactosylated chitosan (GC) nanoparticles (NPs) (TM-GC-NPs) followed by optimization via a four-level and three-factor Box-Behnken statistical experimental design. The optimized nanoparticles showed a particle size of 213.3 ± 6.83 nm with entrapment efficiency of 38.58 ± 1.31% and drug loading of 17.72 ± 0.28%. The NPs were characterized with respect to zeta potential, pH, surface morphology, and differential scanning calorimetry (DSC)...
January 18, 2017: AAPS PharmSciTech
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