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https://www.readbyqxmd.com/read/28530161/dual-microcatheter-coil-embolization-of-acutely-ruptured-wide-necked-intracranial-aneurysms
#1
Pyeong-Ho Yoon, Jae-Wook Lee, Yun-Ho Lee, Young-Sub Kwon, Kook-Hee Yang
The dual microcatheter technique is an alternative treatment for stent-assisted coiling in acutely ruptured wide-necked aneurysms because of no antiplatelet therapy. We assessed the safety and efficacy of this technique in ruptured wide-necked aneurysms. Between March 2008 and March 2016, 56 acutely ruptured aneurysms were treated with the dual microcatheter technique. The angiographic results, treatment-related complications, and clinical outcome were documented. Angiographic follow-up was available in 37 patients at a mean of 20...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/28527815/neuroimaging-and-neuropathological-characteristics-of-cerebellar-injury-in-extremely-low-birth-weight-infants
#2
Mayumi Matsufuji, Nozomi Sano, Hisashi Tsuru, Sachio Takashima
OBJECTIVE: To determine the morphological characteristics and pathogenic factors of cerebellar injury in extremely low birth weight infants (ELBWI). SUBJECTS AND METHODS: Neuroimaging examination was performed on 17 eligible surviving ELBWI. Their MR images were assessed and classified its pattern of cerebellar injuries. Brain pathology was examined on 15 patients, who isolated this neuroimaging subjects. The trend of brain pathologies was revealed. RESULTS: Four types of morphological pattern were recognized: (i) the absence of major portions in the cerebellum (6/17 cases); (ii) focal cerebellar tissue loss (2/17); (iii) unilateral cerebellar atrophy/hypoplasia (3/17); (iv) small cerebellum with entrapped fourth ventricle (6/17)...
May 17, 2017: Brain & Development
https://www.readbyqxmd.com/read/28526764/subarachnoid-hemorrhage-severely-impairs-brain-parenchymal-cerebrospinal-fluid-circulation-in-nonhuman-primate
#3
Romain Goulay, Julien Flament, Maxime Gauberti, Michael Naveau, Nolwenn Pasquet, Clement Gakuba, Evelyne Emery, Philippe Hantraye, Denis Vivien, Romina Aron-Badin, Thomas Gaberel
BACKGROUND AND PURPOSE: Subarachnoid hemorrhage (SAH) is a devastating form of stroke with neurological outcomes dependent on the occurrence of delayed cerebral ischemia. It has been shown in rodents that some of the mechanisms leading to delayed cerebral ischemia are related to a decreased circulation of the cerebrospinal fluid (CSF) within the brain parenchyma. Here, we evaluated the cerebral circulation of the CSF in a nonhuman primate in physiological condition and after SAH. METHODS: We first evaluated in physiological condition the circulation of the brain CSF in Macaca facicularis, using magnetic resonance imaging of the temporal DOTA-Gd distribution after its injection into the CSF...
May 19, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28526701/netrin-1-preserves-blood-brain-barrier-integrity-through-deleted-in-colorectal-cancer-focal-adhesion-kinase-rhoa-signaling-pathway-following-subarachnoid-hemorrhage-in-rats
#4
Zongyi Xie, Budbazar Enkhjargal, Cesar Reis, Lei Huang, Weifeng Wan, Jiping Tang, Yuan Cheng, John H Zhang
BACKGROUND: Netrin-1 (NTN-1) has been established to be a novel intrinsic regulator of blood-brain barrier (BBB) maintenance. This study was carried out to investigate the potential roles of exogenous NTN-1 in preserving BBB integrity after experimental subarachnoid hemorrhage (SAH) as well as the underlying mechanisms of its protective effects. METHODS AND RESULTS: A total of 309 male Sprague-Dawley rats were subjected to an endovascular perforation model of SAH...
May 19, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28524797/the-relationship-of-dose-to-nerve-volume-in-predicting-pain-recurrence-after-stereotactic-radiosurgery-in-trigeminal-neuralgia
#5
Amparo Wolf, Amy Tyburczy, Jason Chao Ye, Girish Fatterpekar, Joshua S Silverman, Douglas Kondziolka
OBJECTIVE Approximately 75%-92% of patients with trigeminal neuralgia (TN) achieve pain relief after Gamma Knife surgery (GKS), although a proportion of these patients will experience recurrence of their pain. To evaluate the reasons for durability or recurrence, this study determined the impact of trigeminal nerve length and volume, the nerve dose-volume relationship, and the presence of neurovascular compression (NVC) on pain outcomes after GKS for TN. METHODS Fifty-eight patients with 60 symptomatic nerves underwent GKS for TN between 2013 and 2015, including 15 symptomatic nerves secondary to multiple sclerosis (MS)...
May 19, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28523383/anterior-sacral-meningocele-presenting-as-intracystic-bleeding
#6
Ignacio Javier Gilete-Tejero, Marta Ortega-Martínez, Jacinto Mata-Gómez, María Rico-Cotelo, Luis Miguel Bernal-García, Beatriz Yerga-Lorenzana, Ignacio Casado-Naranjo
PURPOSE: To report a case of anterior sacral meningocele with intralesional bleeding secondary to sacrococcygeal trauma. Likewise, there is a discussion about the physiopathology and the surgical approach to these types of lesions. METHODS: A 43-year-old man diagnosed with Marfan syndrome suffered sacrococcygeal trauma. He was admitted to the emergency room due to symptoms of headache, nausea, and lower limb subjective weakness. CT and MRI showed a large retroperitoneal mass with hemorrhagic content close to the sacrum...
May 18, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28523215/migraine-prevalence-in-patients-with-unruptured-intracranial-aneurysms-a-case-control-study
#7
Elbert H Witvoet, Nadine Pelzer, Gisela M Terwindt, Gabriël J E Rinkel, Monique H M Vlak, Ale Algra, Marieke J H Wermer
OBJECTIVES: Migraine is a suggested risk factor for aneurysmal subarachnoid hemorrhage (aSAH). An increased risk of aSAH in migraineurs may be explained by an increased prevalence of unruptured intracranial aneurysms (UIA). We performed a case-control study to compare lifetime migraine prevalence in patients with UIA, patients with a history of transient ischemic attact (TIA) or ischemic stroke and controls without a history of aSAH, TIA or ischemic stroke. MATERIALS AND METHODS: Patients with UIA were recruited from two university hospitals...
May 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28521903/motorcycle-related-hospitalizations-of-the-elderly
#8
Ching-Hua Hsieh, Hang-Tsung Liu, Shiun-Yuan Hsu, Hsiao-Yun Hsieh, Yi-Chun Chen
BACKGROUND: To investigate the injury pattern, mechanisms, severity, and mortality of the elderly hospitalized for treatment of trauma following motorcycle accidents. METHODS: Motorcycle-related hospitalization of 994 elderly and 5078 adult patients from the 16,548 hospitalized patients registered in the Trauma Registry System between January 1, 2009 and December 31, 2013. RESULTS: The motorcycle-related elderly trauma patients had higher injury severity, less favorable outcomes, higher proportion of patients admitted to the intensive care unit (ICU), prolonged hospital and ICU stays and higher mortality than those adult motorcycle riders...
April 2017: Biomedical Journal
https://www.readbyqxmd.com/read/28520943/risk-assessment-of-hemorrhage-of-posterior-inferior-cerebellar-artery-aneurysms-in-posterior-fossa-arteriovenous-malformations
#9
Alice L Hung, Wuyang Yang, Maria Braileanu, Tomas Garzon-Muvdi, Justin M Caplan, Geoffrey P Colby, Alexander L Coon, Rafael J Tamargo, Judy Huang
BACKGROUND: Posterior fossa arteriovenous malformations (AVMs) are associated with increased risk of rupture and severe consequences from such rupture. The hemorrhagic risk of prenidal aneurysms (anr) on the posterior inferior cerebellar artery (PICA) may exceed that of the AVM in posterior fossa AVMs fed by PICA (PICA-AVM). OBJECTIVE: To characterize the relative risks of aneurysm and AVM hemorrhage in patients with posterior fossa AVMs. METHODS: We retrospectively reviewed patients diagnosed with AVM...
May 18, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28520916/a-comparison-of-diffusion-weighted-imaging-abnormalities-following-balloon-remodeling-for-aneurysm-coil-embolization-in-the-ruptured-vs-unruptured-setting
#10
Stephen R Lowe, Tarun Bhalla, Holly Tillman, M Imran Chaudry, Aquilla S Turk, Raymond D Turner, Alejandro M Spiotta
BACKGROUND: The prothrombotic milieu seen in subarachnoid hemorrhage (SAH) poses a unique challenge to neurovascular surgeons with regard to device use and microcatheter practice. OBJECTIVE: To determine how demographic factors and balloon practices impact diffusion-weighted imaging (DWI) abnormalities and outcomes in patients with SAH compared to those without (non-SAH). METHODS: We retrospectively analyzed 77 patients with SAH treated by balloon-assisted coiling in a single institution compared with 81 consecutive patients with unruptured aneurysms treated by balloon-assisted coiling at the same institution...
May 17, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28515610/hyperemia-causing-delayed-recovery-in-traumatic-brain-injury
#11
Shalini Nair, Ramanan Rajagopal
Subarachnoid hemorrhage is a common manifestation of traumatic brain injury. A clinical deterioration in Glasgow Coma Scale score without an accompanying radiological worsening is suggestive of vasospasm. However, hyperemia could be another possibility which can easily be considered with corroborating transcranial Doppler (TCD) features. This case report reiterates the value of TCD in such instances.
April 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28515570/association-between-hemodynamic-modifications-and-clinical-outcome-of-intracranial-aneurysms-treated-using-flow-diverters
#12
Nikhil Paliwal, Robert J Damiano, Jason M Davies, Adnan H Siddiqui, Hui Meng
Treatment of intracranial aneurysms (IAs) has been revolutionized by the advent of endovascular Flow Diverters (FDs), which disrupt blood flow within the aneurysm to induce pro-thrombotic conditions, and serves as a scaffold for endothelial ingrowth and arterial remodeling. Despite good clinical success of FDs, complications like incomplete occlusion and post-treatment rupture leading to subarachnoid hemorrhage have been reported. In silico computational fluid dynamic analysis of the pre- and post-treated geometries of IA patients can shed light on the contrasting blood hemodynamics associated with different clinical outcomes...
February 11, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/28514500/histology-of-the-distal-dural-ring
#13
Christopher S Graffeo, Avital Perry, William R Copeland, Aditya Raghunathan, Michael J Link
BACKGROUND: The distal dural ring (DDR) is a conserved intracranial anatomic structure marking the boundary point at which the internal carotid artery (ICA) exits the cavernous sinus (CS) and enters the subarachnoid space. Although the CS has been well described in a range of anatomic studies, to our knowledge no prior study has analyzed the histologic relationship between the ICA and DDR. Correspondingly, our objective was to assess the relationship of the DDR to the ICA and determine whether the DDR can be dissected from the ICA and thus divided, or can only be circumferentially trimmed around the artery...
May 17, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28512446/neuroprotective-roles-of-l-cysteine-in-attenuating-early-brain-injury-and-improving-synaptic-density-via-the-cbs-h2s-pathway-following-subarachnoid-hemorrhage-in-rats
#14
Tong Li, Lingxiao Wang, Quan Hu, Song Liu, Xuemei Bai, Yunkai Xie, Tiantian Zhang, Shishi Bo, Xiangqian Gao, Shuhua Wu, Gang Li, Zhen Wang
l-Cysteine is a semi-essential amino acid and substrate for cystathionine-β-synthase (CBS) in the central nervous system. We previously reported that NaHS, an H2S donor, significantly alleviated brain damage after subarachnoid hemorrhage (SAH) in rats. However, the potential therapeutic value of l-cysteine and the molecular mechanism supporting these beneficial effects have not been determined. This study was designed to investigate whether l-cysteine could attenuate early brain injury following SAH and improve synaptic function by releasing endogenous H2S...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28512443/transcranial-direct-current-stimulation-for-post-concussion-syndrome-study-protocol-for-a-randomized-crossover-trial
#15
Robson Luis Oliveira de Amorim, André Russowsky Brunoni, Mirian Akiko Furutani de Oliveira, Ana Luiza Costa Zaninotto, Marcia Mitie Nagumo, Vinícius Monteiro de Paula Guirado, Iuri Santana Neville, Gláucia Rosana Guerra Benute, Mara Cristina Souza de Lucia, Wellingson Silva Paiva, Almir Ferreira de Andrade, Manoel Jacobsen Teixeira
BACKGROUND: Mild traumatic brain injury (MTBI) represents 70-80% of all treated brain injuries. A considerable proportion of MTBI patients experience post-concussion symptoms for a prolonged period after MTBI, and these symptoms are diagnosed as persistent post-concussion syndrome (PPCS). PPCS is defined as a range of physical, cognitive, and emotional symptoms. However, memory and executive dysfunction seems to be one of the most debilitating symptoms. Recently, non-invasive brain stimulation has been studied as a potential treatment method for traumatic brain injury (TBI) patients...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28512052/cystic-dilation-of-the-ventriculus-terminalis-cdvt-report-of-six-surgical-cases-treated-with-cyst-subarachnoid-shunting-using-t-catheter
#16
Liang Zhang, Zhifeng Zhang, Wuyang Yang, Wenqing Jia, Yulun Xu, Jun Yang
OBJECT: Cystic dilation of the ventriculus terminalis (CDVT) is a rare anatomical variation and may become symptomatic. Existing literature regarding CDVT is limited, and as a result, the clinical characteristics and management strategy of CDVT is unclear. We report in this study six cases of CDVT in our institution, and provide a review of current literature. METHODS: We included six patients with CDVT in Beijing Tiantan Hospital between September 2010 and June 2015...
May 13, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28512045/early-diagnosis-of-delayed-cerebral-ischemia-possible-relevance-for-inflammatory-biomarkers-in-routine-clinical-practice
#17
Bishwas Chamling, Stefan Gross, Birgit Stoffel-Wagner, Gerrit A Schubert, Hans Clusmann, Mark Coburn, Anke Höllig
BACKGROUND: Delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH) is one of the main causes of neurological deterioration. However, it frequently evades timely detection. Early identification and effective reversal may improve the clinical outcome. In this prospective study, we evaluate several serum inflammatory markers after aSAH with regard to the occurrence of DCI. METHODS: On days 1, 4, 7, 10 and 14 after SAH leucocyte count, C-reactive protein, interleukin-6, E-selectin, matrix metallopeptidase 9, intercellular adhesion molecule 1 and leukemia inhibitory factor were assessed in patients´ serum samples...
May 13, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28512041/characteristics-of-blood-pressure-profiles-after-endovascular-coiling-as-predictors-of-clinical-outcome-in-poor-grade-aneurysmal-subarachnoid-hemorrhage
#18
Kefu Cai, Yunfeng Zhang, Lihua Shen, Qiuhong Ji, Tian Xu, Maohong Cao
OBJECTIVE: Accurate identification of patients who will achieve a favorable outcome is almost impossible preoperatively or postoperatively in poor-grade (Hunt and Hess Grade IV and V) aneurysmal subarachnoid hemorrhage (SAH). Whether characteristics of blood pressure profiles during the first 24 hours after endovascular coiling could predict prognosis in poor grade patients was explored. METHODS: Data were retrospectively obtained on all patients undergoing endovascular treatment with poor-grade SAH from Nov...
May 13, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28505972/alzheimer-s-disease-associated-cerebrospinal-fluid-csf-biomarkers-do-not-correlate-with-csf-volumes-or-csf-production-rate
#19
Mikael Edsbagge, Ulf Andreasson, Khalid Ambarki, Carsten Wikkelsø, Anders Eklund, Kaj Blennow, Henrik Zetterberg, Mats Tullberg
BACKGROUND: Neuropathologically, Alzheimer's disease (AD) is characterized by accumulation of a 42 amino acid peptide called amyloid-β (Aβ42) in extracellular senile plaques together with intraneuronal inclusions of hyperphosphorylated tau protein in neurofibrillary tangles and neuronal degeneration. These changes are reflected in the cerebrospinal fluid (CSF), the volumes and production rates of which vary considerably between individuals, by reduced concentration of Aβ42, increased concentration of phosphorylated tau (P-tau) protein, and increased concentration of total tau (T-tau) protein, respectively...
May 8, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28504980/hyperchloremia-is-associated-with-acute-kidney-injury-in-patients-with-subarachnoid-hemorrhage
#20
Ofer Sadan, Kai Singbartl, Prem A Kandiah, Kathleen S Martin, Owen B Samuels
OBJECTIVE: To assess the prevalence of acute kidney injury in patients with subarachnoid hemorrhage patients. DESIGN: Retrospective analysis of all subarachnoid hemorrhage admissions. SETTINGS: Neurocritical care unit. PATIENTS: All patients with a diagnosis of subarachnoid hemorrhage between 2009 and 2014. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Of 1,267 patients included in this cohort, 16...
May 12, 2017: Critical Care Medicine
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