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https://www.readbyqxmd.com/read/29676052/rapamycin-protects-against-early-brain-injury-independent-of-cerebral-blood-flow-changes-in-a-mouse-model-of-subarachnoid-haemorrhage
#1
Kazumasu Sasaki, Shuzo Yamamoto, Tatsushi Mutoh, Yoshiharu Tsuru, Yasuyuki Taki, Ryuta Kawashima
We evaluated the neuroprotective role of rapamycin, a mammalian target of rapamycin (mTOR) kinase inhibitor, in cerebral ischaemia and locomotor function in a mouse model of subarachnoid haemorrhage (SAH). Pretreatment with rapamycin, a mTOR kinase inhibitor, resulted in better recovery from cerebral hypoxia early after SAH than control (P < .05), while the values of peak flow velocity in the middle cerebral artery did not change significantly (P > .05). The ratio of central-area distance/total travelled distance determined by open-field test after day 14 was significantly higher in mice pretreated with rapamycin than in control mice (P < ...
April 19, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29675720/initial-misdiagnosis-of-aneurysmal-subarachnoid-hemorrhage-associating-factors-and-its-prognosis
#2
Se-Yang Oh, Yong Cheol Lim, Yu Shik Shim, Jihye Song, Sang Kyu Park, Sook Young Sim, Myeong Jin Kim, Yong Sam Shin, Joonho Chung
BACKGROUND: Predicting the fate of patients who are given a misdiagnosis of aneurysmal subarachnoid hemorrhage (aSAH) remains unclear. The purpose was to examine factors associated with initial misdiagnosis of aSAH and to investigate the impact of initial misdiagnosis of aSAH on clinical outcomes. METHODS: Between January 2007 and December 2015, medical records and radiographic data for 3118 consecutive patients with aSAH were reviewed. There were 33 patients who had been documented with an initial misdiagnosis of aSAH, and all met the following criteria: (1) failure to correctly identify aSAH upon initial presentation to health care professionals; and 2) subsequently documented aSAH after the initial misdiagnosis...
April 20, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29675579/changes-in-the-lectin-pathway-following-intracerebral-or-spontaneous-subarachnoid-hemorrhage
#3
E Sandgaard, A Troldborg, S V Lauridsen, T Gyldenholm, S Thiel, Anne-Mette Hvas
Previous research indicates that the complement system is activated after occurrence of intracerebral hemorrhage (ICH) and spontaneous subarachnoid hemorrhage (SAH). The role of the lectin pathway (LP) of the complement system in this activation has only scarcely been investigated. The aim of this study was to determine the plasma concentration of the LP proteins in patients with ICH or SAH at admission compared to healthy individuals. Secondly, ICH and SAH patients were followed during the initial 24 h of disease, to investigate changes in LP protein concentrations during the critical acute phase...
April 19, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29673614/lacunar-stroke-cavernous-angioma-and-fusiform-aneurysm-due-to-irradiation-for-pilocytic-astrocytoma-a-case-report
#4
Maruyama Kunitaka, Takuya Akai, Naoki Akioka, Takahiro Tomita, Shoichi Nagai, Satoshi Kuroda
Radiotherapy is a useful modality for the treatment of brain tumors, but may induce brain degeneration, tumor formation, and vasculopathy in the irradiated field. We describe a rare case of a pediatric patient who presented multiple different types of vascular events consecutively in the irradiated field including lacunar stroke because of occlusion of perforating artery, intraventricular hemorrhage from cavernoma, and subarachnoid hemorrhage because of the rupture of fusiform aneurysm, 6 years after radiotherapy against pilocytic astrocytoma...
April 16, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29672747/stress-in-patients-with-un-ruptured-intracranial-aneurysms-vs-population-based-controls
#5
Arno de Wilde, Paut Greebe, Gabriël J E Rinkel, Ale Algra
BACKGROUND: Stress is associated with increased risk of stroke and might predispose to presence and rupture of intracranial aneurysms. OBJECTIVE: To study the association of recent and lifelong stress with unruptured intracranial aneurysm (UIA) and aneurysmal subarachnoid hemorrhage (ASAH). METHODS: In 227 UIA patients (mean age 61 ± 11 yr), 490 ASAH patients (59 ± 11 yr), and 775 controls (51 ± 15 yr) who were randomly retrieved from the general population, we assessed occurrence of major life events and perceived stress during the preceding 12 mo and the entire life...
April 17, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29671828/nf-%C3%AE%C2%BAb-mediated-inflammation-in-the-pathogenesis-of-intracranial-aneurysm-and-subarachnoid-hemorrhage-does-autophagy-play-a-role
#6
REVIEW
Elzbieta Pawlowska, Joanna Szczepanska, Karol Wisniewski, Paulina Tokarz, Dariusz J Jaskólski, Janusz Blasiak
The rupture of saccular intracranial aneurysms (IA) is the commonest cause of non-traumatic subarachnoid hemorrhage (SAH)&mdash;the most serious form of stroke with a high mortality rate. Aneurysm walls are usually characterized by an active inflammatory response, and NF-&kappa;B (nuclear factor kappa-light-chain-enhancer of activated B cells) has been identified as the main transcription factor regulating the induction of inflammation-related genes in IA lesions. This transcription factor has also been related to IA rupture and resulting SAH...
April 19, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29668855/the-negative-ultraslow-potential-electrophysiological-correlate-of-infarction-in-the-human-cortex
#7
Janos Lückl, Coline L Lemale, Vasilis Kola, Viktor Horst, Uldus Khojasteh, Ana I Oliveira-Ferreira, Sebastian Major, Maren K L Winkler, Eun-Jeung Kang, Karl Schoknecht, Peter Martus, Jed A Hartings, Johannes Woitzik, Jens P Dreier
Spreading depolarizations are characterized by abrupt, near-complete breakdown of the transmembrane ion gradients, neuronal oedema, mitochondrial depolarization, glutamate excitotoxicity and activity loss (depression). Spreading depolarization induces either transient hyperperfusion in normal tissue; or hypoperfusion (inverse coupling = spreading ischaemia) in tissue at risk for progressive injury. The concept of the spreading depolarization continuum is critical since many spreading depolarizations have intermediate characteristics, as opposed to the two extremes of spreading depolarization in either severely ischaemic or normal tissue...
April 16, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29668636/spinal-dural-arteriovenous-fistula-presenting-with-subarachnoid-hemorrhage-a-case-report
#8
Jingzhe Han, Duanhua Cao, Hongmei Wang, Ye Ji, Zhilei Kang, Jianguo Zhu
RATIONALE: Subarachnoid hemorrhage (SAH) is a common and serious disease and one of the most important differential diagnoses in the emergency department. PATIENT CONCERNS: A 39-year-old female patient with a 12 years' history of migraine, presented with a sudden headache combined with motor aphasia. Physical examination suggested probable positive neck resistance. SAH was confirmed by magnetic resonance imaging. In addition, spinal digital subtraction angiography and spinal vascular computed tomography angiography indicated spinal arteriovenous malformation (SAVM)...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29660554/effect-of-early-brain-infarction-after-subarachnoid-haemorrhage-a-systematic-review-and-meta-analysis
#9
Bruno Gonçalves, Ricardo Turon, Antenor Mendes, Nivea Melo, Paula Lacerda, Pedro Brasil, Fernando Augusto Bozza, Pedro Kurtz, Cassia Righy
OBJECTIVE: Aneurysmal subarachnoid haemorrhage (aSAH) is an acute cerebrovascular event that leads to devastating consequences. Early brain infarction (EBI) develops very early, within the first 72 hours after bleeding, but may have a significant impact on long-term outcomes. The incidence and impact of EBI in the prognosis of aSAH remain uncertain. We performed a systematic review and meta-analysis to evaluate the incidence of EBI in patients with aSAH and determine the effect of EBI on mortality and functional outcomes...
April 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29660038/external-ventricular-drain-and-hemorrhage-in-aneurysmal-subarachnoid-hemorrhage-patients-on-dual-antiplatelet-therapy-a-retrospective-cohort-study
#10
Joseph S Hudson, Benjamin S Prout, Yasunori Nagahama, Daichi Nakagawa, Waldo R Guerrero, Mario Zanaty, Nohra Chalouhi, Pascal Jabbour, Sudeepta Dandapat, Lauren Allan, Santiago Ortega-Gutierrez, Edgar A Samaniego, David Hasan
BACKGROUND: Stenting and flow diversion for aneurysmal sub arachnoid hemorrhage (aSAH) require the use of dual antiplatelet therapy (DAPT). OBJECTIVE: To investigate whether DAPT is associated with hemorrhagic complication following placement of external ventricular drains (EVD) in patients with aSAH. METHODS: Rates of radiographically identified hemorrhage associated with EVD placement were compared between patients who received DAPT for stenting or flow diversion, and patients who underwent microsurgical clipping or coiling and did not receive DAPT by way of a backward stepwise multivariate analysis...
April 11, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29659999/increased-body-mass-index-associated-with-reduced-risk-of-delayed-cerebral-ischemia-and-subsequent-infarction-after-aneurysmal-subarachnoid-hemorrhage
#11
Lorenzo Rinaldo, Alejandro A Rabinstein, Giuseppe Lanzino
BACKGROUND: Increased body mass index (BMI) may be protective against cerebral ischemia in certain clinical contexts. OBJECTIVE: To investigate whether increased BMI was associated with delayed cerebral ischemia (DCI) and subsequent infarction after aneurysmal subarachnoid hemorrhage (aSAH). METHODS: We retrospectively reviewed the clinical course of patients presenting to our institution for management of aSAH. Patient were segregated according to BMI< or ≥29...
April 4, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29659159/spinal-accessory-motor-neurons-in-the-mouse-a-special-type-of-branchial-motor-neuron
#12
Charles Watson, Petr Tvrdik
The spinal accessory nerve arises from motor neurons in the upper cervical spinal cord. The axons of these motor neurons exit dorsal to the ligamentum denticulatum and form the spinal accessory nerve. The nerve ascends in the spinal subarachnoid space to enter the posterior cranial fossa through the foramen magnum. The spinal accessory nerve then turns caudally to exit through the jugular foramen alongside the vagus and glossopharyngeal nerves, and then travels to supply the sternomastoid and trapezius muscles in the neck...
April 16, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29659050/continuous-electroencephalography-predicts-delayed-cerebral-ischemia-after-subarachnoid-hemorrhage-a-prospective-study-of-diagnostic-accuracy
#13
Eric S Rosenthal, Siddharth Biswal, Sahar F Zafar, Kathryn L O'Connor, Sophia Bechek, Apeksha V Shenoy, Emily J Boyle, Mouhsin M Shafi, Emily J Gilmore, Brandon P Foreman, Nicolas Gaspard, Thabele M Leslie-Mazwi, Jonathan Rosand, Daniel B Hoch, Cenk Ayata, Sydney S Cash, Andrew J Cole, Aman B Patel, M Brandon Westover
OBJECTIVE: Delayed cerebral ischemia (DCI) is a common, disabling complication of subarachnoid hemorrhage (SAH). Preventing DCI is a key focus of neurocritical care, but interventions carry risk and cannot be applied indiscriminately. While retrospective studies have identified continuous EEG (cEEG) measures associated with DCI, no study has characterized the accuracy of cEEG with sufficient rigor to justify using it to triage patients to interventions or clinical trials. We therefore prospectively assessed the accuracy of cEEG for predicting DCI, following the Standards for Reporting Diagnostic Accuracy Studies...
April 16, 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29656002/dangers-of-outpatient-nimodipine-use-after-spontaneous-subarachnoid-hemorrhage-in-accordance-with-the-comprehensive-stroke-center-guidelines
#14
Ching-Jen Chen, Cassie Turnage, Jennifer D Sokolowski, Jeyan S Kumar, M Yashar Kalani, Min S Park
Despite the adverse effects and unclear benefit of the complete 21-day course of nimodipine therapy, The Joint Commission mandates adherence to nimodipine treatment for 21 days after hemorrhage or after hospital discharge if discharged within 21 days for Comprehensive Stroke Center (CSC) certification. We hereby present a 67 year-old male patient with Hunt-Hess grade 2 and Fisher grade 3 non-aneurysmal spontaneous subarachnoid hemorrhage who was discharged with oral nimodipine as stipulated by the CSC guidelines, and subsequently developed symptomatic hypotension...
April 11, 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29652714/growing-evidence-dysautoregulation-may-trigger-ischemic-deficit-after-subarachnoid-hemorrhage
#15
Karol P Budohoski, Marek Czosnyka
No abstract text is available yet for this article.
May 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29652228/prediction-of-clinical-outcome-in-subacute-subarachnoid-hemorrhage-using-diffusion-tensor-imaging
#16
Isabel Fragata, Marta Alves, Ana Luísa Papoila, Patrícia Ferreira, Ana Paiva Nunes, Nuno Canto Moreira, Patrícia Canhão
OBJECTIVE Clinical outcome in nontraumatic subarachnoid hemorrhage (SAH) is multifactorial and difficult to predict. Diffusion tensor imaging (DTI) findings are a prognostic marker in some diseases such as traumatic brain injury. The authors hypothesized that DTI parameters measured in the subacute phase of SAH can be associated with a poor clinical outcome. METHODS Diffusion tensor imaging was prospectively performed in 54 patients at 8-10 days after nontraumatic SAH. Logistic regression analysis was performed to evaluate the association of fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values with a poor clinical outcome (modified Rankin Scale score ≥ 3) at 3 months...
April 13, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29651951/inflammatory-events-following-subarachnoid-hemorrhage-sah
#17
U C Schneider, R Xu, P Vajkoczy
Acute SAH from a ruptured intracranial aneurysm contributes for 30% of all hemorrhagic strokes. The bleeding itself occurs in the subarachnoid space. Nevertheless, injury to the brain parenchyma occurs as a consequence of the bleeding, directly, via several well-defined mechanisms and pathways, but also indirectly, or secondarily. This secondary brain injury following SAH has a variety of causes and possible mechanisms. Amongst others, inflammatory events have been shown to occur in parallel to, to contribute to, or even to initiate programmed cell death (PCD) within the central nervous system (CNS) in human and animal studies alike...
April 11, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29650786/association-of-quantified-location-specific-blood-volumes-with-delayed-cerebral-ischemia-after-aneurysmal-subarachnoid-hemorrhage
#18
W E van der Steen, I A Zijlstra, D Verbaan, A M M Boers, C S Gathier, R van den Berg, G J E Rinkel, B A Coert, Y B W E M Roos, C B L M Majoie, H A Marquering
BACKGROUND AND PURPOSE: Delayed cerebral ischemia is a severe complication of aneurysmal SAH and is associated with a high case morbidity and fatality. The total blood volume and the presence of intraventricular blood on CT after aneurysmal SAH are associated with delayed cerebral ischemia. Whether quantified location-specific (cisternal, intraventricular, parenchymal, and subdural) blood volumes are associated with delayed cerebral ischemia has been infrequently researched. This study aimed to associate quantified location-specific blood volumes with delayed cerebral ischemia...
April 12, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29650059/labyrinthitis-ossificans-in-a-cynomolgus-macaque-macaca-fascicularis
#19
Gayathriy Balamayooran, Hannah M Atkins, Christopher T Whitlow, Samuel T Aycock, Michael A Nader, J Mark Cline, David L Caudell
Labyrinthitis is inflammation of the membranous and bony labyrinth of the inner ear. Typical portals of entry includehematogenous spread from the cochlear vasculature, passage of otitis media pathogens through the round window, and mostcommonly, meningogenic spread from the subarachnoid space. The sequela of chronic inner ear inflammation is labyrinthitisossificans, in which inner ear structures are replaced by fibrous and osseous tissues. Labyrinthitis in humans has been reportedconcurrently with infection due to various viruses (for example, varicella-zoster, measles, mumps) and bacteria (for example,Treponema pallidum, Streptococcus pneumoniae) and may be associated with vertebrobasilar ischemia and meningitis...
April 12, 2018: Comparative Medicine
https://www.readbyqxmd.com/read/29649653/a-label-free-cellulose-sers-biosensor-chip-with-improvement-of-nanoparticle-enhanced-lspr-effects-for-early-diagnosis-of-subarachnoid-hemorrhage-induced-complications
#20
Wansun Kim, Sung Ho Lee, Yong Jin Ahn, Seung Ho Lee, Jiwook Ryu, Seok Keun Choi, Samjin Choi
It is very difficult to predict some complications after subarachnoid hemorrhage (SAH), despite rapid advances in medical science. Herein, we introduce a label-free cellulose surface-enhanced Raman spectroscopy (SERS) biosensor chip with pH-functionalized, gold nanoparticle (AuNP)-enhanced localized surface plasmon resonance (LSPR) effects for identification of SAH-induced cerebral vasospasm and hydrocephalus caused by cerebrospinal fluid (CSF). The SERS biosensor chip was implemented by the synthesis reaction of the AuNPs, which were charged positively through pH level adjustment, onto a negatively-charged cellulose substrate with ξ = -30...
April 4, 2018: Biosensors & Bioelectronics
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