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https://www.readbyqxmd.com/read/29905889/thioredoxin-interacting-protein-mediates-mitochondrion-dependent-apoptosis-in-early-brain-injury-after-subarachnoid-hemorrhage
#1
Yidan Liang, Xudong Che, Qing Zhao, Rami Darwazeh, Hongxia Zhang, Dengzhi Jiang, Jun Zhao, Xiang Xiang, Wang Qin, Liu Liu, Zhaohui He
Early brain injury (EBI) was reported to be the primary cause of high mortality and poor outcomes in subarachnoid hemorrhage (SAH) patients, and apoptosis is regarded as the most important physiopathologic mechanism during EBI. Recently, our team found that thioredoxin-interacting protein (TXNIP) links endoplasmic reticulum stress (ER stress) to neuronal apoptosis and aggravates EBI. However, the other underlying mechanisms remain unknown. Mitochondria are considered to be the central points in integrating apoptotic cell death...
June 15, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29904368/number-of-cigarettes-smoked-per-day-smoking-index-and-intracranial-aneurysm-rupture-a-case-control-study
#2
Xin Feng, Zenghui Qian, Baorui Zhang, Erkang Guo, Luyao Wang, Peng Liu, Xiaolong Wen, Wenjuan Xu, Chuhan Jiang, Youxiang Li, Zhongxue Wu, Aihua Liu
Background and purpose: We aimed to investigate the effect of smoking on the risk of intracranial aneurysm (IA) rupture (IAR), specifically relationship between the number of cigarettes smoked per day (CPD) or smoking index and the risk of IAR. Methods: We performed a single-center case-control study of consecutive patients evaluated or treated for IA at our institution from June 2015 to July 2016. Cases were patients with a ruptured IA. Two age- and sex-matched controls with an unruptured IA were included per case...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29904350/unique-contribution-of-haptoglobin-and-haptoglobin-genotype-in-aneurysmal-subarachnoid-hemorrhage
#3
REVIEW
Spiros L Blackburn, Peeyush T Kumar, Devin McBride, Hussein A Zeineddine, Jenna Leclerc, H Alex Choi, Pramod K Dash, James Grotta, Jaroslaw Aronowski, Jessica C Cardenas, Sylvain Doré
Survivors of cerebral aneurysm rupture are at risk for significant morbidity and neurological deficits. Much of this is related to the effects of blood in the subarachnoid space which induces an inflammatory cascade with numerous downstream consequences. Recent clinical trials have not been able to reduce the toxic effects of free hemoglobin or improve clinical outcome. One reason for this may be the inability to identify patients at high risk for neurologic decline. Recently, haptoglobin genotype has been identified as a pertinent factor in diabetes, sickle cell, and cardiovascular disease, with the Hp 2-2 genotype contributing to increased complications...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29903638/-pneumocephalus-is-defined-as-the-presence-of-air-in-the-epidural-subdural-or-subarachnoid-space-within-the-brain-parenchyma-and-the-ventricular-cavities
#4
María Jesús Álvarez-Holzapfel, Juan Ángel Aibar Durán, Sonia Brió Sanagustin, Cristian de Quintana-Schmidt
No abstract text is available yet for this article.
June 11, 2018: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29903393/one-year-prognosis-of-non-traumatic-cortical-subarachnoid-haemorrhage-a-prospective-series-of-34-patients
#5
R F Galiano Blancart, G Fortea, A Pampliega Pérez, S Martí, V Parkhutik, A V Sánchez Cruz, C Soriano, D Geffner Sclarsky, M T Pérez Saldaña, N López Hernández, I Beltrán, A Lago Martín
INTRODUCTION: Cortical subarachnoid haemorrhage (cSAH) has multiple aetiologies. No prospective study has reported the long-term progression of the condition. The objective of this study is to describe the clinical and aetiological characteristics of patients with cSAH and to gain insight into prognosis. METHODS: We performed a prospective, observational, multi-centre study. Data on clinical and radiological variables were collected; during a one-year follow-up period, we recorded data on mortality, dependence, rebleeding, and the appearance of dementia...
June 11, 2018: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/29903035/is-bulk-flow-plausible-in-perivascular-paravascular-and-paravenous-channels
#6
Mohammad M Faghih, M Keith Sharp
BACKGROUND: Transport of solutes has been observed in the spaces surrounding cerebral arteries and veins. Indeed, transport has been found in opposite directions in two different spaces around arteries. These findings have motivated hypotheses of bulk flow within these spaces. The glymphatic circulation hypothesis involves flow of cerebrospinal fluid from the cortical subarachnoid space to the parenchyma along the paraarterial (extramural, Virchow-Robin) space around arteries, and return flow to the cerebrospinal fluid (CSF) space via paravenous channels...
June 15, 2018: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/29902610/modified-extended-suboccipital-subtonsillar-clipping-of-a-ruptured-proximal-pica-aneurysm-technical-note-with-relevant-anatomical-demonstration
#7
Alberto Di Somma, Paloma Cancela, Magdalena Olivares, Teresa Somma, Antonio López-González, Alvaro Campero, Juan Emmerich, Javier Márquez-Rivas
BACKGROUND: and importance: Lesions located lateral to the lower brainstem, such as proximal posterior inferior cerebellar artery (PICA) aneurysms, are surgically challenging. In this study we report a case of a patient with a left proximal PICA aneurysm that was successfully clipped via a so-called "extended" suboccipital subtonsillar approach, which allowed to obtain proper vascular control without removal of the atlas. The anatomy relevant for this approach has been studied...
June 11, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29902601/study-of-correlation-between-hp-%C3%AE-1-expression-of-haptoglobin2-1-and-clinical-course-in-aneurysmal-subarachnoid-hemorrhage
#8
Bong Jun Kim, Youngmi Kim, Sung-Eun Kim, Jin Pyeong Jeon
OBJECTIVE: Haptoglobin (Hp) comprising two light (α) and two heavy (β) chains has an anti-oxidant effect following free hemoglobin binding. Among three phenotypes including Hp1-1 (two α1), Hp2-1 (α1 and α2), and Hp2-2 (two α2), a higher protective effect for toxic-free hemoglobin was reported for Hp2-2 than Hp1-1. However, few studies have focused on Hp2-1 in outcome. This study examined the α1 and α2 expression, and evaluated the correlation of Hp2-1 with subarachnoid hemorrhage (SAH) outcome...
June 11, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29901648/purulent-meningitis-caused-by-rhodococcus-equi-a-case-report
#9
Le-Xiang Cui, Li-Na Gu, Yan-Bo Hou, Bei-Lin Zhang, Jing-Yao Liu
RATIONALE: Purulent meningitis refers infection of the subarachnoid space by various purulent bacteria and the corresponding inflammation of the leptomeninges. However, purulent meningitis due to Rhodococcus equi is extremely rare. PATIENT CONCERNS: A 40-year-old man presented with fever and intermittent headache for 6 days. Two hours prior to admission, he developed epileptic seizures. DIAGNOSES: Brain computed tomography and magnetic resonance imaging showed intracerebral malacic lesions...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29899537/preliminary-investigation-of-focused-ultrasound-facilitated-drug-delivery-for-the-treatment-of-leptomeningeal-metastases
#10
Meaghan A O'Reilly, Tricia Chinnery, My-Linh Yee, Sheng-Kai Wu, Kullervo Hynynen, Robert S Kerbel, Gregory J Czarnota, Kathleen I Pritchard, Arjun Sahgal
Leptomeningeal metastases (LM) are a serious complication of cancer in the central nervous system (CNS) and are diagnosed in approximately 5% of patients with solid tumors. Effective treatment using systemically administered therapeutics is hindered by the barriers of the CNS. Ultrasound can mediate delivery of drugs through these barriers. The goal of this study was to test the feasibility of using ultrasound-mediated drug delivery to improve the treatment of LM. LM was induced in the spinal cord of athymic rats by injecting HER2-expressing breast cancer cells into the subarachnoid space of the thoracic spine...
June 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29895534/neurologic-outcome-predictors-in-pediatric-intracerebral-hemorrhage-a-prospective-study
#11
Giulia S Porcari, Lauren A Beslow, Rebecca N Ichord, Daniel J Licht, Jonathan T Kleinman, Lori C Jordan
BACKGROUND AND PURPOSE: Intracerebral hemorrhage is a considerable source of morbidity and mortality. This 3-center study describes outcomes of pediatric intracerebral hemorrhage and identifies 2-year neurological outcome predictors. METHODS: Children 29 days to 18 years of age presenting with intracerebral hemorrhage from March 2007 to May 2015 were enrolled prospectively. Exclusion criteria included trauma; intracranial tumor; hemorrhagic transformation of arterial ischemic stroke or cerebral sinovenous thrombosis; isolated subdural, epidural, or subarachnoid hemorrhage; and abnormal baseline neurological function...
June 12, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29892257/focused-neuro-otological-review-of-superficial-siderosis-of-the-central-nervous-system
#12
Aran Yoo, Jonathan Jou, Jeffrey D Klopfenstein, Jorge C Kattah
Background: Infratentorial siderosis (iSS) is a progressive degenerative disorder targeting primarily the cerebellum and cranial nerve eighth; therefore, progressive ataxia and its neuro-otological findings are common. Toxicity from hemosiderin involves selectively vulnerable neurons and glia in these posterior fossa structures. Other neurologic findings may be present, though our focus relates to the cochlea-vestibular cerebellar involvement. Radiographic evidence of siderosis may be the result of recurrent, albeit covert bleeding in the subarachnoid space, or the consequence of an overt post-traumatic or aneurysmal subarachnoid hemorrhage (SAH)...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29891122/a-non-traumatic-rapid-onset-headache-that-is-as-dangerous-as-subarachnoid-hemorrhage-sah-seen-in-the-emergency-department
#13
Matthew M Palilonis, Jeanne L Jacoby
No abstract text is available yet for this article.
May 30, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29890915/prevalence-of-subarachnoid-haemorrhage-among-patients-with-cranial-venous-sinus-thrombosis-in-the-presence-and-absence-of-venous-infarcts
#14
Muhammad Azeemuddin, Muhammad Awais, Fatima Mubarak, Abdul Rehman, Noor Ul-Ain Baloch
Introduction In patients with cranial venous sinus thrombosis, the occurrence of subarachnoid haemorrhage in association with haemorrhagic venous infarcts is a well described phenomenon. However, the presence of subarachnoid haemorrhage in patients with cranial venous sinus thrombosis in the absence of a haemorrhagic venous infarct is exceedingly rare. Methods We retrospectively reviewed charts and scans of all patients who had cranial venous sinus thrombosis confirmed by magnetic resonance venography at our hospital between September 2004 and May 2015...
January 1, 2018: Neuroradiology Journal
https://www.readbyqxmd.com/read/29890540/rehabilitation-after-clipping-of-cerebral-aneurysms-without-acute-subarachnoid-hemorrhage-outcome-analysis-of-100-consecutive-cases
#15
Andreas Jödicke, Karsten Bauer, Andrea Hajdukova
BACKGROUND:  Discharge to rehabilitation is reported in large studies as one important outcome parameter based on hospital codes. Because neurologic outcome scores (e.g., the modified Rankin Scale [mRS]) are missing in International Classification of Diseases (ICD) databases, rehabilitation indirectly serves as a kind of surrogate parameter for overall outcome. Reported fractions of patients with rehabilitation, however, largely differ between studies and seem high for patients with aneurysm clipping...
June 11, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/29889274/posterior-reversible-encephalopathy-syndrome-as-a-complication-of-induced-hypertension-in-subarachnoid-hemorrhage-a-case-control-study
#16
Michelle L Allen, Tobias Kulik, Salah G Keyrouz, Rajat Dhar
BACKGROUND: Induced hypertension (IH) remains the mainstay of medical management for delayed cerebral ischemia (DCI) after subarachnoid hemorrhage (SAH). However, raising blood pressure above normal levels may be associated with systemic and neurological complications, of which posterior reversible encephalopathy syndrome (PRES) has been increasingly recognized. OBJECTIVE: To ascertain the frequency and predisposing factors for PRES during IH therapy. METHODS: We identified 68 patients treated with IH from 345 SAH patients over a 3-yr period...
June 8, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29889252/commentary-posterior-reversible-encephalopathy-syndrome-as-a-complication-of-induced-hypertension-in-subarachnoid-hemorrhage-a-case-control-study
#17
François Dépret, Maxime Coutrot
No abstract text is available yet for this article.
June 8, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29889209/cannula-implantation-into-the-cisterna-magna-of-rodents
#18
Anna L R Xavier, Natalie Linea Hauglund, Stephanie von Holstein-Rathlou, Qianliang Li, Simon Sanggaard, Nanhong Lou, Iben Lundgaard, Maiken Nedergaard
Cisterna magna cannulation (CMc) is a straightforward procedure that enables direct access to the cerebrospinal fluid (CSF) without operative damage to the skull or the brain parenchyma. In anesthetized rodents, the exposure of the dura mater by blunt dissection of the neck muscles allows the insertion of a cannula into the cisterna magna (CM). The cannula, composed either by a fine beveled needle or borosilicate capillary, is attached via a polyethylene (PE) tube to a syringe. Using a syringe pump, molecules can then be injected at controlled rates directly into the CM, which is continuous with the subarachnoid space...
May 23, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29885663/aggf1-attenuates-neuroinflammation-and-bbb-disruption-via-pi3k-akt-nf-%C3%AE%C2%BAb-pathway-after-subarachnoid-hemorrhage-in-rats
#19
Qiquan Zhu, Budbazar Enkhjargal, Lei Huang, Tongyu Zhang, Chengmei Sun, Zhiyi Xie, Pei Wu, Jun Mo, Jiping Tang, Zongyi Xie, John H Zhang
BACKGROUND: Neuroinflammation and blood-brain barrier (BBB) disruption are two critical mechanisms of subarachnoid hemorrhage (SAH)-induced brain injury, which are closely related to patient prognosis. Recently, angiogenic factor with G-patch and FHA domain 1 (Aggf1) was shown to inhibit inflammatory effect and preserve vascular integrity in non-nervous system diseases. This study aimed to determine whether Aggf1 could attenuate neuroinflammation and preserve BBB integrity after experimental SAH, as well as the underlying mechanisms of its protective roles...
June 9, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29884860/global-mirna-expression-profile-reveals-novel-molecular-players-in-aneurysmal-subarachnoid-haemorrhage
#20
Katia de Paiva Lopes, Tatiana Vinasco-Sandoval, Ricardo Assunção Vialle, Fernando Mendes Paschoal, Vanessa Albuquerque P Aviz Bastos, Edson Bor-Seng-Shu, Manoel Jacobsen Teixeira, Elizabeth Sumi Yamada, Pablo Pinto, Amanda Ferreira Vidal, Arthur Ribeiro-Dos-Santos, Fabiano Moreira, Sidney Santos, Eric Homero Albuquerque Paschoal, Ândrea Ribeiro-Dos-Santos
The molecular mechanisms behind aneurysmal subarachnoid haemorrhage (aSAH) are still poorly understood. Expression patterns of miRNAs may help elucidate the post-transcriptional gene expression in aSAH. Here, we evaluate the global miRNAs expression profile (miRnome) of patients with aSAH to identify potential biomarkers. We collected 33 peripheral blood samples (27 patients with cerebral aneurysm, collected 7 to 10 days after the haemorrhage, when usually is the cerebral vasospasm risk peak, and six controls)...
June 8, 2018: Scientific Reports
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