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https://www.readbyqxmd.com/read/28105338/association-between-mmp-3-and-mmp-9-polymorphisms-and-coronary-artery-disease
#1
Osman Beton, Serdal Arslan, Burak Acar, Nil Ozbilum, Ocal Berkan
Matrix metalloproteinase (MMP)-3 and MMP-9 polymorphisms are characterized by plaque stability in coronary arteries. The aim of the current study was to investigate the 5A/6A polymorphism in the MMP-3 gene and C/T polymorphism in the MMP-9 gene in patients with coronary artery disease (CAD). The study population consisted of 400 patients who underwent coronary angiography. There were two groups consisting of 200 consecutive patients with CAD, presenting with stable angina pectoris, and 200 consecutive patients exhibiting normal coronary arteries...
December 2016: Biomedical Reports
https://www.readbyqxmd.com/read/28099219/a-review-of-the-clinical-utility-of-intravascular-ultrasound-ivus-and-optical-coherence-tomography-oct-in-the-assessment-and-treatment-of-coronary-artery-disease
#2
Stephen Daniel Matthews, William H Frishman
Coronary artery disease (CAD) remains one of the leading causes of morbidity and mortality in the United States. As a medical society, we continue to search for ways to better treat CAD and prevent acute coronary syndrome (ACS). As it stands, only statins and anti-platelets agents have been proven to significantly reduce the occurrence of ACS. A histopathological understanding of the pathogenesis of ACS has provided insight into the importance of plaque morphology. Therefore, it has been proposed that increasing the ability to detect true vulnerable, "at-risk" lesions, would foster the use of percutaneous coronary intervention as a means for the prevention of ACS...
January 11, 2017: Cardiology in Review
https://www.readbyqxmd.com/read/28078857/effects-of-sevoflurane-on-cardiopulmonary-function-in-patients-undergoing-coronary-artery-bypass
#3
J Zhang, S Wang
The objective of the current study was to investigate effects of sevoflurane on cardiopulmonary function in patients undergoing coronary artery bypass grafting (CABG). In this study, 60 cases of patients with coronary heart disease (CHD) were selected and randomly divided into the sevoflurane group (group S) and the control group C (group C) with 30 cases in each group. The two groups received intravenous anesthesia. The patients of group C were only given oxygen mask and physiological saline to keep vein open; while the patients of group S were administered with 1% sevoflurane immediately after the beginning of cardiopulmonary bypass (CPB) until the end of the treatment...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28069011/myeloperoxidase-oxidized-high-density-lipoprotein-impairs-atherosclerotic-plaque-stability-by-inhibiting-smooth-muscle-cell-migration
#4
Boda Zhou, Lingyun Zu, Yong Chen, Xilong Zheng, Yuhui Wang, Bing Pan, Min Dong, Enchen Zhou, Mingming Zhao, Youyi Zhang, Lemin Zheng, Wei Gao
BACKGROUND: High density lipoprotein (HDL) has been proved to be a protective factor for coronary heart disease. Notably, HDL in atherosclerotic plaques can be nitrated (NO2-oxHDL) and chlorinated (Cl-oxHDL) by myeloperoxidase (MPO), likely compromising its cardiovascular protective effects. METHOD: Here we determined the effects of NO2-oxHDL and Cl-oxHDL on SMC migration using wound healing and transwell assays, proliferation using MTT and BrdU assays, and apoptosis using Annexin-V assay in vitro, as well as on atherosclerotic plaque stability in vivo using a coratid artery collar implantation mice model...
January 10, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28057795/pleiotropic-effects-of-statins-on-the-cardiovascular-system
#5
REVIEW
Adam Oesterle, Ulrich Laufs, James K Liao
The statins have been used for 30 years to prevent coronary artery disease and stroke. Their primary mechanism of action is the lowering of serum cholesterol through inhibiting hepatic cholesterol biosynthesis thereby upregulating the hepatic low-density lipoprotein (LDL) receptors and increasing the clearance of LDL-cholesterol. Statins may exert cardiovascular protective effects that are independent of LDL-cholesterol lowering called pleiotropic effects. Because statins inhibit the production of isoprenoid intermediates in the cholesterol biosynthetic pathway, the post-translational prenylation of small GTP-binding proteins such as Rho and Rac, and their downstream effectors such as Rho kinase and nicotinamide adenine dinucleotide phosphate oxidases are also inhibited...
January 6, 2017: Circulation Research
https://www.readbyqxmd.com/read/28042398/quality-of-life-in-patients-with-coronary-artery-disease-and-panic-disorder-a-comparative-study
#6
Shruti Srivastava, Skand Shekhar, Manjeet Singh Bhatia, Shridhar Dwivedi
OBJECTIVES: The quality of life (QOL) of patients with coronary artery disease (CAD) is known to be impaired. Non-cardiac chest pain referrals are often under-diagnosed and untreated, and there are hardly any studies comparing the QOL of CAD and panic disorder related (non-cardiac) chest pain referrals (PDRC). METHODS: We assessed the psychiatric morbidity and QOL of patients newly diagnosed with CAD (n = 40) at baseline and six weeks post-treatment and compared their QOL with patients with PDRC (n = 40) and age- and gender-matched healthy controls (n = 57)...
January 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28040288/collateral-filling-efficiency-of-comorbid-chronic-total-occlusion-segment-on-short-term-mortality-in-st-elevation-myocardial-infarction
#7
Toshiharu Fujii, Masataka Nakano, Yohei Ohno, Gaku Nakazawa, Norihiko Shinozaki, Takashi Matsukage, Fuminobu Yoshimachi, Yuji Ikari
BACKGROUND: Collateral filling of chronic total occlusion (CTO) segments is considered to affect hemodynamic stability in primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI) with CTO, however its value as a prognostic indicator for mortality is uncertain. The present study examined the relationship between collateral filling of CTO segments and short-term mortality in patients with STEMI with a comorbid CTO lesion. METHODS: Among 829 STEMI patients who underwent primary PCI, 74 patients with CTO were identified...
December 21, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28004026/flow-cytometric-data-analysis-of-circulating-progenitor-cell-stability
#8
Ernestine A Mahar, Liping Mou, Salim S Hayek, Arshed A Quyyumi, Edmund K Waller
A recent publication by Mekonnen et al. demonstrated that among women with non-obstructive coronary artery disease, higher levels of circulating progenitor cells in the blood (CPC), were associated with impaired coronary flow reserve [1]. We performed a quality control assessment of the stability of circulating blood progenitor cells in blood samples stored at 4 °C, to determine the time period during which blood samples can be analyzed and yield consistent data for progenitor cell content. Healthy volunteers (n=6) were recruited and underwent phlebotomy, and blood was stored in EDTA tubes at 4 °C...
February 2017: Data in Brief
https://www.readbyqxmd.com/read/27989886/intracoronary-imaging-cholesterol-efflux-and-transcriptomes-after-intensive-statin-treatment-the-yellow-ii-study
#9
Annapoorna S Kini, Yuliya Vengrenyuk, Khader Shameer, Akiko Maehara, Meerarani Purushothaman, Takahiro Yoshimura, Mitsuaki Matsumura, Melissa Aquino, Nezam Haider, Kipp W Johnson, Ben Readhead, Brian A Kidd, Jonathan E Feig, Prakash Krishnan, Joseph Sweeny, Milind Mahajan, Pedro Moreno, Roxana Mehran, Jason C Kovacic, Usman Baber, Joel T Dudley, Jagat Narula, Samin Sharma
BACKGROUND: Despite the extensive evidence for the beneficial effects of statins on clinical outcomes, the mechanisms underlying these effects in remain elusive. OBJECTIVES: To assess the changes in plaque morphology by intravascular imaging with a comprehensive evaluation of cholesterol efflux capacity (CEC) and peripheral blood mononuclear cells (PBMC) transcriptomics in patients receiving high-dose statin therapy. METHODS: In a prospective study, 85 patients with stable multivessel coronary artery disease underwent percutaneous coronary intervention for a culprit lesion followed by intracoronary multi-modality imaging including optical coherence tomography (OCT) of an obstructive non-culprit lesion (NCL)...
October 27, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27976798/identification-and-validation-of-micrornas-as-endogenous-controls-for-quantitative-polymerase-chain-reaction-in-plasma-for-stable-coronary-artery-disease
#10
Yuejuan Zhang, Wenxian Tang, Ling Peng, Jinqiang Tang, Zhaokai Yuan
BACKGROUND: Circulating microRNAs (miRNAs) have been proved to serve as biomarkers for diagnosis and assessment of prognosis of coronary artery disease (CAD). Reverse transcription quantitative polymerase chain reaction (RT-qPCR) is a widely-used technique to estimate expression levels of circulating miRNAs. Selection of optimal endogenous control (EC) remains critical to obtain reliable qPCR data of miRNAs expression. However, reference controls for normalization of circulating miRNA in CAD are still lacking...
2016: Cardiology Journal
https://www.readbyqxmd.com/read/27942396/off-pump-coronary-artery-bypass-grafting-in-left-main-stem-stenosis-outcomes-concerns-and-controversies
#11
REVIEW
Leonidas V Athanasopoulos, Thanos Athanasiou
Left main stem (LMS) disease is known to be a poor prognostic factor in terms of morbidity or mortality. Traditionally, it has been treated with constitution of bypass to provide required haemodynamic stability. We searched the literature for evidence on off-pump (OFP) surgery for treating this high-risk group of patients focusing in our review on postoperative outcomes, concerns and controversies. The majority of the studies identified showed favourable or equal outcomes of OFP when compared to conventional approach...
November 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27928211/use-of-heart-rate-variability-to-estimate-lactate-threshold-in-coronary-artery-disease-patients-during-resistance-exercise
#12
Rodrigo P Simões, Renata G Mendes, Viviane Castello-Simões, Aparecida M Catai, Ross Arena, Audrey Borghi-Silva
The aim of this study was to investigate whether it is possible to identify the first turn point of blood lactate (BL) concentration (1(st) lactate threshold - LT1) during a discontinuous resistance exercise protocol in coronary artery disease (CAD) patients and verify if heart rate variability (HRV) responses are consistent with BL responses. A total of 22 elderly men, 12 with CAD and 10 apparently healthy (control group = CG), underwent one-repetition maximum (1RM) testing on an inclined leg press. Discontinuous resistance exercise testing (DRET) was initiated at 10% of the 1RM with subsequent increases of 10% until 30% and after this percentage, 5% increments of 1RM was carried out...
December 2016: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/27882428/progression-of-noncalcified-and-calcified-coronary-plaque-by-ct-angiography-in-sle
#13
Aisha Khan, Armin Arbab-Zadeh, Adnan N Kiani, Laurence S Magder, Michelle Petri
Premature coronary artery disease remains the major cause of late death in systemic lupus erythematosus (SLE). Coronary artery calcium (CAC) represents an advanced stage of atherosclerosis, whereas noncalcified coronary atherosclerotic plaque (NCP) typically is more prone to trigger acute coronary events. The aim of this study was to assess the stability of NCP over time and identify factors associated with changes in NCP in patients with SLE. CT coronary angiography and calcium scanning were performed at baseline and follow-up in thirty-six SLE patients...
January 2017: Rheumatology International
https://www.readbyqxmd.com/read/27879314/genetic-variation-in-the-slc8a1-calcium-signaling-pathway-is-associated-with-susceptibility-to-kawasaki-disease-and-coronary-artery-abnormalities
#14
Chisato Shimizu, Hariklia Eleftherohorinou, Victoria J Wright, Jihoon Kim, Martin P Alphonse, James C Perry, Rolando Cimaz, David Burgner, Nagib Dahdah, Long T Hoang, Chiea Chuen Khor, Andrea Salgado, Adriana H Tremoulet, Sonia Davila, Taco W Kuijpers, Martin L Hibberd, Todd A Johnson, Atsushi Takahashi, Tatsuhiko Tsunoda, Michiaki Kubo, Toshihiro Tanaka, Yoshihiro Onouchi, Rae S M Yeung, Lachlan J M Coin, Michael Levin, Jane C Burns
BACKGROUND: Kawasaki disease (KD) is an acute pediatric vasculitis in which host genetics influence both susceptibility to KD and the formation of coronary artery aneurysms. Variants discovered by genome-wide association studies and linkage studies only partially explain the influence of genetics on KD susceptibility. METHODS AND RESULTS: To search for additional functional genetic variation, we performed pathway and gene stability analysis on a genome-wide association study data set...
December 2016: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/27799085/atheroprotective-effects-of-pure-tocotrienol-supplementation-in-the-treatment-of-rabbits-with-experimentally-induced-early-and-established-atherosclerosis
#15
Thuhairah Abdul Rahman, Noor Faezah Hassim, Nurmazni Zulkafli, Suhaila Muid, Noor Kaslina Kornain, Hapizah Nawawi
BACKGROUND: Atherosclerosis is the main cause of coronary artery disease -related deaths worldwide. The atheroprotective properties of pure tocotrienols (T3) in the absence of alpha-tocopherol (α-TCP) in vitamin E has not been extensively examined. AIM: To determine the atheroprotective properties of T3 in early and established atherosclerosis rabbits. METHODS: Thirty New Zealand white rabbits were divided into two groups, B1 and B2 which represent early [fed 1% high cholesterol diet (HCD) for 2 weeks] and established (fed 1% HCD for 8 weeks) atherosclerosis...
2016: Food & Nutrition Research
https://www.readbyqxmd.com/read/27778191/impact-of-adding-eicosapentaenoic-acid-to-statin-therapy-on-plasma-pentraxin-3-level-in-patients-with-stable-coronary-artery-disease-a-6-month-randomized-controlled-study
#16
Shigemasa Tani, Ken Nagao, Tsukasa Yagi, Wataru Atsumi, Atsushi Hirayama
BACKGROUND: We hypothesized that the additional administration of eicosapentaenoic acid (EPA) in patients with stable coronary artery disease (CAD) receiving statin has the potential to lower the serum pentraxin 3 (PTX3) level, an indicator of plaque stabilization. METHODS: We randomly assigned CAD patients already receiving statin therapy to an EPA group (1800 mg/day, n = 53) or control group (n = 53). RESULTS: No significant difference was found in the change in the plasma PTX3 level between the groups...
February 2017: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/27772606/robotic-assisted-coil-embolization-of-ascending-aortic-pseudoaneurysm
#17
Tony Lu, Shayan Owji, Ponraj Chinnadurai, Thomas M Loh, Adeline Schwein, Alan B Lumsden, Jean Bismuth
A 62-year-old man with coronary artery disease and ischemic cardiomyopathy after coronary artery bypass grafting and insertion of a HeartMate II (Thoratec, Pleasanton, CA) left ventricular assist device (LVAD) presented with spontaneous incisional bleeding and an ascending aortic pseudoaneurysm. Aortic angiography revealed an anomalous connection between the pseudoaneurysm and the LVAD conduit. We were able to partially embolize the tract with standard techniques, but the patient returned with repeated bleeding...
November 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27753812/ssa-04-3-leptin-adiponectin-in-cardiometabolic-disease
#18
Patricio Lopez-Jaramillo
Cardiovascular diseases (CVD) are major causes of death and illness worldwide. In recent decades an increased prevalence of CVD mortality has been reported in low-medium income countries, which has been associated with changes in life styles, deficiencies in health systems and the persistence of social inequities.The metabolic syndrome comprises a cluster of cardiometabolic risk factors, with insulin resistance and increased adiposity as its central features. Identifying individuals with metabolic syndrome is important due to its association with an increased risk of coronary heart disease and type 2 diabetes mellitus (DM2)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27745841/surgical-unroofing-of-hemodynamically-significant-left-anterior-descending-myocardial-bridges
#19
Jack H Boyd, Vedant S Pargaonkar, David H Scoville, Ian S Rogers, Takumi Kimura, Shigemitsu Tanaka, Ryotaro Yamada, Michael P Fischbein, Jennifer A Tremmel, Robert Scott Mitchell, Ingela Schnittger
BACKGROUND: Left anterior descending artery myocardial bridges (MBs) range from clinically insignificant incidental angiographic findings to a potential cause of sudden cardiac death. Within this spectrum, a group of patients with isolated, symptomatic, and hemodynamically significant MBs despite maximally tolerated medical therapy exist for whom the optimal treatment is controversial. We evaluated supraarterial myotomy, or surgical unroofing, of the left anterior descending MBs as an isolated procedure in these patients...
October 1, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27744321/european-risk-models-for-morbidity-eurolung1-and-mortality-eurolung2-to-predict-outcome-following-anatomic-lung-resections-an-analysis-from-the-european-society-of-thoracic-surgeons-database%C3%A2-%C3%A2
#20
Alessandro Brunelli, Michele Salati, Gaetano Rocco, Gonzalo Varela, Dirk Van Raemdonck, Herbert Decaluwe, Pierre Emmanuel Falcoz
OBJECTIVES: To develop models of 30-day mortality and cardiopulmonary morbidity from data on anatomic lung resections deposited in the European Society of Thoracic Surgeons (ESTS) database. METHODS: Retrospective analysis of 47 960 anatomic lung resections from the ESTS database (July 2007-August 2015) (36 376 lobectomies, 2296 bilobectomies, 5040 pneumonectomies and 4248 segmentectomies). Logistic regression analyses were used to test the association between baseline and surgical variables and morbidity or mortality...
October 15, 2016: European Journal of Cardio-thoracic Surgery
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