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https://www.readbyqxmd.com/read/27928211/use-of-heart-rate-variability-to-estimate-lactate-threshold-in-coronary-artery-disease-patients-during-resistance-exercise
#1
Rodrigo P Simões, Renata G Mendes, Viviane Castello-Simões, Aparecida M Catai, Ross Arena, Audrey Borghi-Silva
The aim of this study was to investigate whether it is possible to identify the first turn point of blood lactate (BL) concentration (1(st) lactate threshold - LT1) during a discontinuous resistance exercise protocol in coronary artery disease (CAD) patients and verify if heart rate variability (HRV) responses are consistent with BL responses. A total of 22 elderly men, 12 with CAD and 10 apparently healthy (control group = CG), underwent one-repetition maximum (1RM) testing on an inclined leg press. Discontinuous resistance exercise testing (DRET) was initiated at 10% of the 1RM with subsequent increases of 10% until 30% and after this percentage, 5% increments of 1RM was carried out...
December 2016: Journal of Sports Science & Medicine
https://www.readbyqxmd.com/read/27882428/progression-of-noncalcified-and-calcified-coronary-plaque-by-ct-angiography-in-sle
#2
Aisha Khan, Armin Arbab-Zadeh, Adnan N Kiani, Laurence S Magder, Michelle Petri
Premature coronary artery disease remains the major cause of late death in systemic lupus erythematosus (SLE). Coronary artery calcium (CAC) represents an advanced stage of atherosclerosis, whereas noncalcified coronary atherosclerotic plaque (NCP) typically is more prone to trigger acute coronary events. The aim of this study was to assess the stability of NCP over time and identify factors associated with changes in NCP in patients with SLE. CT coronary angiography and calcium scanning were performed at baseline and follow-up in thirty-six SLE patients...
November 23, 2016: Rheumatology International
https://www.readbyqxmd.com/read/27879314/genetic-variation-in-the-slc8a1-calcium-signaling-pathway-is-associated-with-susceptibility-to-kawasaki-disease-and-coronary-artery-abnormalities
#3
Chisato Shimizu, Hariklia Eleftherohorinou, Victoria J Wright, Jihoon Kim, Martin P Alphonse, James C Perry, Rolando Cimaz, David Burgner, Nagib Dahdah, Long T Hoang, Chiea-Chuen Khor, Andrea Salgado, Adriana H Tremoulet, Sonia Davila, Taco W Kuijpers, Martin L Hibberd, Todd A Johnson, Atsushi Takahashi, Tatsuhiko Tsunoda, Michiaki Kubo, Toshihiro Tanaka, Yoshihiro Onouchi, Rae S M Yeung, Lachlan J M Coin, Michael Levin, Jane C Burns
BACKGROUND: -Kawasaki disease (KD) is an acute pediatric vasculitis in which host genetics influence both susceptibility to KD and the formation of coronary artery aneurysms. Variants discovered by genome-wide association studies (GWAS) and linkage studies only partially explain the influence of genetics on KD susceptibility. METHODS AND RESULTS: -To search for additional functional genetic variation, we performed pathway and gene stability analysis on a GWAS dataset...
November 21, 2016: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/27799085/atheroprotective-effects-of-pure-tocotrienol-supplementation-in-the-treatment-of-rabbits-with-experimentally-induced-early-and-established-atherosclerosis
#4
Thuhairah Abdul Rahman, Noor Faezah Hassim, Nurmazni Zulkafli, Suhaila Muid, Noor Kaslina Kornain, Hapizah Nawawi
BACKGROUND: Atherosclerosis is the main cause of coronary artery disease -related deaths worldwide. The atheroprotective properties of pure tocotrienols (T3) in the absence of alpha-tocopherol (α-TCP) in vitamin E has not been extensively examined. AIM: To determine the atheroprotective properties of T3 in early and established atherosclerosis rabbits. METHODS: Thirty New Zealand white rabbits were divided into two groups, B1 and B2 which represent early [fed 1% high cholesterol diet (HCD) for 2 weeks] and established (fed 1% HCD for 8 weeks) atherosclerosis...
2016: Food & Nutrition Research
https://www.readbyqxmd.com/read/27778191/impact-of-adding-eicosapentaenoic-acid-to-statin-therapy-on-plasma-pentraxin-3-level-in-patients-with-stable-coronary-artery-disease-a-6-month-randomized-controlled-study
#5
Shigemasa Tani, Ken Nagao, Tsukasa Yagi, Wataru Atsumi, Atsushi Hirayama
BACKGROUND: We hypothesized that the additional administration of eicosapentaenoic acid (EPA) in patients with stable coronary artery disease (CAD) receiving statin has the potential to lower the serum pentraxin 3 (PTX3) level, an indicator of plaque stabilization. METHODS: We randomly assigned CAD patients already receiving statin therapy to an EPA group (1800 mg/day, n = 53) or control group (n = 53). RESULTS: No significant difference was found in the change in the plasma PTX3 level between the groups...
October 24, 2016: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/27772606/robotic-assisted-coil-embolization-of-ascending-aortic-pseudoaneurysm
#6
Tony Lu, Shayan Owji, Ponraj Chinnadurai, Thomas M Loh, Adeline Schwein, Alan B Lumsden, Jean Bismuth
A 62-year-old man with coronary artery disease and ischemic cardiomyopathy after coronary artery bypass grafting and insertion of a HeartMate II (Thoratec, Pleasanton, CA) left ventricular assist device (LVAD) presented with spontaneous incisional bleeding and an ascending aortic pseudoaneurysm. Aortic angiography revealed an anomalous connection between the pseudoaneurysm and the LVAD conduit. We were able to partially embolize the tract with standard techniques, but the patient returned with repeated bleeding...
November 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27753812/ssa-04-3-leptin-adiponectin-in-cardiometabolic-disease
#7
Patricio Lopez-Jaramillo
Cardiovascular diseases (CVD) are major causes of death and illness worldwide. In recent decades an increased prevalence of CVD mortality has been reported in low-medium income countries, which has been associated with changes in life styles, deficiencies in health systems and the persistence of social inequities.The metabolic syndrome comprises a cluster of cardiometabolic risk factors, with insulin resistance and increased adiposity as its central features. Identifying individuals with metabolic syndrome is important due to its association with an increased risk of coronary heart disease and type 2 diabetes mellitus (DM2)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27745841/surgical-unroofing-of-hemodynamically-significant-left-anterior-descending-myocardial-bridges
#8
Jack H Boyd, Vedant S Pargaonkar, David H Scoville, Ian S Rogers, Takumi Kimura, Shigemitsu Tanaka, Ryotaro Yamada, Michael P Fischbein, Jennifer A Tremmel, Robert Scott Mitchell, Ingela Schnittger
BACKGROUND: Left anterior descending artery myocardial bridges (MBs) range from clinically insignificant incidental angiographic findings to a potential cause of sudden cardiac death. Within this spectrum, a group of patients with isolated, symptomatic, and hemodynamically significant MBs despite maximally tolerated medical therapy exist for whom the optimal treatment is controversial. We evaluated supraarterial myotomy, or surgical unroofing, of the left anterior descending MBs as an isolated procedure in these patients...
October 1, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27744321/european-risk-models-for-morbidity-eurolung1-and-mortality-eurolung2-to-predict-outcome-following-anatomic-lung-resections-an-analysis-from-the-european-society-of-thoracic-surgeons-database%C3%A2-%C3%A2
#9
Alessandro Brunelli, Michele Salati, Gaetano Rocco, Gonzalo Varela, Dirk Van Raemdonck, Herbert Decaluwe, Pierre Emmanuel Falcoz
OBJECTIVES: To develop models of 30-day mortality and cardiopulmonary morbidity from data on anatomic lung resections deposited in the European Society of Thoracic Surgeons (ESTS) database. METHODS: Retrospective analysis of 47 960 anatomic lung resections from the ESTS database (July 2007-August 2015) (36 376 lobectomies, 2296 bilobectomies, 5040 pneumonectomies and 4248 segmentectomies). Logistic regression analyses were used to test the association between baseline and surgical variables and morbidity or mortality...
October 15, 2016: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/27721534/a-prospective-randomized-study-evaluation-of-the-effect-of-rosuvastatin-in-patients-with-chronic-obstructive-pulmonary-disease-and-pulmonary-hypertension
#10
Bharti Chogtu, Sanitha Kuriachan, Rahul Magazine, K Ranjan Shetty, Asha Kamath, Manu Mathew George, Amruta Tripathy, D Mahesh Kumar
OBJECTIVES: Statins by their anti-inflammatory and endothelial stabilizing effect can be beneficial in patients with chronic obstructive pulmonary disease (COPD) and pulmonary hypertension (PH). The present study was done to evaluate the effect of rosuvastatin on pulmonary functions and quality of life (QOL) in patients with concomitant COPD and PH. MATERIALS AND METHODS: It was a prospective, randomized, double-blind, placebo-controlled, study conducted in patients with COPD and PH...
September 2016: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/27665853/association-of-factor-xiii-val34leu-polymorphism-and-coronary-artery-disease-a-meta-analysis
#11
Jae Hyun Jung, Gwan Gyu Song, Jae-Hoon Kim, Young Ho Seo, Sung Jae Choi
BACKGROUND: Factor XIII plays an important role in the stabilization of the linkage between fibrins and in the pathophysiology of coronary artery disease (CAD). The association between factor XIII Val34Leu polymorphism and CAD risk remains controversial. METHODS: We conducted a meta-analysis of 36 studies involving 26,940 cases and 34,694 controls. Subgroup analyses were performed with division of data into disease (myocardial infarction [MI], CAD without MI), age, and sex...
September 26, 2016: Cardiology Journal
https://www.readbyqxmd.com/read/27650459/impact-of-intra-aortic-balloon-pump-on-short-term-clinical-outcomes-in-st-elevation-myocardial-infarction-complicated-by-cardiogenic-shock-a-real-life-single-center-experience
#12
R de la Espriella-Juan, A Valls-Serral, B Trejo-Velasco, A Berenguer-Jofresa, Ó Fabregat-Andrés, D Perdomo-Londoño, C Albiach-Montañana, J V Vilar-Herrero, D Sanmiguel-Cervera, E Rumiz-Gonzalez, S Morell-Cabedo
OBJECTIVE: To analyze the use and impact of the intra-aortic balloon pump (IABP) upon the 30-day mortality rate and short-term clinical outcome of non-selected patients with ST-elevation acute myocardial infarction (acute STEMI) complicated by cardiogenic shock (CS). DESIGN: A single-center retrospective case-control study was carried out. SETTING: Coronary Care Unit. PATIENTS: Data were collected from 825 consecutive patients with acute STEMI admitted to a Coronary Care Unit from January 2009 to August 2015...
September 17, 2016: Medicina Intensiva
https://www.readbyqxmd.com/read/27643352/ssa-04-3-leptin-adiponectin-in-cardiometabolic-disease
#13
Patricio Lopez-Jaramillo
Cardiovascular diseases (CVD) are major causes of death and illness worldwide. In recent decades an increased prevalence of CVD mortality has been reported in low-medium income countries, which has been associated with changes in life styles, deficiencies in health systems and the persistence of social inequities.The metabolic syndrome comprises a cluster of cardiometabolic risk factors, with insulin resistance and increased adiposity as its central features. Identifying individuals with metabolic syndrome is important due to its association with an increased risk of coronary heart disease and type 2 diabetes mellitus (DM2)...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27615562/pathologic-intimal-thickening-plaque-phenotype-not-as-innocent-as-previously-thought-a-serial-3d-intravascular-ultrasound-virtual-histology-study
#14
Tomas Kovarnik, Zhi Chen, Andreas Wahle, Ling Zhang, Hana Skalicka, Ales Kral, John J Lopez, Jan Horak, Milan Sonka, Ales Linhart
INTRODUCTION AND OBJECTIVES: Pathologic intimal thickening (PIT) has been considered a benign plaque phenotype. We report plaque phenotypic changes in a baseline/follow-up intravascular ultrasound-based virtual histology study. METHODS: A total of 61 patients with stable coronary artery disease were analyzed from the HEAVEN trial (89 patients randomized between routine statin therapy vs atorvastatin 80mg and ezetimibe 10mg) with serial intravascular ultrasound imaging of nonculprit vessels...
September 5, 2016: Revista Española de Cardiología
https://www.readbyqxmd.com/read/27596003/-the-heart-team-in-planning-and-performance-of-revascularization-esc-guidelines-versus-clinical-routine
#15
J-M Sinning, A Welz, G Nickenig
The heart team, consisting of conservative cardiologists, cardiac surgeons and interventional cardiologists, is important for a balanced, multidisciplinary decision-making process for patients suffering from coronary artery disease (CAD). Standard evidence-based, interdisciplinary, institutional protocols can be used for commonly encountered case scenarios to avoid the need for a systematic case by case review. Complex cases with a SYNTAX score of more than 32, diabetes mellitus and lesions of the left main stem or three-vessel disease should in general not be treated by an ad hoc percutaneous coronary intervention (PCI) but first discussed in the heart team...
September 5, 2016: Herz
https://www.readbyqxmd.com/read/27595325/adenosine-to-inosine-rna-editing-controls-cathepsin-s-expression-in-atherosclerosis-by-enabling-hur-mediated-post-transcriptional-regulation
#16
Konstantinos Stellos, Aikaterini Gatsiou, Kimon Stamatelopoulos, Ljubica Perisic Matic, David John, Federica Francesca Lunella, Nicolas Jaé, Oliver Rossbach, Carolin Amrhein, Frangiska Sigala, Reinier A Boon, Boris Fürtig, Yosif Manavski, Xintian You, Shizuka Uchida, Till Keller, Jes-Niels Boeckel, Anders Franco-Cereceda, Lars Maegdefessel, Wei Chen, Harald Schwalbe, Albrecht Bindereif, Per Eriksson, Ulf Hedin, Andreas M Zeiher, Stefanie Dimmeler
Adenosine-to-inosine (A-to-I) RNA editing, which is catalyzed by a family of adenosine deaminase acting on RNA (ADAR) enzymes, is important in the epitranscriptomic regulation of RNA metabolism. However, the role of A-to-I RNA editing in vascular disease is unknown. Here we show that cathepsin S mRNA (CTSS), which encodes a cysteine protease associated with angiogenesis and atherosclerosis, is highly edited in human endothelial cells. The 3' untranslated region (3' UTR) of the CTSS transcript contains two inverted repeats, the AluJo and AluSx(+) regions, which form a long stem-loop structure that is recognized by ADAR1 as a substrate for editing...
October 2016: Nature Medicine
https://www.readbyqxmd.com/read/27585206/the-role-of-a-coronary-artery-calcium-scan-in-type-1-diabetes
#17
Mark R Burge, R Philip Eaton, David S Schade
The coronary artery calcium (CAC) scan has recently emerged as a reproducible noninvasive test to detect asymptomatic atherosclerotic coronary artery disease. It has several advantages over the traditional cardiac stress testing modalities, including lower cost, greater sensitivity for nonobstructing coronary artery lesions, and excellent prognostic value when combined with the Framingham risk parameters. Its chief disadvantage is that it does not identify obstructing coronary artery lesions or noncalcified coronary artery plaque...
September 2016: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/27574379/spontaneous-coronary-artery-dissection-one-disease-variable-presentations-and-different-management-approaches
#18
REVIEW
Abdel Rahman A Al Emam, Ahmed Almomani, Syed A Gilani, Wissam I Khalife
Spontaneous coronary artery dissection (SCAD) is a rare cause of acute coronary syndrome. It occurs predominantly among younger females, typically in the absence of atherosclerotic coronary artery disease. Presentations vary greatly and this condition can be fatal. Given its rarity, there are no management guidelines. We present six patients with SCAD with different presentations and treatment approaches as examples in our literature review. Two patients presented with ST elevation myocardial infarction (STEMI), two with non-STEMI (NSTEMI), and two with cardiac arrest...
September 2016: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
https://www.readbyqxmd.com/read/27561169/bioresorbable-vascular-scaffolds-for-the-treatment-of-coronary-artery-disease-what-have-we-learned-from-randomized-controlled-clinical-trials
#19
David G Rizik, James B Hermiller, Charles A Simonton, Kevin J Klassen, Dean J Kereiakes
Although current everolimus-eluting coronary stents have shown improved event-free survival within the first year following implantation compared with bare-metal stents or earlier generation drug-eluting stents, they remain associated with an ongoing risk for adverse outcomes (thrombosis, myocardial infarction, and restenosis) beyond 1 year at rates similar to those observed following bare-metal stent deployment. This ongoing very late hazard has been attributed to the permanent presence of the metal frame and/or polymer in these stents...
January 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/27541380/the-impact-of-rosuvastatin-on-the-density-score-of-coronary-artery-calcification-in-coronary-artery-disease-patients-with-type-2-diabetes-mellitus-rationale-and-design-of-roscal-study
#20
Wenbin Zhang, Yi Luan, Chongying Jin, Shengjie Xu, Xukun Bi, Yanbo Zhao, Fuyu Qiu, Guosheng Fu, Min Wang
INTRODUCTION: More and more evidence suggests that the density of calcification plays an important role in the plaque stability. However, few studies have investigated the statin treatment on the density of plaque calcification in patients with both coronary artery disease (CAD) and type 2 diabetes mellitus. METHODS: One hundred and twenty-two CAD patients with type 2 diabetes with confirmed coronary artery calcification (CAC) will be recruited consecutively in a 12-month period...
August 19, 2016: Clinical Drug Investigation
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