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https://www.readbyqxmd.com/read/29667724/relationship-between-c-reactive-protein-albumin-ratio-and-coronary-artery-disease-severity-in-patients-with-stable-angina-pectoris
#1
Yavuz Karabağ, Metin Çağdaş, Ibrahim Rencuzogullari, Süleyman Karakoyun, İnanç Artaç, Doğan İliş, Eray Atalay, Mahmut Yesin, Mustafa Ozan Gürsoy, Ibrahim Halil Tanboğa
BACKGROUND: Syntax score (SS), which is an angiographic tool used in grading the complexity of coronary artery disease (CAD), has prognostic importance in coronary artery disease (CAD) and provides important information regarding selection of revascularization strategy. C-reactive protein (CRP) and albumin are indicators of inflammation, and high levels of them are associated with high SS. We aimed to investigate whether baseline CRP to albumin ratio C-Reactive Protein/Albumin Ratio (CAR), an easily available and novel inflammatory marker, is associated with SS...
April 18, 2018: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29605471/thermal-heterogeneity-of-carotid-arteries-as-a-novel-biomarker-in-patients-with-diabetes-mellitus-assessed-for-coronary-artery-disease
#2
G Tzanis, M Bonou, G Benetos, S Biliou, S Liatis, C Kapelios, K Toutouzas, D Tousoulis, J Barbetseas
BACKGROUND: Vulnerable plaque plays crucial role in prognosis of diabetes mellitus (DM). Microwave radiometry (MWR) allows measurement of the temperature of tissues, thus indirectly reflecting inflammation, a characteristic of atherosclerotic plaque stability. Aim of the study was to evaluate the relation of carotid artery inflammation with glycemic control and presence of coronary artery disease (CAD). METHODS: We included 112 patients (65 ± 9 years, 30 ± 5 kg/m2 , 74 DM and 38 non-DM, with a 2:1 ratio) that were referred for scheduled coronary angiography (CA) for evaluation of their clinical condition...
March 29, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29587288/effect-of-sodium-thiosulfate-on-arterial-stiffness-in-end-stage-renal-disease-patients-undergoing-chronic-hemodialysis-sodium-thiosulfate-hemodialysis-study-a-randomized-controlled-trial
#3
Donlawat Saengpanit, Pairoj Chattranukulchai, Monravee Tumkosit, Monchai Siribumrungwong, Pisut Katavetin, Visith Sitprija, Kearkiat Praditpornsilpa, Somchai Eiam-Ong, Paweena Susantitaphong
BACKGROUND: Arterial stiffness (AS) and vascular calcification are significantly related to a high cardiovascular mortality risk in hemodialysis (HD) patients. Intravenous sodium thiosulfate (IV STS) can prevent and delay the vascular calcification progression in uremic states; however, the STS effect on AS has not been assessed. This study aimed to evaluate the STS efficacy on vascular calcification and AS in HD patients. METHODS: Fifty HD patients with abnormal AS, as measured via the cardio-ankle vascular index (CAVI ≥8), were prospectively randomized to open-label 12...
March 23, 2018: Nephron
https://www.readbyqxmd.com/read/29573617/anti-arrhythmogenic-and-anti-inflammatory-effects-of-troxerutin-in-ischemia-reperfusion-injury-of-diabetic-myocardium
#4
Moslem Najafi, Elham Noroozi, Aniseh Javadi, Reza Badalzadeh
INTRODUCTION: Medicinal plants are increasingly used in the treatment of cardiovascular diseases due to their multifaceted properties. This study was designed to investigate anti-arrhythmic and anti-inflammatory potentials of the natural bioflavonoid, troxerutin (TXR) in myocardial ischemia/reperfusion (I/R) injury in diabetic rats. METHODS: Male Wistar rats were randomly divided into 4 groups (control, control + TXR [150 mg/kg, daily], diabetic, and diabetic + TXR)...
March 21, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29564986/exploring-the-influence-of-mutation-on-transthyretin-aggregation-in-heart-disease
#5
Ankita Sharma, Monu, Sagarika Biswas
BACKGROUND: Transthyretin (TTR) is the transporter protein (55 kDA) that carries retinol binding protein and thyroxin (T4) in its functional tetramer form. Presence of mutation in this protein (TTR) may lead to the dissociation of tetramers to monomer which unfolds and self associates to form amyloid aggregates. Aggregation of this protein has been found to be associated with various life threatening disorders such as coronary artery disease (CAD) which is the major cause of mortality and morbidity worldwide...
March 20, 2018: Current Computer-aided Drug Design
https://www.readbyqxmd.com/read/29542299/effects-of-mindfulness-based-art-therapy-on-psychological-symptoms-in-patients-with-coronary-artery-disease
#6
Seung Ho Jang, Jae Hee Lee, Hye Jin Lee, Sang Yeol Lee
BACKGROUND: Mindfulness-based art therapy (MBAT) induces emotional relaxation in coronary artery disease (CAD) patients, and is a treatment known to improve psychological stability. The objective of this study was to evaluate the treatment effects of MBAT for CAD patients. METHODS: A total of 44 CAD patients were selected as participants, 21 patients belonged to a MBAT group, and 23 patients belonged to the control group. The patients in the MBAT group were given 12 sessions of treatments...
March 19, 2018: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/29503411/low-levels-of-plasma-osteoglycin-in-patients-with-complex-coronary-lesions
#7
Toshiki Seki, Emi Saita, Yoshimi Kishimoto, Susumu Ibe, Yoshichika Miyazaki, Kotaro Miura, Reiko Ohmori, Yukinori Ikegami, Kazuo Kondo, Yukihiko Momiyama
AIM: Osteoglycin is one of proteoglycans that are biologically active components of vascular extracellular matrix. However, the role of osteoglycin in atherosclerosis remains unclear. METHODS: We investigated plasma osteoglycin levels and the presence, severity, and lesion morphology of coronary artery disease (CAD) in 462 patients undergoing elective coronary angiography. RESULTS: Of 462 patients, 245 had CAD. Osteoglycin levels were higher in patients with CAD than without CAD (median 29...
March 5, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29484525/effect-of-factor-xiii-levels-and-polymorphisms-on-the-risk-of-myocardial-infarction-in-young-patients
#8
László Balogh, Éva Katona, Zoltán A Mezei, Judit Kállai, Réka Gindele, István Édes, László Muszbek, Zoltán Papp, Zsuzsanna Bereczky
Factor XIII (FXIII) stabilizes and protects the fibrin network. Its role in myocardial infarction (MI) is still to be clarified. To evaluate the association of FXIII levels with MI in young patients and to investigate how the FXIII-A p.Val34Leu, FXIII-B p.His95Arg, and IVS11, c.1952 + 144 C>G (Intron K) polymorphisms influence FXIII levels and MI risk. Patients with ST elevation MI below 40 years of age (MI, n = 119), age-matched clinical controls (CC, n = 101) without MI and coronary artery disease, and healthy controls (HC, n = 120) were investigated for FXIII activity, FXIII-A2 B2 , FXIII-B concentrations and for the polymorphisms...
February 26, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29426278/cytochrome-p450-family-4-subfamily-f-member-2-cyp4f2-rs1558139-rs2108622-polymorphisms-and-susceptibility-to-several-cardiovascular-and-cerebrovascular-diseases
#9
Tao Zhang, Kuiying Yu, Xuhua Li
BACKGROUND: Inconsistent conclusions have been reported for the genetic relationship between CYP4F2 (Cytochrome P450 Family 4 Subfamily F Member 2) polymorphisms and the susceptibility to cardiovascular and cerebrovascular diseases. METHODS: We performed a meta-analysis to assess the potential role of rs1558139 C/T and rs2108622 G/A polymorphisms of CYP4F2 in the risks of cardiovascular and cerebrovascular diseases. The retrieval of four databases, including PubMed, Web of Science (WOS), China National Knowledge Infrastructure (CNKI) and WANFANG DATA, was conducted...
February 9, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29407600/impact-of-cd14-cd16-monocytes-on-coronary-plaque-vulnerability-assessed-by-optical-coherence-tomography-in-coronary-artery-disease-patients
#10
Hiroyuki Yamamoto, Naofumi Yoshida, Toshiro Shinke, Hiromasa Otake, Masaru Kuroda, Kazuhiko Sakaguchi, Yushi Hirota, Takayoshi Toba, Hachidai Takahashi, Daisuke Terashita, Kenzo Uzu, Natsuko Tahara, Yuto Shinkura, Kouji Kuroda, Yoshinori Nagasawa, Yuichiro Nagano, Yoshiro Tsukiyama, Ken-Ichi Yanaka, Takuo Emoto, Naoto Sasaki, Tomoya Yamashita, Wataru Ogawa, Ken-Ichi Hirata
BACKGROUND AND AIMS: This study examined the impact of CD14++CD16+ monocytes on coronary plaque vulnerability, as assessed by optical coherence tomography (OCT), and investigated their association with daily glucose fluctuation. Although increased CD14++CD16+ monocyte levels have been reported to increase cardiovascular events, their impact on coronary plaque vulnerability in coronary artery disease (CAD) patients with or without diabetes mellitus (DM) remains unclear. METHODS: This prospective observational study included 50 consecutive patients with CAD, receiving lipid-lowering therapy and undergoing coronary angiography and OCT...
January 17, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29401724/emerging-roles-of-tumor-necrosis-factor-stimulated-gene-6-in-the-pathophysiology-and-treatment-of-atherosclerosis
#11
REVIEW
Rena Watanabe, Yuki Sato, Nana Ozawa, Yui Takahashi, Shinji Koba, Takuya Watanabe
Tumor necrosis factor-stimulated gene-6 (TSG-6) is a 35-kDa glycoprotein that has been shown to exert anti-inflammatory effects in experimental models of arthritis, acute myocardial infarction, and acute cerebral infarction. Several lines of evidence have shed light on the pathophysiological roles of TSG-6 in atherosclerosis. TSG-6 suppresses inflammatory responses of endothelial cells, neutrophils, and macrophages as well as macrophage foam cell formation and vascular smooth muscle cell (VSMC) migration and proliferation...
February 5, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29399204/thrombi-produced-in-stagnation-point-flows-have-a-core-shell-structure
#12
Bradley A Herbig, Scott L Diamond
Introduction: In regions of flow separation/reattachment within diseased arteries, the local hemodynamics can result in stagnation point flow that provides an atypical environment in atherosclerosis. Impinging flows occur with recirculation eddies distal of coronary stenosis or diseased carotid bifurcations. Methods: By perfusing whole blood directly perpendicular to a fibrillar collagen thrombotic surface, a microfluidic device produced a stagnation point flow...
December 2017: Cellular and Molecular Bioengineering
https://www.readbyqxmd.com/read/29395706/epidemiology-of-kawasaki-disease-in-canada-2004-to-2014-comparison-of-surveillance-using-administrative-data-vs-periodic-medical-record-review
#13
Cedric Manlhiot, Sunita O'Shea, Bailey Bernknopf, Michael LaBelle, Nita Chahal, Rejane F Dillenburg, Lillian S Lai, Dirk Bock, Brendan Lew, Sameer Masood, Mathew Mathew, Brian W McCrindle
BACKGROUND: We have previously documented an increase in the incidence of Kawasaki disease (KD) in Ontario followed by a stabilization from 1995 to 2006. We sought to validate the estimation of incidence of KD using administrative data and to describe the epidemiology of KD across Canada from 2004 to 2014. METHODS: We queried the Canadian Hospital Discharge Database for hospital admissions associated with a discharge diagnosis of KD. The data set was manually curated and estimates of incidence were compared with those obtained from the retrospective triennial surveillances of KD performed in 2007 and 2010...
December 15, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29378206/psrc1-overexpression-attenuates-atherosclerosis-progression-in-apoe-mice-by-modulating-cholesterol-transportation-and-inflammation
#14
Kai Guo, Lu Hu, Dan Xi, Jinzhen Zhao, Jichen Liu, Tiantian Luo, Yusheng Ma, Wenyan Lai, Zhigang Guo
AIMS: Human genome-wide association studies (GWAS) have found that proline/serine-rich coiled-coil 1 (PSRC1) encodes a protein that is associated with serum lipid levels and coronary artery disease. In addition, our previous study showed that the cholesterol efflux capacity is decreased in macrophages following a treatment silencing Psrc1, indicating that PSRC1 has anti-atherosclerotic effects. However, the role of PSRC1 in the development of atherosclerosis is unknown. This study aims to explore the effect of PSRC1 on atherosclerosis and its underlying mechanisms...
January 25, 2018: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/29356018/the-evolving-view-of-coronary-artery-calcium-and-cardiovascular-disease-risk
#15
REVIEW
Isac C Thomas, Nketi I Forbang, Michael H Criqui
Calcification of the coronary artery is a complex pathophysiologic process that is intimately associated with atherosclerosis. Extensive investigation has demonstrated the value of identifying and quantifying coronary artery calcium (CAC) in atherosclerotic cardiovascular disease (CVD) prognostication. However, over the last several years, an increasing body of evidence has suggested that CAC has underappreciated aspects that modulate, and at times attenuate, future CVD risk. The most commonly used measure of CAC, the Agatston unit, effectively models both higher density and higher area of CAC as risk factors for future CVD events...
January 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29334512/association-between-alcohol-use-and-angina-symptoms-among-outpatients-from-the-veterans-health-administration
#16
Emily C Williams, Chris L Bryson, Haili Sun, David H Au, Katharine A Bradley
BACKGROUND: Alcohol use is associated with angina incidence, but associations between alcohol use and experience of angina among patients with coronary artery disease (CAD) have not been described. METHODS: Outpatients with CAD from 7 clinics in the Veterans Health Administration were surveyed; alcohol use was measured using the validated Alcohol Use Disorders Identification Test-Consumption scores categorized into 6 groups: nondrinking, low-risk drinking, and mild, moderate, severe, and very severe unhealthy alcohol use...
March 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/29290360/trimethylamine-n-oxide-a-harmful-protective-or-diagnostic-marker-in-lifestyle-diseases
#17
REVIEW
Artur Nowiński, Marcin Ufnal
Diet has been considered a general health determinant for many years. Recent research shows a connection between gut microbiota composition that is shaped by our diet and lifestyle diseases. Several studies point to a positive correlation between elevated plasma trimethylamine N-oxide (TMAO), a gut bacteria metabolite, and an increased risk for cardiovascular diseases, diabetes, and cancer. Therefore, it has been suggested that TMAO is a link between the diet, gut microbiota, and illness. Emerging experimental and clinical evidence shows that TMAO may be involved in the etiology of hypertension, atherosclerosis, coronary artery disease, diabetes, and renal failure...
February 2018: Nutrition
https://www.readbyqxmd.com/read/29258527/case-report-osteogenesis-imperfecta-internal-mammary-artery-graft-nitinol-clips
#18
Ludovic Melly, Anne-Sophie Dincq, Claude Hanet, Benoît Rondelet
BACKGROUND: Osteogenesis imperfecta is a genetic disorder of connective tissue causing mostly left-sided heart valves and aortic root pathologies, but a coronary artery involvement reflecting an increased sensitivity to cardiovascular risk factors is also suspected in this patient population. CASE PRESENTATION: We report a 38-year-old patient with an osteogenesis imperfecta and a typical presentation of an acute myocardial infarction. The coronary angiogram showed a coronary 3-vessel disease...
December 19, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29221351/extracorporeal-membrane-oxygenation-system-as-a-bridge-to-reparative-surgery-in-ventricular-septal-defect-complicating-acute-inferoposterior-myocardial-infarction
#19
Jose Rozado, Isaac Pascual, Pablo Avanzas, Daniel Hernandez-Vaquero, Ruben Alvarez, Rocio Díaz, Beatriz Díaz, María Martín, Amelia Carro, Guillermo Muñiz, Jacobo Silva, Cesar Moris
Post-infarction ventricular septal defect (VSD) is a rare but potentially lethal complication of acute myocardial infarction. Medical management is usually futile, so definitive surgery remains the treatment of choice but the risk surgery is very high and the optimal timing for surgery is still under debate. A 55-year-old man with no previous medical history attended the emergency-room for 12 h evolution of oppressive chest pain and strong anginal pain 7 days ago. On physical examination, blood pressure was 96/70 mmHg, pansystolic murmur over left sternal border without pulmonary crackles...
September 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29211217/application-of-unilateral-pectoralis-major-muscle-flap-in-the-treatment-of-sternal-wound-dehiscence
#20
Grazielle de Souza Horácio, Pedro Soler Coltro, Antonio Albacete, Juliano Baron Almeida, Vinícius Zolezi da Silva, Ivan de Rezende Almeida, Alfredo José Rodrigues, Jayme Adriano Farina
OBJECTIVE: This study aims to report the use of the unilateral pectoralis major muscle flap for the treatment of the sternal wound dehiscence. METHODS: A retrospective study including patients who underwent unilateral pectoralis major muscle flap was performed for the treatment of sternotomy dehiscence due to coronary artery bypass, valve replacement, congenital heart disease correction and mediastinitis, between 1997 and 2016. Data from the epidemiological profile of patients, length of hospital stay, postoperative complications and mortality rate were obtained...
September 2017: Brazilian Journal of Cardiovascular Surgery
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