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Maulidiani, F Abas, A Khatib, V Perumal, V Suppaiah, A Ismail, M Hamid, K Shaari, N H Lajis
ETHNOPHARMACOLOGICAL RELEVANCE: 'Pegaga' is a traditional Malay remedy for a wide range of complaints. Among the 'pegaga', Centella asiatica has been used as a remedy for diabetes mellitus. Thus, we decided to validate this claim by evaluating the in vivo antidiabetic property of C. asiatica (CA) on T2DM rat model using the holistic (1)H NMR-based metabolomics approach. METHOD: In this study, an obese diabetic (mimic of T2DM condition) animal model was developed using Sprague-Dawley rats fed with a high-fat diet and induced into diabetic condition by the treatment of a low dose of streptozotocin (STZ)...
March 2, 2016: Journal of Ethnopharmacology
M Krichbaum, B Kulzer
No abstract text is available yet for this article.
January 19, 2012: MMW Fortschritte der Medizin
Yao-Wu Liu, Xia Zhu, Qian Lu, Jian-Yun Wang, Wei Li, Ya-Qin Wei, Xiao-Xing Yin
ETHNOPHARMACOLOGICAL RELEVANCE: As a well-known Chinese Materia Medica Rhizoma Anemarrhenae has multiple pharmacological activities including antipyretic, anti-inflammatory, anti-diabetic actions, etc. This study was designed to investigate effects of total saponins from Rhizoma Anemarrhenae (TS) on diabetes-associated cognitive decline in rats and influence on amyloid-beta (Aβ) levels in brain and inflammation. MATERIALS AND METHODS: Diabetic rats induced by intraperitoneal administration of streptozotocin, were randomized into two groups: diabetes and TS-treated diabetes...
January 6, 2012: Journal of Ethnopharmacology
O Khmel'mitskiĭ, V P Petlenko
No abstract text is available yet for this article.
1972: Arkhiv Patologii
W P Faulk, J P Girard, H D Welscher
35 insulin-treated diabetics and 25 control persons were studied for in vivo and in vitro manifestations of hypersensitivity to insulin and its isolated polypeptide chains. Delayed hypersensitivity reactions were determined by skin testing, and blastogenic conversion tests were done with peripheral blood lymphocytes. None of the controls and 62.9% of the patients gave positive reactions in the blastogenic test, most of these reacted to the intact molecule, fewer patients responded to B chains, and very few responded to A chains...
1975: International Archives of Allergy and Applied Immunology
B J Frankel, J E Gerich, R E Fanska, G C Gerritsen, G M Grodsky
Nonketotic, genetically diabetic Cinese hamsters show subnormal pancreatic insulin release and impaired suppression of glucagon in response to glucose. To study the pancreatic effects of other agents, dynamic insulin and glucagon release was measured from the in vitro perfused pancreases of normal and diabetic Chinese hamsters in response to various combinations of arginine (20mM), glucose (100 or 150 mg. per 100 ml.), and theophylline (10 mM). Theophylline alone caused identical insulin and glucagon release in diabetics and normals...
March 1975: Diabetes
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