Shaoting Zhang, Liangying Zhang, Dan Zhang, Yue Guo, Yisha Gao, Zongying Jiang, Shujing Li, Anbu Liu, Xu Cao, Jinhai Tian, Sien Zhao, Yuanyuan Yu, Wei Yang, Ru Bai, Ling Huang, Hongli Yan, Hui Zhao, Jianmin Sun
Gastrointestinal stromal tumors (GISTs) are predominately induced by KIT mutants. In this study, we found that four and a half LIM domains 2 (FHL2) was highly expressed in GISTs and KIT signaling dramatically increased FHL2 transcription while FHL2 inhibited KIT transcription. In addition, our results showed that FHL2 associated with KIT and increased the ubiquitination of both wild-type KIT and primary KIT mutants in GISTs, leading to decreased expression and activation of KIT although primary KIT mutants were less inhibited by FHL2 than wild-type KIT...
April 17, 2024: Molecular Carcinogenesis