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cystic lesions of the pancreas

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https://www.readbyqxmd.com/read/29736662/serous-pancreatic-cystadenoma-with-compression-of-wirsung-s-duct
#1
Enio Campos Amico, José Roberto Alves, Adriano de Araújo Lima Liguori, Rogério Lacerda Sousa
Serous cystadenoma of the pancreas is a common cystic neoplasm typically of benign evolution that rarely communicates with the pancreatic ductal system. We present several images originating from two cases of serous cystadenoma of the pancreas which led to compression and dilatation of Wirsung's duct. These cases suggest that when the diagnosis of pancreatic microcystic lesion is detected, associated, or not associated with a central fibrous scar and a low carcinoembryonic antigen level in the aspirated fluid, the presence of dilatation of Wirsung's duct does not exclude the diagnosis of serous pancreatic cystadenoma...
May 7, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29732356/clinical-significance-of-pancreatic-intraepithelial-neoplasia-in-resectable-pancreatic-cancer-on-survivals
#2
Da-Young Yu, Young-Dong Yu, Wan-Bae Kim, Hyung-Joon Han, Sae-Byul Choi, Dong-Sik Kim, Sang-Yong Choi, Joo-Young Kim, Hyeyoon Chang, Baek-Hui Kim
Purpose: Noninvasive precursor lesions for pancreatic adenocarcinoma include pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasm, and mucinous cystic neoplasm. PanIN is often found synchronously adjacent to resected pancreatic ductal adenocarcinoma (PDAC) tumors. However, its prognostic significance on outcome after PDAC resection is unknown. The purpose of the current study was to determine if the presence of PanIN has a prognostic or predictive effect on survival after resection for PDAC with curative intent...
May 2018: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29713060/pre-neoplastic-pancreas-cells-enter-a-partially-mesenchymal-state-following-transient-tgf-%C3%AE-exposure
#3
Jesse Handler, Jane Cullis, Antonina Avanzi, Emily A Vucic, Dafna Bar-Sagi
Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease and a major health problem in the United States. While the cytokine TGF-β has been implicated in PDAC development, it can exert both pro-tumorigenic and anti-tumorigenic effects that are highly context dependent and incompletely understood. Using three-dimensional (3D) cultures of Kras G12D -expressing mouse pancreatic epithelial cells we demonstrated that while exposure to exogenous TGF-β induced growth arrest of the Kras G12D cells, its subsequent removal allowed the cells to enter a hyper-proliferative, partially mesenchymal (PM), and progenitor-like state...
May 1, 2018: Oncogene
https://www.readbyqxmd.com/read/29695287/the-importance-of-endoscopic-ultrasound-fine-needle-aspiration-in-the-diagnosis-of-solid-pseudopapillary-tumor-of-the-pancreas-two-case-reports
#4
Diogo Turiani Hourneaux De Moura, Martin Coronel, Igor Braga Ribeiro, Galileu Ferreira Ayala Farias, Maria Auxiliadora Choez, Rodrigo Rocha, Marcello Pecoraro Toscano, Eduardo Guimarães Hourneaux De Moura
BACKGROUND: Solid pseudopapillary tumor of the pancreas, otherwise known as solid and cystic tumor or Frantz tumor, is an unusual form of pancreatic carcinoma, with unknown etiopathogenesis, that accounts for 0.2 to 2.7% of all pancreatic tumors. It is defined as an exocrine pancreatic neoplasia that mainly affects women between the second and third decade of life, and its management is not well defined. Endoscopic ultrasound offers a key anatomical advantage in accessing the pancreas and endoscopic ultrasound fine-needle aspiration has become the gold standard method for the diagnosis of pancreatic lesions...
April 26, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29670173/overexpression-of-her2-in-the-pancreas-promotes-development-of-intraductal-papillary-mucinous-neoplasms-in-mice
#5
Wataru Shibata, Hiroto Kinoshita, Yohko Hikiba, Takeshi Sato, Yasuaki Ishii, Soichiro Sue, Makoto Sugimori, Nobumi Suzuki, Kosuke Sakitani, Hideaki Ijichi, Ryutaro Mori, Itaru Endo, Shin Maeda
Pancreatic ductal adenocarcinoma (PDA) has a 5-year survival rate of less than 5% and is the sixth leading cause of cancer death. Although KRAS mutations are one of the major driver mutations in PDA, KRAS mutation alone is not sufficient to induce invasive pancreatic cancer in mice model. HER2, also known as ERBB2, is a receptor tyrosine kinase, and overexpression of HER2 is associated with poor clinical outcomes in pancreatic cancer. However, no report has shown whether HER2 and its downstream signaling contributes to the pancreatic cancer development...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29650941/-a-case-of-an-intraductal-papillary-mucinous-neoplasm-which-rapidly-worsened-and-penetrated-into-the-stomach-and-the-transverse-colon
#6
Akira Sogawa, Kei Nakamura, Tomoyuki Nagata, Satoshi Mochizuki, Yuen Nakase, Shozo Kitai, Seishirou Inaba, Keiji Shimada
We report a case of a 71-year-old woman.She visited our hospital with a complaint of high fever and abdominal distention. She has been pointed out intraductal papillary mucinous neoplasm(IPMN)4 years ago.Abdominal CT showed cystic legion, 80mm in diameter, on the pancreas.The lesion was unclear at the boundary between the main pancreatic duct and in contact with the stomach, transverse colon.Upper endoscopic and colonoscopic examination revealed the exhaustion image from the intestional tract but not pointed out the malignant findings...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29623746/synchronous-pancreatic-serous-cystic-neoplasm-and-duodenal-neuroendocrine-tumor-case-report-and-review-of-the-literature
#7
Ann Brinch Madelung, Sönke Detlefsen
Simultaneous presence of pancreatic serous cystic neoplasms and neuroendocrine neoplasms is rare. We present a case with the incidental finding of a duodenal neuroendocrine tumor (NET) with 2 lymph node metastases in a Whipple resection specimen performed to remove a pancreatic cystic neoplasm that postoperatively turned out to represent a serous cystic neoplasm (SCN). The patient was a 75-year-old female. She presented with loss of appetite and weight. Preoperative contrast-enhanced computed tomography scan of the abdomen showed a multicystic lesion in the head of pancreas...
April 1, 2018: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29622708/epidermoid-cyst-within-an-intrapancreatic-accessory-spleen
#8
Anghela Paredes, Eliza Wright Beal, Mary E Dillhoff
This is a case of an epidermoid cyst in an intrapancreatic accessory spleen at the tail of the pancreas. Concurrent epidermoid cyst within the accessory spleen is an exceedingly rare entity. The patient initially presented with abdominal pain, nausea and vomiting. Imaging studies revealed a 3.6 cm cystic mass in the tail of the pancreas that was concerning for a mucinous cystic neoplasm (MCN). The patient underwent a robotic distal pancreatectomy for a suspected diagnosis of MCN, which following histologically examination was found to be an epidermoid cyst of an intrapancreatic accessory spleen...
April 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29606941/a-surgically-resected-pancreatic-schwannoma-with-obstructive-jaundice-with-special-reference-to-differential-diagnosis-from-other-cystic-lesions-in-the-pancreas
#9
Takayoshi Watanabe, Kenichiro Araki, Norihiro Ishii, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Hiroyuki Kuwano, Ken Shirabe
Pancreatic schwannomas are uncommon. About 60% of pancreatic schwannomas develop cystic lesions, and the differential diagnosis from other cystic pancreatic tumors is difficult. A 43-year-old man presented for evaluation of liver dysfunction detected during a medical checkup. Blood testing detected obstructive jaundice. A computed tomography scan revealed a well-defined polycystic tumor of about 5 cm at the pancreatic head. We performed surgical resection to treat the patient's symptoms and facilitate long-term management...
January 2018: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/29589164/progression-patterns-in-the-remnant-pancreas-after-resection-of-non-invasive-or-micro-invasive-intraductal-papillary-mucinous-neoplasms-ipmn
#10
Mohammad Al Efishat, Marc A Attiyeh, Anne A Eaton, Mithat Gönen, Olca Basturk, David Klimstra, Michael I D'Angelica, Ronald P DeMatteo, T Peter Kingham, Vinod Balachandran, William R Jarnagin, Peter J Allen
BACKGROUND: Although IPMN are thought to represent a whole-gland disease, segmental resection remains the most frequently performed treatment. We sought to determine the rates, patterns, and predictors of IPMN progression in the pancreatic remnant following segmental resection of noninvasive or microinvasive IPMN. METHODS: A prospectively maintained database was queried to identify all patients who underwent resection of noninvasive or microinvasive IPMN (≤ 10 mm of invasive component) between 1989 and 2015...
March 27, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29589102/dilemmas-for-the-pathologist-in-the-oncologic-assessment-of-pancreatoduodenectomy-specimens-an-overview-of-different-grossing-approaches-and-the-relevance-of-the-histopathological-characteristics-in-the-oncologic-assessment-of-pancreatoduodenectomy-specimens
#11
REVIEW
Eline Soer, Lodewijk Brosens, Marc van de Vijver, Frederike Dijk, Marie-Louise van Velthuysen, Arantza Farina-Sarasqueta, Hans Morreau, Johan Offerhaus, Lianne Koens, Joanne Verheij
A pancreatoduodenectomy specimen is complex, and there is much debate on how it is best approached by the pathologist. In this review, we provide an overview of topics relevant for current clinical practice in terms of gross dissection, and macro- and microscopic assessment of the pancreatoduodenectomy specimen with a suspicion of suspected pancreatic cancer. Tumor origin, tumor size, degree of differentiation, lymph node status, and resection margin status are universally accepted as prognostic for survival...
March 27, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29568658/surgical-management-of-a-giant-adrenal-pseudocyst-a-case-report-and-review-of-the-literature-in-the-last-decade
#12
Daniel Paramythiotis, Petros Bangeas, Anestis Karakatsanis, Patroklos Goulas, Irini Nikolaou, Vasileios Rafailidis, Konstantinos Kouskouras, Vasileios Papadopoulos, Sofia Lypiridou, Georgia Karayannopoulou, Antonios Michalopoulos
Adrenal pseudocysts are rare entities and occurred in the 5th and the 6th decades of life. They are discovered accidentally, while appearing with nonspecific clinical and imaging findings. We report a case of a 28-year-old woman presented in our Emergency Department complaining about upper abdomen pain. Computed tomography revealed a hypodense cystic lesion containing hyperdense material. The size of a mass was 11. 7 × 9.3 × 6.6 cm in diameter close to the pancreas, but the origin was from the left adrenal gland...
2018: Case Reports in Surgery
https://www.readbyqxmd.com/read/29550957/subspecialized-radiology-review-at-multidisciplinary-pancreas-conference-impact-on-patient-management
#13
C M Chingkoe, A Brook, A J Moser, K J Mortele
PURPOSE: At our tertiary medical center, multidisciplinary subspecialists meet twice a week during a CME-accredited conference to discuss oncologic and non-oncologic patients with pancreatic diseases at which time a subspecialized abdominal staff radiologist reinterprets the patient's relevant imaging studies. This study assesses the changes in patient management due to imaging reinterpretation during multidisciplinary pancreas conference (MPC). MATERIALS AND METHODS: In this retrospective, IRB-approved, HIPAA-compliant study, imaging studies of all patients discussed at MPC between July 1 and December 31, 2015 were assessed for technical adequacy, and original reports analyzed for congruency with reinterpretation...
March 17, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29545970/a-new-combined-criterion-to-better-predict-malignant-lesions-in-patients-with-pancreatic-cystic-neoplasms
#14
Chungen Lan, Xin Li, Xiuchao Wang, Jihui Hao, He Ren
Objective: Cystic lesions of the pancreas have been increasingly recognized. Some lesions exhibit benign behavior, while others have unequivocal malignant potential. Thus, accurate identification of malignancy in patients diagnosed with pancreatic cystic neoplasms (PCNs) remains a major challenge. The aim of this study was to define a combined criterion to better predict malignant lesions in patients with PCNs. Methods: We retrospectively analyzed 165 patients who underwent resection of PCNs from October 2011 to May 2017...
February 2018: Cancer Biology & Medicine
https://www.readbyqxmd.com/read/29538198/alveolar-echinococcosis-in-the-head-of-pancreas-a-case-report
#15
Rong-Xing Zhou, Hai-Jie Hu, Wen-Jie Ma, Yong Jiang, Fu-Yu Li
RATIONALE: Pancreatic alveolar echinococcosis (AE) is an exceptionally rare disease; no more than 10 cases have been published to date. It is characterized as extensive local tissue infringement and destruction; thus, extended surgical resection, such as duodenopancreatectomy, is often needed to obtain a negative resection margin so as to improve the long-term outcome and prognosis. PATIENT CONCERNS: A middle-aged Tibetan man was admitted due to a 16-year history of recurrent pain in the right upper abdomen...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29536430/neuroendocrine-neoplasm-of-pancreas-with-cystic-degeneration-mimicking-mucinous-cystic-neoplasm
#16
Uayporn Kaosombatwattana, Yoshiki Hirooka, Hiroki Kawashima, Eizaburo Ohno, Takuya Ishikawa, Hiroki Suhara, Hidemi Goto
Endoscopic ultrasound is increasingly being used for evaluation of pancreatic diseases and pancreatic tumors. Among various pancreatic cystic lesions, cystic degeneration of pancreatic neuroendocrine neoplasm is of the challenge in making diagnosis. Although unique characteristic of each type of pancreatic cystic lesions has been proposed abundantly, typical morphology of cystic degeneration of pancreatic neuroendocrine neoplasm is still unclear. We, herein, reported a case of 66-year-old woman who was incidentally found to have a cystic lesion in the tail of pancreas upon screening transabdominal ultrasonography...
March 13, 2018: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/29530477/lessons-learned-from-29-lymphoepithelial-cysts-of-the-pancreas-institutional-experience-and-review-of-the-literature
#17
Vincent P Groot, Sameer S Thakker, Georgios Gemenetzis, Michaël Noë, Ammar A Javed, Richard A Burkhart, Behnoud B Noveiry, John L Cameron, Matthew J Weiss, Christopher J VandenBussche, Elliot K Fishman, Ralph H Hruban, Christopher L Wolfgang, Anne Marie Lennon, Jin He
BACKGROUND: Lymphoepithelial cysts (LECs) are rare pancreatic cystic lesions. Since LECs are benign, preoperative diagnosis is important to differentiate from a cystic neoplasm and avoid unnecessary surgery. The aim of this study was to identify clinical, radiographic and cytopathologic features associated with LECs. METHODS: A retrospective review was performed of patients diagnosed with LEC between 1995 and 2017 at our hospital. Clinicopathologic and radiographic imaging features were documented...
March 9, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29517631/prospective-follow-up-study-of-the-recurrence-of-pancreatic-cancer-diagnosed-at-an-early-stage-the-value-of-endoscopic-ultrasonography-for-early-diagnosis-of-recurrence-in-the-remnant-pancreas
#18
Juri Ikemoto, Keiji Hanada, Tomoyuki Minami, Akihito Okazaki, Tomoyuki Abe, Hironobu Amano, Shuji Yonehara
OBJECTIVES: Most patients with pancreatic cancer (PC) demonstrate recurrences in the form of metastatic disease. We prospectively evaluated recurrence in PC cases diagnosed at an early stage. METHODS: Thirty cases of PC stage 0 or IA were prospectively followed for at least 1 year after initial surgery. We performed blood tests and contrast-enhanced computed tomography (CT) every 3 to 6 months. Endoscopic ultrasonography (EUS) was performed if CT revealed abnormal findings in the remnant pancreas (RP)...
April 2018: Pancreas
https://www.readbyqxmd.com/read/29509575/serous-cystic-neoplasms-of-the-pancreas-endoscopic-ultrasonographic-versus-computed-tomography-and-magnetic-resonance-imaging-features-of-surgically-removed-masses
#19
Hyeonseung Hwang, Jeong-Sik Yu, Eun-Suk Cho, Joo Hee Kim, Jae-Joon Chung
Our purpose was to assess the endoscopic ultrasonography (EUS) features of serous cystic neoplasms (SCNs) of the pancreas in determining the surgical removal compared with computed tomography (CT) and magnetic resonance imaging (MRI) features. For 33 consecutive patients with 34 surgically confirmed SCNs over the past 11 years, preoperative EUS features were compared with those of CT and MRI (CT&MRI). Besides the lesion size and location, a retrospective analysis of the various imaging features was performed by 2 observers to understand the characteristics that determine the need for surgical intervention in terms of multiplicity of locules, calcification, mural thickening, mural nodules, ductal communication, and main pancreatic duct dilatation in addition to the gross morphologic type: microcystic, macrocystic (>1 cm), mixed, or solid...
March 5, 2018: Ultrasound Quarterly
https://www.readbyqxmd.com/read/29483418/-surgical-resection-of-an-intraductal-papillary-mucinous-carcinoma-observed-on-imaging-four-years-after-the-initial-diagnosis
#20
Hiroaki Seki, Nobutaka Yasui, Akihiko Shimada, Hidetoshi Matsumoto
We herein report a 75-year-old woman who presented with an intraductal papillary mucinous carcinoma(IPMC)who was treated with surgical resection 4 years after the initial diagnosis was made. She previously underwent a high anterior resection of the rectum for rectal cancer at 71 years of age. Preoperative CT revealed a multilocular cystic mass measuring 6 cm in size in the body of the pancreas, which was considered benign. We followed up the intraductal papillary mucinous neoplasm(IPMN) by using annual CT imaging for 4 years...
February 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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