keyword
https://read.qxmd.com/read/38529395/clinical-features-of-early-onset-type-2-diabetes-and-its-association-with-triglyceride-glucose-body-mass-index-a-cross-sectional-study
#21
JOURNAL ARTICLE
Yanjuan Jiang, Xiaoyang Lai
OBJECTIVE: The incidence of early-onset type 2 diabetes (T2D) has increased significantly, with insulin resistance (IR) and obesity being the main drivers of its onset. This study aims to investigate the clinical characteristics of early-onset T2D and its association with triglyceride glucose body mass index (TyG-BMI), an emerging surrogate of IR. METHODS: A total of 1000 adults newly diagnosed with T2D were enrolled and divided into early-onset T2D (18~40 years, N=500) and late-onset T2D groups (≥40 years, N=500)...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38529189/sesquiterpene-lactones-as-emerging-biomolecules-to-cease-cancer-by-targeting-apoptosis
#22
REVIEW
Chou-Yi Hsu, Sadegh Rajabi, Maryam Hamzeloo-Moghadam, Abhinav Kumar, Marc Maresca, Pallavi Ghildiyal
Apoptosis is a programmed cell death comprising two signaling cascades including the intrinsic and extrinsic pathways. This process has been shown to be involved in the therapy response of different cancer types, making it an effective target for treating cancer. Cancer has been considered a challenging issue in global health. Cancer cells possess six biological characteristics during their developmental process known as cancer hallmarks. Hallmarks of cancer include continuous growth signals, unlimited proliferation, resistance to proliferation inhibitors, apoptosis escaping, active angiogenesis, and metastasis...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38529168/prognostic-value-of-hemoglobin-concentration-on-renal-outcomes-with-diabetic-kidney-disease-a-retrospective-cohort-study
#23
JOURNAL ARTICLE
Xiaojie Chen, Jianteng Xie, Yifan Zhang, Shaogui Zhang, Sheng Li, Min Lu, Danfeng Liu, Weiting He, Hokhim Yau, Runli Jia, Yaxi Zhu, Wenjian Wang
OBJECTIVE: Diabetic kidney disease (DKD) patients with anemia face an elevated risk of glomerular filtration rate decline. However, the association between hemoglobin and estimated Glomerular Filtration Rate (eGFR) progression remains to be elucidated. METHODS: A retrospective cohort of 815 subjects with DKD was followed from January 2010 to January 2023. A Cox proportional hazard regression model was utilized to explore the predictive role of hemoglobin in renal outcomes...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38528482/effect-of-multidisciplinary-care-on-diabetic-kidney-disease-a-retrospective-cohort-study
#24
JOURNAL ARTICLE
Ayano Hayashi, Kayoko Mizuno, Kanna Shinkawa, Kazunori Sakoda, Satomi Yoshida, Masato Takeuchi, Motoko Yanagita, Koji Kawakami
BACKGROUND: Diabetic kidney disease (DKD) is the most common disease among patients requiring dialysis for the first time in Japan. Multidisciplinary care (MDC) may prevent the progression of kidney failure. However, the effectiveness and timing of MDC to preserve kidney function in patients with DKD is unclear. Therefore, the aim of this study was to investigate whether MDC for patients with DKD affects the preservation of kidney function as well as the timing of MDC in clinical practice...
March 25, 2024: BMC Nephrology
https://read.qxmd.com/read/38528175/insulin-and-glycolysis-dependency-of-cardioprotection-by-nicotinamide-riboside
#25
JOURNAL ARTICLE
Y Xiao, Q Wang, H Zhang, R Nederlof, D Bakker, B A Siadari, M W Wesselink, B Preckel, N C Weber, M W Hollmann, B V Schomakers, M van Weeghel, C J Zuurbier
Decreased nicotinamide adenine dinucleotide (NAD+ ) levels contribute to various pathologies such as ageing, diabetes, heart failure and ischemia-reperfusion injury (IRI). Nicotinamide riboside (NR) has emerged as a promising therapeutic NAD+ precursor due to efficient NAD+ elevation and was recently shown to be the only agent able to reduce cardiac IRI in models employing clinically relevant anesthesia. However, through which metabolic pathway(s) NR mediates IRI protection remains unknown. Furthermore, the influence of insulin, a known modulator of cardioprotective efficacy, on the protective effects of NR has not been investigated...
March 25, 2024: Basic Research in Cardiology
https://read.qxmd.com/read/38527426/how-safe-are-proprotein-convertase-subtilisinekexin-type-9-inhibitors-in-diabetes
#26
JOURNAL ARTICLE
Tian Chen, Naifeng Liu
PURPOSE OF REVIEW: To examine the safety of proprotein convertase subtilisinekexin type 9 (PCSK9) inhibitors in patients with diabetes, specifically focusing on their impact on glucose metabolism. RECENT FINDINGS: Patients with diabetes often require intensified lipid-lowering therapy. PCSK9 inhibitors can reduce low-density lipoprotein cholesterol (LDL-C) concentrations by approximately 60%, and significantly reduce cardiovascular risk when added to statin therapy...
March 20, 2024: Current Opinion in Lipidology
https://read.qxmd.com/read/38527400/the-redox-sensitive-gsk3%C3%AE-is-a-key-regulator-of-glomerular-podocyte-injury-in-type-2-diabetic-kidney-disease
#27
JOURNAL ARTICLE
Mengxuan Chen, Yudong Fang, Yan Ge, Shuhao Qiu, Lance Dworkin, Rujun Gong
Emerging evidence suggests that GSK3β, a redox-sensitive transducer downstream of insulin signaling, acts as a convergent point for myriad pathways implicated in kidney injury, repair, and regeneration. However, its role in diabetic kidney disease remains controversial. In cultured glomerular podocytes, exposure to a milieu of type 2 diabetes elicited prominent signs of podocyte injury and degeneration, marked by loss of homeostatic marker proteins like synaptopodin, actin cytoskeleton disruption, oxidative stress, apoptosis, and stress-induced premature senescence, as shown by increased staining for senescence-associated β-galactosidase activity, amplified formation of γH2AX foci, and elevated expression of mediators of senescence signaling, like p21 and p16INK4A ...
March 16, 2024: Redox Biology
https://read.qxmd.com/read/38526625/regulation-of-cancer-progression-by-ck2-an-emerging-therapeutic-target
#28
REVIEW
Shakeel Hussain, Yilei Guo, Yu Huo, Juanjuan Shi, Yongzhong Hou
Casein kinase II (CK2) is an enzyme with pleiotropic kinase activity that catalyzes the phosphorylation of lots of substrates, including STAT3, p53, JAK2, PTEN, RELA, and AKT, leading to the regulation of diabetes, cardiovascular diseases, angiogenesis, and tumor progression. CK2 is observed to have high expression in multiple types of cancer, which is associated with poor prognosis. CK2 holds significant importance in the intricate network of pathways involved in promoting cell proliferation, invasion, migration, apoptosis, and tumor growth by multiple pathways such as JAK2/STAT3, PI3K/AKT, ATF4/p21, and HSP90/Cdc37...
March 25, 2024: Medical Oncology
https://read.qxmd.com/read/38526557/the-potential-impact-of-cgm-use-on-diabetes-related-attitudes-and-behaviors-in-adults-with-t2d-a-qualitative-investigation-of-the-patient-experience
#29
JOURNAL ARTICLE
Taylor Clark, William Polonsky, Emily Soriano
BACKGROUND: Despite the known glycemic benefits of continuous glucose monitoring (CGM) for adults with type 2 diabetes (T2D), the attitudinal and behavioral changes underlying these glycemic improvements remain understudied. This study aimed to qualitatively explore these changes among a sample of adults with T2D. METHODS: In-depth, semi-structured interviews were conducted with adults with T2D who had been using CGM for 3 - 6 months as part of a larger community project in Ohio...
March 25, 2024: Diabetes Technology & Therapeutics
https://read.qxmd.com/read/38526231/high-throughput-methods-for-the-discovery-of-small-molecule-modulators-of-pancreatic-beta-cell-function-and-regeneration
#30
JOURNAL ARTICLE
Sean M McCarty, Martin C Clasby, Jonathan Z Sexton
The progression of type II diabetes (T2D) is characterized by a complex and highly variable loss of beta-cell mass, resulting in impaired insulin secretion. Many T2D drug discovery efforts aimed at discovering molecules that can protect or restore beta-cell mass and function have been developed using limited beta-cell lines and primary rodent/human pancreatic islets. Various high-throughput screening methods have been used in the context of drug discovery, including luciferase-based reporter assays, glucose-stimulated insulin secretion, and high-content screening...
March 25, 2024: Assay and Drug Development Technologies
https://read.qxmd.com/read/38526063/triple-threat-how-diabetes-results-in-worsened-bacterial-infections
#31
REVIEW
Benjamin P Darwitz, Christopher J Genito, Lance R Thurlow
Diabetes mellitus, characterized by impaired insulin signaling, is associated with increased incidence and severity of infections. Various diabetes-related complications contribute to exacerbated bacterial infections, including hyperglycemia, innate immune cell dysfunction, and infection with antibiotic-resistant bacterial strains. One defining symptom of diabetes is hyperglycemia, resulting in elevated blood and tissue glucose concentrations. Glucose is the preferred carbon source of several bacterial pathogens, and hyperglycemia escalates bacterial growth and virulence...
March 25, 2024: Infection and Immunity
https://read.qxmd.com/read/38525377/sglt2-inhibitors-beyond-glycemic-control
#32
JOURNAL ARTICLE
Irtiza Hasan, Tasnuva Rashid, Vishal Jaikaransingh, Charles Heilig, Emaad M Abdel-Rahman, Alaa S Awad
Multiple randomized controlled trials have extensively examined the therapeutic effectiveness of sodium-glucose cotransporter 2 (SGLT2) inhibitors, ushering in a transformative approach to treating individuals with type 2 diabetes mellitus (DM). Notably, emerging reports have drawn attention to the potential positive impacts of SGLT2 inhibitors in nondiabetic patients. In an effort to delve into this phenomenon, a comprehensive systematic literature review spanning PubMed (NLM), Medline (Ovid), and Cochrane Library, covering publications from 2000 to 2024 was undertaken...
March 2024: Journal of Clinical & Translational Endocrinology
https://read.qxmd.com/read/38525342/multilevel-perceptions-of-the-virtual-delivery-of-the-university-of-california-diabetes-prevention-program-on-re-aim-domains-due-to-covid-19-mandates
#33
JOURNAL ARTICLE
Tamra Burns Loeb, Maryam Gholami, Kate Ramm, Kelly Shedd, Samantha Soetenga, Nicholas J Jackson, Un Young Rebecca Chung, O Kenrik Duru, Carol M Mangione, Alison B Hamilton, Tannaz Moin
BACKGROUND: The University of California's Diabetes Prevention Program (UC DPP) Initiative was implemented across all 10 UC campuses in 2018. The COVID-19 pandemic and accompanying mandates required swift changes to program delivery, including pivoting from in-person to virtual delivery (i.e., Zoom). Our goal was to assess multilevel constituent perceptions of the use of a virtual platform to deliver UC DPP due to COVID-19 mandates. METHODS: We conducted qualitative interviews with 68 UC DPP participants, coordinators, and leaders to examine the use of virtual platform delivery on the reach, effectiveness, adoption, implementation, and maintenance (RE-AIM) of UC DPP...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38525098/effects-of-prior-reproductive-losses-on-risk-of-cardiovascular-diseases-within-six-months-of-a-first-live-birth
#34
JOURNAL ARTICLE
Maka Tsulukidze, David C Reardon, Christopher Craver
OBJECTIVE: There is emerging evidence suggesting that pregnancy loss (induced or natural) is associated with an increased risk of cardiovascular diseases (CVD). This prospective longitudinal study investigates the effect of prior pregnancy losses on CVD risk during the first six months following a first live birth. METHODS: Medicaid claims of 1,002,556 low-income women were examined to identify history of pregnancy losses, CVD, diabetes, and hyperlipidemia prior to first live birth...
June 2024: Int J Cardiol Cardiovasc Risk Prev
https://read.qxmd.com/read/38525095/appendicitis-a-hidden-danger-of-glp-1-receptor-agonists
#35
Sarah Casella, Katelyn Galli
Introduction: While glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have become increasingly prescribed, use is often inhibited by the gastrointestinal adverse effects that patients must endure. Nausea, vomiting, and cholelithiasis are most commonly associated with use, with little to no data or labeling reflecting risk of appendicitis or associated symptoms. Appendicitis etiology is theorized to develop secondary to obstruction of the vermiform via infection or fecalith causing an increase in intraluminal pressure...
April 2024: Journal of Pharmacy Technology: JPT: Official Publication of the Association of Pharmacy Technicians
https://read.qxmd.com/read/38524964/diabetic-ketoacidosis-with-the-use-of-alpelisib-in-a-patient-with-metastatic-breast-cancer-without-diabetes
#36
Lakshmi Polisetty, Sneha Teresa Selvin, Jia Wei Tan
Diabetic ketoacidosis (DKA) is a life-threatening medical condition. Alpelisib, a new drug used to treat phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha mutated breast cancer, is reported to cause DKA as a rare adverse effect. We present a case of alpelisib-induced DKA in a patient with metastatic breast cancer without diabetes. An 81-year-old female with a history of hormone receptor-positive, human epidermal growth factor receptor 2-negative metastatic breast cancer presented to the emergency room with clinical features and blood work consistent with DKA...
April 2024: JCEM Case Rep
https://read.qxmd.com/read/38524939/rapid-improvement-of-severe-fatty-liver-in-a-case-of-fulminant-type-1-diabetes-following-insulin-treatment
#37
Sonomi Noda, Nozomi Harai, Saki Komai, Takahiko Inukai, Tomomi Watanabe, Tadatsugu Hosokawa, Airi Antoku, Yuko Muroi, Ryosuke Hayashida, Hideyuki Okuma, Yuichiro Suzuki, Kyoichiro Tsuchiya
A 36-year-old woman presented to the emergency room with a consciousness disorder after developing abdominal pain with diarrhea for 2 days. She presented with marked hyperglycemia, ketoacidosis, and increased serum free fatty acid (FFA) levels; however, no elevation in the glycated hemoglobin (HbA1c) levels was observed. Based on the marked depletion of insulin secretion, the patient was diagnosed as diabetic ketoacidosis attributed to fulminant type 1 diabetes (FT1D). Computed tomography on admission revealed severe fatty liver (FL), which improved 17 h following insulin treatment...
April 2024: Diabetology International
https://read.qxmd.com/read/38524929/practice-of-complementary-and-alternative-medicine-use-in-north-indian-children-with-type-1-diabetes-an-exploratory-study
#38
JOURNAL ARTICLE
Priyanka Walia, Latika Rohilla, Devi Dayal
PURPOSE: Intermittent or concurrent use of Complementary and Alternative medicines (CAM) with insulin may have adverse effects in children with Type 1 Diabetes (T1DM). This study explores the practices of CAM use in children with T1DM. METHODS: An exploratory study was conducted among parents of children with T1DM attending a tertiary-level diabetes clinic. Data were collected using a structured pre-tested questionnaire. RESULTS: Two-hundred parents were invited; 183 (91...
April 2024: Diabetology International
https://read.qxmd.com/read/38524871/coenzyme-q10-a-key-antioxidant-in-the-management-of-diabetes-induced-cardiovascular-complications-an-overview-of-mechanisms-and-clinical-evidence
#39
REVIEW
Fatemeh Samimi, Nasim Namiranian, Ali Sharifi-Rigi, Morvarid Siri, Omid Abazari, Sanaz Dastghaib
BACKGROUND: Diabetes mellitus (DM) presents a significant global health challenge with considerable cardiovascular implications. Coenzyme Q10 (CoQ10) has gained recognition for its potential as a natural antioxidant supplement in the management of diabetes and its associated cardiovascular complications. AIM: This comprehensive review systematically examines the scientific rationale underlying the therapeutic properties of CoQ10 in mitigating the impact of diabetes and its cardiovascular consequences...
2024: International Journal of Endocrinology
https://read.qxmd.com/read/38524631/anti-osteoporotic-treatments-in-the-era-of-non-alcoholic-fatty-liver-disease-friend-or-foe
#40
REVIEW
Maria Eleni Chondrogianni, Ioannis Kyrou, Theodoros Androutsakos, Christina-Maria Flessa, Evangelos Menenakos, Kamaljit Kaur Chatha, Yekaterina Aranan, Athanasios G Papavassiliou, Eva Kassi, Harpal S Randeva
Over the last years non-alcoholic fatty liver disease (NAFLD) has grown into the most common chronic liver disease globally, affecting 17-38% of the general population and 50-75% of patients with obesity and/or type 2 diabetes mellitus (T2DM). NAFLD encompasses a spectrum of chronic liver diseases, ranging from simple steatosis (non-alcoholic fatty liver, NAFL) and non-alcoholic steatohepatitis (NASH; or metabolic dysfunction-associated steatohepatitis, MASH) to fibrosis and cirrhosis with liver failure or/and hepatocellular carcinoma...
2024: Frontiers in Endocrinology
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