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https://www.readbyqxmd.com/read/28303332/deep-brain-stimulation-of-the-centromedian-thalamic-nucleus-for-essential-tremor-a-case-report
#1
Vibhash D Sharma, Klaus Mewes, Thomas Wichmann, Cathrin Buetefisch, Jon T Willie, Mahlon DeLong
The centromedian nucleus (CM) of the thalamus is an important site with anatomical connections to different cortical and subcortical motor areas; however, its role in tremor disorders is not clear, although deep brain stimulation (DBS) of the CM has been described to be effective in the treatment of parkinsonian tremor. We report a case of a patient with medication-refractory essential tremor (ET) who had excellent tremor suppression with DBS of the CM. The CM and the nearby region should be explored as a potential target for the treatment of ET and other forms of tremor...
March 16, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28288113/germline-mutations-in-abl1-cause-an-autosomal-dominant-syndrome-characterized-by-congenital-heart-defects-and-skeletal-malformations
#2
Xia Wang, Wu-Lin Charng, Chun-An Chen, Jill A Rosenfeld, Aisha Al Shamsi, Lihadh Al-Gazali, Marianne McGuire, Nicholas Ah Mew, Georgianne L Arnold, Chunjing Qu, Yan Ding, Donna M Muzny, Richard A Gibbs, Christine M Eng, Magdalena Walkiewicz, Fan Xia, Sharon E Plon, James R Lupski, Christian P Schaaf, Yaping Yang
ABL1 is a proto-oncogene well known as part of the fusion gene BCR-ABL1 in the Philadelphia chromosome of leukemia cancer cells. Inherited germline ABL1 changes have not been associated with genetic disorders. Here we report ABL1 germline variants cosegregating with an autosomal dominant disorder characterized by congenital heart disease, skeletal abnormalities, and failure to thrive. The variant c.734A>G (p.Tyr245Cys) was found to occur de novo or cosegregate with disease in five individuals (families 1-3)...
March 13, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28276806/psychobiological-impact-of-ethnic-discrimination-in-turkish-immigrants-living-in-germany
#3
Susanne Fischer, Urs M Nater, Jana Strahler, Nadine Skoluda, Leander Dieterich, Orgun Oezcan, Ricarda Mewes
Perceived ethnic discrimination has a negative impact on health. One of the key mechanisms may be a dysregulation of stress-responsive systems. Our aims were to investigate whether (1) acute face-to-face ethnic discrimination induces a stress response, and (2) to compare long-term endocrine functioning between immigrants and nonimmigrants. 30 male Turkish immigrants living in Germany underwent an ethnic discrimination condition and a control condition in the laboratory. Perceived ethnic discrimination, stress, salivary alpha-amylase and cortisol were measured four times...
March 5, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/28267148/elevated-hair-cortisol-concentrations-in-recently-fled-asylum-seekers-in-comparison-to-permanently-settled-immigrants-and-non-immigrants
#4
R Mewes, H Reich, N Skoluda, F Seele, U M Nater
Recently fled asylum seekers generally live in stressful conditions. Their residency status is mostly insecure and, similar to other immigrants, they experience stress due to acculturation. Moreover, they often suffer from traumatization and posttraumatic stress disorder (PTSD). All of these factors can result in chronic maladaptive biological stress responses in terms of hyper- or hypocortisolism and, ultimately, illness. We believe the current study is the first to compare hair cortisol concentration (HCC) of recently fled asylum seekers with PTSD to those without PTSD, and to compare HCC of asylum seekers to HCC of permanently settled immigrants and non-immigrant individuals...
March 7, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28231295/the-pathogens-profile-in-children-with-otitis-media-with-effusion-and-adenoid-hypertrophy
#5
G P Buzatto, E Tamashiro, J L Proenca-Modena, T H Saturno, M C Prates, T B Gagliardi, L R Carenzi, E T Massuda, M A Hyppolito, F C P Valera, E Arruda, W T Anselmo-Lima
OBJECTIVES: To evaluate the presence of viruses and bacteria in middle ear and adenoids of patients with and without otitis media with effusion (OME). METHODS: Adenoid samples and middle ear washes (MEW) were obtained from children with OME associated with adenoid hypertrophy undergoing adenoidectomy and tympanostomy, and compared to those obtained from patients undergoing cochlear implant surgery, as a control group. Specific DNA or RNA of 9 respiratory viruses (rhinovirus, influenza virus, picornavirus, syncytial respiratory virus, metapneumovirus, coronavirus, enterovirus, adenovirus and bocavirus) and 5 bacteria (S...
2017: PloS One
https://www.readbyqxmd.com/read/28230997/universal-exciton-size-in-organic-polymers-is-determined-by-nonlocal-orbital-exchange-in-time-dependent-density-functional-theory
#6
Stefanie A Mewes, Felix Plasser, Andreas Dreuw
The exciton size of the lowest singlet excited state in a diverse set of organic π-conjugated polymers is studied and found to be a universal, system-independent quantity of approximately 7 Å in the single-chain picture. With time-dependent density functional theory (TDDFT), its value as well as the overall description of the exciton is almost exclusively governed by the amount of nonlocal orbital exchange. This is traced back to the lack of the Coulomb attraction between the electron and hole quasiparticles in pure TDDFT, which is reintroduced only with the admixture of nonlocal orbital exchange...
February 28, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28215372/the-managing-epilepsy-well-network-advancing-epilepsy-self-management
#7
EDITORIAL
Martha Sajatovic, Barbara C Jobst, Ross Shegog, Yvan A Bamps, Charles E Begley, Robert T Fraser, Erica K Johnson, Dilip K Pandey, Rakale C Quarells, Peter Scal, Tanya M Spruill, Nancy J Thompson, Rosemarie Kobau
Epilepsy, a complex spectrum of disorders, affects about 2.9 million people in the U.S. Similar to other chronic disorders, people with epilepsy face challenges related to management of the disorder, its treatment, co-occurring depression, disability, social disadvantages, and stigma. Two national conferences on public health and epilepsy (1997, 2003) and a 2012 IOM report on the public health dimensions of epilepsy highlighted important knowledge gaps and emphasized the need for evidence-based, scalable epilepsy self-management programs...
March 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28196741/a-common-vision-and-the-power-of-collaboration-the-managing-epilepsy-well-network-mew
#8
EDITORIAL
Barbara C Jobst
No abstract text is available yet for this article.
February 11, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28193215/analysing-trends-and-forecasting-malaria-epidemics-in-madagascar-using-a-sentinel-surveillance-network-a-web-based-application
#9
Florian Girond, Laurence Randrianasolo, Lea Randriamampionona, Fanjasoa Rakotomanana, Milijaona Randrianarivelojosia, Maherisoa Ratsitorahina, Télesphore Yao Brou, Vincent Herbreteau, Morgan Mangeas, Sixte Zigiumugabe, Judith Hedje, Christophe Rogier, Patrice Piola
BACKGROUND: The use of a malaria early warning system (MEWS) to trigger prompt public health interventions is a key step in adding value to the epidemiological data routinely collected by sentinel surveillance systems. METHODS: This study describes a system using various epidemic thresholds and a forecasting component with the support of new technologies to improve the performance of a sentinel MEWS. Malaria-related data from 21 sentinel sites collected by Short Message Service are automatically analysed to detect malaria trends and malaria outbreak alerts with automated feedback reports...
February 13, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28188577/sofa-score-in-septic-patients-incremental-prognostic-value-over-age-comorbidities-and-parameters-of-sepsis-severity
#10
Francesca Innocenti, Camilla Tozzi, Chiara Donnini, Eleonora De Villa, Alberto Conti, Maurizio Zanobetti, Riccardo Pini
Several widely used scoring systems for septic patients have been validated in an ICU setting, and may not be appropriate for other settings like Emergency Departments (ED) or High-Dependency Units (HDU), where a relevant number of these patients are managed. The purpose of this study is to find reliable tools for prognostic assessment of septic patients managed in an ED-HDU. In 742 patients diagnosed with sepsis/severe sepsis/septic shock, not-intubated, admitted in ED between June 2008 and April 2016, SOFA, qSOFA, PIRO, MEWS, Charlson Comorbidity Index, MEDS, and APACHE II were calculated at ED admission (T0); SOFA and MEWS were also calculated after 24 h of ED-High-Dependency Unit stay (T1)...
February 10, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/28186411/controlling-near-infrared-chromophore-electronic-properties-through-metal-ligand-orbital-alignment
#11
Nicole M Mews, Andreas Berkefeld, Gerald Hörner, Hartmut Schubert
Transition-metal complexes of radical ligands can exhibit low-energy electronic transitions in the near-infrared (NIR) spectral region. NIR band energy and intensity sensitively depend on the degree of electronic coupling of the chromophore. Using the example of open-shell complexes derived from platinum and a 1,4-terphenyldithiophenol, we present a novel approach toward spectroscopically distinct NIR dyes for which the degree of electronic coupling correlates with the relative orientation of radical ligand and metal orbitals...
February 10, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28179046/medium-and-long-term-prognostic-validity-of-competing-classification-proposals-for-the-former-somatoform-disorders
#12
S Schumacher, W Rief, K Klaus, E Brähler, R Mewes
BACKGROUND: DSM-5 introduced a fundamental revision of the category of somatoform disorders, which resulted in the new somatic symptom disorder (SSD) and related disorders. However, prognostic validity of SSD remains unclear, while other classification proposals, such as bodily distress disorder (BDD) or polysymptomatic distress disorder (PSDD), might be promising alternatives for the new ICD-11. Therefore, the comparison of the different approaches concerning long-term prognosis of disorder-relevant factors is of special interest...
February 9, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28177163/how-boron-doping-shapes-the-optoelectronic-properties-of-canonical-and-phenylene-containing-oligoacenes-a-combined-experimental-and-theoretical-investigation
#13
Sven Kirschner, Jan-Michael Mewes, Michael Bolte, Hans-Wolfram Lerner, Andreas Dreuw, Matthias Wagner
Optimized syntheses of 6,13-dimesityl-6,13-dihydro-6,13-diborapentacene (DBP) and a related compound (DBI) featuring two biphenylene-2,3-diyl units in place of naphthalene-2,3-diyl moieties are reported. Striking differences between the optoelectronic properties of DBP and DBI have been experimentally observed, and explained by quantum-chemical calculations. DBP is a member of the oligoacene family, DBI is a linear [N]phenylene derivative. The yellow DBP shows blue photoluminescence, the deep red DBI is non-fluorescent...
February 8, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28172527/knime4ngs-a-comprehensive-toolbox-for-next-generation-sequencing-analysis
#14
Maximilian Hastreiter, Tim Jeske, Jonathan Hoser, Michael Kluge, Kaarin Ahomaa, Marie-Sophie Friedl, Sebastian J Kopetzky, Jan-Dominik Quell, H-Werner Mewes, Robert Küffner
No abstract text is available yet for this article.
January 9, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28157242/one-pot-synthesis-of-ultrastable-pentanuclear-alkylzinc-complexes
#15
Hana Bunzen, Maciej Grzywa, Andreas Kalytta-Mewes, Dirk Volkmer
Two organometallic pentanuclear zinc complexes, namely [Zn5Et4(Me2bta)6] and [Zn5Me4(Me2bta)6], containing tridentate N-donor ligands (5,6-dimethylbenzotriazolate, Me2bta) were prepared by a one-pot synthesis. These compounds represent the first examples of organometallic complexes featuring a Kuratowski-type bond topology. Zinc ions were introduced as organometallic precursors (either diethylzinc or dimethylzinc was used), which upon mixing with the ligand yielded the desired complexes spontaneously. The organometallic complexes were characterized by a range of analytical techniques including NMR- and FT-IR spectroscopy, mass spectrometry, and elemental analysis...
February 3, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28139451/correlates-of-quality-of-life-among-individuals-with-epilepsy-enrolled-in-self-management-research-from-the-us-centers-for-disease-control-and-prevention-managing-epilepsy-well-network
#16
Martha Sajatovic, Curtis Tatsuoka, Elisabeth Welter, Daniel Friedman, Tanya M Spruill, Shelley Stoll, Satya S Sahoo, Ashley Bukach, Yvan A Bamps, Joshua Valdez, Barbara C Jobst
RATIONALE: Epilepsy is a chronic neurological condition that causes substantial burden on patients and families. Quality of life may be reduced due to the stress of coping with epilepsy. For nearly a decade, the Centers for Disease Control (CDC) Prevention Research Center's Managing Epilepsy Well (MEW) Network has been conducting research on epilepsy self-management to address research and practice gaps. Studies have been conducted by independent centers across the U.S. Recently, the MEW Network sites, collaboratively, began compiling an integrated database to facilitate aggregate secondary analysis of completed and ongoing studies...
January 27, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28113454/cryo-balloon-catheter-localization-based-on-a-support-vector-machine-approach
#17
Tanja Kurzendorfer, Philip W Mewes, Andreas Maier, Norbert Strobel, Alexander Brost
Cryo-balloon catheters have attracted an increasing amount of interest in the medical community as they can reduce patient risk during left atrial pulmonary vein ablation procedures. As cryo-balloon catheters are not equipped with electrodes, they cannot be localized automatically by electro-anatomical mapping systems. As a consequence, X-ray fluoroscopy has remained an important means for guidance during the procedure. Most recently, image guidance methods for fluoroscopy-based procedures have been proposed, but they provide only limited support for cryo-balloon catheters and require significant user interaction...
March 9, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28088129/in-vitro-eye-irritation-testing-using-the-open-source-reconstructed-hemicornea-a-ring-trial
#18
Karsten R Mewes, Maria Engelke, Michaela Zorn-Kruppa, Melinda Bartok, Rashmi Tandon, Johanna M Brandner, Dirk Petersohn
Aim of the present ring trial was to prove whether two new methodological approaches for the in vitro classification of eye irritating chemicals can be reliably transferred from the developers' laboratories to other sites.Both test methods are based on the well-established open source reconstructed 3D hemicornea models. In the first approach, the initial depth of injury in the hemicornea model after chemical treatment is derived from the quantitative analysis of histological sections. In the second approach tissue viability, as a measure for corneal damage after chemical treatment, is analyzed separately for epithelium and stroma of the hemicornea model...
January 14, 2017: ALTEX
https://www.readbyqxmd.com/read/28075238/safety-of-stationary-grinding-machines-impact-resistance-of-work-zone-enclosures
#19
Detlef Mewes, Christian Adler
Guards on machine tools are intended to protect persons from being injured by parts ejected with high kinetic energy from the work zone of the machine. Stationary grinding machines are a typical example. Generally such machines are provided with abrasive product guards closely enveloping the grinding wheel. However, many machining tasks do not allow the use of abrasive product guards. In such cases, the work zone enclosure has to be dimensioned so that, in case of failure, grinding wheel fragments remain inside the machine's working zone...
January 11, 2017: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/28069905/evaluation-of-the-threshold-value-for-the-modified-early-warning-score-mews-in-medical-septic-patients-a-secondary-analysis-of-an-italian-multicentric-prospective-cohort-snoopii-study
#20
D Tirotta, M Gambacorta, M La Regina, T Attardo, A Lo Gullo, F Panzone, A Mazzone, M Campanini, F Dentali
BACKGROUND: Due to aging and resources limitation, septic patients are often admitted to medical wards (MWs). Early warning deterioration is a relevant issue in this setting. Unfortunately, a suitable prognostic score has not been identified, yet. AIM: To explore the ability of Modified Early Warning Score (MEWS) to predict the in-hospital mortality in septic patients admitted to MWs. DESIGN: Secondary analysis of a multicentric prospective study...
January 9, 2017: QJM: Monthly Journal of the Association of Physicians
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