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Mariska Weenk, Harry van Goor, Maartje van Acht, Lucien Jlpg Engelen, Tom H van de Belt, Sebastian J H Bredie
BACKGROUND: Vital sign measurements in hospitalized patients by nurses are time consuming and prone to operational errors. The Checkme, a smart all-in-one device capable of measuring vital signs, could improve daily patient monitoring by reducing measurement time, inter-observer variability, and incorrect inputs in the Electronic Health Record (EHR). We evaluated the accuracy of self measurements by patient using the Checkme in comparison with gold standard and nurse measurements. METHODS AND FINDINGS: This prospective comparative study was conducted at the Internal Medicine ward of an academic hospital in the Netherlands...
2018: PloS One
Angela Adler, Pia Kirchmeier, Julian Reinhard, Barbara Brauner, Irmtraud Dunger, Gisela Fobo, Goar Frishman, Corinna Montrone, H-Werner Mewes, Matthias Arnold, Andreas Ruepp
BACKGROUND: Thoroughly annotated data resources are a key requirement in phenotype dependent analysis and diagnosis of diseases in the area of precision medicine. Recent work has shown that curation and systematic annotation of human phenome data can significantly improve the quality and selectivity for the interpretation of inherited diseases. We have therefore developed PhenoDis, a comprehensive, manually annotated database providing symptomatic, genetic and imprinting information about rare cardiac diseases...
January 25, 2018: Orphanet Journal of Rare Diseases
Felix M Wunner, Onur Bas, Navid T Saidy, Paul D Dalton, Elena M De-Juan Pardo, Dietmar W Hutmacher
This tutorial reflects on the fundamental principles and guidelines for electrospinning writing with polymer melts, an additive manufacturing technology with great potential for biomedical applications. The technique facilitates the direct deposition of biocompatible polymer fibers to fabricate well-ordered scaffolds in the sub-micron to micro scale range. The establishment of a stable, viscoelastic, polymer jet between a spinneret and a collector is achieved using an applied voltage and can be direct-written...
December 23, 2017: Journal of Visualized Experiments: JoVE
Miguel Castilho, Gernot Hochleitner, Wouter Wilson, Bert van Rietbergen, Paul D Dalton, Jürgen Groll, Jos Malda, Keita Ito
Reinforcing hydrogels with micro-fibre scaffolds obtained by a Melt-Electrospinning Writing (MEW) process has demonstrated great promise for developing tissue engineered (TE) constructs with mechanical properties compatible to native tissues. However, the mechanical performance and reinforcement mechanism of the micro-fibre reinforced hydrogels is not yet fully understood. In this study, FE models, implementing material properties measured experimentally, were used to explore the reinforcement mechanism of fibre-hydrogel composites...
January 19, 2018: Scientific Reports
F Hamilton, D Arnold, A Baird, M Albur, P Whiting
OBJECTIVES: Early Warning scores are used to evaluate patients in many hospital settings. It is not clear if these are accurate in predicting mortality in sepsis. We performed a systematic review and meta-analysis of multiple studies in sepsis. Our aim was to estimate the accuracy of EWS for mortality in this setting. METHODS: PubMED, CINAHL, Cochrane, Web of Science and EMBASE were searched to October 2016. Studies of adults with sepsis who had EWS calculated using any appropriate tool (e...
January 11, 2018: Journal of Infection
Bartlomiej Bartkowiak, Ashley M Snyder, Andrew Benjamin, Andrew Schneider, Nicole M Twu, Matthew M Churpek, Kevin K Roggin, Dana P Edelson
OBJECTIVE: Assess the accuracy of 3 early warning scores for predicting severe adverse events in postoperative inpatients. SUMMARY OF BACKGROUND DATA: Postoperative clinical deterioration on inpatient hospital services is associated with increased morbidity, mortality, and cost. Early warning scores have been developed to detect inpatient clinical deterioration and trigger rapid response activation, but knowledge regarding the application of early warning scores to postoperative inpatients is limited...
January 12, 2018: Annals of Surgery
J Mew
No abstract text is available yet for this article.
January 12, 2018: British Dental Journal
Stefanie A Mewes, Felix Plasser, Anna Krylov, Andreas Dreuw
Benchmarking is an every-day task in computational chemistry, yet making meaningful comparisons between different methods is non-trivial. Benchmark studies often focus on the most obvious quantities such as energy differences. But to gain insight, it is desirable to explain the discrepancies between theoretical methods in terms of underlying wavefunctions and, consequently, physically relevant quantities. We present a new strategy of benchmarking excited-state calculations, which goes beyond excitation energies and oscillator strengths and involves the analysis of exciton properties based on the one-particle transition density matrix...
January 11, 2018: Journal of Chemical Theory and Computation
Yoon J Jang, Abigail L LaBella, Timothy P Feeney, Nancy Braverman, Mendel Tuchman, Hiroki Morizono, Nicholas Ah Mew, Ljubica Caldovic
The ornithine transcarbamylase (OTC) gene is on the X chromosome and its product catalyzes the formation of citrulline from ornithine and carbamylphosphate in the urea cycle. About 10-15% of patients, clinically diagnosed with OTC deficiency (OTCD), lack identifiable mutations in the coding region or splice junctions of the OTC gene on routine molecular testing. We collected DNA from such patients via retrospective review and by prospective enrollment. In nine of 38 subjects (24%), we identified a sequence variant in the OTC regulatory regions...
December 27, 2017: Human Mutation
Reny Luhur, Joanne D Schuijf, Jügen Mews, Jörg Blobel, Bernd Hamm, Alexander Lembcke
OBJECTIVE: To assess the accuracy of an iterative reconstruction (IR) technique for coronary artery calcium scoring with reduced radiation dose. METHODS: 163 consecutive patients underwent twofold scanning by 320-row detector computed tomography (CT) at 120 kVp. A low-dose scan at 25% tube current but with standard scan length (14 cm) was followed by a standard dose scan with routine tube current but reduced scan length (10 cm). Reduced dose images were constructed using filtered back-projection (FBP) and IR (adaptive iterative dose reduction in 3 dimensions, or AIDR3D)...
December 20, 2017: British Journal of Radiology
Martin Duckheim, Katharina Klee, Nina Götz, Paul Helle, Patrick Groga-Bada, Lars Mizera, Meinrad Gawaz, Christine S Zuern, Christian Eick
Syncope is a common cause for admission to the emergency department (ED). Due to limited clinical resources there is great interest in developing risk stratification tools that allow identifying patients with syncope who are at low risk and can be safely discharged. Deceleration capacity (DC) is a strong risk predictor in postinfarction and heart failure patients. The aim of this study was to evaluate whether DC provides prognostic information in patients presenting to ED with syncope.We prospectively enrolled 395 patients presenting to the ED due to syncope...
December 2017: Medicine (Baltimore)
Janne C Mewes, Lotte M G Steuten, Charlotte IJsbrandy, Maarten J IJzerman, Wim H van Harten
BACKGROUND: To increase the adherence of health professionals and cancer survivors to evidence-based physical exercise, effective implementation strategies (ISTs) are required. OBJECTIVES: To examine to what extent these ISTs provide value for money and which IST has the highest expected value. METHODS: The net benefit framework of health economic evaluations is used to conduct a value-of-implementation analysis of nine ISTs. Seven are directed to health professionals and two to cancer survivors...
December 2017: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Mylène de Ruijter, Andrei Hrynevich, Jodie N Haigh, Gernot Hochleitner, Miguel Castilho, Jürgen Groll, Jos Malda, Paul D Dalton
One challenge in biofabrication is to fabricate a matrix that is soft enough to elicit optimal cell behavior while possessing the strength required to withstand the mechanical load that the matrix is subjected to once implanted in the body. Here, melt electrowriting (MEW) is used to direct-write poly(ε-caprolactone) fibers "out-of-plane" by design. These out-of-plane fibers are specifically intended to stabilize an existing structure and subsequently improve the shear modulus of hydrogel-fiber composites. The stabilizing fibers (diameter = 13...
December 14, 2017: Small
K G Steenbergen, J-M Mewes, L F Pašteka, H W Gäggeler, G Kresse, E Pahl, P Schwerdtfeger
The cohesive energy of bulk copernicium is accurately determined using the incremental method within a relativistic coupled-cluster approach. For the lowest energy structure of hexagonal close-packed (hcp) symmetry, we obtain a cohesive energy of -36.3 kJ mol-1 (inclusion of uncertainties leads to a lower bound of -39.6 kJ mol-1), in excellent agreement with the experimentally estimated sublimation enthalpy of -38 kJ mol-1 [R. Eichler et al., Angew. Chem. Int. Ed., 2008, 47, 3262]. At the coupled-cluster singles, doubles and perturbative triples level of theory, we find that the hcp structure is energetically quasi-degenerate with both face-centred and body-centred cubic structures...
December 4, 2017: Physical Chemistry Chemical Physics: PCCP
Lili Tang, Kurt Fritzsche, Rainer Leonhart, Ying Pang, Jinjiang Li, Lili Song, Irmela Fischer, Maike Koch, Alexander Wuensch, Ricarda Mewes, Rainer Schaefert
BACKGROUND: To evaluate the relationship between quality of life (QOL) and physical as well as psychological variables in Chinese breast cancer patients. METHODS: This multicenter cross-sectional study enrolled 254 Chinese breast cancer patients in different stages and treatment phases. They answered standard instruments assessing QOL (EORTC), somatic symptom severity (PHQ-15), depression (PHQ-9), anxiety (GAD-7), health-related anxiety (WI-7), illness perception (BIPQ), and sense of coherence (SOC-9)...
December 1, 2017: Health and Quality of Life Outcomes
Malcolm Green, Harvey Lander, Ashley Snyder, Paul Hudson, Matthew Churpek, Dana Edelson
INTRODUCTION: Traditionally, paper based observation charts have been used to identify deteriorating patients, with emerging recent electronic medical records allowing electronic algorithms to risk stratify and help direct the response to deterioration. OBJECTIVE(S): We sought to compare the Between the Flags (BTF) calling criteria to the Modified Early Warning Score (MEWS), National Early Warning Score (NEWS) and electronic Cardiac Arrest Risk Triage (eCART) score...
February 2018: Resuscitation
Erina Ghosh, Larry Eshelman, Lin Yang, Eric Carlson, Bill Lord
INTRODUCTION: Early detection of deterioration could facilitate more timely interventions which are instrumental in reducing transfer to higher levels of care such as Intensive Care Unit (ICU) and mortality.(1,2) METHODS AND RESULTS: We developed the Early Deterioration Indicator (EDI) which uses log likelihood risk of vital signs to calculate continuous risk scores. EDI was developed using data from 11864 general ward admissions. To validate EDI, we calculated EDI scores on an additional 2418 general ward stays and compared it to the Modified Early Warning Score (MEWS) and National Early Warning Score (NEWS)...
November 6, 2017: Resuscitation
Roman Pfister, Peter Ihle, Birgit Mews, Elisabeth Kohnen, Marcus Wähner, Ute Karbach, Hasan Aslan, Hans-Wilhelm Höpp, Christian Alfons Schneider
AIMS: Structured management programmes deliver optimized care in heart failure patients and improve outcome. We examined the feasibility of including patients with migration background speaking little or no German in a heart failure management programme. METHODS AND RESULTS: After adaption of script material and staff to Turkish language we aimed to recruit 300 Turkish and 300 German (control group) patients within 18 months using the operational basis of a local heart failure management programme for screening, contact and inclusion...
2017: PloS One
Sven-Hendrik Lohmann, Christian Strelow, Alf Mews, Tobias Kipp
By performing spectroscopic single-particle measurements at cryogenic temperatures over the course of hours we study both the spectral diffusion as well as the diffusion of the decay rates of the fluorescence emission of core/shell CdSe/CdS dot/rod nanoparticles. A special analysis of the measurements allow for a correlation of data for single neutral excitons only, undisturbed by the possible emission of other excitonic complexes. We find a nearly linear dependency of the fluorescence decay rate on the emission energy...
November 8, 2017: ACS Nano
Nana Xiong, Yaoyin Zhang, Jing Wei, Rainer Leonhart, Kurt Fritzsche, Ricarda Mewes, Xia Hong, Jinya Cao, Tao Li, Jing Jiang, Xudong Zhao, Lan Zhang, Rainer Schaefert
BACKGROUND: The aim of this study was to test the operationalization of DSM-5 somatic symptom disorder (SSD) psychological criteria among Chinese general hospital outpatients. METHODS: This multicenter, cross-sectional study enrolled 491 patients from 10 general hospital outpatient departments. The structured clinical "interview about cognitive, affective, and behavioral features associated with somatic complaints" was used to operationalize the SSD criteria B. For comparison, DSM-IV somatoform disorders were assessed with the Mini International Neuropsychiatric Interview plus...
November 7, 2017: BMC Psychiatry
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