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https://www.readbyqxmd.com/read/29659593/the-complexity-of-patients-hospitalized-in-internal-medicine-wards-evaluated-by-fadoi-complimed-score-s-a-hypothetical-approach
#1
Erminio Bonizzoni, Gualberto Gussoni, Giancarlo Agnelli, Raffaele Antonelli Incalzi, Moira Bonfanti, Franco Mastroianni, Marco Candela, Carlotta Franchi, Stefania Frasson, Antonio Greco, Micaela La Regina, Roberta Re, Giorgio Vescovo, Mauro Campanini
OBJECTIVES: The aim of this study is to develop a new predictive model to measure complexity of patients in medical wards. SETTING: 29 Internal Medicine departments in Italy. MATERIALS AND METHODS: The study cohort was made of 541 consecutive patients hospitalized for any cause, aged more than 40 years and with at least two chronic diseases. First, we applied a hierarchical cluster analysis and the principal component analysis (PCA) to a panel of questionnaires [comorbidity (Charlson, CIRS), clinical stability (MEWS), social frailty (Flugelman), cognitive dysfunction (SPSMQ), depression (5-item GDS), functional dependence (ADL, IADL, Barthel), risk of sore threats (Exton-Smith scale), nutrition (MNA), pain (NRPS), adherence to therapy (Morisky scale)], in order to select domains informative for the definition of complexity...
2018: PloS One
https://www.readbyqxmd.com/read/29656556/melt-electrowriting-of-thermoplastic-elastomers
#2
Gernot Hochleitner, Eva Fürsattel, Reiner Giesa, Jürgen Groll, Hans-Werner Schmidt, Paul D Dalton
Melt electrowriting (MEW), an additive manufacturing process, is established using polycaprolactone as the benchmark material. In this study, a thermoplastic elastomer, namely, poly(urea-siloxane), is synthesized and characterized to identify how different classes of polymers are compatible with MEW. This polyaddition polymer has reversible hydrogen bonding from the melt upon heating/cooling and highly resolved structures are achieved by MEW. The influence of applied voltage, temperature, and feeding pressure on printing outcomes behavior is optimized...
April 14, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29653185/sex-differences-in-the-development-of-hepatic-steatosis-in-cafeteria-diet-induced-obesity-in-young-mice
#3
Fabiana Rodrigues Silva Gasparin, Fernando Olinto Carreño, Juliana Moraes Mewes, Eduardo Hideo Gilglioni, Clairce Luzia Salgueiro Pagadigorria, Maria Raquel Marçal Natali, Karina Sayuri Utsunomiya, Rodrigo Polimeni Constantin, Amanda Tomie Ouchida, Carlos Curti, Ingrid C Gaemers, Ronald Petrus Johannes Oude Elferink, Jorgete Constantin, Emy Luiza Ishii-Iwamoto
The present study was planned to improve our understanding about sex differences in the development of hepatic steatosis in cafeteria diet-induced obesity in young mice. Female (FCaf) and male (MCaf) mice fed a cafeteria diet had similar body weight gain and adiposity index, but FCaf had a more extensive steatosis than MCaf. FCaf livers exhibited a higher non-alcoholic fatty liver disease activity score, elevated lipid percentage area (+34%) in Sudan III staining and increased TG content (+25%) compared to MCaf...
April 10, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29651595/heart-rate-variability-for-rapid-risk-stratification-of-emergency-patients-with-malignant-disease
#4
K Boehm, M Duckheim, L Mizera, P Groga-Bada, N Malek, F Kreth, M Gawaz, C S Zuern, C Eick
INTRODUCTION: Neoplasms are the second most common diseases in western countries. Many patients with malignant diseases repeatedly present themselves in the emergency department (ED). Due to limited capacities, appropriate risk stratification strategies for cancer patients have to be developed. This study assesses if deceleration capacity (DC) of heart rate as a parameter of heart rate variability predicts mortality in emergency patients with malignant diseases. METHODS: Prospectively, 140 adults with different entities of malignant diseases who presented in the medical ED were included...
April 12, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29651093/maxillary-position
#5
J Mew
No abstract text is available yet for this article.
April 13, 2018: British Dental Journal
https://www.readbyqxmd.com/read/29561154/tuning-of-thiyl-thiolate-complex-near-infrared-chromophores-of-platinum-through-geometrical-constraints
#6
Nicole M Mews, Gerald Hörner, Hartmut Schubert, Andreas Berkefeld
The chemistry of radical-ligand complexes of the transition metals has developed into a vibrant field of research that spans from fundamental studies on the relationship between the chemical and electronic structures to applications in catalysis and functional materials chemistry. In general, fine-tuning of the relevant properties relies on an increasingly diversifying pool of radical-proligand structures. Surprisingly, the variability of the conformational freedom and the number of distinct bonding modes supported by many radical proligands is limited...
March 21, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29555458/crimped-elastomer-scaffolds-prepared-through-mew-with-non-linear-extension-behaviour-mimicking-that-of-ligaments-and-tendons
#7
Gernot Hochleitner, Fei Chen, Carina Blum, Paul D Dalton, Brian Amsden, Jürgen Groll
Ligaments and tendons are comprised of aligned, crimped collagen fibrils that provide tissue-specific mechanical properties with non-linear extension behaviour, exhibiting low stress at initial strain (toe region behaviour). To approximate this behaviour, we report fibrous scaffolds with sinusoidal patterns by melt electrowriting (MEW) below the critical translation speed (CTS) by exploitation of the natural flow behaviour of the polymer melt. More specifically, we synthesised photopolymerizable poly(L-lactide-co-ε-caprolactone-co-acryloyl carbonate) (p(LLA-co-ε-CL-co-AC)) and poly(ε-caprolactone-co-acryloyl carbonate) (p(ε-CL-co-AC)) by ring-opening polymerization (ROP)...
March 16, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29523820/zfp226-is-a-novel-artificial-transcription-factor-for-selective-activation-of-tumor-suppressor-kibra
#8
Katrin Schelleckes, Boris Schmitz, Malte Lenders, Mirja Mewes, Stefan-Martin Brand, Eva Brand
KIBRA has been suggested as a key regulator of the hippo pathway, regulating organ size, cell contact inhibition as well as tissue regeneration and tumorigenesis. Recently, alterations of KIBRA expression caused by promotor methylation have been reported for several types of cancer. Our current study aimed to design an artificial transcription factor capable of re-activating expression of the tumor suppressor KIBRA and the hippo pathway. We engineered a new gene named 'ZFP226' encoding for a ~23 kDa fusion protein...
March 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29518139/frazzled-can-act-through-distinct-molecular-pathways-in-epithelial-cells-to-regulate-motility-apical-constriction-and-localisation-of-e-cadherin
#9
Sofia Golenkina, Vishal Chaturvedi, Robert Saint, Michael J Murray
Netrin receptors of the DCC/NEO/UNC-40/Frazzled family have well established roles in cell migration and axon guidance but can also regulate epithelial features such as adhesion, polarity and adherens junction (AJ) stability. Previously, we have shown that overexpression of Drosophila Frazzled (Fra) in the peripodial epithelium (PE) inhibits wing disc eversion and also generates cellular protrusions typical of motile cells. Here, we tested whether the molecular pathways by which Fra inhibits eversion are distinct from those driving motility...
2018: PloS One
https://www.readbyqxmd.com/read/29510956/-social-problems-in-primary-health-care-prevalence-responses-course-of-action-and-the-need-for-support-from-a-general-practitioners-point-of-view
#10
Thomas Zimmermann, Claudia Mews, Thomas Kloppe, Britta Tetzlaff, Moritz Hadwiger, Olaf von dem Knesebeck, Martin Scherer
BACKGROUND: Very often patients utilize primary care services for health conditions related to social problems. These problems, which are not primarily medical, can severely influence the course of an illness and its treatment. Little is known about the extent to which problems like unemployment or loneliness occur in a general practice setting. OBJECTIVES: What are the most frequent health-related social problems perceived by general practitioners (GPs)? How are these problems associated with GP- or practice characteristics? How do general practitioners deal with the social problems they perceive and what kind of support do they need? MATERIALS AND METHODS: Cross-sectional, postal questionnaire survey with questions derived from "Chapter Z social problems" of the International Classification of Primary Care - 2nd edition...
March 3, 2018: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/29504297/demographic-and-clinical-correlates-of-seizure-frequency-findings-from-the-managing-epilepsy-well-network-database
#11
Erdong Chen, Martha Sajatovic, Hongyan Liu, Ashley Bukach, Curtis Tatsuoka, Elisabeth Welter, Samantha S Schmidt, Yvan A Bamps, Shelley C Stoll, Tanya M Spruill, Daniel Friedman, Charles E Begley, Ross Shegog, Robert T Fraser, Erica K Johnson, Barbara C Jobst
BACKGROUND AND PURPOSE: Epilepsy is a chronic neurological disease that represents a tremendous burden on both patients and society in general. Studies have addressed how demographic variables, socioeconomic variables, and psychological comorbidity are related to the quality of life (QOL) of people with epilepsy (PWE). However, there has been less focus on how these factors may differ between patients who exhibit varying degrees of seizure control. This study utilized data from the Managing Epilepsy Well (MEW) Network of the Centers for Disease Control and Prevention with the aim of elucidating differences in demographic variables, depression, and QOL between adult PWE...
February 28, 2018: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/29502911/inborn-errors-of-metabolism-with-hyperammonemia-urea-cycle-defects-and-related-disorders
#12
REVIEW
Marshall L Summar, Nicholas Ah Mew
The urea cycle disorders are a group of inherited biochemical diseases caused by a complete or partial deficiency of any one of the enzymes or transport proteins required to convert toxic ammonia into urea and to produce arginine and citrulline. The clinical manifestations of these disorders are mostly the result of acute or chronic hyperammonemia, which affects the central nervous system. Affected individuals can also develop hepatic dysfunction. These disorders can present at any age from the immediate newborn to later in life...
April 2018: Pediatric Clinics of North America
https://www.readbyqxmd.com/read/29498148/the-value-of-the-modified-early-warning-score-for-unplanned-intensive-care-unit-admissions-of-patients-treated-in-hospital-general-wards
#13
Michail Zografakis-Sfakianakis, Eelco De Bree, Manolis Linardakis, Argyri Messaritaki, Helen Askitopoulou, Alexandra Papaioannou, Panagiotis Aggouridakis
AIM: To determine the value of the Modified Early Warning Score (MEWS) for general ward patients and its potential use as an alarm tool for ward nurses. METHODS: A combined prospective-retrospective observational study was conducted with 153 patients in a university hospital (2013-2014). All patients were admitted to the intensive care unit (ICU) from general wards. Parameters retrospectively studied were 5 MEWS values at 4 hourly intervals, up to 20 hours before ICU admission...
March 1, 2018: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/29480415/accelerated-step-up-infliximab-use-is-associated-with-sustained-primary-response-in-pediatric-crohn-s-disease
#14
J Ling, D Buurman, M Ravikumara, C Mews, K Thacker, Z Grover
BACKGROUND: Earlier introduction of infliximab (IFX) in Crohn's disease (CD) may be associated with a sustained remission. METHODS AND AIMS: Children on scheduled IFX therapy for predominant luminal CD after successful induction (drop in PCDAI by ≥ 15) and a minimum of 2-year IFX follow-up were included. We compared outcomes of children treated with early (within 3 months from diagnosis) versus later IFX (after failing conventional therapy ≥ 3 months) and identify clinical predictors of sustained primary response (SPR) in our cohort...
February 26, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29474128/non-animal-methods-to-predict-skin-sensitization-i-the-cosmetics-europe-database
#15
Sebastian Hoffmann, Nicole Kleinstreuer, Nathalie Alépée, David Allen, Anne Marie Api, Takao Ashikaga, Elodie Clouet, Magalie Cluzel, Bertrand Desprez, Nichola Gellatly, Carsten Goebel, Petra S Kern, Martina Klaric, Jochen Kühnl, Jon F Lalko, Silvia Martinozzi-Teissier, Karsten Mewes, Masaaki Miyazawa, Rahul Parakhia, Erwin van Vliet, Qingda Zang, Dirk Petersohn
Cosmetics Europe, the European Trade Association for the cosmetics and personal care industry, is conducting a multi-phase program to develop regulatory accepted, animal-free testing strategies enabling the cosmetics industry to conduct safety assessments. Based on a systematic evaluation of test methods for skin sensitization, five non-animal test methods (DPRA (Direct Peptide Reactivity Assay), KeratinoSensTM , h-CLAT (human cell line activation test), U-SENSTM , SENS-IS) were selected for inclusion in a comprehensive database of 128 substances...
February 23, 2018: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/29474122/non-animal-methods-to-predict-skin-sensitization-ii-an-assessment-of-defined-approaches
#16
Nicole C Kleinstreuer, Sebastian Hoffmann, Nathalie Alépée, David Allen, Takao Ashikaga, Warren Casey, Elodie Clouet, Magalie Cluzel, Bertrand Desprez, Nichola Gellatly, Carsten Göbel, Petra S Kern, Martina Klaric, Jochen Kühnl, Silvia Martinozzi-Teissier, Karsten Mewes, Masaaki Miyazawa, Judy Strickland, Erwin van Vliet, Qingda Zang, Dirk Petersohn
Skin sensitization is a toxicity endpoint of widespread concern, for which the mechanistic understanding and concurrent necessity for non-animal testing approaches have evolved to a critical juncture, with many available options for predicting sensitization without using animals. Cosmetics Europe and the National Toxicology Program Interagency Center for the Evaluation of Alternative Toxicological Methods collaborated to analyze the performance of multiple non-animal data integration approaches for the skin sensitization safety assessment of cosmetics ingredients...
February 23, 2018: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/29473006/benthic-grazing-in-a-eutrophic-river-cascading-effects-of-zoobenthivorous-fish-mask-direct-effects-of-herbivorous-fish
#17
Madlen Gerke, Daniel Cob Chaves, Marc Richter, Daniela Mewes, Jörg Schneider, Dirk Hübner, Carola Winkelmann
Benthic grazing strongly controls periphyton biomass. The question therefore arises whether benthic grazing could be used as a tool to reduce excessive growth of periphyton in nutrient-enriched rivers. Although benthic invertebrate grazers reduce the growth of periphyton, this is highly context dependent. Here we assessed whether the only obligate herbivorous fish in European rivers, the common nase ( Chondrostoma nasus L.), is able to reduce periphyton biomass in a eutrophic river. We conducted three consecutive in situ experiments at low, intermediate and high densities of nase in the river using standard tiles on the river bottom naturally covered with periphyton that were accessible to fish and tiles that excluded fish foraging with electric exclosures...
2018: PeerJ
https://www.readbyqxmd.com/read/29465568/preliminary-evidence-the-stress-reducing-effect-of-listening-to-water-sounds-depends-on-somatic-complaints-a-randomized-trial
#18
Myriam Verena Thoma, Ricarda Mewes, Urs M Nater
BACKGROUND: Listening to natural sounds is applied in health contexts in order to induce relaxation. However, it remains unclear whether this effect is equally efficacious in all individuals or whether it depends on interindividual differences. Given that individuals differ in how they are impaired by somatic complaints, we investigated whether somatic complaints moderate the stress-reducing effect of listening to water sounds. METHODS: Sixty healthy women (Mage = 25 years) were randomly allocated to 3 different conditions (listening to water sounds, a relaxing piece of music, or no auditory stimulus: n = 20 per condition) for 10 minutes before they were exposed to a standardized psychosocial stress task...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29457945/factors-that-influence-nurses-assessment-of-patient-acuity-and-response-to-acute-deterioration
#19
Mark Dalton, John Harrison, Anitra Malin, Conan Leavey
BACKGROUND: nurses play a crucial role in the early recognition and management of the deteriorating patient. They are responsible for the care they provide to their patients, part of which is the monitoring of vital signs (blood pressure, pulse, respiratory rate and temperature), which are fundamental in the surveillance of deterioration. The aim of this study was to discover what factors influence how nurses assess patient acuity and their response to acute deterioration. METHODS: a generic qualitative approach was used...
February 22, 2018: British Journal of Nursing: BJN
https://www.readbyqxmd.com/read/29432461/a-smart-all-in-one-device-to-measure-vital-signs-in-admitted-patients
#20
Mariska Weenk, Harry van Goor, Maartje van Acht, Lucien Jlpg Engelen, Tom H van de Belt, Sebastian J H Bredie
BACKGROUND: Vital sign measurements in hospitalized patients by nurses are time consuming and prone to operational errors. The Checkme, a smart all-in-one device capable of measuring vital signs, could improve daily patient monitoring by reducing measurement time, inter-observer variability, and incorrect inputs in the Electronic Health Record (EHR). We evaluated the accuracy of self measurements by patient using the Checkme in comparison with gold standard and nurse measurements. METHODS AND FINDINGS: This prospective comparative study was conducted at the Internal Medicine ward of an academic hospital in the Netherlands...
2018: PloS One
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