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https://www.readbyqxmd.com/read/28196741/a-common-vision-and-the-power-of-collaboration-the-managing-epilepsy-well-network-mew
#1
EDITORIAL
Barbara C Jobst
No abstract text is available yet for this article.
February 11, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28193215/analysing-trends-and-forecasting-malaria-epidemics-in-madagascar-using-a-sentinel-surveillance-network-a-web-based-application
#2
Florian Girond, Laurence Randrianasolo, Lea Randriamampionona, Fanjasoa Rakotomanana, Milijaona Randrianarivelojosia, Maherisoa Ratsitorahina, Télesphore Yao Brou, Vincent Herbreteau, Morgan Mangeas, Sixte Zigiumugabe, Judith Hedje, Christophe Rogier, Patrice Piola
BACKGROUND: The use of a malaria early warning system (MEWS) to trigger prompt public health interventions is a key step in adding value to the epidemiological data routinely collected by sentinel surveillance systems. METHODS: This study describes a system using various epidemic thresholds and a forecasting component with the support of new technologies to improve the performance of a sentinel MEWS. Malaria-related data from 21 sentinel sites collected by Short Message Service are automatically analysed to detect malaria trends and malaria outbreak alerts with automated feedback reports...
February 13, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28188577/sofa-score-in-septic-patients-incremental-prognostic-value-over-age-comorbidities-and-parameters-of-sepsis-severity
#3
Francesca Innocenti, Camilla Tozzi, Chiara Donnini, Eleonora De Villa, Alberto Conti, Maurizio Zanobetti, Riccardo Pini
Several widely used scoring systems for septic patients have been validated in an ICU setting, and may not be appropriate for other settings like Emergency Departments (ED) or High-Dependency Units (HDU), where a relevant number of these patients are managed. The purpose of this study is to find reliable tools for prognostic assessment of septic patients managed in an ED-HDU. In 742 patients diagnosed with sepsis/severe sepsis/septic shock, not-intubated, admitted in ED between June 2008 and April 2016, SOFA, qSOFA, PIRO, MEWS, Charlson Comorbidity Index, MEDS, and APACHE II were calculated at ED admission (T0); SOFA and MEWS were also calculated after 24 h of ED-High-Dependency Unit stay (T1)...
February 10, 2017: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/28186411/controlling-near-infrared-chromophore-electronic-properties-through-metal-ligand-orbital-alignment
#4
Nicole M Mews, Andreas Berkefeld, Gerald Hörner, Hartmut Schubert
Transition-metal complexes of radical ligands can exhibit low-energy electronic transitions in the near-infrared (NIR) spectral region. NIR band energy and intensity sensitively depend on the degree of electronic coupling of the chromophore. Using the example of open-shell complexes derived from platinum and a 1,4-terphenyldithiophenol, we present a novel approach toward spectroscopically distinct NIR dyes for which the degree of electronic coupling correlates with the relative orientation of radical ligand and metal orbitals...
February 10, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28179046/medium-and-long-term-prognostic-validity-of-competing-classification-proposals-for-the-former-somatoform-disorders
#5
S Schumacher, W Rief, K Klaus, E Brähler, R Mewes
BACKGROUND: DSM-5 introduced a fundamental revision of the category of somatoform disorders, which resulted in the new somatic symptom disorder (SSD) and related disorders. However, prognostic validity of SSD remains unclear, while other classification proposals, such as bodily distress disorder (BDD) or polysymptomatic distress disorder (PSDD), might be promising alternatives for the new ICD-11. Therefore, the comparison of the different approaches concerning long-term prognosis of disorder-relevant factors is of special interest...
February 9, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28177163/how-boron-doping-shapes-the-optoelectronic-properties-of-canonical-and-phenylene-containing-oligoacenes-a-combined-experimental-and-theoretical-investigation
#6
Sven Kirschner, Jan-Michael Mewes, Michael Bolte, Hans-Wolfram Lerner, Andreas Dreuw, Matthias Wagner
Optimized syntheses of 6,13-dimesityl-6,13-dihydro-6,13-diborapentacene (DBP) and a related compound (DBI) featuring two biphenylene-2,3-diyl units in place of naphthalene-2,3-diyl moieties are reported. Striking differences between the optoelectronic properties of DBP and DBI have been experimentally observed, and explained by quantum-chemical calculations. DBP is a member of the oligoacene family, DBI is a linear [N]phenylene derivative. The yellow DBP shows blue photoluminescence, the deep red DBI is non-fluorescent...
February 8, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28172527/knime4ngs-a-comprehensive-toolbox-for-next-generation-sequencing-analysis
#7
Maximilian Hastreiter, Tim Jeske, Jonathan Hoser, Michael Kluge, Kaarin Ahomaa, Marie-Sophie Friedl, Sebastian J Kopetzky, Jan-Dominik Quell, H-Werner Mewes, Robert Küffner
No abstract text is available yet for this article.
January 9, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28157242/one-pot-synthesis-of-ultrastable-pentanuclear-alkylzinc-complexes
#8
Hana Bunzen, Maciej Grzywa, Andreas Kalytta-Mewes, Dirk Volkmer
Two organometallic pentanuclear zinc complexes, namely [Zn5Et4(Me2bta)6] and [Zn5Me4(Me2bta)6], containing tridentate N-donor ligands (5,6-dimethylbenzotriazolate, Me2bta) were prepared by a one-pot synthesis. These compounds represent the first examples of organometallic complexes featuring a Kuratowski-type bond topology. Zinc ions were introduced as organometallic precursors (either diethylzinc or dimethylzinc was used), which upon mixing with the ligand yielded the desired complexes spontaneously. The organometallic complexes were characterized by a range of analytical techniques including NMR- and FT-IR spectroscopy, mass spectrometry, and elemental analysis...
February 3, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28139451/correlates-of-quality-of-life-among-individuals-with-epilepsy-enrolled-in-self-management-research-from-the-us-centers-for-disease-control-and-prevention-managing-epilepsy-well-network
#9
Martha Sajatovic, Curtis Tatsuoka, Elisabeth Welter, Daniel Friedman, Tanya M Spruill, Shelley Stoll, Satya S Sahoo, Ashley Bukach, Yvan A Bamps, Joshua Valdez, Barbara C Jobst
RATIONALE: Epilepsy is a chronic neurological condition that causes substantial burden on patients and families. Quality of life may be reduced due to the stress of coping with epilepsy. For nearly a decade, the Centers for Disease Control (CDC) Prevention Research Center's Managing Epilepsy Well (MEW) Network has been conducting research on epilepsy self-management to address research and practice gaps. Studies have been conducted by independent centers across the U.S. Recently, the MEW Network sites, collaboratively, began compiling an integrated database to facilitate aggregate secondary analysis of completed and ongoing studies...
January 27, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28113454/cryo-balloon-catheter-localization-based-on-a-support-vector-machine-approach
#10
Tanja Kurzendorfer, Philip W Mewes, Andreas Maier, Norbert Strobel, Alexander Brost
Cryo-balloon catheters have attracted an increasing amount of interest in the medical community as they can reduce patient risk during left atrial pulmonary vein ablation procedures. As cryo-balloon catheters are not equipped with electrodes, they cannot be localized automatically by electro-anatomical mapping systems. As a consequence, X-ray fluoroscopy has remained an important means for guidance during the procedure. Most recently, image guidance methods for fluoroscopy-based procedures have been proposed, but they provide only limited support for cryo-balloon catheters and require significant user interaction...
March 9, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28088129/in-vitro-eye-irritation-testing-using-the-open-source-reconstructed-hemicornea-a-ring-trial
#11
Karsten R Mewes, Maria Engelke, Michaela Zorn-Kruppa, Melinda Bartok, Rashmi Tandon, Johanna M Brandner, Dirk Petersohn
Aim of the present ring trial was to prove whether two new methodological approaches for the in vitro classification of eye irritating chemicals can be reliably transferred from the developers' laboratories to other sites.Both test methods are based on the well-established open source reconstructed 3D hemicornea models. In the first approach, the initial depth of injury in the hemicornea model after chemical treatment is derived from the quantitative analysis of histological sections. In the second approach tissue viability, as a measure for corneal damage after chemical treatment, is analyzed separately for epithelium and stroma of the hemicornea model...
January 14, 2017: ALTEX
https://www.readbyqxmd.com/read/28075238/safety-of-stationary-grinding-machines-impact-resistance-of-work-zone-enclosures
#12
Detlef Mewes, Christian Adler
Guards on machine tools are intended to protect persons from being injured by parts ejected with high kinetic energy from the work zone of the machine. Stationary grinding machines are a typical example. Generally such machines are provided with abrasive product guards closely enveloping the grinding wheel. However, many machining tasks do not allow the use of abrasive product guards. In such cases, the work zone enclosure has to be dimensioned so that, in case of failure, grinding wheel fragments remain inside the machine's working zone...
January 11, 2017: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/28069905/evaluation-of-the-threshold-value-for-the-modified-early-warning-score-mews-in-medical-septic-patients-a-secondary-analysis-of-an-italian-multicentric-prospective-cohort-snoopii-study
#13
D Tirotta, M Gambacorta, M La Regina, T Attardo, A Lo Gullo, F Panzone, A Mazzone, M Campanini, F Dentali
BACKGROUND: Due to aging and resources limitation, septic patients are often admitted to medical wards (MWs). Early warning deterioration is a relevant issue in this setting. Unfortunately, a suitable prognostic score has not been identified, yet. AIM: To explore the ability of Modified Early Warning Score (MEWS) to predict the in-hospital mortality in septic patients admitted to MWs. DESIGN: Secondary analysis of a multicentric prospective study...
January 9, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28069593/knime4ngs-a-comprehensive-toolbox-for-next
#14
Maximilian Hastreiter, Tim Jeske, Jonathan Hoser, Michael Kluge, Kaarin Ahomaa, Marie-Sophie Friedl, Sebastian J Kopetzky, Jan-Dominik Quell, H- Werner Mewes, Robert Küffner
: Analysis of Next Generation Sequencing (NGS) data requires the processing of large datasets by chaining various tools with complex input and output formats. In order to automate data analysis, we propose to standardize NGS tasks into modular workflows. This simplifies reliable handling and processing of NGS data, and corresponding solutions become substantially more reproducible and easier to maintain. Here, we present a documented, linux-based, toolbox of 42 processing modules that are combined to construct workflows facilitating a variety of tasks such as DNAseq and RNAseq analysis...
January 9, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28007335/precision-medicine-in-rare-disease-mechanisms-of-disparate-effects-of-n-carbamyl-l-glutamate-on-mutant-cps1-enzymes
#15
Dashuang Shi, Gengxiang Zhao, Nicholas Ah Mew, Mendel Tuchman
This study documents the disparate therapeutic effect of N-carbamyl-l-glutamate (NCG) in the activation of two different disease-causing mutants of carbamyl phosphate synthetase 1 (CPS1). We investigated the effects of NCG on purified recombinant wild-type (WT) mouse CPS1 and its human corresponding E1034G (increased ureagenesis on NCG) and M792I (decreased ureagenesis on NCG) mutants. NCG activates WT CPS1 sub-optimally compared to NAG. Similar to NAG, NCG, in combination with MgATP, stabilizes the enzyme, but competes with NAG binding to the enzyme...
December 8, 2016: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/27995259/on-the-accuracy-of-the-general-state-specific-polarizable-continuum-model-for-the-description-of-correlated-ground-and-excited-states-in-solution
#16
Jan-Michael Mewes, John M Herbert, Andreas Dreuw
Equilibrium and non-equilibrium formulations of the state-specific polarizable-continuum model (SS-PCM) are evaluated in combination with correlated ground- and excited-state densities provided by the algebraic-diagrammatic construction method (ADC) for the polarization propagator via the computationally efficient intermediate-state representation (ISR) formalism. Since the influence of the SS-PCM onto quantum-chemical method is naturally limited to the presence of the apparent surface charges in the one-electron Hamiltonian and hence fully contained in the polarized MOs, the herein presented solvent model can be combined with all implemented orders and variants of ADC...
January 4, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27942621/unravelling-the-early-photochemical-behavior-of-8-substituted-7-hydroxyquinolinyl-methyl-acetates-through-electronic-structure-theory-and-ultrafast-transient-absorption-spectroscopy
#17
Jiani Ma, Jan-Michael Mewes, Kyle T Harris, Timothy M Dore, David Lee Phillips, Andreas Dreuw
The photophysical processes and photochemical reactions in the ultrafast time region of (8-bromo-7-hydroxyquinolin-2-yl)methyl acetate (BHQ-OAc) in acetonitrile and neutral aqueous solutions were investigated using quantum chemical calculations and femtosecond transient absorption spectroscopy. After initial excitation into the π,π* excited state, BHQ-OAc undergoes an ultrafast intersystem crossing (ISC) into a π,π* excited triplet state on a timescale of 16 ps. The n,π* and π,π* excited singlet and triplet states involved in the photochemistry were identified by means of their characteristic excited state absorption (ESA) bands and from second order coupled-cluster (CC2) calculations...
January 4, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27872954/osteitis-a-retrospective-feasibility-study-comparing-single-source-dual-energy-ct-to-mri-in-selected-patients-with-suspected-acute-gout
#18
Torsten Diekhoff, Michael Scheel, Sandra Hermann, Jürgen Mews, Bernd Hamm, Kay-Geert A Hermann
OBJECTIVE: Dual-energy computed tomography detects tophi in patients with chronic gout. However, other information that can be obtained from the same scan is not the focus of the current research, e.g., the detection of bone marrow edema (BME) using virtual bone marrow imaging (VBMI). The aim of this study was to evaluate if BME in patients with acute arthritis can be detected with VBMI using magnetic resonance imaging (MRI) as the standard of reference. MATERIALS AND METHODS: This retrospective study included 11 patients who underwent both MRI and dual-energy computed tomography (mean interval of 40 days)...
February 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/27832561/improved-hospital-mortality-with-a-low-met-dose-the-importance-of-a-modified-early-warning-score-and-communication-tool
#19
D V Mullany, M Ziegenfuss, M A Goleby, H E Ward
Rapid response systems have been mandated for the recognition and management of the deteriorating patient. Increasing medical emergency team (MET) dose may be associated with improved outcomes. Large numbers of MET calls may divert resources from the program providing the service unless additional personnel are provided. To describe the implementation and outcomes of a multifaceted rapid response system (RRS) in a teaching hospital, we conducted an observational study. The RRS consisted of the introduction of a MET together with 1) redesign of the ward observation chart with the vital sign variables colour-coded to identify variation from normal; 2) mandated minimum frequency of vital sign measurement; 3) three formal levels of escalation based on the degree of physiological instability as measured by a modified early warning score (MEWS); 4) COMPASS© education and e-learning package with a two-hour face-to-face small group tutorial; 5) practise in escalation and communication using the ISBAR (Identify, Situation, Background, Assessment, Response/Recommendation) communication tool...
November 2016: Anaesthesia and Intensive Care
https://www.readbyqxmd.com/read/27811448/the-comparison-of-modified-early-warning-score-and-glasgow-coma-scale-age-systolic-blood-pressure-scores-in-the-assessment-of-nontraumatic-critical-patients-in-emergency-department
#20
Ö Köksal, G Torun, E Ahun, D Sığırlı, S B Güney, M O Aydın
INTRODUCTION: The purpose of this study is to assess and compare the discriminatory ability of the Glasgow coma scale (GCS)-age-systolic blood pressure (GAP) score and modified early warning scoring system (mEWS) score for 4-week mortality, for the patients being in the triage category 1 and 2 who refer to Emergency Department (ED). METHODS: Five hundred and two nontraumatic cases being in the triage category 1 and 2 who were ≥18-year-old and who referred to ED were assessed prospectively...
November 2016: Nigerian Journal of Clinical Practice
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