keyword
https://read.qxmd.com/read/37356213/current-and-future-role-of-double-lung-transplantation-for-bilateral-lung-cancer
#21
REVIEW
Jeeyeon Lee, Samuel J Schellenberg, Liam Il-Young Chung, Ankit Bharat, Young Kwang Chae
Technological advances have progressively enhanced the survival rate of lung transplant recipients and expanded its indications for various diseases, including the recent coronavirus disease 2019 (COVID-19). However, according to the International Society for Heart and Lung Transplantation, lung cancer constituted a mere 0.1% of the indications for lung transplantation over the past two decades. This statistic has remained stagnant, and numerous lung cancer patients continue to be excluded from lung transplantation candidacy...
June 17, 2023: Transplantation Reviews
https://read.qxmd.com/read/37187320/lung-transplant-survival-with-past-and-concomitant-cardiac-revascularization
#22
JOURNAL ARTICLE
Theresa Tran, Mohammed A Kashem, Ahad Firoz, Roh Yanagida, Norihisa Shigemura, Yoshiya Toyoda
BACKGROUND: Coronary artery disease is common among lung transplant (LTx) candidates and has historically been viewed as a contraindication to the procedure. Survival outcomes of lung transplant recipients with concomitant coronary artery disease who had prior or perioperative revascularization remain a topic of conversation. METHODS: A retrospective analysis of all single and double lung transplant patients from Feb, 2012 to Aug, 2021 at a single center was performed (n = 880)...
May 13, 2023: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/37041499/short-telomere-syndrome-presenting-with-pulmonary-fibrosis-liver-cirrhosis-and-hepatopulmonary-syndrome-a-case-report
#23
JOURNAL ARTICLE
Andrew Baird, Marcio Gomes, Carolina A Souza, Kate Magner, Gonzalo Alvarez
BACKGROUND: Idiopathic pulmonary fibrosis is thought to result from aberrant post-injury activation of epithelial cells leading to fibroblast proliferation and activation. A number of genetic aetiologies have been implicated in this disease process, including, among others, the short telomere syndromes. Short telomere syndromes follow an autosomal dominant pattern of inheritance resulting in shortened telomere length, which consequently leads to accelerated cell death. Organs with rapid cell turnover are most affected...
April 11, 2023: BMC Pulmonary Medicine
https://read.qxmd.com/read/36967372/effect-of-donor-smoking-and-substance-use-on-post-lung-transplant-outcomes
#24
JOURNAL ARTICLE
Jesse M Rappaport, Hafiz Umair Siddiqui, Lucy Thuita, Marie Budev, Kenneth R McCurry, Eugene H Blackstone, Usman Ahmad
OBJECTIVE: The study objective was to determine effects of donor smoking and substance use on primary graft dysfunction, allograft function, and survival after lung transplant. METHODS: From January 2007 to February 2020, 1366 lung transplants from 1291 donors were performed in 1352 recipients at Cleveland Clinic. Donor smoking and substance use history were extracted from the Uniform Donor Risk Assessment Interview and medical records. End points were post-transplant primary graft dysfunction, longitudinal forced expiratory volume in 1 second (% of predicted), and survival...
February 7, 2023: Journal of Thoracic and Cardiovascular Surgery
https://read.qxmd.com/read/36963446/pulmonary-epithelial-markers-in-phenotypes-of-chronic-lung-allograft-dysfunction
#25
JOURNAL ARTICLE
Liran Levy, Sajad Moshkelgosha, Ella Huszti, Sarah Hunter, Benjamin Renaud-Picard, Gregory Berra, Mitsuaki Kawashima, Juan Fernandez-Castillo, Eyal Fuchs, Milagros Dianti, Rasheed Ghany, Shaf Keshavjee, Lianne G Singer, Jussi Tikkanen, Tereza Martinu
BACKGROUND: Airway epithelial injury is thought to be a key event in the pathogenesis of chronic lung allograft dysfunction (CLAD). We investigated whether markers of epithelial activity and injury in bronchoalveolar lavage fluid (BAL) correlate with CLAD diagnosis and major CLAD phenotypes: bronchiolitis obliterans syndrome (BOS) vs. restrictive allograft syndrome (RAS)-related phenotypes (including RAS, mixed phenotype, and all other patients with RAS-like opacities). METHODS: CLAD status and phenotypes were retrospectively determined in a cohort of all consecutive adult, first, bilateral lung transplants performed 2010-2015, with available BAL samples...
March 22, 2023: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/36895261/-candida-parapsilosis-infection-after-double-lung-transplantation-in-a-patient-with-pulmonary-fibrosis-caused-by-covid-19
#26
Hong-Rui Chen, Mei Xue, Hao Zhou, Yao-Gong Wu, Yan Chen, Wan-Xin Chen
Pulmonary fibrosis is a complication in patients with coronavirus disease 2019 (COVID-19). Extensive pulmonary fibrosis is a severe threat to patients' life and lung transplantation is last resort to prolong the life of patients. We reported a case of critical type COVID-19 patient, though various treatment measures were used, including anti-virus, anti-infection, improving immunity, convalescent plasma, prone position ventilation, and airway cleaning by fiber-optic bronchoscope, although his COVID-19 nucleic acid test turned negative, the patient still developed irreversible extensive pulmonary fibrosis, and respiratory mechanics suggested that lung compliance could not be effectively recovered...
2023: CytoJournal
https://read.qxmd.com/read/36757715/one-year-outcomes-of-lung-transplantation-for-covid-19-associated-end-stage-lung-disease-in-the-united-states
#27
JOURNAL ARTICLE
Kenji Okumura, Soma Jyothula, Thomas Kaleekal, Abhay Dhand
BACKGROUND: Lung transplantation can provide quality of life and survival benefits in patients with COVID-19 associated end-stage lung disease. Characteristics and outcomes of these lung transplant recipients are limited to mostly single center experiences or provide a short-term follow up. METHODS: Characteristics of deceased donors and adult lung transplant recipients for COVID-19 associated end stage lung disease between August-2020 and June-2022 were analyzed using the de-identified United Network for Organ Sharing database...
February 9, 2023: Clinical Infectious Diseases
https://read.qxmd.com/read/36514019/design-and-rationale-for-the-prospective-treatment-efficacy-in-ipf-using-genotype-for-nac-selection-precisions-clinical-trial
#28
JOURNAL ARTICLE
Anna J Podolanczuk, John S Kim, Christopher B Cooper, Joseph A Lasky, Susan Murray, Justin M Oldham, Ganesh Raghu, Kevin R Flaherty, Cathie Spino, Imre Noth, Fernando J Martinez
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with few treatment options. N-acetylcysteine (NAC) is a well-tolerated, inexpensive treatment with antioxidant and anti-fibrotic properties. The National Heart, Lung, and Blood Institute (NHLBI)-sponsored PANTHER (Prednisone Azathioprine and NAC therapy in IPF) trial confirmed the harmful effects of immunosuppression in IPF, and did not show a benefit to treatment with NAC. However, a post hoc analysis revealed a potential beneficial effect of NAC in a subgroup of individuals carrying a specific genetic variant, TOLLIP rs3750920 TT genotype, present in about 25% of patients with IPF...
December 13, 2022: BMC Pulmonary Medicine
https://read.qxmd.com/read/36380578/fungal-infection-and-colonization-in-lung-transplant-recipients-with-chronic-lung-allograft-dysfunction
#29
JOURNAL ARTICLE
Kelly M Pennington, Meghan Aversa, Tereza Martinu, Bradley Johnson, Shahid Husain
BACKGROUND: The incidence and impact of de novo fungal airway colonization and infection in lung transplant recipients (LTRs) with known chronic lung allograft dysfunction (CLAD) has not been established. We aimed to determine the 1-year cumulative incidence and risk factors of de novo fungal colonization or infection in LTRs with CLAD and assess the impact of colonization or infection on post-CLAD survival. METHODS: Prospectively collected Toronto Lung Transplant Program database and chart review were used for double-LTRs who were diagnosed with CLAD from January 1, 2016 to January 1, 2020 and who were free of airway fungi within 1 year prior to CLAD onset...
December 2022: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://read.qxmd.com/read/36311553/disseminated-tuberculosis-in-a-lung-transplant-recipient-presenting-as-tenosynovitis-subcutaneous-nodules-and-liver-abscesses
#30
Lilian Vargas Barahona, José Henao-Cordero, Joshua Smith, Alice Gray, Carrie B Marshall, Sias Scherger, Valida Bajrovic, Yiannis Koullias
Tuberculosis is of particular concern in lung transplant recipients. We present the case of a patient who received a double lung transplant from a deceased donor from Mexico and developed disseminated tuberculosis 60 days post-transplant manifested as tenosynovitis, liver abscesses, and subcutaneous nodules with no definitive lung allograft involvement. The recipient did not have evidence of tuberculosis on explanted lungs, had a negative interferon gamma release assay pre-transplant, and did not have risk factors for this infection...
January 2022: Therapeutic Advances in Infectious Disease
https://read.qxmd.com/read/36277208/characterization-of-chronic-lung-allograft-dysfunction-phenotypes-using-spectral-and-intrabreath-oscillometry
#31
JOURNAL ARTICLE
Anne Fu, Anastasiia Vasileva, Nour Hanafi, Natalia Belousova, Joyce Wu, Sarada Sriya Rajyam, Clodagh M Ryan, Zoltán Hantos, Chung-Wai Chow
Background: Chronic lung allograft dysfunction (CLAD) is the major cause of death beyond 2 years after lung transplantation and develops in 50% of all patients by 5 years post-transplant. CLAD is diagnosed on the basis of a sustained drop of 20% for at least 3 months in the forced expiratory volume (FEV1 ), compared to the best baseline value achieved post-transplant. CLAD presents as two main phenotypes: bronchiolitis obliterans syndrome (BOS) is more common and has better prognosis than restrictive allograft syndrome (RAS)...
2022: Frontiers in Physiology
https://read.qxmd.com/read/36275208/patient-engagement-in-the-development-of-cf-cbt-a-cystic-fibrosis-specific-cognitive-behavioral-intervention-for-adults
#32
JOURNAL ARTICLE
Deborah Friedman, Maysa M Kaskas, Alexandra L Quittner, Beth A Smith, Anna M Georgiopoulos
Individuals with cystic fibrosis (CF) are at high risk for depression and anxiety, with negative consequences for health and quality of life. Cystic Fibrosis Foundation/European Cystic Fibrosis Society guidelines recommend routine screening, treatment, and preventative efforts. Cognitive-behavioral therapy (CBT) has a large evidence-base for depression/anxiety prevention and treatment. However, traditional CBT protocols require adaptation to address the emotional challenges of coping with CF, stressors related to disease management, and barriers to access to care...
2022: Frontiers in Psychology
https://read.qxmd.com/read/36148594/endovascular-trans-atrial-stenting-of-pulmonary-vein-stenosis-after-lung-transplantation
#33
Michaela Orlitová, Marc Gewillig, Jan Van Slambrouck, Dirk Vlasselaers, Bart Jacobs, Arne P Neyrinck, Lieven Depypere, Laurent Godinas, Robin Vos, Geert M Verleden, Dirk Van Raemdonck, Laurens J Ceulemans
Pulmonary vein stenosis (PVS) and pulmonary vein occlusion (PVO) represent rare complications after lung transplantation (LTx) with limited therapeutic options and high risk of graft loss. We present two cases of successful endovascular trans-atrial stenting following double-LTx. A 60-year-old female with chronic obstructive pulmonary disease who underwent double lobar-LTx was diagnosed at post-operative day 72 with a high grade PVS on the left side. A 22-year-old female with idiopathic pulmonary arterial hypertension who underwent double-LTx was diagnosed 9 days later with PVO of the left upper lobe vein...
September 23, 2022: American Journal of Transplantation
https://read.qxmd.com/read/36115497/inhaled-treprostinil-dose-in-pulmonary-hypertension-associated-with-interstitial-lung-disease-and-its-effects-on-clinical-outcomes
#34
JOURNAL ARTICLE
Steven D Nathan, Chunqin Deng, Christopher S King, Hilary M DuBrock, Jean Elwing, Sudarshan Rajagopal, Franz Rischard, Sandeep Sahay, Meredith Broderick, Eric Shen, Peter Smith, Victor F Tapson, Aaron B Waxman
BACKGROUND: Pulmonary hypertension (PH) complicates the course of many patients with fibrotic interstitial lung disease (ILD). Inhaled treprostinil has been shown to improve functional ability and delay clinical worsening in patients with PH-ILD. RESEARCH QUESTION: Do higher doses of inhaled treprostinil have greater benefits in preventing clinical worsening and achieving clinical improvement? STUDY DESIGN AND METHODS: Post-hoc analysis of the INCREASE study, a 16-week double-blind, randomized, placebo-controlled trial of inhaled treprostinil in patients with PH due to ILD...
September 14, 2022: Chest
https://read.qxmd.com/read/36060170/post-double-lung-transplant-emergent-cervical-spine-surgery-and-covid-pandemic-a-triple-threat-to-perioperative-management
#35
JOURNAL ARTICLE
Alex Sapa, Lashmi Venkatraghavan, Tumul Chowdhury
No abstract text is available yet for this article.
July 2022: Journal of Anaesthesiology, Clinical Pharmacology
https://read.qxmd.com/read/35887891/diabetes-is-an-independent-risk-factor-for-cancer-after-heart-and-or-lung-transplantation
#36
JOURNAL ARTICLE
Hristo Kirov, Alexandros Moschovas, Tulio Caldonazo, Imke Schwan, Gloria Faerber, Tim Sandhaus, Thomas Lehmann, Torsten Doenst
BACKGROUND: De novo cancers are feared complications after heart or lung transplantation. Recent data suggest that diabetes mellitus (DM) might also be a risk factor for cancer. We hypothesized that transplanted diabetic patients are at greater risk of developing cancer compared to non-diabetic ones. METHODS: We reviewed 353 patients post-heart and/or -lung transplantation from our center between October 1999 and June 2021. Patients with follow-up <180 days ( n = 87) were excluded from the analysis...
July 15, 2022: Journal of Clinical Medicine
https://read.qxmd.com/read/35806227/non-classical-hla-determinants-of-the-clinical-response-after-autologous-stem-cell-transplantation-for-systemic-sclerosis
#37
JOURNAL ARTICLE
Wahid Boukouaci, Pauline Lansiaux, Nathalie C Lambert, Christophe Picard, Emmanuel Clave, Audrey Cras, Zora Marjanovic, Dominique Farge, Ryad Tamouza
Systemic Sclerosis (SSc) is a chronic autoimmune disease with high morbidity and mortality. Autologous Hematopoietic Stem Cell Transplantation (AHSCT) is the best therapeutic option for rapidly progressive SSc, allowing increased survival with regression of skin and lung fibrosis. The immune determinants of the clinical response after AHSCT have yet to be well characterized. In particular, the pivotal role of the Human Leukocyte Antigen (HLA) system is not well understood, including the role of non-classical immuno-modulatory HLA-E and HLA-G molecules in developing tolerance and the role of Natural Killer cells (NK) in the immunomodulation processes...
June 29, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/35648112/interdisciplinary-management-for-the-first-patient-with-post-covid-double-lung-transplantation-in-inpatient-rehabilitation-in-the-united-states-a-case-report
#38
JOURNAL ARTICLE
Tessa Herrmann, Jacqueline Iglesias, Samantha Smith
OBJECTIVE: In the setting of the COVID-19 pandemic, lung transplantation is being used as a life-saving treatment. This case report describes the rehabilitation course of the first documented individual in the United States post bilateral lung transplant for COVID-19. METHODS (CASE DESCRIPTION): The patient is a 28-year-old woman who was previously healthy and who failed all other life-saving medical interventions before undergoing bilateral lung transplantation, resulting in an extended hospital stay and significant physical debility...
September 4, 2022: Physical Therapy
https://read.qxmd.com/read/35589861/corticotropin-releasing-hormone-as-an-identifier-of-bronchiolitis-obliterans-syndrome
#39
JOURNAL ARTICLE
Anna Niroomand, Haider Ghaidan, Oskar Hallgren, Lennart Hansson, Hillevi Larsson, Darcy Wagner, Martina Mackova, Kieran Halloran, Snejana Hyllén, Sandra Lindstedt
Lung transplantion (LTx) recipients have low long-term survival and a high incidence of bronchiolitis obliterans syndrome (BOS), an inflammation of the small airways in chronic rejection of a lung allograft. There is great clinical need for a minimally invasive biomarker of BOS. Here, 644 different proteins were analyzed to detect biomarkers that distinguish BOS grade 0 from grades 1-3. The plasma of 46 double lung transplant patients was analyzed for proteins using a high-component, multiplex immunoassay that enables analysis of protein biomarkers...
May 19, 2022: Scientific Reports
https://read.qxmd.com/read/35501172/results-of-lung-transplantations-among-cystic-fibrosis-patients-a-single-center-study
#40
JOURNAL ARTICLE
Maciej Urlik, Tomasz Stącel, Magdalena Latos, Mirosław Nęcki, Fryderyk Zawadzki, Piotr Pasek, Piotr Przybyłowski, Marek Ochman
BACKGROUND: Lung transplantation remains the ultimate treatment for patients who have exhausted all other therapeutic options in the course of end-stage lung disease due to cystic fibrosis (CF). The aim of the study was to assess the results of lung transplantations performed via mini-thoracotomy in a single center. METHODS: This retrospective study assesses the survival and need for reoperation among 56 primary lung transplant recipients due to CF in a single center between 2018 and 2021...
May 2022: Transplantation Proceedings
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