Qingyong Xu, Mohamed Elrefaei, Jean-Luc Taupin, Kelley Mk Hitchman, Steven Hiho, Alison Gareau, Carlo Iasella, Marilyn Marrari, Natalia Belousova, Maria Bettinotti, Tathagat Narula, Francisco Alvarez, Pablo G Sanchez, Bronwyn Levvey, Glen Westall, Gregory Snell, Deborah J Levine, Adriana Zeevi, Antoine Roux
BACKGROUND: Chronic Lung Allograft Dysfunction (CLAD) is the major cause of adverse outcomes in lung transplant recipients. Multiple factors, such as infection, alloimmunity, and autoimmunity, may lead to CLAD. Here, we aim to examine the role of non-HLA antibodies in CLAD in a large retrospective cohort. METHODS: We analyzed non-HLA antibodies in the pre-and post-transplant sera of 226 (100 CLAD, 126 stable) lung transplant recipients from 5 centers, and we used a separate cohort to confirm our findings...
December 21, 2023: Journal of Heart and Lung Transplantation