keyword
https://read.qxmd.com/read/38341659/impact-of-cryoablation-on-operative-outcomes-in-thoracotomy-patients
#1
JOURNAL ARTICLE
Kian Pourak, Rachel Kubiak, Kumaran Arivoli, Kiran Lagisetty, William Lynch, Jules Lin, Andrew Chang, Rishindra M Reddy
OBJECTIVES: Cryoablation is increasingly being utilized as an alternative to epidurals for patients undergoing thoracotomies. Current evidence suggests cryoablation may decrease post-operative analgesia utilization, but could increase operative times. We hypothesized that the adoption of intraoperative cryoablation to manage post-thoracotomy pain would result in reduced length of stay and reduced perioperative analgesia compared to routine epidural use. METHODS: A retrospective analysis was performed from a single, quaternary referral center, prospective database on patients receiving thoracotomies between 01/2020-03/2022...
February 10, 2024: Interdiscip Cardiovasc Thorac Surg
https://read.qxmd.com/read/38310997/impact-of-minimally-invasive-lung-transplantation-on-early-outcomes-and-analgesia-use-a-matched-cohort-study
#2
JOURNAL ARTICLE
Jason Thomas, Qiudong Chen, Jad Malas, Darina Barnes, Amy Roach, Achille Peiris, Sharmini Premananthan, Aasha Krishnan, Georgina Rowe, George Gill, Lorenzo Zaffiri, Joanna Chikwe, Dominic Emerson, Pedro Catarino, Reinaldo Rampolla, Dominick Megna
INTRODUCTION: Minimally invasive (MI) approaches to lung transplantation (LTx) offer the prospect of faster recovery compared to traditional incisions, however, little data exist describing the impact of surgical technique on early outcomes and analgesia use. METHODS: A prospectively maintained institutional registry identified 170 patients who underwent LTx between 01/2017 and 06/2022. Post-COVID acute respiratory distress syndrome, repeat, and multiorgan transplants were excluded (n=27) leaving 37 MILTx and 106 traditional LTx patients...
February 2, 2024: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/38309959/-standard-technical-specifications-for-methacholine-chloride-methacholine-bronchial-challenge-test-2023
#3
JOURNAL ARTICLE
(no author information available yet)
The methacholine challenge test (MCT) is a standard evaluation method of assessing airway hyperresponsiveness (AHR) and its severity, and has significant clinical value in the diagnosis and treatment of bronchial asthma. A consensus working group consisting of experts from the Pulmonary Function and Clinical Respiratory Physiology Committee of the Chinese Association of Chest Physicians, the Task Force for Pulmonary Function of the Chinese Thoracic Society, and the Pulmonary Function Group of Respiratory Branch of the Chinese Geriatric Society jointly developed this consensus...
February 12, 2024: Chinese Journal of Tuberculosis and Respiratory Diseases
https://read.qxmd.com/read/38240878/unveiling-the-complexities-of-lung-transplantation-in-situs-inversus
#4
JOURNAL ARTICLE
Chitaru Kurihara, Taisuke Kaiho, Ankit Bharat
BACKGROUND: Lung transplantation for situs inverse is considered technically challenging because of the reverse positioning of the organs. By providing a detailed description of the surgical procedure, perioperative care, and post-transplant follow-up, we aim to contribute valuable information to the existing knowledge base. We presented two cases of successful bilateral sequential lung transplantation in situs inverse patients. CASE PRESENTATION: Our first patient was a 28-year-old, non-smoking woman with Kartagener syndrome and advanced bronchiectasis that developed into pneumonia and required repeated hospital admissions...
January 19, 2024: Surgical Case Reports
https://read.qxmd.com/read/38202198/intraoperative-extracorporeal-support-during-lung-transplantation-not-just-for-the-high-risk-patient
#5
REVIEW
Daniel Laskey, Brian Housman, Gbalekan Dawodu, Scott Scheinin
The use of intraoperative mechanical support during lung transplantation has traditionally been a controversial topic. Trends for intraoperative mechanical support strategies swing like a pendulum. Historically, cardiopulmonary bypass (CPB) was the modality of choice during transplantation. It provides full hemodynamic support including oxygenation and decarboxylation. Surgical exposure is improved by permitting the drainage of the heart and provides more permissive retraction. CPBs contain drainage reservoirs with hand-held pump suction catheters promoting blood conservation through collection and re-circulation...
December 29, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/38141896/chronic-lung-allograft-dysfunction-is-associated-with-an-increased-number-of-non-hla-antibodies
#6
JOURNAL ARTICLE
Qingyong Xu, Mohamed Elrefaei, Jean-Luc Taupin, Kelley Mk Hitchman, Steven Hiho, Alison Gareau, Carlo Iasella, Marilyn Marrari, Natalia Belousova, Maria Bettinotti, Tathagat Narula, Francisco Alvarez, Pablo G Sanchez, Bronwyn Levvey, Glen Westall, Gregory Snell, Deborah J Levine, Adriana Zeevi, Antoine Roux
BACKGROUND: Chronic Lung Allograft Dysfunction (CLAD) is the major cause of adverse outcomes in lung transplant recipients. Multiple factors, such as infection, alloimmunity, and autoimmunity, may lead to CLAD. Here, we aim to examine the role of non-HLA antibodies in CLAD in a large retrospective cohort. METHODS: We analyzed non-HLA antibodies in the pre-and post-transplant sera of 226 (100 CLAD, 126 stable) lung transplant recipients from 5 centers, and we used a separate cohort to confirm our findings...
December 21, 2023: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/38116170/oscillometry-in-stable-single-and-double-lung-allograft-recipients-transplanted-for-interstitial-lung-disease-results-of-a-multi-center-australian-study
#7
MULTICENTER STUDY
Joan P Y Sim, Kristopher Nilsen, Brigitte M Borg, Bronwyn Levvey, Jaideep Vazirani, Samantha Ennis, Marshall Plit, Gregory I Snell, David R Darley, Katrina O Tonga
Peak spirometry after single lung transplantation (SLTx) for interstitial lung disease (ILD) is lower than after double lung transplantation (DLTx), however the pathophysiologic mechanisms are unclear. We aim to assess respiratory mechanics in SLTx and DLTx for ILD using oscillometry. Spirometry and oscillometry (tremoflo® C-100) were performed in stable SLTx and DLTx recipients in a multi-center study. Resistance (R5 , R5-19 ) and reactance (X5 ) were compared between LTx recipient groups, matched by age and gender...
2023: Transplant International
https://read.qxmd.com/read/38050347/survival-outcomes-after-double-lung-transplantation-for-refractory-lung-limited-cancers-and-incidence-of-post-transplant-lung-cancer
#8
JOURNAL ARTICLE
Jeeyeon Lee, Maria Jose Aguilera Chuchuca, Jisang Yu, Liam Il-Young Chung, Ankit Bharat, Young Kwang Chae
BACKGROUND To evaluate the role of double-lung transplantation (DLT) for lung cancer, the survival outcomes of patients who underwent DLT for lung cancer and the incidence of de novo lung cancer after DLT were assessed. MATERIAL AND METHODS Data from all cases reported in the literature were pooled for analysis and additional data were collected from the Organ Procurement Transplantation Network (OPTN) registry. Recurrence-free survival (RFS), overall survival (OS), and cancer-specific survival (CSS) of patients who underwent DLT for lung cancer were determined...
December 5, 2023: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://read.qxmd.com/read/37922037/impaired-immune-responses-and-prolonged-viral-replication-in-lung-allograft-recipients-infected-with-sars-cov-2-in-the-early-phase-after-transplantation
#9
JOURNAL ARTICLE
Olaf M Glueck, Xiaoling Liang, Irina Badell, Paul R Wratil, Alexander Graf, Stefan Krebs, Helmut Blum, Johannes C Hellmuth, Clemens Scherer, Alexandra Hollaus, Patricia M Spaeth, Burak Karakoc, Thimo Fuchs, Julia Zimmermann, Teresa Kauke, Andreas Moosmann, Oliver T Keppler, Christian Schneider, Maximilian Muenchhoff
PURPOSE: Lung transplant recipients are at increased risk of severe disease following infection with severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) due to high-dose immunosuppressive drugs and the lung is the main organ affected by Coronavirus disease 2019 (COVID-19). Several studies have confirmed increased SARS-CoV-2-related mortality and morbidity in patients living with lung allografts; however, detailed immunological studies of patients with SARS-CoV-2 infection in the early phase following transplantation remain scarce...
November 3, 2023: Infection
https://read.qxmd.com/read/37887781/-pneumocystis-jirovecii-pneumonia-after-heart-transplantation-two-case-reports-and-a-review-of-the-literature
#10
REVIEW
Carlo Burzio, Eleonora Balzani, Silvia Corcione, Giorgia Montrucchio, Anna Chiara Trompeo, Luca Brazzi
Post-transplant Pneumocystis jirovecii pneumonia (PcP) is an uncommon but increasingly reported disease among solid organ transplantation (SOT) recipients, associated with significant morbidity and mortality. Although the introduction of PcP prophylaxis has reduced its overall incidence, its prevalence continues to be high, especially during the second year after transplant, the period following prophylaxis discontinuation. We recently described two cases of PcP occurring more than one year after heart transplantation (HT) in patients who were no longer receiving PcP prophylaxis according to the local protocol...
October 21, 2023: Pathogens
https://read.qxmd.com/read/37851297/population-health-model-predicting-the-long-term-impact-of-sotatercept-on-morbidity-and-mortality-in-patients-with-pulmonary-arterial-hypertension-pah
#11
JOURNAL ARTICLE
Vallerie McLaughlin, Adnan Alsumali, Rongzhe Liu, Rogier Klok, Eliana C Martinez, Iman Nourhussein, David Bernotas, Jestinah Chevure, Christine Pausch, Janethe De Oliveira Pena, Dominik Lautsch, Marius M Hoeper
INTRODUCTION: Pulmonary arterial hypertension (PAH) is a rare, progressive disease associated with significant morbidity and mortality. The phase 3 STELLAR trial tested sotatercept plus background therapy (BGT) versus placebo plus BGT. BGT was comprised of mono-, double-, or triple-PAH targeted therapy. Building on STELLAR findings, we employed a population health model to assess the potential long-term clinical impact of sotatercept. METHODS: Based on the well-established ESC/ERS 4-strata risk assessment approach, we developed a six-state Markov-type model (low risk, intermediate-low risk, intermediate-high risk, high risk, lung/heart-lung transplant, and death) to compare the clinical outcomes of sotatercept plus BGT versus BGT alone over a lifetime horizon...
October 18, 2023: Advances in Therapy
https://read.qxmd.com/read/37838526/influence-of-donor-type-donation-after-brain-death-versus-donation-after-circulatory-death-on-lung-transplant-outcomes
#12
JOURNAL ARTICLE
Benito Cantador, Paula Moreno, Francisco Javier González, Eloísa Ruiz, Alba María Fernández, Antonio Álvarez
BACKGROUND: We sought to analyze the influence of lung donor type (brain death [BD] vs controlled donation after cardiac death [DCD]) on lung graft viability and to compare short-term outcomes of lung transplantation using grafts from BD and DCD donors. METHODS: This was a retrospective study of the lung donor population and lung transplants performed at our Institution between January 2020 and December 2022. Demographic characteristics of the donors and donation type (BD vs DCD) were assessed...
October 12, 2023: Transplantation Proceedings
https://read.qxmd.com/read/37758562/effect-of-mycetoma-in-lung-transplant-patients-a-single-center-experience
#13
JOURNAL ARTICLE
Supriya Singh, Jessica Lum, Aneela Majeed
BACKGROUND: Mycetomas are uncommon in lung transplant recipients. Prior studies have shown increased mortality associated with mycetoma in lung transplant recipients (LTR). We reviewed our center's experience in outcome of LTRs with pre -or post-transplant mycetoma. METHODS: We retrospectively reviewed electronic health records of LTRs performed at our institute between January 1, 2013 to December 31, 2020. RESULTS: Mycetoma was present in less than 1 percent of LTR patients (7/1086)...
September 25, 2023: Transplantation Proceedings
https://read.qxmd.com/read/37754826/epidemiology-and-long-term-outcomes-in-thoracic-transplantation
#14
REVIEW
Abey S Abraham, Manila Singh, Matthew S Abraham, Sanchit Ahuja
Over the past five decades, outcomes for lung transplantation have significantly improved in the early post-operative period, such that lung transplant is now the gold standard treatment for end-stage respiratory disease. The major limitation that impacts lung transplant survival rates is the development of chronic lung allograft dysfunction (CLAD). CLAD affects around 50% of lung transplant recipients within five years of transplantation. We must also consider other factors impacting the survival rate such as the surgical technique (single versus double lung transplant), along with donor and recipient characteristics...
September 18, 2023: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/37716872/ciltacabtagene-autoleucel-in-patients-with-prior-allogeneic-stem-cell-transplant-in-the-cartitude-1-study
#15
JOURNAL ARTICLE
Myo Htut, Binod Dhakal, Adam D Cohen, Thomas Martin, Jesus G Berdeja, Saad Z Usmani, Mounzer Agha, Carolyn C Jackson, Deepu Madduri, William Deraedt, Enrique Zudaire, Tzu-Min Yeh, Xiaoying Xu, Lida Pacaud, Muhammad Akram, Sundar Jagannath
BACKGROUND: Patients with prior allogeneic stem cell transplant (alloSCT) are typically excluded from trials of chimeric antigen receptor (CAR) T cell therapies, because their engineered cells may include allogeneic T cells. Ciltacabtagene autoleucel (cilta-cel) demonstrated early, deep, durable responses and manageable safety in heavily pretreated relapsed/refractory multiple myeloma patients. We retrospectively analyzed patients who received alloSCT prior to cilta-cel in CARTITUDE-1...
August 22, 2023: Clinical Lymphoma, Myeloma & Leukemia
https://read.qxmd.com/read/37703908/effect-of-once-per-day-tacrolimus-versus-twice-per-day-ciclosporin-on-3-year-incidence-of-chronic-lung-allograft-dysfunction-after-lung-transplantation-in-scandinavia-scanclad-a-multicentre-randomised-controlled-trial
#16
RANDOMIZED CONTROLLED TRIAL
Göran Dellgren, Thomas Kromann Lund, Peter Raivio, Inga Leuckfeld, Johan Svahn, Erik C Holmberg, Peter Skov Olsen, Maija Halme, Arnt Fiane, Sandra Lindstedt, Gerdt C Riise, Jesper Magnusson
BACKGROUND: Evidence is low regarding the choice of calcineurin inhibitor for immunosuppression after lung transplantation. We aimed to compare the use of tacrolimus once per day with ciclosporin twice per day according to the current definition of chronic lung allograft dysfunction (CLAD) after lung transplantation. METHODS: ScanCLAD is an investigator-initiated, open-label, multicentre, randomised, controlled trial in Scandinavia evaluating whether an immunosuppressive protocol based on anti-thymocyte globulin induction followed by tacrolimus (once per day), mycophenolate mofetil, and corticosteroids reduces the incidence of CLAD after de novo lung transplantation compared with a protocol using ciclosporin (twice per day), mycophenolate mofetil, and corticosteroids...
January 2024: Lancet Respiratory Medicine
https://read.qxmd.com/read/37663524/a-comprehensive-landscape-of-de-novo-malignancy-after-double-lung-transplantation
#17
JOURNAL ARTICLE
Jeeyeon Lee, Andrew Won Jun Yang, Liam Il-Young Chung, Jisang Yu, Yunjoo Lee, Hye Sung Kim, Hyun Joon Shin, Young-Geun Choi, Ankit Bharat, Young Kwang Chae
Although the association between post-transplant malignancy (PTM) and immunosuppressive therapy after organ transplantation has been studied, an integrated review of PTM after lung transplantation is lacking. We investigated the incidence and types of de novo PTM and its impact on survival following double lung transplantation (DLT). The incidence and type of PTM as well as the annual and cumulative risks of each malignancy after DLT were analyzed. The overall survival (OS) of recipients with or without PTM was compared by the Kaplan-Meier survival method and landmark analysis...
2023: Transplant International
https://read.qxmd.com/read/37625646/center-variability-in-the-prognostic-value-of-a-cumulative-acute-cellular-rejection-a-score-for-long-term-lung-transplant-outcomes
#18
JOURNAL ARTICLE
N Belousova, E Huszti, Q Li, A Vasileva, R Ghany, R Gabarin, M El Sanharawi, C Picard, D Hwang, L Levy, S Keshavjee, C W Chow, A Roux, T Martinu
The Acute Rejection Score (A-score) in lung transplant recipients, calculated as the average of acute cellular rejection A-grades across transbronchial biopsies, summarises the cumulative burden of rejection over time. We assessed the association between A-score and transplant outcomes in two geographically distinct cohorts. The primary cohort included 772 double lung transplant recipients. The analysis was repeated in 300 patients from an independent comparison cohort. Time-dependent multivariable Cox models were constructed to evaluate the association between A-score and CLAD or graft failure...
August 23, 2023: American Journal of Transplantation
https://read.qxmd.com/read/37465681/case-report-kinetics-and-durability-of-humoral-and-cellular-response-of-sars-cov-2-messenger-rna-vaccine-in-a-lung-and-kidney-transplant-recipient
#19
James Long, Mithil Soni, Pawel Muranski, Maureen J Miller, Cathleen Conry-Cantilena, Valeria De Giorgi
We present a case report of a 63-year-old female health care worker who is 15 years status post double lung transplant and six years status post living related donor kidney transplant who is healthy on a chronic immunosuppression regimen including prednisone, mycophenolate, and tacrolimus who received the SARS-CoV-2 mRNA vaccine (Pfizer-BioNTech BNT162b2) primary series and had poor initial humoral response to the COVID-19 mRNA vaccine, then demonstrated a robust, sustained immune response against S1 and S2 antigens for over seven months after receiving the recommended vaccine doses, including booster dose, without developing COVID-19 or other serious adverse events...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37397580/primary-lung-adenocarcinoma-in-transplanted-lung-in-post-bilateral-lung-transplantation
#20
Fathima Shafra Mubarak, Sanjay Agrawal, Jagan Rao
KEY CLINICAL MESSAGE: Primary lung cancer was reported by a bilateral lung transplant patient without any risk factors. Single lung transplantation should be contemplated instead of double lung transplantation as it has been shown to increase the risk of lung cancers. ABSTRACT: This is a case report of a 37-year-old woman, with no history of smoking, who developed adenocarcinoma in her transplanted lung 17 years post transplantation. The development of lung cancer 17 years after transplantation is considered as a rare finding in this case report...
July 2023: Clinical Case Reports
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